Does vaterite otolith deformation affect post-release survival and predation susceptibility of hatchery-reared juvenile Atlantic salmon?

publishedVersio

Pneumopathie induite par l'hydroxyurée. [Hydroxyurea-induced pneumonia].

International audienceIntroduction: Hydroxyurea is an antimetabolite widely used in the treatment of myeloproliferative diseases. Usual side effects are mainly hematological, gastrointestinal, neurological disorders and induced-fevers. More rarely, hydroxyurea-induced pneumonitis are reported. Case report: We report a case of a patient treated for polycythemia vera. She was admitted 20 days after introduction of hydroxyurea for a high fever, productive cough and clear sputum associated with nausea. Chest CT-scan found diffuse bilateral ground-glass opacities. The microbiological investigations were negative. Symptoms disappeared few days after discontinuation of treatment. Its reintroduction led to recurrence of symptoms. Conclusion: This additional case completes the 15 cases of hydroxyurea-induced pneumonitis described in the literature. Two forms of this disease seem to exist: an acute form with fever occurring in the month following introduction of hydroxyurea; and a chronic form without fever. Even if it is uncommon, pulmonologists should be aware of this complication

Genetic structure of Sufflogobius bibarbatus in the Benguela upwelling ecosystem using microsatellite markers

The bearded goby Sufflogobius bibarbatus is an abundant endemic small fish species on the continental shelf of the northern Benguela. The goby habitat is characterised by generally low bottom oxygen concentrations that vary spatially and seasonally. In the present study of population structure, 13 samples of S. bibarbatus from inner and outer shelf areas between 19°S and 32°S were screened using ten microsatellite loci. The genetic data were analysed in relation to isolation by distance and depth. Furthermore, for the first time, this study examined genetic data in relation to bottom oxygen concentration at the sampling locations. The data show low but significant genetic heterogeneity (G‐test; FST = 0.007, p < .05). There was weak but significant genetic differentiation along a latitudinal gradient across all sampling sites from 19.50°S to 32.37°S (Mantel test; r = .464, p = .001), but this disappeared when the southernmost sample was removed. On the other hand, a positive correlation of bottom oxygen concentration with pairwise FST (r = .336; p = .017) was observed among the sampling sites from the Northern Benguela shelf area. Overall, the data are complex but suggest that isolation by distance and bottom oxygen concentration may play a role in the genetic structuring of S. bibarbatus. The findings are discussed in relation to the species’ life history features and oceanographic characteristics of the Benguela upwelling ecosystem.publishedVersio

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression

Blood flow shapes vascular networks by orchestrating endothelial cell behavior and function. How endothelial cells read and interpret flow-derived signals is poorly understood. Here, we show that endothelial cells in the developing mouse retina form and use luminal primary cilia to stabilize vessel connections selectively in parts of the remodeling vascular plexus experiencing low and intermediate shear stress. Inducible genetic deletion of the essential cilia component intraflagellar transport protein 88 (IFT88) in endothelial cells caused premature and random vessel regression without affecting proliferation, cell cycle progression, or apoptosis. IFT88 mutant cells lacking primary cilia displayed reduced polarization against blood flow, selectively at low and intermediate flow levels, and have a stronger migratory behavior. Molecularly, we identify that primary cilia endow endothelial cells with strongly enhanced sensitivity to bone morphogenic protein 9 (BMP9), selectively under low flow. We propose that BMP9 signaling cooperates with the primary cilia at low flow to keep immature vessels open before high shear stress-mediated remodeling

Recherches de marqueurs biologiques associés à la survenue de séquelles après un épisode symptomatique d'embolie pulmonaire

PARIS-BIUP (751062107) / SudocSudocFranceF

Note sur une fontaine de rue du quartier de Saint-Romain-en-Gal (Rhône)

