Decisão de terceirização durante o processo de desenvolvimento de novos serviços de Tecnologia da Informação (TI): Uma contribuição à teoria de processo de desenvolvimento de novos serviços

O setor de serviços é de grande relevância para a economia de países desenvolvidos. Diante dessa importância, tem-se buscado um melhor entendimento sobre o processo de desenvolvimento de novos serviços, uma vez que a inovação tem se caracterizado como um fator de diferencial competitivo. Um dos pontos relevantes para pesquisa nesta área diz respeito à terceirização. Portanto, etse artigo busca contribuir para um melhor entendimento da terceirização no desenvolvimento de novos serviços. Para tanto, o objetivo do artigo é verificar como são considerados os diferentes aspectos envolvidos durante o desenvolvimento de novos serviços e como se dá o processo decisório nestas situações. Para atingir a esse objetivo, serão revisados alguns tópicos da literatura relevantes ao tema, que serão discutidos à luz das informações obtidas em um estudo de caso. Ao final, o artigo apresenta uma possível estrutura hierárquica de decisão para esse problema, assim como suas limitações e recomendações de estudos futuros

RELAÇÕES ENTRE INSTITUIÇÕES PÚBLICAS E PRIVADAS NA GERAÇÃO DE DESENVOLVIMENTO SUSTENTÁVEL: POTENCIALIDADES E LIMITAÇÕES DA REGIÃO DO ALTO PARANAÍBA – MG

This study aimed to show in the current context the potentials and limitations surrounding the existing partnerships between the public and private organizations located in the Alto Paranaíba, Minas Gerais. At the discussion were incorporated elements that can characterize actions and initiatives between the public and private, aimed at developing the area searched. For this, information resultant of the Zoneamento Ecológico-Econômico of the State of Minas Gerais (ZEE-MG) contributed significantly to data analysis and information collected. In this context, it was possible to identify great potential for development of agribusiness, in addition to the wealth of water region, serving as a parameter to consider while sustainable development. Therefore, several institutional components were investigated in 31 municipalities belonging to the Alto Paranaíba and can be viewed as potential generators of public policies and partnerships towards the sustainability of the region. The results pointed to scenarios of potential and limitations, challenges and expectations, but attention to the continuous and uninterrupted monitoring of the environment of the region. The considerations of the study allow us to highlight in the foreground the social function of the organizations studied, especially in relations by means of collective or institutional networks and second, some evidence found so far, allowed the incorporation of new issues and goals specific to the study, and contributing now to further environmental issues. O estudo objetivou mostrar dentro do contexto atual as potencialidades e limitações que circundam as parcerias existentes entre as organizações públicas e privadas localizadas na região do Alto Paranaíba, Minas Gerais. Foram incorporados à discussão elementos que possam caracterizar ações e iniciativas, entre o público e o privado, voltadas ao desenvolvimento sustentável da região pesquisada. Para isso, informações oriundas do Zoneamento Ecológico-Econômico do Estado de Minas Gerais (ZEE-MG) contribuíram significativamente para análise dos dados e informações coletadas. Nesse contexto, foi possível identificar grande potencial para desenvolvimento do agronegócio, além da riqueza em recursos hídricos e da biodiversidade existente. Tais fatores propiciam o crescimento econômico da região, servindo de parâmetro para se pensar ao mesmo tempo em desenvolvimento sustentável. Sendo assim, vários foram os componentes institucionais pesquisados nos 31 municípios pertencentes ao Alto Paranaíba, podendo ser vistos como potenciais geradores de políticas públicas e parcerias voltadas para a sustentabilidade da região. Os resultados encontrados apontaram para cenários de potencialidades e limitações, desafios e expectativas, mas alertando para o contínuo e ininterrupto monitoramento do meio ambiente da região. As Considerações do estudo nos permitem em primeiro plano destacar a função social das organizações estudadas, principalmente em relações coletivas ou por meio de redes institucionais e segundo, algumas evidências encontradas até então, permitiram a incorporação de novas questões e objetivos específicos ao estudo, contribuindo atualmente para futuras questões ambientais.

Fatigue and microgap behaviour of a three-unit implant-fixed dental prosthesis combining conventional and dynamic abutments

This is an in vitro study composed by a fatigue test followed by an optical microscopy analysis. Dynamic abutments concept, recently introduced on screw-retained implant dental prosthesis, consists on the screw channel customisation according to the individual needs of each rehabilitation. Geometry and tightening torque differences advise the assessment of their mechanical performance. Clarify whether the combination of dynamic and conventional abutments in a three-unit implant-fixed prosthesis has detrimental effects either on the mechanical performance under cyclic loading or on the implant-abutment microgap dimensions. The fatigue test was performed in agreement with the ISO standard 14801. Then on the samples that resisted 5 million cycles, the implant-abutment microgap was measured on dynamic and conventional abutments using optical microscopy. Two unloaded samples were used as control group. The samples supported a load of 1050 N. The implant-abutment microgap measurement did not show statistically significant differences (p=.086) between loaded and unloaded groups, but the loaded conventional abutments showed a significant lower implant-abutment microgap (p=.05) than the loaded dynamic abutments. The combination of conventional and dynamic abutments do not seem to produce a decrease in fatigue resistance to a level below the mastication forces or an increase in the joint dimensions.The study was supported in part by SciTech - Science and Technology for Competitive and Sustainable Industries, and the R&D project was cofinanced by the North Portugal Regional Operational Program ("NORTE2020") and the European Regional Development Fund (FEDER)

DISTRIBUIÇÃO DA MEIOFAUNA EM DOIS HABITATS ESTUARINOS DA APA DO RIO MAMANGUAPE (NE BRASIL)

As assembleias infaunais são conhecidas por terem um papel importante em termos do uso da energia em ecossistemas estuarinos através de processos de decomposição. Estes organismos têm diferentes funções ecológicas, tais como ciclagem de nutrientes, degradação de poluentes, a dispersão, o processo de produção secundária, aeração e bioturbação, desempenhando um papel chave na cadeia alimentar dos ecossistemas de mangue. O objetivo deste estudo foi comparar as assembleias infaunais de dois ambientes estuarinos com diferentes tipos de sedimentos. As amostras foram coletadas em quatro estações ao longo do estuário, considerando dois tipos de substrato (areia e lama). Um total de 102 indivíduos pertencentes a nove táxons foram registrados. Foram observadas diferenças significativas na densidade dentro e entre os substratos amostrados, observando-se o maior número médio de indivíduos por cm³ e diversidade no fundo lamacento. Maior riqueza e equitabilidade foram encontradas na areia. Assim, as informações sobre as assembleias infaunais nos dois tipos de substratos estudados , contribui para a descrição biológica da área de estudo , tornando-se estudos adicionais necessários que se concentram em fatores físico- químicos, tamanho de partículas e matéria orgânica , uma vez que esses fatores têm sido fortemente correlacionada com a distribuição de organismos bentônicos

Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal

We estimated comparative primary and booster vaccine effectiveness (VE) of SARS-CoV-2 Omicron BA.5 and BA.2 lineages against infection and disease progression. During April-June 2022, we implemented a case-case and cohort study and classified lineages using whole-genome sequencing or spike gene target failure. For the case-case study, we estimated the adjusted odds ratios (aORs) of vaccination using a logistic regression. For the cohort study, we estimated VE against disease progression using a penalized logistic regression. We observed no reduced VE for primary (aOR 1.07 [95% CI 0.93-1.23]) or booster (aOR 0.96 [95% CI 0.84-1.09]) vaccination against BA.5 infection. Among BA.5 case-patients, booster VE against progression to hospitalization was lower than that among BA.2 case-patients (VE 77% [95% CI 49%-90%] vs. VE 93% [95% CI 86%-97%]). Although booster vaccination is less effective against BA.5 than against BA.2, it offers substantial protection against progression from BA.5 infection to severe disease.The acquisition of sequencing equipment and reagents used in this study by the Instituto Nacional de Saúde Doutor Ricardo Jorge was partially funded by the HERA project (grant no. 2021/PHF/23776) supported by the European Commission through the European Centre for Disease Control, and also partially funded by the GenomePT project (grant no. POCI-01-0145-FEDER-022184), supported by COMPETE 2020–Operational Programme for Competitiveness and Internationalisation, Lisboa Portugal Regional Operational Programme, Algarve Portugal Regional Operational, under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund, and by the Portuguese Science and Technology Foundation. Algarve Biomedical Center Laboratory received public funding through the Project ALG-D2-2021-06 Variants Screen in Southern Portugal– Monitoring Variants of Concern in Southern Portugal and the Portuguese Science and Technology Foundation national support through the Comprehensive Health Research Center (grant no. UIDP/04923/2020)info:eu-repo/semantics/publishedVersio

Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients- A Clinical Perspective Study

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. Therefore, the objective of this study was to analyze correlation between sociocultural, occupational, and lifestyle risk factors with levels of genetic instability in non-neoplastic cells of breast cancer patients. Total 150 individuals were included in the study that included 50 breast cancer patients submitted to chemotherapy (QT), 50 breast cancer patients submitted to radiotherapy (RT), and 50 healthy women without any cancer. Cytogenetic biomarkers for apoptosis and DNA damage were evaluated in samples of buccal epithelial and peripheral blood cells through micronuclei and comet assay tests. Elder age patients (61–80 years) had higher levels of apoptosis (catriolysis by karyolysis) and DNA damage at the diagnosis (baseline damage) with increased cell damage during QT and especially during RT. We also reported the increased frequencies of cytogenetic biomarkers in patients who were exposed to ionizing radiation as well as for alcoholism and smoking. QT and RT induced high levels of fragmentation (karyorrhexis) and nuclear dissolution (karyolysis) and DNA damage. Correlations were observed between age and karyorrhexis at diagnosis; smoking and karyolysis during RT; and radiation and karyolysis during QT. These correlations indicate that risk factors may also influence the genetic instability in non-neoplastic cells caused to the patients during cancer therapies

Consenso brasileiro para o tratamento da esclerose múltipla : Academia Brasileira de Neurologia e Comitê Brasileiro de Tratamento e Pesquisa em Esclerose Múltipla

O crescent arsenal terapêutico na esclerose múltipla (EM) tem permitido tratamentos mais efetivos e personalizados, mas a escolha e o manejo das terapias modificadoras da doença (TMDs) tem se tornado cada vez mais complexos. Neste contexto, especialistas do Comitê Brasileiro de Tratamento e Pesquisa em Esclerose Múltipla e do Departamento Científico de Neuroimunologia da Academia Brasileira de Neurologia reuniram-se para estabelecer este Consenso Brasileiro para o Tratamento da EM, baseados no entendimento de que neurologistas devem ter a possibilidade de prescrever TMDs para EM de acordo com o que é melhor para cada paciente, com base em evidências e práticas atualizadas. Por meio deste documento, propomos recomendações práticas para o tratamento da EM, com foco principal na escolha e no manejo das TMDs, e revisamos os argumentos que embasam as estratégias de tratamento na EM.The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurology have convened to establish this Brazilian Consensus for the Treatment of MS, based on their understanding that neurologists should be able to prescribe MS DMTs according to what is better for each patient, based on up-to-date evidence and practice. We herein propose practical recommendations for the treatment of MS, with the main focus on the choice and management of DMTs, as well as present a review of the scientific rationale supporting therapeutic strategies in MS

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio