978 research outputs found
De triggertheorie voor codewisseling: De oorspronkelijke en een aangepaste versie (‘The trigger theory for codeswitching: The original and an adjusted version’).
Multichronic complexity in second language development
Taking a dynamic systems perspective on second language development, this paper argues that development is change over time, which is never stable and has no end state. Moreover, time can be defined at different scales: from the millisecond, minute, week and year to the lifespan. At all scales we can see change over time in language development at different levels of granularity; however, the time scale and level of granularity we use determines to a great extent what we find. What seems a change at one level may be nothing more than natural variation at another one.Keywords: Multichronic complexity, language development, variation, time scale
The Living Rainforest Sustainable Greenhouses
The Living Rainforest (www.livingrainforest.org) is an educational charity that uses rainforest ecology as a metaphor for communicating general sustainability issues to the public. Its greenhouses and office buildings are to be renovated using the most sustainable methods currently available. This will be realised through construction of a high insulating greenhouse covering with a k-value of less than 2 Wm-2K-1, passive seasonal storage of excess summer solar energy in the ground by a ground source heat exchanger and exploitation of this low grade solar energy for heating in winter by a heat pump. In winter the heat pump will produce cold water to cool the ground allowing a passive cooling function in summer via the GSHE. It will be demonstrated that a GSHE is an alternative for an open aquifer in regions with no aquifer availability. The heat pump will deliver the heating baseload, the peak load will be delivered by a biomass boiler, fired with locally-sourced low-cost wood chips. It is expected that the energy saving will be about 75%, resulting in a major cost reduction. The low k-value of the covering is linked to a light transmission of 75 %. This is high enough for the demands of the vegetation in The Living Rainforest. Because the inner greenhouse climate demands are comparable to that of ornamentals, the results will be applicable to commercial ornamental production. In future low k-value coverings will also be available with high light transmission, allowing wider application of the results. This paper focuses on the correlation between k-value, light transmission and energy demand in order to investigate the trade-off between light transmittance (a major energy gain) and heat loss. The effects of these design parameters on storage and harvesting capacity are also considered but appear to have a low sensitivity. The renovated greenhouse site at The Living Rainforest will show that new greenhouses and ecology can be linked to sustainability and this will be communicated and demonstrated to the public
Institutional status and use of national languages in Europe:Contributions to the development of a European language policy
Diffuse far-infrared and ultraviolet emission in the NGC4435/4438 system: tidal stream or Galactic cirrus?
We report the discovery of diffuse far-infrared and far-ultraviolet emission
projected near the interacting pair NGC4435/4438, in the Virgo cluster. This
feature spatially coincides with a well known low surface-brightness optical
plume, usually interpreted as tidal debris. If extragalactic, this stream would
represent not only one of the clearest examples of intracluster dust, but also
a rare case of intracluster molecular hydrogen and large-scale intracluster
star formation. However, the ultraviolet, far-infrared, HI and CO emission as
well as the dynamics of this feature are extremely unusual for tidal streams
but are typical of Galactic cirrus clouds. In support to the cirrus scenario,
we show that a strong spatial correlation between far-infrared and
far-ultraviolet cirrus emission is observed across the center of the Virgo
cluster, over a scale of several degrees. This study demonstrates how dramatic
Galactic cirrus contamination can be, even at optical and ultraviolet
wavelengths and at high galactic latitudes. If ignored, the presence of diffuse
light scattered by Galactic dust clouds could significantly bias our
interpretation of low surface-brightness features and diffuse light observed
around galaxies and in clusters of galaxies.Comment: 6 pages, 4 figures. Accepted for publication in MNRAS Letter
The dusty SF history of high-z galaxies, modelling tools and future prospects
We summarize recent advances in the determination of the cosmic history of
star formation and other properties of high-z galaxies, and the relevance of
this information in our understanding of the formation of structures. We
emphasize the importance of dust reprocessing in the high--z universe, as
demonstrated in particular by IR and sub-mm data. This demand a panchromatic
approach to observations and suitable modelling tools. We spend also some words
on expectations from future instruments.Comment: 8 pages, to be published in "The link between stars and cosmology",
26-30 March, 2001, Puerto Vallarta, Mexico, by Kluwer, eds. M. Chavez, A.
Bressan, A. Buzzoni, and D. Mayy
The translation, validity and reliability of the German version of the Fremantle Back Awareness Questionnaire
Background: The Fremantle Back Awareness Questionnaire (FreBAQ) claims to assess disrupted self-perception of the back. The aim of this study was to develop a German version of the Fre-BAQ (FreBAQ-G) and assess its test-retest reliability, its known-groups validity and its convergent validity with another purported measure of back perception.
