System of the Electronic Information Display

Import 05/08/2014Práce se zabývá vytvořením světelného ukazatele skóre pro rekreační sporty. Světelná tabule obsahuje umělou inteligenci, která dokáže samostatně vyhodnocovat pravidla zvolené hry, ukazatel tedy bude multifunkční a po spuštění bude možno zvolit typ hry. Prozatím se uvažuje o čtyřech integrovaných hrách: Volejbal, Nohejbal, Petangue a doplňková funkce zápisník. V komerční sféře se takovéto světelné tabule cenově pohybují v řádech desetitisíců českých korun. Navíc je nutno, aby takovouto tabuli obsluhoval operátor. U světelné tabule, která je objektem této práce, se uvažuje s dálkovým ovládáním velikosti klíčenky s možností plné ovladatelnosti světelné tabule. Koncepce počítá s obsluhou této klíčenky, a skrze ni se světelnou tabulí, v osobě jednoho z hráčů, v čemž je tedy výhoda oproti komerčním projektům. V této práci počítám s vývojem vlastních zobrazovacích jednotek, LED displejů a s konstrukcí odolného a estetického hardwaru.The subject of this thesis is making a light board for recreational sports. The light board contains an artificial intelligence, which is capable of evaluating the rules of a chosen game. The light board is multifunctional and after each start provides a selection of game types. Currently the following game modes are available: Volleyball and its variations played in legs, Petanque and a notepad function. In the commercial sphere, the cost of this light board can be calculated to tens of thousands, although the actual cost is relative to the functionality given to the board controller. The lighting board is controlled by a small controller that can be easily handled by one of the players; this feature is one of the subjects of this work and places it at an advantage over other score boards currently available on the market. This thesis will also explore the development of the board’s LED display and its tough, esthetic exterior.450 - Katedra kybernetiky a biomedicínského inženýrstvívýborn

Design of range calculation algorithms and optimization of energy flow control for electric vehicles

Práce se zaměřuje na výpočet dojezdu bateriových elektrických vozidel a řízení toku energií v nich. Činí tak pomocí pokročilých algoritmů založených na kombinaci matematického a datového modelu. Tato metoda by se mohla stát velmi účinným a nezbytným nástrojem k přijetí elektromobility širokou veřejností a k odstranění strachu z nízkého dojezdu. Největší výzvou v řešení tohoto problému je vytvoření dostatečně přesného a zároveň robustního algoritmu. Práce se zaměřuje na vývoj algoritmu pomocí datového a matematického modelu. Tento algoritmus dovede nejen přesně určit dojezd za daných podmínek, ale rovněž je schopen řídit energie ve vozidle tak, aby bylo dosaženo cíle trasy dle nastaveného optimalizačního kritéria. Práce zahrnuje mimo jiné shrnutí této relativně nové problematiky, vývoj modelů, vývoj a nasazení algoritmu a srovnání s reálnými daty.This thesis focuses on the calculation of the range of battery electric vehicles and the control of energy flow in them. It does so by using advanced algorithms based on a combination of mathematical and data model. This method could become a highly effective and necessary tool for the acceptance of electromobility by the general public and to eliminate the range anxiety. The greatest challenge in solving this problem is to create a sufficiently accurate and at the same time robust algorithm. This thesis focuses on the development of an algorithm using data and a mathematical model. This algorithm can accurately determine the range under given conditions in addition to that is also able to control the energy in the vehicle so that the destination of the route is always reached according to the set optimization criteria. This thesis includes a summary of this relatively new issue, the development of model, the development and deployment of algorithms and its comparisons with real data.450 - Katedra kybernetiky a biomedicínského inženýrstvívyhově

Control and Information System for Electric Vehicle

Import 03/11/2016Tato práce se zabývá vývojem řídicího a informačního systému a výrobou prototypu elektrického jednostopého vozidla s důrazem na použití bezkartáčového motoru s permanentními magnety a baterií jako zdrojem elektrické energie. Vyvinutý řídicí systém umožňuje provádět konfiguraci parametrů vozidla operátorem, kterému rovněž budou zobrazovány potřebné údaje, jako například rychlost, ujetou vzdálenost nebo procesní teploty. Dále také budou zobrazována data ze správy bateriového systému (BMS), jako například dojezd na stávající kapacitu baterie, okamžitý výkon a další. Zobrazovací jednotka byla vybrána na základě experimentálně zajištěných parametrů při provozu vozidla, zejména čitelnost při různých světelných podmínkách byla rozhodující. Vozidlo je vybaveno standardní regulací rychlosti, možností reverzace i nadstandardními funkcemi, jakými je tempomat, světla a klakson. Hlavním přínosem práce je vytvoření elektrické dvoustupňové převodovky, která pracuje na nepříliš často využívaném principu přepínání motoru mezi konfiguracemi zapojení do hvězdy a do trojúhelníku.This thesis deals with a development of control and information system and a production of prototype of electric wheeled vehicle with an emphasis on a use of brushless engine with permanent magnets and battery which us a power source. The developed control system allows to configure parameters of the vehicle by an operator, which also will have necessary information, such as speed, distance travelled, or process temperature diplayed. Data from a battery management system (BMS), such as the range of actual capacity of the battery, instantaneous power and more, can be displayed as well. A display unit has been chosen based on experimental parameters which had been obtained during operation of the vehicle, especially the legibility under various light conditions was crucial. The vehicle is equipped with a standard speed control, reverse options and premium functions such as cruise control, lights and horn. The main contribution of this thesis is the creation of an electric two-stage gear, which works on rarely used principle when an engine is switching between star configuration and triangle configuration.450 - Katedra kybernetiky a biomedicínského inženýrstvívelmi dobř

