16 research outputs found
The birth of a human-specific neural gene by incomplete duplication and gene fusion
- Author
- A Fortna
- AJ Sharp
- BE Davy
- BJ O’Roak
- BJ O’Roak
- BP Coe
- Bradley J. Nelson
- C Charrier
- Carl Baker
- D Reich
- EA Boyle
- Evan E. Eichler
- F Antonacci
- F Antonacci
- F Cunningham
- F Hach
- F Hach
- Francesca Antonacci
- GTEx Consortium
- GV Glazko
- H Olbrich
- HC Mefford
- HR Dawe
- I Lazaridis
- J Felsenstein
- J Harrow
- J Huddleston
- J Jun
- J Prado-Martinez
- JA Bailey
- JA Bailey
- JB Hiatt
- JD Parsons
- JD Thompson
- John Huddleston
- JP Bielawski
- JR Lupski
- K Prüfer
- K Tamura
- K Vandepoele
- K-F Lechtreck
- K-F Lechtreck
- Lana Harshman
- M Florio
- M Kimura
- M Kozak
- M Kozak
- M Lynch
- M Meyer
- M Nei
- M O’Bleness
- M O’Bleness
- Mario Ventura
- Max L. Dougherty
- MC Popesco
- Megan Y. Dennis
- Michael H. Duyzend
- MY Dennis
- MY Dennis
- N Brunetti-Pierri
- N Saitou
- NA Doggett
- NL Bray
- Osnat Penn
- P Stankiewicz
- PH Sudmant
- PH Sudmant
- PH Sudmant
- PH Sudmant
- Q Fu
- R Bernier
- RE Thurman
- Richard Sandstrom
- S Chen
- S Girirajan
- S John
- S Ohno
- T Kurosaki
- T Marques-Bonet
- T Ota
- WJ Kent
- WJ Kent
- X Nuttle
- Xander Nuttle
- Z Jiang
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background: Gene innovation by duplication is a fundamental evolutionary process but is difficult to study in humans due to the large size, high sequence identity, and mosaic nature of segmental duplication blocks. The human-specific gene hydrocephalus-inducing 2, HYDIN2, was generated by a 364 kbp duplication of 79 internal exons of the large ciliary gene HYDIN from chromosome 16q22.2 to chromosome 1q21.1. Because the HYDIN2 locus lacks the ancestral promoter and seven terminal exons of the progenitor gene, we sought to characterize transcription at this locus by coupling reverse transcription polymerase chain reaction and long-read sequencing. Results: 5' RACE indicates a transcription start site for HYDIN2 outside of the duplication and we observe fusion transcripts spanning both the 5' and 3' breakpoints. We observe extensive splicing diversity leading to the formation of altered open reading frames (ORFs) that appear to be under relaxed selection. We show that HYDIN2 adopted a new promoter that drives an altered pattern of expression, with highest levels in neural tissues. We estimate that the HYDIN duplication occurred ~3.2 million years ago and find that it is nearly fixed (99.9%) for diploid copy number in contemporary humans. Examination of 73 chromosome 1q21 rearrangement patients reveals that HYDIN2 is deleted or duplicated in most cases. Conclusions: Together, these data support a model of rapid gene innovation by fusion of incomplete segmental duplications, altered tissue expression, and potential subfunctionalization or neofunctionalization of HYDIN2 early in the evolution of the Homo lineage
The North American tree-ring fire-scar network
- Author
- Adam T. Naito
- Alan J. Tepley
- Alan Taylor
- Alexis H. Arizpe
- Alicia Azpeleta Tarancón
- Amanda B. Stan
- Andres Holz
- Andrew G. Merschel
- Anthony Caprio
- Brandon M. Collins
- Calvin Farris
- Cameron E. Naficy
- Charles W. Lafon
- Christopher Baisan
- Christopher D. O'Connor
- Christopher H. Guiterman
- Colleen Sutheimer
- Craig D. Allen
- Daniel C. Dey
- David Gervais
- David W. Huffman
- Denyse A. Dawe
- Dominique Arseneault
- Donald A. Falk
- Donald McKenzie
- Ellis Q. Margolis
- Erana J. Taylor
- Erica Bigio
- Evan Larson
- Franco Biondi
- Gabriel D. Cahalan
- Grant L. Harley
- Hang Li
- Helen M. Poulos
- Ichchha Thapa
- Igor Drobyshev
- James D. Johnston
- James H. Speer
- Jean M. Huffman
- Jeanne Portier
- Jed Meunier
- Jesse Minor
- Jill E. Harvey
- Jonathan D. Coop
- Jose Iniguez
- Joseph M. Marschall
- Julián Cerano‐Paredes
- Karen B. Arabas
- Keith Lombardo
- Kelsey Copes‐Gerbitz
- Kerry L. Metlen
- Kevin M. Robertson
- Kira M. Hoffman
- Kurt F. Kipfmueller
- Lane B. Johnson