Methods: The FreBaQ-G was translated following international guidelines for the transcultural adaptation of questionnaires. Thirty-five patients with non-specific CLBP and 48 healthy participants were recruited. Assessor one administered the FreBAQ-G to each patient with CLBP on two separate days to quantify intra-observer reliability. Assessor two administered the FreBaQ-G to each patient on day 1. The scores were compared to those obtained by assessor one on day 1 to assess inter-observer reliability. Known-groups validity was quantified by comparing the FreBAQ-G score between patients and healthy controls. To assess convergent validity, patient\u27s FreBAQ-G scores were correlated to their two-point discrimination (TPD) scores.
Results: Intra- and Inter-observer reliability were both moderate with ICC3.1 = 0.88 (95%CI: 0.77 to 0.94) and 0.89 (95%CI: 0.79 to 0.94), respectively. Intra- and inter-observer limits of agreement (LoA) were 6.2 (95%CI: 5.0±8.1) and 6.0 (4.8±7.8), respectively. The adjusted mean difference between patients and controls was 5.4 (95%CI: 3.0 to 7.8, p\u3c0.01). Patient\u27s FreBAQ-G scores were not associated with TPD thresholds (Pearson\u27s r = -0.05, p = 0.79).
Conclusions: The FreBAQ-G demonstrated a degree of reliability and known-groups validity. Interpretation of patient level data should be performed with caution because the LoA were substantial. It did not demonstrate convergent validity against TPD. Floor effects of some items of the FreBAQ-G may have influenced the validity and reliability results. The clinimetric properties of the FreBAQ-G require further investigation as a simple measure of disrupted self-perception of the back before firm recommendations on its use can be made
Resident memory T cells in the atherosclerotic lesion associate with reduced macrophage content and increased lesion stability
Tissue resident memory T (TRM) cells are a T-cell subset that resides at the site of prior antigen recognition to protect the body against reoccurring encounters. Besides their protective function, TRM cells have also been implicated in inflammatory disorders. TRM cells are characterized by the expression of CD69 and transcription factors Hobit (homolog of Blimp-1 [B lymphocyte-induced maturation protein 1] in T cells) and Blimp-1. As the majority of T cells in the arterial intima expresses CD69, TRM cells may contribute to the pathogenesis of atherosclerosis as well. Here, we aimed to assess the presence and potential role of TRM cells in atherosclerosis.To identify TRM cells in human atherosclerotic lesions, a single-cell RNA-sequencing data set was interrogated, and T-cell phenotypes were compared with that of integrated predefined TRM cells. The presence and phenotype of TRM in atherosclerotic lesions was corroborated using a mouse model that enabled tracking of Hobit-expressing TRM cells. To explore the function of TRM cells during atherogenesis, RAG1-/- (RAG1 deficient) LDLr-/- (low-density lipoprotein receptor knockout) mice received a bone marrow transplant from HobitKO/CREBlimp-1flox/flox mice, which exhibit abrogated TRM cell formation, whereafter the mice were fed a Western-type diet for 10 weeks.Human atherosclerotic lesions contained T cells that exhibited a TRM cell-associated gene signature. Moreover, a fraction of these T cells clustered together with predefined TRM cells upon integration. The presence of Hobit-expressing TRM cells in the atherosclerotic lesion was confirmed in mice. These lesion-derived TRM cells were characterized by the expression of CD69 and CD49α. Moreover, we demonstrated that this small T-cell subset significantly affects lesion composition, by reducing the amount of intralesional macrophages and increasing collagen content.TRM cells, characterized by the expression of CD69 and CD49α, constitute a minor population in atherosclerotic lesions and are associated with increased lesion stability in a Hobit and Blimp-1 knockout mouse model.Biopharmaceutic
DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition i
The Nucleosome Remodeling and Deacetylase (NURD) complex is a key regulator of cell differentiation that has also been implicated in tumorigenesis. Loss of the NURD subunit Deleted in Oral Cancer 1 (DOC1) is associated with human oral squamous cell carcinomas (OSCCs). Here, we show that restoration of DOC1 expression in OSCC cells leads to a reversal of epithelial-mesenchymal transition (EMT). This is caused by the DOC1-dependent targeting of NURD to repress key transcriptional regulators of EMT. NURD recruitment drives extensive epigenetic reprogramming, including eviction of the SWI/SNF remodeler, formation of inaccessible chromatin, H3K27 deacetylation, and binding of PRC2 and KDM1A, followed by H3K27 methylation and H3K4 demethylation. Strikingly, depletion of SWI/SNF mimics the effects of DOC1 re-expression. Our results suggest that SWI/SNF and NURD function antagonistically to control chromatin state and transcription. We propose that disturbance of this dynamic equilibrium may lead to defects in gene expression that promote oncogenesis
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