This public fountain discovered in the late sixties and hastily restored with concrete slabs is the best preserved one of Saint-Romain-en-Gal, an area of ancient Vienne on the right bank of the Rhône river. In 1993, when the fountain was planned to be used again, the basin was re-examined: it shows traces of ancient repairing ant its bottom is made of fragments of the first fountain almost completely dismantled.Découverte à la fin des années soixante et rapidement restaurée avec des dalles de béton, cette fontaine publique est la mieux conservée de Saint-Romain-en-Gal, un quartier de Vienne antique sur la rive droite du Rhône. En 1993, un projet de remise en eau a fourni l'occasion de réexaminer le bassin qui porte les traces d'une réfection antique et dont le fond est apparu constitué des fragments d'une premiere fontaine presque entièrement démontée.Delaval Eric, Clappier Anne-Marie. Note sur une fontaine de rue du quartier de Saint-Romain-en-Gal (Rhône). In: Revue archéologique de Narbonnaise, tome 31, 1998. pp. 185-192

Pneumopathies secondaires à l'injection de Lipiocis ou Lipiodol radioactif

RENNES1-BU Santé (352382103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

LE LEIOMYOME BENIN METASTASIANT PULMONAIRE (A PROPOS D'UNE OBSERVATION)

RENNES1-BU Santé (352382103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

0.355-micrometer direct detection wind lidar under testing during a field campaign in consideration of ESA's ADM-Aeolus mission

International audienceThe atmospheric wind field information is a key issue to numerical weather prediction (NWP) and climate studies. The Atmospheric Dynamic Mission-Aeolus is cur- rently developed by the European Space Agency (ESA) to launch a wind sensing Doppler lidar in mid-2015. The high spectral resolution lidar concept is using backscattered laser signals from molecules and particles to provide accurate hor- izontal wind velocity measurements in the depth of atmo- sphere. The Aeolus lidar, so-called ALADIN, will operate in UV at 0.355 μm. The combination of air molecules and UV laser light is intended to provide wind data evenly distributed everywhere in the lower atmosphere (below 30 km altitude). The goal of the ESA's Aeolus mission is to enhance the present meteorological observations system over sparse wind data regions, and more importantly to provide direct wind in- formation in the tropics where no geostrophic wind can be derived from mass fields obtained from passive radiometer satellite. The 0.355 μm lidar concept was under testing dur- ing a field campaign conducted at the Haute-Provence Obser- vatory, France, in 1999. Several active remote sensors were deployed on the site, and it was the opportunity to address the self-consistency of wind measurements made by differ- ent lidars, a 72 MHz radar, and conventional balloon radio soundings. The paper presents the comparison of different remote sensors using two criteria: Pearson cross-correlation coefficient and root mean square error. The methodology dis- cussed here may be useful in future ESA Aeolus validation campaigns involving different kinds of instruments

Does vaterite otolith deformation affect post-release survival and predation susceptibility of hatchery-reared juvenile Atlantic Salmon?

Sagittal otoliths are calcareous structures in the inner ear of fishes involved in hearing and balance. They are usually composed of aragonite; however, aragonite can be replaced by vaterite, a deformity which is more common in hatchery-reared than in wild fish. Vaterite growth may impair hearing and balance and affect important fitness-related behaviours such as predator avoidance. Captive rearing techniques that prevent hearing loss may have the potential to improve fish welfare and the success of restocking programmes. The aim of this study was to test the effect of structural tank enrichment on vaterite development in the otoliths of hatchery-reared juvenile Atlantic salmon Salmo salar, and to assess the effects of vaterite on immediate predation mortality and long-term survival after release into the wild. Fry were reared in a structurally enriched or in a conventional rearing environment and given otolith marks using alizarin during the egg stage to distinguish between the treatment groups. Otoliths were scrutinised for the presence and coverage of vaterite at 6, 13, and 16 weeks after start feeding, and the growth traits were measured for enriched and control fry when housed in tanks. In a subsequent field experiment, juveniles were released in the Rasdalen river (western Norway), and otoliths of enriched reared and control reared fry were scrutinised from samples collected immediately prior to release, from predator (trout Salmo trutta) stomachs 48 h after release and from recaptures from the river 2–3 months after release. Vaterite otoliths occurred as early as 6 weeks after start feeding in hatchery-reared S. salar. Vaterite occurrence and coverage increased with fish length. Enriched rearing had no direct effect on vaterite formation, but enriched reared fry grew slower than control fry. After release into the wild, fewer salmon fry with vaterite otoliths had been eaten by predators, and a higher proportion of fry with vaterite otoliths than those lacking vaterite were recaptured in the river 2–3 months after release. Contrary to expectations, this suggests that vaterite does not increase predation mortality nor reduce survival rates in the wild during the early life stages