81 research outputs found
Model analysis of the world data on the pion transition form factor
We discuss the impact of recent Belle data on our description of the pion
transition form factor based on the assumption that a perturbative formalism
and a nonperturbative one can be matched in a physically acceptable manner at a
certain hadronic scale . We discuss the implications of the different
parameters of the model in comparing with world data and conclude that within
experimental errors our description remains valid. Thus we can assert that the
low nonperturbative description together with an additional term
at the matching scale have a strong influence on the behavior up to very
high values of .Comment: 6 pages and 3 figures. Contains a comparison with other models and
additional reference
The pion transition form factor and the pion distribution amplitude
Recent BaBaR data on the pion transition form factor, whose Q^2 dependence is
much steeper then predicted by asymptotic Quantum Chromodynamics (QCD), have
caused a renewed interest in its theoretical description. We present here a
formalism based on a model independent low energy description and a high energy
description based on QCD, which match at a scale Q_0. The high energy
description incorporates a flat pion distribution amplitude, phi(x)=1, at the
matching scale Q_0 and QCD evolution from Q_0 to Q>Q_0. The flat pion
distribution is connected, through soft pion theorems and chiral symmetry, to
the pion valance parton distribution at the same low scale Q_0. The procedure
leads to a good description of the data, and incorporating additional twist
three effects, to an excellent description of the data.Comment: 11 pages, 5 postscript figures, uses epsfig.sty and 1 appendi
UK informative inventory report (1990 to 2013)
This is the 10th Informative Inventory Report (IIR) from the UK National Atmospheric Emissions Inventory (NAEI) Programme. The report is compiled to accompany the UKâs 2015 data submission under the United Nations Economic Commission for Europe (UNECE) Convention on Long-Range Transboundary Air Pollution (CLRTAP) and contains detailed information on annual emission estimates of air quality pollutants by source in the UK from 1990 onwards
UK Greenhouse Gas Inventory 1990 to 2021: annual report for submission under the Framework Convention on Climate Change
This is the United Kingdomâs National Inventory Report (NIR) submitted in 2023 to the United
Nations Framework Convention on Climate Change (UNFCCC). It contains national
greenhouse gas emission estimates for the period 1990-2021, and descriptions of the methods
used to produce the estimates.
The greenhouse gas inventory (GHGI) is based on the same datasets used by the UK in the
National Atmospheric Emissions Inventory (NAEI) for reporting atmospheric emissions under
other international agreements. The GHGI is therefore consistent with these other air
emissions inventories where they overlap.
The greenhouse gas inventory is compiled on behalf of the UK Department for Energy Security
and Net Zero (DESNZ) for the Science and Innovation for Climate and Energy (SICE)
Directorate, by Ricardo Energy & Environment. We acknowledge the positive support and
advice from DESNZ throughout the work, and we are grateful for the help of all those who have
contributed to this NIR. A list of the contributors can be found in Chapter 18.
The GHGI is compiled according to the Intergovernmental Panel on Climate Change (IPCC)
2006 Guidelines (IPCC, 2006). Each year the inventory is updated to include the latest data
available. Improvements to the methodology are backdated as necessary to ensure a
consistent time series. Methodological changes are made to take account of new data sources,
or new guidance from IPCC, and new research, sponsored by DESNZ or otherwise
Pathogenic variants in the human m(6)A reader YTHDC2 are associated with primary ovarian insufficiency
Primary ovarian insufficiency (POI) affects 1% of women and carries significant medical and psychosocial sequelae. Approximately 10% of POI has a defined genetic cause, with most implicated genes relating to biological processes involved in early fetal ovary development and function. Recently, Ythdc2, an RNA helicase and N6-methyladenosine reader, has emerged as a regulator of meiosis in mice. Here, we describe homozygous pathogenic variants in YTHDC2 in 3 women with early-onset POI from 2 families: C. 2567C>G, p.P856R in the helicase-associated (HA2) domain and c.1129G>T, p.E377*. We demonstrated that YTHDC2 is expressed in the developing human fetal ovary and is upregulated in meiotic germ cells, together with related meiosisassociated factors. The p.P856R variant resulted in a less flexible protein that likely disrupted downstream conformational kinetics of the HA2 domain, whereas the p.E377*variant truncated the helicase core. Taken together, our results reveal that YTHDC2 is a key regulator of meiosis in humans and pathogenic variants within this gene are associated with POI
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses
Common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody responses. Incomplete genetic penetrance and ample phenotypic expressivity in CVID suggest the participation of additional pathogenic mechanisms. Monozygotic (MZ) twins discordant for CVID are uniquely valuable for studying the contribution of epigenetics to the disease. Here, we generate a single-cell epigenomics and transcriptomics census of naĂŻve-to-memory B cell differentiation in a CVID-discordant MZ twin pair. Our analysis identifies DNA methylation, chromatin accessibility and transcriptional defects in memory B-cells mirroring defective cell-cell communication upon activation. These findings are validated in a cohort of CVID patients and healthy donors. Our findings provide a comprehensive multi-omics map of alterations in naĂŻve-to-memory B-cell transition in CVID and indicate links between the epigenome and immune cell cross-talk. Our resource, publicly available at the Human Cell Atlas, gives insight into future diagnosis and treatments of CVID patients
Double parton correlations and constituent quark models: a light front approach to the valence sector
An explicit evaluation of the double parton distribution functions (dPDFs), within a relativistic Light-Front approach to constituent quark models, is presented. dPDFs encode information on the correlations between two partons inside a target and represent the non-perturbative QCD ingredient for the description of double parton scattering in proton-proton collisions, a crucial issue in the search of new Physics at the LHC. Valence dPDFs are evaluated at the low scale of the model and the perturbative scale of the experiments is reached by means of QCD evolution. The present results show that the strong correlation effects present at the scale of the model are still sizable, in the valence region, at the experimental scale. At the low values of x presently studied at the LHC the correlations become less relevant, although they are still important for the spin-dependent contributions to unpolarized proton scattering
The Italian arm of the PREPARE study: an international project to evaluate and license a maternal vaccine against group B streptococcus.
BACKGROUND: Group B streptococcus (GBS) is a leading cause of sepsis, pneumonia and meningitis in infants, with long term neurodevelopmental sequelae. GBS may be associated with poor pregnancy outcomes, including spontaneous abortion, stillbirth and preterm birth. Intrapartum antibiotic prophylaxis (IAP) is currently the only way to prevent early-onset disease (presenting at 0 to 6âdays of life), although it has no impact on the disease presenting over 6âdays of life and its implementation is challenging in resource poor countries. A maternal vaccine against GBS could reduce all GBS manifestations as well as improve pregnancy outcomes, even in low-income countries. MAIN BODY: The term "PREPARE" designates an international project aimed at developing a maternal vaccination platform to test vaccines against neonatal GBS infections by maternal immunization. It is a non-profit, multi-center, interventional and experimental study (promoted by the St George University of London. [UK]) with the aim of developing a maternal vaccination platform, determining pregnancy outcomes, and defining the extent of GBS infections in children and mothers in Africa. PREPARE also aims to estimate the protective serocorrelates against the main GBS serotypes that cause diseases in Europe and Africa and to conduct two trials on candidate GBS vaccines. PREPARE consists of 6 work packages. In four European countries (Italy, UK, Netherlands, France) the recruitment of cases and controls will start in 2020 and will end in 2022. The Italian PREPARE network includes 41 centers. The Italian network aims to collect: GBS isolates from infants with invasive disease, maternal and neonatal sera (cases); cord sera and GBS strains from colonized mothers whose infants do not develop GBS infection (controls). SHORT CONCLUSION: PREPARE will contribute information on protective serocorrelates against the main GBS serotypes that cause diseases in Europe and Africa. The vaccine that will be tested by the PREPARE study could be an effective strategy to prevent GBS disease
Field Measurements of the Atmospheric Dry Deposition Fluxes and Velocities of Polycyclic Aromatic Hydrocarbons to the Global Oceans
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
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