- Larissa L. Yocom
- Laura Platt
- Lauren A. Stachowiak
- Lauren F. Howard
- Lori D. Daniels
- M. Adele Fenwick
- M. Lisa Floyd
- Malcolm North
- Manuel K. Lopez
- Marc‐André Parisien
- Martin P. Girardin
- Matthew D. Hurteau
- Micah R. Schmidt
- Michael Stambaugh
- Miguel L. Villarreal
- Monica T. Rother
- Peter J. Weisberg
- Peter Z. Fulé
- R. Stockton Maxwell
- Ramzi Touchan
- Raphaël D. Chavardès
- Rosemary L. Sherriff
- Scott Stephens
- Sean A. Parks
- Stanley G. Kitchen
- Thomas Saladyga
- Thomas W. Swetnam
- Valerie Trouet
- William Flatley
- William J. Platt
- Yves Bergeron
- Ze'ev Gedalof
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Fire regimes in North American forests are diverse and modern fire records are often too short to capture important patterns, trends, feedbacks, and drivers of variability. Tree-ring fire scars provide valuable perspectives on fire regimes, including centuries-long records of fire year, season, frequency, severity, and size. Here, we introduce the newly compiled North American tree-ring fire-scar network (NAFSN), which contains 2562 sites, >37,000 fire-scarred trees, and covers large parts of North America. We investigate the NAFSN in terms of geography, sample depth, vegetation, topography, climate, and human land use. Fire scars are found in most ecoregions, from boreal forests in northern Alaska and Canada to subtropical forests in southern Florida and Mexico. The network includes 91 tree species, but is dominated by gymnosperms in the genus Pinus. Fire scars are found from sea level to >4000-m elevation and across a range of topographic settings that vary by ecoregion. Multiple regions are densely sampled (e.g., >1000 fire-scarred trees), enabling new spatial analyses such as reconstructions of area burned. To demonstrate the potential of the network, we compared the climate space of the NAFSN to those of modern fires and forests; the NAFSN spans a climate space largely representative of the forested areas in North America, with notable gaps in warmer tropical climates. Modern fires are burning in similar climate spaces as historical fires, but disproportionately in warmer regions compared to the historical record, possibly related to under-sampling of warm subtropical forests or supporting observations of changing fire regimes. The historical influence of Indigenous and non-Indigenous human land use on fire regimes varies in space and time. A 20th century fire deficit associated with human activities is evident in many regions, yet fire regimes characterized by frequent surface fires are still active in some areas (e.g., Mexico and the southeastern United States). These analyses provide a foundation and framework for future studies using the hundreds of thousands of annually- to sub-annually-resolved tree-ring records of fire spanning centuries, which will further advance our understanding of the interactions among fire, climate, topography, vegetation, and humans across North America
Mammal responses to global changes in human activity vary by trophic group and landscape
- Author
- Allen Maximilian L.
- Alston Jesse M.
- Alvarenga Guilherme C.
- Amir Zachary
- Anhalt-Depies Christine
- Appel Cara
- Arroyo-Arce Stephanny
- Balme Guy
- Bar-Massada Avi
- Barcelos Daniele
- Barr Evan
- Barthelmess Erika L.
- Baruzzi Carolina
- Basak Sayantani M.
- Beenaerts Natalie
- Beirne Christopher
- Belmaker Jonathan
- Belova Olgirda
- Bezarević Branko
- Bird Tori
- Bogan Daniel A.
- Bogdanović Neda
- Boyce Andy
- Boyce Mark
- Brandt LaRoy
- Brodie Jedediah F.
- Brooke Jarred
- Bubnicki Jakub W.
- Burton A. Cole
- Cagnacci Francesca
- Calderón Francisco Samuel Álvarez
- Carr Benjamin Scott
- Carvalho João
- Casaer Jim
- Chen Ron
- Chow Emily
- Churski Marcin
- Cincotta Connor
- Coates T. D.
- Compton Justin
- Coon Courtney
- Cove Michael V.
- Crupi Anthony P.
- Darracq Andrea K.
- Davis Miranda
- Dawe Kimberly
- De Waele Valerie
- Descalzo Esther
- Diserens Tom A.
