89 research outputs found
Combination toceranib and lomustine shows frequent high grade toxicities when used for treatment of non-resectable or recurrent mast cell tumours in dogs: A European multicentre study
In vivo stem cell tracking using scintigraphy in a canine model of DMD
One of the main challenges in cell therapy for muscle diseases is to efficiently target the muscle. To address this issue and achieve better understanding of in vivo cell fate, we evaluated the relevance of a non-invasive cell tracking method in the Golden Retriever Muscular Dystrophy (GRMD) model, a well-recognised model of Duchenne Muscular Dystrophy (DMD). Mesoangioblasts were directly labelled with 111In-oxine, and injected through one of the femoral arteries. The scintigraphy images obtained provided the first quantitative mapping of the immediate biodistribution of mesoangioblasts in a large animal model of DMD. The results revealed that cells were trapped by the first capillary filters: the injected limb and the lung. During the days following injection, radioactivity was redistributed to the liver. In vitro studies, performed with the same cells prepared for injecting the animal, revealed prominent cell death and 111In release. In vivo, cell death resulted in 111In release into the vasculature that was taken up by the liver, resulting in a non-specific and non-cell-bound radioactive signal. Indirect labelling methods would be an attractive alternative to track cells on the mid- and long-term
Photonic crystal carpet: Manipulating wave fronts in the near field at 1550 nm
Ground-plane cloaks, which transform a curved mirror into a flat one, and
recently reported at wavelengths ranging from the optical to the visible
spectrum, bring the realm of optical illusion a step closer to reality.
However, all carpet-cloaking experiments have thus far been carried out in the
far-field. Here, we demonstrate numerically and experimentally that a
dielectric photonic crystal (PC) of a complex shape made of a honeycomb array
of air holes can scatter waves in the near field like a PC with a at boundary
at stop band frequencies. This mirage effect relies upon a specific arrangement
of dielectric pillars placed at the nodes of a quasi-conformal grid dressing
the PC. Our carpet is shown to work throughout the range of wavelengths 1500nm
to 1650nm within the stop band extending from 1280 to 1940 nm. The device has
been fabricated using a single- mask advanced nanoelectronics technique on
III-V semiconductors and the near field measurements have been carried out in
order to image the wave fronts's curvatures around the telecommunication
wavelength 1550 nm.Comment: 6 page
Towards a codification of practical knowledge
International audienceAs practical knowledge seems to have a central place in organisational issues, we focus on possibilities to study and formalize it. From an unusual theoretical perspective, we view practical knowledge as embodied knowing which only is only manifest through action in a particular situation. Although this knowledge is largely implicit, we try to make what is 'articulable' explicit. After highlighting the stakes involved in the codification of practices, we review the ontological and epistemological assumptions underlying the method developed. It is founded on participant observation, a video recording of a situated subjective perspective and an ex post interview using this perspective to aid an actor to make part of his/her practical knowledge explicit. We present its implementation within research on polar expeditions in order to understand how an experienced actor deals with risks. In conclusion, we point out (1) the importance of this kind of data in knowledge management, (2) some lines of further research
Surface Plasmon mediated near-field imaging and optical addressing in nanoscience
We present an overview of recent progress in plasmonics. We focus our study
on the observation and excitation of surface plasmon polaritons (SPPs) with
optical near-field microscopy. We discuss in particular recent applications of
photon scanning tunnelling microscope (PSTM) for imaging of SPP propagating in
metal and dielectric wave guides. We show how near-field scanning optical
microscopy (NSOM) can be used to optically and actively address remotely
nano-objects such as quantum dots. Additionally we compare results obtained
with near-field microscopy to those obtained with other optical far-field
methods of analysis such as leakage radiation microscopy (LRM)
Problems in assessment of learning: The social construction of questions and answers in the scholastic context
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