Tratamiento conservador del hallux valgus juvenil mediante ortesis nocturnas

Se presentan los resultados obtenidos con tratamiento conservador del hallux valgus juvenil con el uso de ortesis nocturnas confeccionadas a medida, con material termoplástico, en 18 pacientes con edades de 8 a 15 años (media: 12 años). El tiempo medio de tratamiento fue de 18 meses y los pacientes fueron seguidos después del tratamiento por igual período de tiempo. Debe destacarse el alto abandono del método que alcanzó la cifra del 44%. Fueron utilizados como parámetros de valoración de resultados las medidas radiográficas de los ángulos de valguismo del hallux (AVH) e intermetatarsiano l-II (AIM), obtenidas antes y después de terminado el período de observación. El valor medio inicial del AVH fue de 22° y al final fue de 20°. Las medidas de los valores del AIM fueron 11 y 10,7°, respectivamente. Ambas medidas no se diferencian entre sí desde el punto de vista estadístico, lo que lleva a concluir que el tratamiento utilizado no fue capaz de corregir las deformidades básicas del hallus valgus infantil, pero evita la progresión de esas deformidades.The results of conservative treatment of adolescent hallux valgus using custom made nocturnal splints in 18 patients ranging in age from 8 to 15 years (mean 12) are presented. The average period of treatment and follow-up was 18 months. There was a high rate (44%) of treatment abandon. As assessment parameters were used radiographic measures of the hallux valgus angle and the intermetatarsal I-II angle. Measures were obtained before treatment and at the end of follow-up. The initial mean valgus angle was 22° and the last mean value 20°. The mean valus of the intermetatarsal angle were respectively 11° and 10,7°. There were no significant statistical differences, indicating that the treatment of hallux valgus using nocturnal splintage do not correct the deformity but avoid its progression

A joint Fermi-GBM and Swift-BAT analysis of gravitational-wave candidates from the third gravitational-wave observing run

We present Fermi Gamma-ray Burst Monitor (Fermi-GBM) and Swift Burst Alert Telescope (Swift-BAT) searches for gamma-ray/X-ray counterparts to gravitational-wave (GW) candidate events identified during the third observing run of the Advanced LIGO and Advanced Virgo detectors. Using Fermi-GBM onboard triggers and subthreshold gamma-ray burst (GRB) candidates found in the Fermi-GBM ground analyses, the Targeted Search and the Untargeted Search, we investigate whether there are any coincident GRBs associated with the GWs. We also search the Swift-BAT rate data around the GW times to determine whether a GRB counterpart is present. No counterparts are found. Using both the Fermi-GBM Targeted Search and the Swift-BAT search, we calculate flux upper limits and present joint upper limits on the gamma-ray luminosity of each GW. Given these limits, we constrain theoretical models for the emission of gamma rays from binary black hole mergers

Constraints on the cosmic expansion history from GWTC–3

We use 47 gravitational wave sources from the Third LIGO–Virgo–Kamioka Gravitational Wave Detector Gravitational Wave Transient Catalog (GWTC–3) to estimate the Hubble parameter H(z), including its current value, the Hubble constant H0. Each gravitational wave (GW) signal provides the luminosity distance to the source, and we estimate the corresponding redshift using two methods: the redshifted masses and a galaxy catalog. Using the binary black hole (BBH) redshifted masses, we simultaneously infer the source mass distribution and H(z). The source mass distribution displays a peak around 34 M⊙, followed by a drop-off. Assuming this mass scale does not evolve with the redshift results in a H(z) measurement, yielding ${H}_{0}={68}_{-8}^{+12}\,\mathrm{km}\ \,\ {{\rm{s}}}^{-1}\,{\mathrm{Mpc}}^{-1}$ (68% credible interval) when combined with the H0 measurement from GW170817 and its electromagnetic counterpart. This represents an improvement of 17% with respect to the H0 estimate from GWTC–1. The second method associates each GW event with its probable host galaxy in the catalog GLADE+, statistically marginalizing over the redshifts of each event's potential hosts. Assuming a fixed BBH population, we estimate a value of ${H}_{0}={68}_{-6}^{+8}\,\mathrm{km}\ \,\ {{\rm{s}}}^{-1}\,{\mathrm{Mpc}}^{-1}$ with the galaxy catalog method, an improvement of 42% with respect to our GWTC–1 result and 20% with respect to recent H0 studies using GWTC–2 events. However, we show that this result is strongly impacted by assumptions about the BBH source mass distribution; the only event which is not strongly impacted by such assumptions (and is thus informative about H0) is the well-localized event GW190814

Search for gravitational-wave transients associated with magnetar bursts in advanced LIGO and advanced Virgo data from the third observing run

Gravitational waves are expected to be produced from neutron star oscillations associated with magnetar giant f lares and short bursts. We present the results of a search for short-duration (milliseconds to seconds) and longduration (∼100 s) transient gravitational waves from 13 magnetar short bursts observed during Advanced LIGO, Advanced Virgo, and KAGRA’s third observation run. These 13 bursts come from two magnetars, SGR1935 +2154 and SwiftJ1818.0−1607. We also include three other electromagnetic burst events detected by FermiGBM which were identified as likely coming from one or more magnetars, but they have no association with a known magnetar. No magnetar giant flares were detected during the analysis period. We find no evidence of gravitational waves associated with any of these 16 bursts. We place upper limits on the rms of the integrated incident gravitational-wave strain that reach 3.6 × 10−²³ Hz at 100 Hz for the short-duration search and 1.1 ×10−²² Hz at 450 Hz for the long-duration search. For a ringdown signal at 1590 Hz targeted by the short-duration search the limit is set to 2.3 × 10−²² Hz. Using the estimated distance to each magnetar, we derive upper limits upper limits on the emitted gravitational-wave energy of 1.5 × 1044 erg (1.0 × 1044 erg) for SGR 1935+2154 and 9.4 × 10^43 erg (1.3 × 1044 erg) for Swift J1818.0−1607, for the short-duration (long-duration) search. Assuming isotropic emission of electromagnetic radiation of the burst fluences, we constrain the ratio of gravitational-wave energy to electromagnetic energy for bursts from SGR 1935+2154 with the available fluence information. The lowest of these ratios is 4.5 × 103