- Drimaj Jakub
- Duľa Martin
- Ellis-Felege Susan
- Ellison Caroline
- Ertürk Alper
- Fantle-Lepczyk Jean
- Farra Simone Dal
- Favreau Jorie
- Fennell Mitch
- Ferreras Pablo
- Ferretti Francesco
- Fiderer Christian
- Finnegan Laura
- Fisher Jason T.
- Fisher-Reid M. Caitlin
- Flaherty Elizabeth A.
- Fležar Urša
- Flousek Jiří
- Foca Jennifer M.
- Ford Adam
- Franzetti Barbara
- Frey Sandra
- Fritts Sarah
- Frýbová Šárka
- Furnas Brett
- Gaynor Kaitlyn M.
- Gerber Brian
- Geyle Hayley M.
- Giménez Diego G.
- Giordano Anthony J.
- Gomercic Tomislav
- Gompper Matthew E.
- Granados Alys
- Gray Morgan
- Green Austin
- Gräbin Diogo Maia
- Hagen Robert
- Hagen Robert (Bob)
- Hammerich Steven
- Hanekom Catharine
- Hansen Christopher
- Hasstedt Steven
- Hebblewhite Mark
- Heurich Marco
- Hofmeester Tim R.
- Hubbard Tru
- Jachowski David
- Jansen Patrick A.
- Jaspers Kodi Jo
- Jensen Alex
- Jordan Mark
- Kaizer Mariane C.
- Kays Roland
- Kelly Marcella J.
- Kohl Michel T.
- Kramer-Schadt Stephanie
- Krofel Miha
- Krug Andrea
- Kuhn Kellie M.
- Kuijper Dries P. J.
- Kuprewicz Erin K.
- Kusak Josip
- Kutal Miroslav
- Lafferty Diana J. R.
- LaRose Summer
- Lashley Marcus
- Lathrop Richard
- Lee Thomas E.
- Lepczyk Christopher
- Lesmeister Damon B.
- Licoppe Alain
- Linnell Marco
- Loch Jan
- Long Robert
- Lonsinger Robert C.
- Louvrier Julie
- Luskin Matthew Scott
- MacKay Paula
- Maher Sean
- Manet Benoît
- Mann Gareth K. H.
- Marshall Andrew J.
- Mason David
- McDonald Zara
- McKay Tracy
- McShea William J.
- Mechler Matt
- Miaud Claude
- Millspaugh Joshua J.
- Monteza-Moreno Claudio M.
- Moreira-Arce Dario
- Mullen Kayleigh
- Nagy Christopher
- Naidoo Robin
- Namir Itai
- Nelson Carrie
- Oberosler Valentina
- Osorio Christian
- Ossi Federico
- O’Mara M. Teague
- O’Neill Brian
- Palencia Pablo
- Pearson Kimberly
- Pedrotti Luca
- Pekins Charles E.
- Pendergast Mary
- Pinho Fernando F.
- Plhal Radim
- Pocasangre-Orellana Xochilt
- Price Melissa
- Procko Michael
- Proctor Mike D.
- Ramalho Emiliano Esterci
- Ranc Nathan
- Reljic Slaven
- Remine Katie
- Rentz Michael
- Revord Ronald
- Reyna-Hurtado Rafael
- Risch Derek
- Ritchie Euan G.
- Romero Andrea
- Rota Christopher
- Rovero Francesco
- Rowe Helen
- Rutz Christian
- Salvatori Marco
- Sandow Derek
- Schalk Christopher M.
- Scherger Jenna
- Schipper Jan
- Scognamillo Daniel G.
- Semenzato Paola
- Sevin Jennifer
- Shamon Hila
- Shier Catherine
- Silva-Rodríguez Eduardo A.
- Sindicic Magda
- Smyth Lucy K.
- Soyumert Anil
- Sprague Tiffany
- St. Clair Colleen Cassady
- Stenglein Jennifer
- Stephens Philip A.
- Stevens Michael
- Stevenson Cassondra
- Stępniak Kinga Magdalena
- Sun Catherine
- Ternyik Bálint
- Thomson Ian
- Torres Rita T.
- Tremblay Joan
- Urrutia Tomas
- Vacher Jean-Pierre
- Visscher Darcy
- Webb Stephen L.
- Weber Julian
- Weiss Katherine C. B.
- Whipple Laura S.
- Whittier Christopher A.
- Whittington Jesse
- Wierzbowska Izabela
- Wikelski Martin
- Williamson Jacque
- Wilmers Christopher C.
