144 research outputs found
Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment
Improved Orbital Parameters and Transit Monitoring for HD 156846b
HD 156846b is a Jovian planet in a highly eccentric orbit (e = 0.85) with a
period of 359.55 days. The pericenter passage at a distance of 0.16 AU is
nearly aligned to our line of sight, offering an enhanced transit probability
of 5.4% and a potentially rich probe of the dynamics of a cool planetary
atmosphere impulsively heated during close approach to a bright star (V = 6.5).
We present new radial velocity (RV) and photometric measurements of this star
as part of the Transit Ephemeris Refinement and Monitoring Survey (TERMS). The
RV measurements from Keck-HIRES reduce the predicted transit time uncertainty
to 20 minutes, an order of magnitude improvement over the ephemeris from the
discovery paper. We photometrically monitored a predicted transit window under
relatively poor photometric conditions, from which our non-detection does not
rule out a transiting geometry. We also present photometry that demonstrates
stability at the millimag level over its rotational timescale.Comment: 7 pages, 4 figures, accepted for publication in Ap
Refined stellar, orbital and planetary parameters of the eccentric HAT-P-2 planetary system
We present refined parameters for the extrasolar planetary system HAT-P-2
(also known as HD 147506), based on new radial velocity and photometric data.
HAT-P-2b is a transiting extrasolar planet that exhibits an eccentric orbit. We
present a detailed analysis of the planetary and stellar parameters, yielding
consistent results for the mass and radius of the star, better constraints on
the orbital eccentricity, and refined planetary parameters. The improved
parameters for the host star are M_star = 1.36 +/- 0.04 M_sun and R_star = 1.64
+/- 0.08 R_sun, while the planet has a mass of M_p = 9.09 +/- 0.24 M_Jup and
radius of R_p = 1.16 +/- 0.08 R_Jup. The refined transit epoch and period for
the planet are E = 2,454,387.49375 +/- 0.00074 (BJD) and P = 5.6334729 +/-
0.0000061 (days), and the orbital eccentricity and argument of periastron are e
= 0.5171 +/- 0.0033 and omega = 185.22 +/- 0.95 degrees. These orbital elements
allow us to predict the timings of secondary eclipses with a reasonable
accuracy of ~15 minutes. We also discuss the effects of this significant
eccentricity including the characterization of the asymmetry in the transit
light curve. Simple formulae are presented for the above, and these, in turn,
can be used to constrain the orbital eccentricity using purely photometric
data. These will be particularly useful for very high precision, space-borne
observations of transiting planets.Comment: Revised version, accepted for publication in MNRAS, 11 pages, 6
figure
Evaluation of MetriGenix custom 4D™ arrays applied for detection of breast cancer subtypes
BACKGROUND: Previously, a total of five breast cancer subtypes have been identified based on variation in gene expression patterns. These expression profiles were also shown to be associated with different prognostic value. In this study tumour samples from 27 breast cancer patients, previously subtyped by expression analysis using DNA microarrays, and four controls from normal breast tissue were included. A new MetriGenix 4D™ array proposed for diagnostic use was evaluated. METHODS: We applied MetriGenix custom 4D™ arrays for the detection of previously defined molecular subtypes of breast cancer. MetriGenix 4D™ arrays have special features including probe immobilization in microchannels with chemiluminescence detection that enable shorter hybridization time. RESULTS: The MetriGenix 4D™ array platform was evaluated with respect to both the accuracy in classifying the samples as well as the performance of the system itself. In a cross validation analysis using "Nearest Shrunken Centroid classifier" and the PAM software, 77% of the samples were classified correctly according to earlier classification results. CONCLUSION: The system shows potential for fast screening; however, improvements are needed
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma
Analysis of LIGO data for gravitational waves from binary neutron stars
We report on a search for gravitational waves from coalescing compact binary
systems in the Milky Way and the Magellanic Clouds. The analysis uses data
taken by two of the three LIGO interferometers during the first LIGO science
