Projeto de intervenção para diminuir as complicações causadas pela hipertensão arterial na Unidade Básica de Saúde Dona Sra. Aparecida Conceição Ferreira no município de Uberaba-Minas Gerais

A Hipertensão Arterial Sistêmica (HAS) é considerada um grave problema de saúde pública global, devido a sua alta prevalência e baixas taxas de controle. É uma doença multifatorial, sendo caracterizada por uma pressão sistólica maior ou igual a 140mmhg e uma pressão diastólica maior ou igual a 90mmhg. A HAS associa-se a várias complicações como: acidente vascular encefálico, doença arterial periférica, insuficiência cardíaca, doença renal crônica, infarto agudo do miocárdio e doença arterial coronariana, causando 9,4 milhões de mortes a cada ano em todo o mundo. Dessa forma, devido às consequências causadas pela doença, o objetivo desse trabalho foi elaborar um projeto de intervenção sobre a HAS, na área de abrangência da "Unidade Básica de Saúde Dona Sra. Aparecida Conceição Ferreira" no município de Uberaba e identificar os principais fatores de risco presentes nos pacientes. Para o desenvolvimento desse plano foi utilizado o Método do Planejamento Estratégico Situacional. A pesquisa é de caráter narrativo, em que foram levantados dados de caráter qualitativo, fundamentado na literatura cientifica em questões consideradas amplas ou abertas. Os dados coletados foram colocados em uma planilha eletrônica do Excel 2010 e posteriormente foram submetidos à análise estatística por meio do programa Statistical Package for the Social Sciences (SPSS versão 13.0). Para obter as informações necessárias, foram utilizados os prontuários individuais e familiares, além dos dados recolhidos pelo Sistema de Informação da Atenção Básica e no Plano Municipal de Saúde do Município. A pressão arterial, o peso corporal e a circunferência abdominal também foram avaliados e monitorados nos pacientes. Portanto por meio desse projeto de intervenção pretende-se oferecer uma melhora na qualidade de vida dos pacientes participantes do projet

"My Perfect PlatformWould Be Telepathy" - Reimagining the Design of Social Media with Autistic Adults

https://doi.org/10.1145/3544548.3580673https://doi.org/10.1145/3544548.3580673https://doi.org/10.1145/3544548.3580673https://doi.org/10.1145/3544548.3580673https://doi.org/10.1145/3544548.358067

Factors identified with higher levels of career satisfaction of physicians in Andalusia, Spain

The satisfaction of physicians is a worldwide issue linked with the quality of health services; their satisfaction needs to be studied from a multi-dimensional perspective, considering lower- and higher-order needs. The objectives of this study were to: i) measure the career satisfaction of physicians; ii) identify differences in the dimensions of career satisfaction; and iii) test factors that affect higherand lower-order needs of satisfaction among physicians working in Andalusian hospitals (Spain). Forty-one percent of 299 eligible physicians participated in a study conducted in six selected hospitals. Physicians reported higher professional, inherent, and performance satisfaction than personal satisfaction. Foreign physicians reported higher levels of personal and performance satisfaction than local physicians, and those who received nonmonetary incentives had higher professional and performance satisfaction. In conclusion, physicians in the selected Andalusian hospitals reported low levels of personal satisfaction. Non-monetary incentives were more relevant to influence their career satisfaction. Further investigations are recommended to study differences in the career satisfaction between foreign and local physicians

La antropología en la planificación regional como elemento para la gestión integrada de recursos hídricos

Aquí se considera que los escritos de Ángel Palerm sobre Planificación, son una excelente herramienta de introducción a la Gestión Integrada de los Recursos Hídricos (GIRH). De allí que el objetivo de este trabajo sea la revisión e identificación de las principales propuestas palermianas sobre los conceptos y herramientas de cómo llevar a cabo la planificación y el desarrollo, con el fi n de presentarlos como una introducción y reflexión a la gestión integrada de los recursos hídricos (GIRH). Para lograrlo, se analiza el material y los documentos reunidos y publicados de Ángel Palerm sobre el tema, que datan desde 1950 hasta 1980, ordenando los casos, los conceptos, las herramientas y las formas metodológicas que Palerm utilizó para la planificación