- Windle Todd
- Wittmer Heiko U.
- Zharikov Yuri
- Zorn Adam
- Ćirović Duško
- Černe Rok
- Şekercioğlu Çağan H.
- Publication venue
- Publication date
- 18/03/2024
- Field of study
Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in 102 projects around the world, changes in the amount and timing of animal activity varied widely. Under higher human activity, mammals were less active in undeveloped areas but unexpectedly more active in developed areas while exhibiting greater nocturnality. Carnivores were most sensitive, showing the strongest decreases in activity and greatest increases in nocturnality. Wildlife managers must consider how habituation and uneven sensitivity across species may cause fundamental differences in human–wildlife interactions along gradients of human influence.Peer reviewe
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
- Anderson E
- Anderson G
- Anderson R
- Anderson T
- Andersson H
- Andersson L
- Andreo J
- Andres C
- Andresen D
- Andrews G
- Andrews L
- Andrews R
- Andrioli V
- Angermann Ce
- Annas T
- Ansell V
- Antonio-drabek C
- Antonishen D
- Antonishen M
- Anuschek V
- Appel Kf
- Appel S
- Appleyard D
- Archer A
- Armitage J
- Armstrong L
- Armstrong M
- Arnesson K
- Arnold M
- Arora P
- Arp H
- Asbill B
- Ashbrook-raby C
- Ashton L
- Assarsson E
- Audet K
- Augenbraun C
- Aung HNIN THANDA
- Auscher S
- Ausner J
- Aviles R
- Awasty V
- Axelsson U
- Ayers S
- Ayub H
- Babar G
- Babington G
- Backlund M
- Badal B
- Baggiore C
- Baghiana S
- Bai H
- Bai J
- Baigent C
- Baillargeon G
- Bakbak A
- Baker S
- Baldin Mg
- Baldini E
- Baldwin E
- Ballantyne C
- Baltic A
- Banerjee S
- Bang Hansen M
- Banks K
- Bansilal S
- Barkley-daughtry S
- Barnes D
- Barnes E
- Barnett S
- Baroni Claudio
- Barry S
- Barter P
- Bartolomei Mecatti B
- Barton I
- Barton J
- Baré C
- Bashton D
- Basler M
- Bastani L
- Basvi P
- Batchlett K
- Bateman S
- Battistelli E
- Baty J
- Bauersachs J
- Bauman A
- Bavendiek U
- Baxter A
- Bayly G
- Bays H
- Beasley T
- Beck P
- Beck S
- Becker P
- Beebe S
- Been M
- Begg R
- Behm K
- Beilker J
- Beißner S
- Bekfani T
- Belanger B
- Belew K
- Bellaby J
- Bellamy C
- Bellini S
- Beneat Am
- Benedetto K
- Benoni S
- Bentivenga L
- Benton R
- Berg Schmidt E
- Berg-johansen J
- Berge C
- Bergengen L
- Bergmark B
- Bergmark C
- Bergsten P
- Bergström Ml
- Bergström O
- Bergvall L
- Bernardinangeli M
- Bernstein R
- Berry C
- Berry M
- Bertoli D
- Bertram W
- Bescak D
- Bescak K
- Betzl G
- Bhargava A
- Bhargava R
- Bhatia
- Bian B
- Bian H
- Bian X
- Bianchini Filippo
- Bibi A
- Bies J
- Bigelow A
- Biggers J
- Bilazarian S
- Billings C
- Binley E
- Biondi A
- Bird C
- Birner C
- Bisceglia T
- Bittar N
- Bittel B
- Bitzer V
- Biundo V
- Bjerge Kaspersen B
- Bjergo J
- Bjorkas A
- Björkman-larnefeldt M
- Bjørhovde V
- Black L
- Blackwood S
- Blake J
- Blankenberg S
- Blaustein R
- Blechert Å
- Bloksgaard Nilesen S
- Blower G
- Board J
- Boccalandro F
- Boccati S
- Boelmans K
- Boesgaard T
- Boggs L
- Bohn A
- Bohula May E
- Bolzani V
- Boman K
- Bongartz A
- Booth J
- Borg L
- Borucki K
- Bosiljanoff E
- Bosiljanoff P
- Bosnjak B
- Bossaers J
- Boulware W
- Bourhaial H
- Bowman L
- Bowsher Brown K
- Bowsher-brown K
- Brachmann J
- Bradley A
- Brady R
- Brandon P
- Braun-dullaeus R
- Braunwald E
- Bray C
- Breakspear S
- Breakwell L
- Brennan G
- Brenner S
- Bretton E
- Brettschneider B
- Breunig M
- Brewster A
- Brian S
- Brigden G
- Briggs S
- Brilloff S
- Brink-kjaer T
- Broadway K
- Broberg M
