Polar UVI images to study steady magnetospheric convection events: Initial results

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94804/1/grl20687.pd

Dependence of the global dayside reconnection rate on interplanetary magnetic field By and the earth’s dipole tilt

In the recent years, significant attention has been given to the combined effect of Interplanetary Magnetic Field (IMF) duskward component (By) and dipole tilt on the global magnetosphere-ionosphere system response. Numerous studies have pointed out that when the Earth’s magnetic dipole is tilted away from the Sun (negative dipole tilt during northern winter), and IMF has a positive By component, the effects on ionospheric currents, particle precipitation, ionospheric convection, and average size of the auroral oval, is significantly more enhanced, compared to when IMF By is negative. Furthermore, this IMF By polarity effect reverses when Earth’s dipole is tilted in the opposite direction. The underlying cause has remained unclear. Our analysis shows that substorms tend to be stronger during the same IMF By and dipole tilt polarity combination. Taken together with earlier results showing also more frequent substorms during the same conditions, our observations suggests that when IMF By and dipole tilt have opposite signs, there is a more efficient global dayside reconnection rate. We also show analysis of the occurrence frequency of periods of Steady Magnetospheric Convection, substorm onset latitude, and the isotropic boundary of proton precipitation, that are all consistent with our conclusion that the combination of IMF By and dipole tilt polarity affect the global dayside reconnection rate.publishedVersio

Characterizing the 18 April 2002 storm‐time sawtooth events using ground magnetic data

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95189/1/jgra17938.pd

Simulating the one‐dimensional structure of Titan's upper atmosphere: 1. Formulation of the Titan Global Ionosphere‐Thermosphere Model and benchmark simulations

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94638/1/jgre2819.pd

Simulating the one‐dimensional structure of Titan's upper atmosphere: 3. Mechanisms determining methane escape

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94596/1/jgre2822.pd

Paneth Cell Alterations During Ischemia-reperfusion, Follow-up, and Graft Rejection After Intestinal Transplantation

BACKGROUND Ischemia-reperfusion (IR) injury is inevitable during intestinal transplantation (ITx) and executes a key role in the evolution towards rejection. Paneth cells (PC) are crucial for epithelial immune defense and highly vulnerable to IR injury. We investigated the effect of ITx on PC after reperfusion (T0), during follow-up, and rejection. Moreover, we investigated whether PC loss was associated with impaired graft homeostasis. METHODS Endoscopic biopsies, collected according to center-protocol and at rejection episodes, were retrospectively included (n=28 ITx, n=119 biopsies) Biopsies were immunohistochemically co-stained for PC (lysozyme) and apoptosis, and PC/crypt and lysozyme intensity were scored. RESULTS We observed a decrease in PC/crypt and lysozyme intensity in the first week after ITx (W1) compared to T0. There was a tendency towards a larger decline in PC/crypt (p=0.08) and lysozyme intensity (p=0.08) in W1 in patients who later developed rejection compared to patients without rejection. Follow-up biopsies showed that the PC number recovered, whereas lysozyme intensity remained reduced. This persisting innate immune defect may contribute to the well-known vulnerability of the intestine to infection. There was no clear evidence that PC were affected throughout rejection. CONCLUSION This study revealed a transient fall in PC numbers in the early post-ITx period, but a permanent reduction in lysozyme intensity following ITx. Further research is needed to determine the potential clinical impact of PC impairment after ITx

Global 30–240 keV proton precipitation in the 17–18 April 2002 geomagnetic storms: 1. Patterns

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95215/1/jgra18503.pd

Simulating the one‐dimensional structure of Titan's upper atmosphere: 2. Alternative scenarios for methane escape

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94984/1/jgre2821.pd

Perioperative strategy in colonic surgery; LAparoscopy and/or FAst track multimodal management versus standard care (LAFA trial)

BACKGROUND: Recent developments in large bowel surgery are the introduction of laparoscopic surgery and the implementation of multimodal fast track recovery programs. Both focus on a faster recovery and shorter hospital stay. The randomized controlled multicenter LAFA-trial (LAparoscopy and/or FAst track multimodal management versus standard care) was conceived to determine whether laparoscopic surgery, fast track perioperative care or a combination of both is to be preferred over open surgery with standard care in patients having segmental colectomy for malignant disease. METHODS/DESIGN: The LAFA-trial is a double blinded, multicenter trial with a 2 × 2 balanced factorial design. Patients eligible for segmental colectomy for malignant colorectal disease i.e. right and left colectomy and anterior resection will be randomized to either open or laparoscopic colectomy, and to either standard care or the fast track program. This factorial design produces four treatment groups; open colectomy with standard care (a), open colectomy with fast track program (b), laparoscopic colectomy with standard care (c), and laparoscopic surgery with fast track program (d). Primary outcome parameter is postoperative hospital length of stay including readmission within 30 days. Secondary outcome parameters are quality of life two and four weeks after surgery, overall hospital costs, morbidity, patient satisfaction and readmission rate. Based on a mean postoperative hospital stay of 9 +/- 2.5 days a group size of 400 patients (100 each arm) can reliably detect a minimum difference of 1 day between the four arms (alfa = 0.95, beta = 0.8). With 100 patients in each arm a difference of 10% in subscales of the Short Form 36 (SF-36) questionnaire and social functioning can be detected. DISCUSSION: The LAFA-trial is a randomized controlled multicenter trial that will provide evidence on the merits of fast track perioperative care and laparoscopic colorectal surgery in patients having segmental colectomy for malignant disease