Surgical management of chronic calcific deposit resembling tendon sheath infection in the index finger: A rare case report and literature review

BackgroundCalcific tendonitis rarely occurs in the fingers, and it is easily misdiagnosed. Herein we describe the case of a patient with multiple calcific lesions within the flexor digitorum superficialis and the extensor digitorum tendons of the distal interphalangeal joints of the right index finger, and the surgical treatment of those lesions.Case presentationThe patient was a 66-year-old man who reported pain and swelling in his right index finger for one year. He was diagnosed with chronic calcific tendonitis based on his symptoms and radiology images. He was successfully treated surgically, and histopathological examination confirmed the diagnosis. After one month, the patient had healed well, and there was no recurrence.ConclusionsThis is the first report of a patient suffering from chronic calcific tendonitis in a finger who failed conservative treatment and was successfully treated with surgery. The outcome demonstrates that surgical debridement can yield a good outcome in patients with chronic calcific tendonitis

MicroRNA-206 regulates surfactant secretion by targeting VAMP-2

AbstractLung surfactant secretion is a highly regulated process. Our previous studies have shown that VAMP-2 is essential for surfactant secretion. In the present study we investigated the role of miR-206 in surfactant secretion through VAMP-2. VAMP-2 was confirmed to be a target of miR-206 by 3′-untranslational region (3′-UTR) luciferase assay. Mutations in the predicated miR-206 binding sites reduced the binding of miR-206 to the 3′-UTR of VAMP-2. miR-206 decreased the expression of VAMP-2 protein and decreased the lung surfactant secretion in alveolar type II cells. In conclusion, miR-206 regulates lung surfactant secretion by limiting the availability of VAMP-2 protein

A Simple All-Fiber Solc Filter Based on 45-Tilted Fiber Gratings

A simple all-fiber Solc filter (AFSF), which consists of two 45°-tilted fiber gratings (45°-TFGs) UV-inscribed in the polarization-maintaining fiber (PMF) and a series of PMF cavities, is proposed and demonstrated. The performance of the proposed filter has been theoretically simulated and experimentally verified. Both the simulated and experimental results show that the bandwidth of the filter could be tuned by the PMF sub-cavity length and the number of PMF cavities. And the free spectral range (FSR) only depends on the sub-cavity length. As a proof of that, the bandwidths of AFSF with different number of PMF sub-cavity (N=2, N=3, N=4) and the same PMF sub-cavity length of 30cm are 4 nm, 2.6nm, and 2nm, respectively. The FSRs of 3-stage AFSF with different PMF sub-cavity length (L=20 cm and L=40 cm) are 15.3 nm and 7.97 nm, respectively. Furthermore, we have also investigated the tunability of the AFSF by controlling the temperature of PMF cavity with a tuning sensitivity around 1.205 nm°/c. Compared with existing fiber-optic Solc filters, the AFSF with prominent advantages such as extremely simple and robust structure, thermal tunability in wavelength, and low cost will bring a bright future for applications in optical communication and sensing systems

Theoretical analysis and experimental demonstration of the radiation mode distribution of 45° TFG

In this paper, we have theoretically analyzed and experimentally demonstrated the spatial distribution of the radiation mode of 45° tilted fiber grating (TFG). The simulation results have shown the intensity distribution of the radiation mode along the fiber axis exhibited an exponential reduction. In experiment, we have observed the radiation mode pattern of a 5-mm long 45°TFG. The captured profiles along the radial direction and axial direction were in good agreement with the simulated results of the model

Numerical and Experimental Characterization of Radiation Mode of 45° Tilted Fiber Grating

In this paper, we have numerically and experimentally investigated the radiation mode of 45° tilted fiber grating (45° TFG). By introducing the axial distributions into the volume current method, we have established a three-dimensional theoretical model to analyze spatial distributions of the radiation mode of 45° TFG, and measured the radiation mode spatial distributions in experiment. Both numerical and experimental results show that the radiation mode of 45° TFG exhibits an exponential reduction along the fiber axial direction, and a quasi-Gaussian profile along the radial direction of fiber. Additionally, we have also measured the detailed polarization-dependent azimuthal intensity distributions of radiation modes of both s-and p-polarized core modes. The degree of polarization of radiation mode is around 99.886%, which is independent of the length and the polarization extinction ratio of the grating. Moreover, for the first time, we have experimentally observed a very weak p-polarized component existing in the radiation mode, which has matched well with the simulation results

VIGOR, an annotation program for small viral genomes

<p>Abstract</p> <p>Background</p> <p>The decrease in cost for sequencing and improvement in technologies has made it easier and more common for the re-sequencing of large genomes as well as parallel sequencing of small genomes. It is possible to completely sequence a small genome within days and this increases the number of publicly available genomes. Among the types of genomes being rapidly sequenced are those of microbial and viral genomes responsible for infectious diseases. However, accurate gene prediction is a challenge that persists for decoding a newly sequenced genome. Therefore, accurate and efficient gene prediction programs are highly desired for rapid and cost effective surveillance of RNA viruses through full genome sequencing.</p> <p>Results</p> <p>We have developed VIGOR (Viral Genome ORF Reader), a web application tool for gene prediction in influenza virus, rotavirus, rhinovirus and coronavirus subtypes. VIGOR detects protein coding regions based on sequence similarity searches and can accurately detect genome specific features such as frame shifts, overlapping genes, embedded genes, and can predict mature peptides within the context of a single polypeptide open reading frame. Genotyping capability for influenza and rotavirus is built into the program. We compared VIGOR to previously described gene prediction programs, ZCURVE_V, GeneMarkS and FLAN. The specificity and sensitivity of VIGOR are greater than 99% for the RNA viral genomes tested.</p> <p>Conclusions</p> <p>VIGOR is a user friendly web-based genome annotation program for five different viral agents, influenza, rotavirus, rhinovirus, coronavirus and SARS coronavirus. This is the first gene prediction program for rotavirus and rhinovirus for public access. VIGOR is able to accurately predict protein coding genes for the above five viral types and has the capability to assign function to the predicted open reading frames and genotype influenza virus. The prediction software was designed for performing high throughput annotation and closure validation in a post-sequencing production pipeline.</p

A chemical survey of exoplanets with ARIEL

Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio

Compact linear polarization spectrometer based on radiation mode shaped in-fiber diffraction grating

We propose a compact linear polarization spectrometer based on the in-fiber polarization-dependent diffraction grating. The beam profile of radiated light of the grating is shaped to be a Gaussian profile to improve the performance of the spectrometer, where the size of the focused light spot is reduced from 44 um to 33 um with the shaped radiation mode of the grating. Based on the experimental results, the proposed spectrometer can achieve 0.05 nm resolution and 115 nm wavelength responding range from 1495 nm to 1610 nm. To verify the performance of the proposed fiber spectrometer, we measure the transmission spectra of an excessively tilted fiber grating, which has a pair of orthogonal polarization transmission spectra. Compared with the traditional measuring method, the proposed fiber spectrometer integrates the polarizing and spectral analyzing functions in the measuring system and achieves the polarization-sensitive spectral analysis, which shows good wavelength consistency and perfect polarization characteristics