8 research outputs found
Alcohol extract of Echinacea pallida reverses stress-delayed wound healing in mice
Healing of open skin wounds begins with an inflammatory response. Restraint stress has been well documented to delay wound closure, partially via glucocorticoid (GC)-mediated immunosuppression of inflammation. Echinacea, a popular herbal immunomodulator, is purported to be beneficial for wound healing. To test the hypothesis, an alcohol extract of E. pallida was administrated orally to mice for 3 days prior to, and 4 days post wounding with a dermal biopsy on the dorsum. Concominantly, mice were exposed to 3 cycles of daily restraint stress prior to, and 4 cycles post wounding. Echinacea accelerated wound closure in the stressed mice, but had no apparent wound healing effect for the non-stressed mice when compared to their respective controls. To test if the positive healing effect is through modulation of GC release, plasma corticosterone concentrations were measured in unwounded mice treated with restraint stress and the herbal extract for 4 days. Plasma GC in restraint stressed mice gavaged with Echinacea was not different from mice treated with restraint only, but was increased compared to the vehicle control. This data suggests that the improved wound healing effect of Echinacea in stressed mice is not mediated through modulation of GC signaling
The Vehicle, Fall 1982
Vol. 24, No. 1
Table of Contents
Winter SurveillanceB.L. Davidsonpage 3
The InvitationBecky Lawsonpage 4
Check In, Check OutSteve Sandstrompage 4
On The Front Porch StepKeila Tooleypage 5
Old Greek ManDevon Flesorpage 5
Exotic PassionsBecky Lawsonpage 6
PhotographLisa Owenspage 7
Beyond The ThornsBrook Wilsonpage 8
Ritual Of HeatB.L. Davidsonpage 11
The GamerBecky Lawsonpage 12
It\u27s OverKeila Tooleypage 13
DreamJohn Stockmanpage 14
Silver DollarGina J. Grillopage 15
The DancerJessica Lewispage 16
Snapshots Of Rural IllinoisIsabel M. Parrottpage 16
The Last SeasonTheresa Whitesidepage 17
DrawingKaren Haneypage 17
Rotary LuncheonJessica Lewispage 18
Factory TourLinda Fraembspage 18
The ImmigrantsD.L. Lewispage 19
At Shedd AquariumLinda Fraembspage 20
The GuardianBecky Lewispage 20
Digital LifeEverett Tackettpage 21
Full ServiceScott Graypage 22
Dust ShowLinda A. Brownpage 23
At SixMaureen Foertschpage 24
DrawingJean Imherrpage 24
ReflectionMaggie Kennedypage 25
Cat DefiningBecky Lawsonpage 26
Ode To An Unread NewspaperLinda Fraembspage 26
GumSteve Sandstrompage 27
The DancerChrystal Clarkpage 27
PoemD.L. Lewispage 28
For LucyStacey Flanniganpage 29
An AbortionDevon Flesorpage 29
ReveriesKeila Tooleypage 30
Sunday Morning After Tequila With LemonScott Graypage 33
Staging A Living Jewel BoxMichelle Mitchellpage 34
The Other WomanStacey Flanniganpage 35
The Natural LookMichelle Mitchellpage 35
Poem To A Girl Named SandalsJohn Stockmanpage 36
PhotographLisa Owenspage 37
In The Balcony Of The Bijou On A Saturday NightScott Graypage 38
The Canadian Soccer PlayerBecky Lawsonpage 39
The HealingJohn Stockmanpage 39
AppeasedDevon Flesorpage 40
CodaJohn Stockmanpage 40https://thekeep.eiu.edu/vehicle/1040/thumbnail.jp
Alcohol extracts of Echinacea inhibit production of nitric oxide and tumor necrosis factor-alpha by macrophages in vitro
It has been suggested that Echinacea has anti-inflammatory activity in vivo. Nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-1beta are important mediators in the inflammatory response. The effect of alcohol extracts of E. angustifolia (EA), E. pallida (EPA) and E. purpurea (EP) on the production of these inflammatory mediators in both LPS-stimulated RAW 264.7 macrophages in vitro and murine peritoneal exudate cells (PECs) in vivo were investigated. As macrophages produce these inflammatory mediators in response to pathogenic infection, parallel cultures of macrophages were studied for phagocytosis and intracellular killing of Salmonella enterica. EPA and EP in vitro inhibited NO production and TNF-α release in a dose-dependent manner. RAW 264.7 cells treated with EA or EP showed decreased killing over 24 h, although EA enhanced bacterial phagocytosis. Upon bacterial infection, RAW 264.7 cells produce high levels of NO; however, an Echinacea-mediated decrease in NO production was observed. Echinacea alcohol extracts administered orally at 130 mg/kg per day for seven days had a weak effect on NO production and phagocytosis by LPS-stimulated PECs. The results indicated that all Echinacea species significantly decreased inflammatory mediators in vitro, however, only EA and EP reduced bacterial killing. Oral administration of Echinacea alcohol extracts did not adversely affect the development and anti-bacterial function of inflammatory PECs in vivo, however, NO production was decreased during bacterial infection of PECs.This is an Accepted Manuscript of an article published by Taylor & Francis in Food and Agricultural Immunology on 2007, available online: http://www.tandfonline.com/10.1080/09540100701797363</p
Alcohol extract of Echinacea pallida reverses stress-delayed wound healing in mice
Healing of open skin wounds begins with an inflammatory response. Restraint stress has been well documented to delay wound closure, partially via glucocorticoid (GC)-mediated immunosuppression of inflammation. Echinacea, a popular herbal immunomodulator, is purported to be beneficial for wound healing. To test the hypothesis, an alcohol extract of E. pallida was administrated orally to mice for 3 days prior to, and 4 days post wounding with a dermal biopsy on the dorsum. Concominantly, mice were exposed to 3 cycles of daily restraint stress prior to, and 4 cycles post wounding. Echinacea accelerated wound closure in the stressed mice, but had no apparent wound healing effect for the non-stressed mice when compared to their respective controls. To test if the positive healing effect is through modulation of GC release, plasma corticosterone concentrations were measured in unwounded mice treated with restraint stress and the herbal extract for 4 days. Plasma GC in restraint stressed mice gavaged with Echinacea was not different from mice treated with restraint only, but was increased compared to the vehicle control. This data suggests that the improved wound healing effect of Echinacea in stressed mice is not mediated through modulation of GC signaling.This is a manuscript of an article from Phytomedicine 16 (2009): 669, doi: 10.1016/j.phymed.2009.02.010. Posted with permission.</p
Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo
Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software