81 research outputs found

    Numerical approximation of the Euler-Maxwell model in the quasineutral limit

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    International audienceWe derive and analyze an Asymptotic-Preserving scheme for the Euler-Maxwell system in the quasi-neutral limit. We prove that the linear stability condition on the time-step is independent of the scaled Debye length λ\lambda when λ→0\lambda \to 0. Numerical validation performed on Riemann initial data and for a model Plasma Opening Switch device show that the AP-scheme is convergent to the Euler-Maxwell solution when Δx/λ→0\Delta x/ \lambda \to 0 where Δx\Delta x is the spatial discretization. But, when λ/Δx→0\lambda /\Delta x \to 0, the AP-scheme is consistent with the quasi-neutral Euler-Maxwell system. The scheme is also perfectly consistent with the Gauss equation. The possibility of using large time and space steps leads to several orders of magnitude reductions in computer time and storage

    Native American mtDNA prehistory in the American Southwest

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    This study examines the mtDNA diversity of the proposed descendants of the multiethnic Hohokam and Anasazi cultural traditions, as well as Uto-Aztecan and Southern-Athapaskan groups, to investigate hypothesized migrations associated with the Southwest region. The mtDNA haplogroups of 117 Native Americans from southwestern North America were determined. The hypervariable segment I (HVSI) portion of the control region of 53 of these individuals was sequenced, and the within-haplogroup diversity of 18 Native American populations from North, Central, and South America was analyzed. Within North America, populations in the West contain higher amounts of diversity than in other regions, probably due to a population expansion and high levels of gene flow among subpopulations in this region throughout prehistory. The distribution of haplogroups in the Southwest is structured more by archaeological tradition than by language. Yumans and Pimans exhibit substantially greater genetic diversity than the Jemez and Zuni, probably due to admixture and genetic isolation, respectively. We find no evidence of a movement of mtDNA lineages northward into the Southwest from Central Mexico, which, in combination with evidence from nuclear markers, suggests that the spread of Uto-Aztecan was facilitated by predominantly male migration. Southern Athapaskans probably experienced a bottleneck followed by extensive admixture during the migration to their current homeland in the Southwest. Am J Phys Anthropol 120:108–124, 2003. © 2003 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34277/1/10138_ftp.pd

    The Republican Divide on Wilderness Policy

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    Wilderness is an issue that exposes a deep political fault line within the Republican Party. Republican leaders such as Theodore Roosevelt are credited with laying the philosophical and legal groundwork that resulted in establishment of the National Wilderness Preservation System. Republicans who worked for wilderness protection cited benefits such as protecting the nation\u27s natural and historical heritage, conserving resources for the future, and providing opportunities for beneficial outdoor recreation. Other Republican leaders, however, have fought wilderness protection on the grounds that preservation is an inappropriate government constraint on free markets and is harmful to the economy by limiting commodity production of timber, forage, and minerals

    New tools to study the consequences of micronucleation and micronucleus rupture

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    Thesis (Ph.D.)--University of Washington, 2023Micronuclei are aberrant nuclear compartments that trap a portion of a cell's chromatin in a distinct organelle separate from the nucleus and are drivers of inflammation, DNA damage, chromosome instability, and chromothripsis. Many of the consequences of micronucleus formation stem from micronucleus rupture: the sudden loss of micronucleus compartmentalization, resulting in mislocalization of nuclear factors and the exposure of chromatin to the cytosol for the remainder of interphase. Micronuclei form primarily from segregation errors during mitosis, errors that also give rise to other, non-exclusive phenotypes, including aneuploidy and chromatin bridges. The stochastic formation of micronuclei and phenotypic overlap confounds the use of population-level assays or hypothesis discovery, requiring labor-intensive techniques to visually identify and follow micronucleated cells individually. In this work, I present a novel technique for automatically identifying and isolating micronucleated cells generally and cells with ruptured micronuclei specifically using a de novo neural net combined with Visual Cell Sorting. As a proof of concept, I compare the early transcriptomic responses to micronucleation and micronucleus rupture with previously published responses to aneuploidy, revealing micronucleus rupture to be a potential driver of the aneuploidy response. In addition, I present an unfinished tool using the bacterial enzyme deoxyadenosine methyltransferase (Dam) for the population-level identification of chromatin, rather than cells, that were trapped in a ruptured micronucleus. This tool, dubbed Dam Tracker, depended on the sequestration of Dam in the cytosol away from chromatin in intact nuclear compartments, which is made difficult during mitosis when nuclear envelopes are disassembled. Should this obstacle be overcome, this tool could open new avenues of research on the long-term consequences of micronucleus rupture to chromatin
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