Lokal authority with a social hall

Cílem této diplomové práce je zpracování stavební části projektu provedení stavby nového obecního úřadu se společenským sálem daného rozsahu. Práce se v úvodu zabývá problematikou střešních konstrukčních soustav, na kterou navazuje návrh a posudek vazníkové střešní konstrukce společenského sálu. V další části práce je vypracována technická zpráva a výkresová část projektu. Práce dále obsahuje tepelně technické posouzení obvodových konstrukcí a energetický štítek obálky budovy.The main goal of the diploma thesis is construction project of new local authority with a social hall in a given range. In the introductory part is mentioned overview of roof structural systems, which is followed by the design and static report of the timber truss roof of social hall. Then follows elaboration of the technical report and drawing documentation. In the next part the thesis contains a thermal and technical assessment of building nad building envelope energy label.225 - Katedra pozemního stavitelstvívýborn

Multi-storey residential house made of wood-based materials

Cílem této bakalářské práce je vypracovat návrh a posudek hlavní nosné konstrukce vícepodlažního obytného domu s konstrukčním systémem těžkého dřevěného skeletu na základě vnitřních sil získaných z prostorového výpočetního modelu. V úvodní části práce je zmíněn přehled historických a novodobých konstrukčních systému z materiálu na bázi dřeva, vyskytujících se na našem území v současnosti. Poté se práce zabývá návrhem celkové dispozice obytného domu a popisem jeho konstrukčního řešení. V hlavní části práce jsou popsány skladby konstrukcí se zatížením a posouzení rozhodujících nosných prvků a spojů, včetně ztužení a kotvení. V závěrečné části je popsán zjednodušený montážní postup nosné i nenosné konstrukce obytného domu.The main goal of this bachelor thesis is to design the main parts of load-bearing structure of multi-storey residential house with the heavy frame timber system. The designing of load-bearing structure is based on internal forces from 3D computational model. In the introductory part is mentioned overview of historical and modern load-bearing structural systems made of wood-based materials occuring nowadays in our locations. After that the thesis deals with the designing of disposition and description load-bearing structural solution of multi-storey residential house. In the main part are discribed compositions of walls and roofs under the loads and the assessment of the main load-bearing elements and joints, including anchoring and toughening of the structure. In the last part of the thesis is described simplified structural procedure of load-bearing and non-load-bearing structure of multi-storey residential house.221 - Katedra konstrukcívýborn

Synaptic Transmission from Horizontal Cells to Cones Is Impaired by Loss of Connexin Hemichannels

In the vertebrate retina, horizontal cells generate the inhibitory surround of bipolar cells, an essential step in contrast enhancement. For the last decades, the mechanism involved in this inhibitory synaptic pathway has been a major controversy in retinal research. One hypothesis suggests that connexin hemichannels mediate this negative feedback signal; another suggests that feedback is mediated by protons. Mutant zebrafish were generated that lack connexin 55.5 hemichannels in horizontal cells. Whole cell voltage clamp recordings were made from isolated horizontal cells and cones in flat mount retinas. Light-induced feedback from horizontal cells to cones was reduced in mutants. A reduction of feedback was also found when horizontal cells were pharmacologically hyperpolarized but was absent when they were pharmacologically depolarized. Hemichannel currents in isolated horizontal cells showed a similar behavior. The hyperpolarization-induced hemichannel current was strongly reduced in the mutants while the depolarization-induced hemichannel current was not. Intracellular recordings were made from horizontal cells. Consistent with impaired feedback in the mutant, spectral opponent responses in horizontal cells were diminished in these animals. A behavioral assay revealed a lower contrast-sensitivity, illustrating the role of the horizontal cell to cone feedback pathway in contrast enhancement. Model simulations showed that the observed modifications of feedback can be accounted for by an ephaptic mechanism. A model for feedback, in which the number of connexin hemichannels is reduced to about 40%, fully predicts the specific asymmetric modification of feedback. To our knowledge, this is the first successful genetic interference in the feedback pathway from horizontal cells to cones. It provides direct evidence for an unconventional role of connexin hemichannels in the inhibitory synapse between horizontal cells and cones. This is an important step in resolving a long-standing debate about the unusual form of (ephaptic) synaptic transmission between horizontal cells and cones in the vertebrate retina

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Mechanical thrombectomy in acute stroke : five years of experience in Poland

Objectives: Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland. Methods and results: We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data sets that include 61 clinical, radiological and outcome measures. Results: Most of the CSCs (74%) were founded at University Hospitals and most (65.2%) work round the clock. In 78.3% of them, the working teams are composed of neurologists and neuro-radiologists. All CSCs perform CT and angio-CT before MT. In total 586 patients were subjected to MT and data from 531 of them were analyzed. Mean time laps from stroke onset to groin puncture was 250 99 min. 90.3% of the studied patients had MT within 6 h from stroke onset; 59.3% of them were treated with IV rt-PA prior to MT; 15.1% had IA rt-PA during MT and 4.7% - emergent stenting of a large vessel. M1 of MCA was occluded in 47.8% of cases. The Solitaire device was used in 53% of cases. Successful recanalization (TICI2b–TICI3) was achieved in 64.6% of cases and 53.4% of patients did not experience hemorrhagic transformation. Clinical improvement on discharge was noticed in 53.7% of cases, futile recanalization - in 30.7%, mRS of 0–2 - in 31.4% and mRS of 6 in 22% of cases. Conclusion: Our results can help harmonize standards for MT in Poland according to international guideline