run and illustrates a method of setting upper limits on inspiral event rates
using interferometer data. The analysis pipeline is described with particular
attention to data selection and coincidence between the two interferometers. We
establish an observational upper limit of 1.7 \times 10^{2}M_\odot$.Comment: 17 pages, 9 figure
Setting upper limits on the strength of periodic gravitational waves from PSR J1939+2134 using the first science data from the GEO 600 and LIGO detectors
Data collected by the GEO 600 and LIGO interferometric gravitational wave detectors during their first observational science run were searched for continuous gravitational waves from the pulsar J1939+2134 at twice its rotation frequency. Two independent analysis methods were used and are demonstrated in this paper: a frequency domain method and a time domain method. Both achieve consistent null results, placing new upper limits on the strength of the pulsar's gravitational wave emission. A model emission mechanism is used to interpret the limits as a constraint on the pulsar's equatorial ellipticity
First upper limits from LIGO on gravitational wave bursts
We report on a search for gravitational wave bursts using data from the first
science run of the LIGO detectors. Our search focuses on bursts with durations
ranging from 4 ms to 100 ms, and with significant power in the LIGO sensitivity
band of 150 to 3000 Hz. We bound the rate for such detected bursts at less than
1.6 events per day at 90% confidence level. This result is interpreted in terms
of the detection efficiency for ad hoc waveforms (Gaussians and sine-Gaussians)
as a function of their root-sum-square strain h_{rss}; typical sensitivities
lie in the range h_{rss} ~ 10^{-19} - 10^{-17} strain/rtHz, depending on
waveform. We discuss improvements in the search method that will be applied to
future science data from LIGO and other gravitational wave detectors.Comment: 21 pages, 15 figures, accepted by Phys Rev D. Fixed a few small typos
and updated a few reference
Improving the sensitivity to gravitational-wave sources by modifying the input-output optics of advanced interferometers
We study frequency dependent (FD) input-output schemes for signal-recycling
interferometers, the baseline design of Advanced LIGO and the current
configuration of GEO 600. Complementary to a recent proposal by Harms et al. to
use FD input squeezing and ordinary homodyne detection, we explore a scheme
which uses ordinary squeezed vacuum, but FD readout. Both schemes, which are
sub-optimal among all possible input-output schemes, provide a global noise
suppression by the power squeeze factor, while being realizable by using
detuned Fabry-Perot cavities as input/output filters. At high frequencies, the
two schemes are shown to be equivalent, while at low frequencies our scheme
gives better performance than that of Harms et al., and is nearly fully
optimal. We then study the sensitivity improvement achievable by these schemes
in Advanced LIGO era (with 30-m filter cavities and current estimates of
filter-mirror losses and thermal noise), for neutron star binary inspirals, and
for narrowband GW sources such as low-mass X-ray binaries and known radio
pulsars. Optical losses are shown to be a major obstacle for the actual
implementation of these techniques in Advanced LIGO. On time scales of
third-generation interferometers, like EURO/LIGO-III (~2012), with
kilometer-scale filter cavities, a signal-recycling interferometer with the FD
readout scheme explored in this paper can have performances comparable to
existing proposals. [abridged]Comment: Figs. 9 and 12 corrected; Appendix added for narrowband data analysi
Upper limits on the strength of periodic gravitational waves from PSR J1939+2134
The first science run of the LIGO and GEO gravitational wave detectors
presented the opportunity to test methods of searching for gravitational waves
from known pulsars. Here we present new direct upper limits on the strength of
waves from the pulsar PSR J1939+2134 using two independent analysis methods,
one in the frequency domain using frequentist statistics and one in the time
domain using Bayesian inference. Both methods show that the strain amplitude at
Earth from this pulsar is less than a few times .Comment: 7 pages, 1 figure, to appear in the Proceedings of the 5th Edoardo
Amaldi Conference on Gravitational Waves, Tirrenia, Pisa, Italy, 6-11 July
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