Open data from the third observing run of LIGO, Virgo, KAGRA, and GEO

The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in 2019 April and lasting six months, O3b starting in 2019 November and lasting five months, and O3GK starting in 2020 April and lasting two weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main data set, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages

Clinical Assessment Of Efficacy And Safety From Cordia Verbenacea Standartized Extract In Tendinitis And Chronical Miofacial Pain Patients [avaliação Clínica Da Eficácia E Segurança Do Uso De Extrato Padronizado Da Cordia Verbenacea Em Pacientes Portadores De Tendinite E Dor Miofascial]

The cream of Cordia verbenacea was evaluated regarding efficacy and use safety in 459 subjects (phase I+II+III). The achieved results related to the use safety of the medicine topically applied on different areas of skin integument, showed excellent tolerability of the product, clinically confirming the results achieved on preclinical toxicological studies(4,10,11,12). There was only one report of adverse event observed in one patient treated with cream of Cordia verbenacea with possible causal relation to the medicine (increase of sensibility), while the other 5 reports of adverse events in this group did not show relation to the drug. In the control group (diclofenaco dietilamônio), 15 occurrences of adverse events were reported, 4 of them were probably associated with the drug (cephalea, epigastralgia, vermilion, and pock on the area of application). The cream of Cordia verbenacea was evaluated regarding efficacy, on myofascial pain and tendinitis treatment, in 169 patients. 171 patients treated with diclofenaco dietilamônio 1% gel, were used as a control group. The same dose regimen was administered to both groups (topical use - 3 times a day). The distribution of the affections studied was also equally divided between both groups. The results referring to the use of the medicine topically applied on different areas of the body demonstrated excellent efficacy on the treatment of the evaluated musculoskeletal affections. According to all information presented in this report, in which the excellent efficacy and tolerability of the cream of Cordia verbenacea 0,5% gel was demonstrated, this product may be considered a progress and an important contribution for the therapeutic arsenal of muscoeskeletal affections where inflammatory processes exist. © Copyright Moreira Jr. Editora.621-24046Bonfiglioli, R., Brandão, G., Garcia, R., Miranda, J.B., Relatório final fase III. Estudo fase III, aberto, aleatório, prospectivo e comparativo para avaliação da eficácia e tolerabilidade do uso tópico da Cordia verbenacea e diclofenaco dietilamônio, em pacientes com tendinite crônica e dor miofascial (2004) Arquivo Aché, , São Paulo, maio deBonfiglioli, R., Brandão, G., Gamba, R., Relatório final fase II. Estudo fase II, aberto, aleatório, prospectivo e comparativo para avaliação da eficácia e tolerabilidade do uso tópico da Cordia verbenacea e diclofenaco dietilamônio, em pacientes com tendinite crônica e dor miofascial (2004) Arquivo Aché, , São Paulo, março deCalixto, J.B., Avaliação do efeito antiinflamatório tópico do creme da Cordia verbenacea 0,5% (2003) Arquivo Aché, , São Paulo, fevereiro deCalixto, J.B., Caracterização das ações antiinflamató rias e antinociceptivas do óleo essencial obtida da Cordia verbenacea (2003) Arquivo Aché, , São Paulo, janeiro deCalixto, J.B., Análise toxicológica do creme e do ȯleo essencial de Cordia verbenacea (2002) Arquivo Aché, , São Paulo, FevereiroCalixto, J.B., Análise farmacológica "in vivo" e "in vitro" das propriedades antiinflamatórias, antinociceptivas e imunomodulatórias da Cordia verbenacea (Erva baleeira) (2001) Arquivo Aché, , São Paulo, janeiro deCalixto, J.B., Análise das propriedades antiinflamatórias tópicas de extratos e óleo essenciais obtidos da Cordia verbenacea (Erva baleeira) (2001) Arquivo Aché, , São Paulo, agosto deCalixto, J.B., Desenvolvimento de fitoterȧpico com ação antiinflamatória e antinocicpetiva (tópica e sistêmica) a partir da Cordia verbenacea. Seleção de marcadores ativos, análise das variações sazonais e dos mecanismos de ação do óleo essencial e de seus componentes (2004) Arquivo Aché, , São Paulo, junho deMigliano, M.B., Toxicidade dérmica aguda (14 dias) em cães Beagle (2002) Arquivo Aché, , São Paulo, junho dePestana, C.B., Teste de irritação ocular a curto prazo em coelhos (2004) Arquivo Aché, , março deRitto, J.L.A., Caracterização farmacognóstica da Erva Baleeira e laudo de identificação botânica de amostra cultivada em Paulínia - SP (2004) Arquivo Aché, , São Paulo, janeiro deVergnanini, A.L., Estudo clínico, aberto, da tolerabilidade cutânea, com aplicação tópica supervisionada e controle laboratorial do produto creme de Cordia verbenacea 0,5% (2002) Arquivo Aché, , São Paulo, abril d

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora