Examining the Relationships and Patterns of Adult Patient Deviation in Populations of Disparity for Colorectal Cancer Screening In Southeast Georgia

Background: The findings from previous studies on the socio-demographic and socio-economic factors associated with non-adherence to Colorectal Cancer Screening (CRCS) in populations of health disparities are inconsistent, and few studies have utilized an integrative approach to deliver a CRCS intervention to at-risk adults. Methods: A cross-sectional study was conducted using data from the 2009-2010 Southeast Georgia Cancer Alliance Integrative project survey to describe the rates of negative patient deviation (non-adherence) to CRCS. Results: Almost 70% of at-risk adult participants were non-adherent to CRCS. Participants under 45 years of age were 1.8 times as likely to report a negative deviation compared to participants 45 years of age and older. Males were 1.7 times as likely to be non-adherent to CRCS compared to females. Obese participants were 7.8 times as likely to be non-adherent to CRCS compared to underweight, normal weight and overweight participants. A strong correlation existed between county of residence and negative deviation to CRCS. The results of the study support that age, gender, BMI and county of residence were significant factors that showed strong associations to non-adherence to CRCS. Conclusion: The findings suggest, understanding the relationships that exist between non-adherence to CRCS and factors that determine health outcomes are essential to reducing the mortality and morbidity of CRC. INDEX WORDS: Colorectal Cancer Screening, Colorectal Cancer, Non-adherence, Negative Patient Deviation, Southeast Georgia Cancer Alliance Integrative project, Populations/groups of health disparity, Colorectal Cancer prevention, Colonoscopy and FOB

Biosecurity and readiness of smallholder pig farmers against potential African Swine Fever outbreak and other pig diseases in Baybay City, Leyte, Philippines

Preventing African Swine Fever (ASF) outbreaks require an active involvement of pig growers as they are in the frontline of detection, notification, and the application of strict biosecurity measures. The Eastern Visayas (Region VIII) in Central Philippines is still free of ASF but the risk can be remarkable given the high volume of pigs that enter in this region as a market hub to large pig producers both coming from Luzon (north) and Mindanao (south). This study was conducted to better understand the readiness and biosecurity practices of smallholder pig farmers who comprise most of the pig growers in the City of Baybay, Leyte. Using multiple correspondence analysis (MCA) and agglomerative hierarchical clustering (AHC) technique of data from 350 pig farmer-respondents, our study found several areas in pig raising activities that need to be highlighted. While pig farmers were generally aware of the threat posed by ASF and have relatively good biosecurity practices, only 32.90% were convinced that the City of Baybay is prepared in the case of an ASF outbreak. Moreover, the importance of vaccination, footbath, and controlling swill feeding need to be emphasized (Cluster 2, 58.29%).  More efforts should be directed towards preparing and training pig farmers on disease monitoring and surveillance and improving further its biosecurity practices with special focus on bioexclusion. Similar studies should be conducted to nearby local government units particularly those located near entry and exit borders of the Eastern Visayas region

Effects of surface contamination on the interfacial properties of CO2/water/calcite systems

Understanding the wetting properties of reservoir rocks can be of great benefit for advanced applications such as the effective trapping and geological storage of CO2. Despite their importance, not all mechanisms responsible for wetting mineral surfaces in subsurface environments are well understood. Factors such as temperature, pressure and salinity are often studied, achieving results with little unanimity; other possible factors are left somewhat unexplored. One such factor is the effect of contamination. In the present study, the effects of adding a non-aqueous organic contaminant, ethanol, on the CO2–water interfacial tension (IFT) and the CO2/water/calcite contact angle were investigated using molecular dynamics simulations. Within the conditions studied, relatively small amounts of ethanol cause a significant decrease in the CO2–water IFTs, as well as a pronounced increase in the water-calcite-CO2 three phase contact angle. The latter result is due to the decrease of the IFT between CO2 and water and the strong adsorption of ethanol on the solid substrate. These findings could be helpful for explaining how impurities can affect experimental data and could lead to effective carbon sequestration strategies

Climate variability in the subarctic area for the last 2 millennia

To put recent climate change in perspective, it is necessary to extend the instrumental climate records with proxy data from paleoclimate archives. Arctic climate variability for the last 2 millennia has been investigated using statistical and signal analyses from three regionally averaged records from the North Atlantic, Siberia and Alaska based on many types of proxy data archived in the Arctic 2k database v1.1.1. In the North Atlantic and Alaska, the major climatic trend is characterized by long-term cooling interrupted by recent warming that started at the beginning of the 19th century. This cooling is visible in the Siberian region at two sites, warming at the others. The cooling of the Little Ice Age (LIA) was identified from the individual series, but it is characterized by wide-range spatial and temporal expression of climate variability, in contrary to the Medieval Climate Anomaly. The LIA started at the earliest by around AD 1200 and ended at the latest in the middle of the 20th century. The widespread temporal coverage of the LIA did not show regional consistency or particular spatial distribution and did not show a relationship with archive or proxy type either. A focus on the last 2 centuries shows a recent warming characterized by a well-marked warming trend parallel with increasing greenhouse gas emissions. It also shows a multidecadal variability likely due to natural processes acting on the internal climate system on a regional scale. A similar to 16-30-year cycle is found in Alaska and seems to be linked to the Pacific Decadal Oscillation, whereas similar to 20-30- and similar to 50-90-year periodicities characterize the North Atlantic climate variability, likely in relation with the Atlantic Multidecadal Oscillation. These regional features are probably linked to the sea ice cover fluctuations through ice-temperature positive feedback.Peer reviewe

