329 research outputs found
Scoping studies: towards a methodological framework
This paper focuses on scoping studies, an approach to reviewing the literature which to date has received little attention in the research methods literature. We distinguish between different types of scoping studies and indicate where these stand in relation to full systematic reviews. We outline a framework for conducting a scoping study based on our recent experiences of reviewing the literature on services for carers for people with mental health problems. Where appropriate, our approach to scoping the field is contrasted with the procedures followed in systematic reviews. We emphasize how including a consultation exercise in this sort of study may enhance the results, making them more useful to policy makers, practitioners and service users. Finally, we consider the advantages and limitations of the approach and suggest that a wider debate is called for about the role of the scoping study in relation to other types of literature reviews
Classification of Flat Directions in Perturbative Heterotic Superstring Vacua with Anomalous U(1)
We develop techniques to classify D- and F-flat directions for N=1
supersymmetric string vacua of the perturbative heterotic string theory, which
possess an anomalous U(1) gauge group at the tree level. Genus-one corrections
generate a Fayet-Iliopoulos term for the D-term of U(1)_A, which is canceled by
non-zero vacuum expectation values (VEVs) of certain massless multiplets in
such a way that the anomalous U(1) is broken, while maintaining the D- and
F-flatness of the effective field theory. A systematic analysis of flat
directions is given for non-zero VEVs of non-Abelian singlets, and the
techniques are illustrated for a specific model. The approach sets the stage to
classify the D- and F-flat directions for a large class of perturbative string
vacua. This classification is a prerequisite to address systematically the
phenomenological consequences of these models.Comment: 26 page
Modulation of LISA free-fall orbits due to the Earth-Moon system
We calculate the effect of the Earth-Moon (EM) system on the free-fall motion
of LISA test masses. We show that the periodic gravitational pulling of the EM
system induces a resonance with fundamental frequency 1 yr^-1 and a series of
periodic perturbations with frequencies equal to integer harmonics of the
synodic month (9.92 10^-7 Hz). We then evaluate the effects of these
perturbations (up to the 6th harmonics) on the relative motions between each
test masses couple, finding that they range between 3mm and 10pm for the 2nd
and 6th harmonic, respectively. If we take the LISA sensitivity curve, as
extrapolated down to 10^-6 Hz, we obtain that a few harmonics of the EM system
can be detected in the Doppler data collected by the LISA space mission. This
suggests that the EM system gravitational near field could provide an absolute
calibration for the LISA sensitivity at very low frequencies.Comment: 15 pages, 5 figure
A thermoresponsive and magnetic colloid for 3D cell expansion and reconfiguration
A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postculture by the simple process of lowering the temperature and applying an external magnetic field. The colloidal gel can be reconfigured with thermal and magnetic stimuli to allow patterning of cells in discrete zones and to control movement of cells within the porous matrix during culture
From weak coupling to spinning strings
We identify the gauge theory dual of a spinning string of minimal energy with
spins S_1, S_2 on AdS_5 and charge J on S^5. For this purpose we focus on a
certain set of local operators with two different types of covariant
derivatives acting on complex scalar fields. We analyse the corresponding
nested Bethe equations for the ground states in the limit of large spins. The
auxiliary Bethe roots form certain string configurations in the complex plane,
which enable us to derive integral equations for the leading and sub-leading
contribution to the anomalous dimension. The results can be expressed through
the observables of the sl(2) sub-sector, i.e. the cusp anomaly f(g) and the
virtual scaling function B_L(g), rendering the strong-coupling analysis
straightforward. Furthermore, we also study a particular sub-class of these
operators specialising to a scaling limit with finite values of the second spin
at weak and strong coupling.Comment: 23 pages, 3 figures, minor changes, references adde
Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which mycoplasma hyopneumoniae regulates surface topography
Mycoplasma hyopneumoniae causes enormous economic losses to swine production worldwide by colonizing the ciliated epithelium in the porcine respiratory tract, resulting in widespread damage to the mucociliary escalator, prolonged inflammation, reduced weight gain, and secondary infections. Protein Mhp684 (P146) comprises 1,317 amino acids, and while the N-terminal 400 residues display significant sequence identity to the archetype cilium adhesin P97, the remainder of the molecule is novel and displays unusual motifs. Proteome analysis shows that P146 preprotein is endogenously cleaved into three major fragments identified here as P50P146, P40P146, and P85P146 that reside on the cell surface. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) identified a semitryptic peptide that delineated a major cleavage site in Mhp684. Cleavage occurred at the phenylalanine residue within sequence 672ATEF2QQ677, consistent with a cleavage motif resembling S/T-X-F2XD/E recently identified in Mhp683 and other P97/P102 family members. Biotinylated surface proteins recovered by avidin chromatography and separated by two-dimensional gel electrophoresis (2-D GE) showed that more-extensive endoproteolytic cleavage of P146 occurs. Recombinant fragments F1P146-F3P146 that mimic P50P146, P40P146, and P85P146 were constructed and shown to bind porcine epithelial cilia and biotinylated heparin with physiologically relevant affinity. Recombinant versions of F3P146 generated from M. hyopneumoniae strain J and 232 sequences strongly bind porcine plasminogen, and the removal of their respective C-terminal lysine and arginine residues significantly reduces this interaction. These data reveal that P146 is an extensively processed, multifunctional adhesin of M. hyopneumoniae. Extensive cleavage coupled with variable cleavage efficiency provides a mechanism by which M. hyopneumoniae regulates protein topography
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Adapting coordinated specialty care in the post-COVID-19 era: study protocol for an integrative mixed-methods study
Background
Coordinated Specialty Care (CSC) programs provide evidence-based services for young people with a recent onset of a psychotic disorder. OnTrackNY is a nationally recognized model of CSC treatment in New York state. In 2019, OnTrackNY was awarded a hub within the Early Psychosis Intervention Network (EPINET) to advance its learning health care system (LHS). The OnTrackNY network is comprised of 23 CSC teams across New York state. OnTrack Central, an intermediary organization, provides training and implementation support to OnTrackNY teams. OnTrack Central coordinates a centralized data collection protocol for quality improvement and evaluation of program fidelity and a mechanism to support practice based-research. OnTrackNY sitesâ breadth coupled with OnTrack Central oversight provides an opportunity to examine the impacts of the COVID-19 crisis in New York State, and supplementary funding was awarded to the OnTrackNY EPINET hub in 2021 for that purpose.
Methods
This project will examine the implications of modifications to service delivery within the OnTrackNY LHS during and after the COVID-19 crisis. We will use the Framework for Reporting Adaptations and Modification-Enhanced (FRAME) to classify systematically, code, and analyze modifications to CSC services and ascertain their impact. We will utilize integrative mixed methods. Qualitative interviews with multi-level stakeholders (program participants, families, providers, team leaders, agency leaders, trainers (OnTrack Central), and decision-makers at the state and local levels) will be used to understand the process of making decisions, information about modifications to CSC services, and their impact. Analysis of OnTrackNY program data will facilitate examining trends in team staffing and functioning, and participant service utilization and outcomes. Study findings will be summarized in a CSC Model Adaptation Guide, which will identify modifications as fidelity consistent or not, and their impact on service utilization and care outcomes.
Discussion
A CSC Model Adaptation Guide will inform CSC programs, and the state and local mental health authorities to which they are accountable, regarding modifications to CSC services and the impact of these changes on care process, and participant service utilization and outcomes. The guide will also inform the development of tailored technical assistance that CSC programs may need within OnTrackNY, the EPINET network, and CSC programs nationally.
Trial registration
NCT04021719
, July 16th, 2019
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