A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects

BACKGROUND AND AIMS: Metformin, the most prescribed drug for the treatment of type 2 diabetes mellitus, has been recently reported to promote weight loss by upregulating the anorectic cytokine growth differentiation factor 15 (GDF15). Since the antidiabetic effects of metformin are mostly mediated by the activation of AMPK, a key metabolic sensor in energy homeostasis, we examined whether the activation of this kinase by metformin was dependent on GDF15. METHODS: Cultured hepatocytes and myotubes, and wild-type and Gdf15(-/-) mice were utilized in a series of studies to investigate the involvement of GDF15 in the activation of AMPK by metformin. RESULTS: A low dose of metformin increased GDF15 levels without significantly reducing body weight or food intake, but it ameliorated glucose intolerance and activated AMPK in the liver and skeletal muscle of wild-type mice but not Gdf15(-/-) mice fed a high-fat diet. Cultured hepatocytes and myotubes treated with metformin showed AMPK-mediated increases in GDF15 levels independently of its central receptor GFRAL, while Gdf15 knockdown blunted the effect of metformin on AMPK activation, suggesting that AMPK is required for the metformin-mediated increase in GDF15, which in turn is needed to sustain the full activation of this kinase independently of the CNS. CONCLUSION: Overall, these findings uncover a novel mechanism through which GDF15 upregulation by metformin is involved in achieving and sustaining full AMPK activation by this drug independently of the CNS

The L-sigma Relation of Local HII Galaxies

We present for the first time a new data set of emission line widths for 118 star-forming regions in HII galaxies (HIIGs). This homogeneous set is used to investigate the L-sigma relation in conjunction with optical spectrophotometric observations. Peculiarities in the line profiles such as sharp lines, wings, asymmetries, and in some cases more than one component in emission were verified. From a new independent homogeneous set of spectrophotometric data we derived physical condition parameters and performed the statistical principal component analysis. We have investigated the potential role of metallicity (O/H), Hbeta equivalent width (WHbeta) and ionization ratio [OIII]/[OII] to account for the observational scatter of L-sigma relation. Our results indicate that the L-sigma relation for HIIGs is more sensitive to the evolution of the current starburst event (short-term evolution) and dated by WHbeta or even the [OIII]/[OII] ratio. The long-term evolution measured by O/H also plays a potential role in determining the luminosity of the current burst for a given velocity dispersion and age as previously suggested. Additionally, galaxies showing Gaussian line profiles present more tight correlations indicating that they are best targets for the application of the parametric relations as an extragalactic cosmological distance indicator. Best fits for a restricted homogeneous sample of 45 HIIGs provide us a set of new extragalactic distance indicators with an RMS scatter compatible with observational errors of Delta_log(LHalpha) = 0.2 dex or 0.5 mag. Improvements may still come from future optimized observational programs to reduce the observational uncertainties on the predicted luminosities of HIIGs in order to achieve the precision required for the application of these relations as tests of cosmological models.Comment: 53 pages, 15 figures, 4 complete tables Accepted for publication in The Astrophysical Journa

Mechanochromic Luminescent Tetrathiazolylthiophenes: Evaluating the Role of Intermolecular Interactions through Pressure and Temperature-Dependent Raman Spectroscopy

The Raman spectrum of the mechanochromic luminescent tetrathiazolylthiophene has been investigated as a function of pressure and temperature. This study verifies the sensitivity of the Raman spectroscopy as a technique to characterize and understand the structural effects causing any mechanochromic changes. Continuous and evident Raman shifts and changes in intensities of the strongest lines in the spectra occur while increasing pressure or lowering temperature. These spectral changes are related to the modulation of intermolecular C–H···N hydrogen bonding previously identified for this system. The Raman bands involved are assigned to collective normal modes associated to the CC bond stretching of the rings and reveal that the modulation of local hydrogen bonding interaction has indeed an effect that has an impact on the whole conjugated structure of the molecule. Pressure-dependent Raman spectra have been also computed by means of periodic density functional theory calculations of the crystal, giving an accurate prediction of the experimental trends