Wharton’s jelly-derived mesenchymal stromal cells as a promising cellular therapeutic strategy for the management of graft-versus-host disease

Citation: McGuirk, J. P., Robert Smith, J., Divine, C. L., Zuniga, M., & Weiss, M. L. (2015). Wharton’s jelly-derived mesenchymal stromal cells as a promising cellular therapeutic strategy for the management of graft-versus-host disease. Pharmaceuticals, 8(2), 196-220. doi:10.3390/ph8020196Allogeneic hematopoietic cell transplantation (allo-HCT), a treatment option in hematologic malignancies and bone marrow failure syndromes, is frequently complicated by Graft-versus-host disease (GVHD). The primary treatment for GVHD involves immune suppression by glucocorticoids. However, patients are often refractory to the steroid therapy, and this results in a poor prognosis. Therefore alternative therapies are needed to treat GVHD. Here, we review data supporting the clinical investigation of a novel cellular therapy using Wharton’s jelly (WJ)-derived mesenchymal stromal cells (MSCs) as a potentially safe and effective therapeutic strategy in the management of GVHD. Adult-derived sources of MSCs have demonstrated signals of efficacy in the management of GVHD. However, there are limitations, including: limited proliferation capacity; heterogeneity of cell sources; lengthy expansion time to clinical dose; expansion failure in vitro; and a painful, invasive, isolation procedure for the donor. Therefore, alternative MSC sources for cellular therapy are sought. The reviewed data suggests MSCs derived from WJ may be a safe and effective cellular therapy for GVHD. Laboratories investigated and defined the immune properties of WJ-MSCs for potential use in cellular therapy. These cells represent a more uniform cell population than bone marrow-derived MSCs, displaying robust immunosuppressive properties and lacking significant immunogenicity. They can be collected safely and painlessly from individuals at birth, rapidly expanded and stored cryogenically for later clinical use. Additionally, data we reviewed suggested licensing MSCs (activating MSCs by exposure to cytokines) to enhance effectiveness in treating GVHD. Therefore, WJCs should be tested as a second generation, relatively homogeneous allogeneic cell therapy for the treatment of GVHD. © 2015 by the authors; licensee MDPI, Basel, Switzerland

Adaptive Optics Imaging of the AU Microscopii Circumstellar Disk: Evidence for Dynamical Evolution

We present an H-band image of the light scattered from circumstellar dust around the nearby (10 pc) young M star AU Microscopii (AU Mic, GJ 803, HD 197481), obtained with the Keck adaptive optics system. We resolve the disk both vertically and radially, tracing it over 17-60 AU from the star. Our AU Mic observations thus offer the possibility to probe at high spatial resolution (0.04" or 0.4 AU per resolution element) for morphological signatures of the debris disk on Solar-System scales. Various sub-structures (dust clumps and gaps) in the AU Mic disk may point to the existence of orbiting planets. No planets are seen in our H-band image down to a limiting mass of 1 M_Jup at >20 AU, although the existence of smaller planets can not be excluded from the current data. Modeling of the disk surface brightness distribution at H-band and R-band, in conjunction with the optical to sub-millimeter spectral energy distribution, allows us to constrain the disk geometry and the dust grain properties. We confirm the nearly edge-on orientation of the disk inferred from previous observations, and deduce an inner clearing radius <=10 AU. We find evidence for a lack of small grains in the inner (<60 AU) disk, either as a result of primordial disk evolution, or because of destruction by Poynting-Robertson and/or corpuscular drag. A change in the power-law index of the surface brightness profile is observed near 33 AU, similar to a feature known in the profile of the beta Pic circumstellar debris disk. By comparing the time scales for inter-particle collisions and Poynting-Robertson drag between the two systems, we argue that the breaks are linked to one of these two processes.Comment: 17 pages, 7 figures, 1 table; accepted by Ap

Thin Sea Ice, Thick Snow, and Widespread Negative Freeboard Observed During N-ICE2015 North of Svalbard

In recent years, sea-ice conditions in the Arctic Ocean changed substantially toward a younger and thinner sea-ice cover. To capture the scope of these changes and identify the differences between individual regions, in situ observations from expeditions are a valuable data source. We present a continuous time series of in situ measurements from the N-ICE2015 expedition from January to June 2015 in the Arctic Basin north of Svalbard, comprising snow buoy and ice mass balance buoy data and local and regional data gained from electromagnetic induction (EM) surveys and snow probe measurements from four distinct drifts. The observed mean snow depth of 0.53 m for April to early June is 73% above the average value of 0.30 m from historical and recent observations in this region, covering the years 1955–2017. The modal total ice and snow thicknesses, of 1.6 and 1.7 m measured with ground-based EM and airborne EM measurements in April, May, and June 2015, respectively, lie below the values ranging from 1.8 to 2.7 m, reported in historical observations from the same region and time of year. The thick snow cover slows thermodynamic growth of the underlying sea ice. In combination with a thin sea-ice cover this leads to an imbalance between snow and ice thickness, which causes widespread negative freeboard with subsequent flooding and a potential for snow-ice formation. With certainty, 29% of randomly located drill holes on level ice had negative freeboard