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- Brooks J
- Brooks-wolfe A
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- Brueggemann B
- Bruney C
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- Bryson V
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- Buccolieri M
- Buchholz M
- Buckley C
- Buda M
- Buerger M
- Buesing M
- Bukoski K
- Bulbulia R
- Bunn D
- Buresh R
- Burgess A
- Burke A
- Burkhardt V
- Burns S
- Burog W
- Bursey E
- Burton C
- Bushong D
- Butler E
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- Butman S
- Byng-hollander E
- Bönigk H
- Börjesson M
- Cai J
- Cakir M
- Caldarola P
- Calhoun E
- Call T
- Camerer M
- Campbell A
- Campbell Evan
- Campey L
- Campidonico U
- Cannon Cp
- Canto J
- Cao W
- Capponi E
- Capps N
- Capstraw E
- Caranzetti F
- Carey C
- CARIDAD HERNANDEZ JOSE MANUEL
- Carlos S
- Carlsen H
- Carlsson M
- Caro H
- Carrington M
- Carroll A
- Carter L
- Carver A
- Casey MAEVE ANN
- Casey MAEVE ANN
- Casolo G
- Castedal H
- Castro-foskett K
- Cathcart C
- Cauthren T
- Cavender M
- Cawley P
- Cayler J
- Cebe J
- Cederholm Ac
- Centofante L
- Ceresa M
- Cesanelli R
- Ceseri M
- Cha J
- Cha L
- Chackathayil J
- Chai X
- Chambers J
- Chausse I
- Chavagnon T
- Che H
- Chehayeb R
- Chen F
- Chen G
- Chen L
- Chen Minghe
- Chen Weipeng
- Chen X
- Chen Y
- Chen Z
- Cheng C
- Cheng Y
- Cherian G
- Cherrico M
- Chi L
- Chidambara H
- Childs A
- Chiodi Riccardo
- Chirio C
- Chmilewski S
- Christensen A
- Christensen B
- Christensen S
- Chu Y
- Chun-furlong D
- Chung K
- Chung R
- Ciampanelli E
- Ciuica S
- Clark A
- Clark S
- Clark W
- Clarke R
- Claxton E. Jr
- Clayton-evans L
- Clemens L
- Clements M
- Clemmensen P
- Cleveland T
- Cleverley P
- Cluley C
- Coates G
- Cobb L
- Cochrane H
- Cockram L
- Cockrell D
- Cohen R
- Colacone T
- Colfer H
- Colhoun H
- Colicchia J
- Collet A
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- Corcoran B
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- Cosmi F
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- Crandall L
- Creamer J
- Crescenti C
- Crews C
- Crisci C
- Crivellari ADAM MARIA ROMANO
- Crouch S
- Crowther J
- Cryderman A
- Cucchi GIANNI MARIO
- Cui G
- Cui R
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- Cummings J
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- Curless R
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- Custer C
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- Danish Rizvi M
- Darlington H
- Darrel-asherel E
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- Dayanandan R
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- De Burca B
- De Donno O
- De La Garza J
- De Lorenzi E
- De Matteis C
- De Servi S
- De Silva R
- Dechert M
- Defosse C
- Defraia C
- Del Mastro E
- Dela Cruz C
- Delgado T
- Delozier A
- Delucca P
- Demets D
- Deng X
- Dengler T
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- Desantis J
- Deslongchamp F
- Desousa C
- Destefano R
- Dettmer M
- Dhaliwal M
- Di Biase M
- DI BUONO Antonio
- Di Donato A
- Di Matteo C
- Di Pasquale G
- Di Ruocco M
- Diao Q
- Diaz L
- Dickinson RONALD CELESTE
- Dieckheuer U
- Dietrich D
- Diget H
- Dignon C
- Dinesen P
- Ding S
- Dionisopoulos P
- Dixon L
- Dolan M
- Domercant J
- Domingue N
- Donahoe S
- Donaldson D
- Dong Yingtian
- Donley B
- Donlin A
- Donà P
- Doty B
- Doucette W
- Doughty A
- Douglas J
- Downing J
- Drephal C
- Drexler A
- Drexler M
- Drouin K
- Drösch H
- Du N
- Du W
- Du Y
- Duan L
- Dubal S
- Dugan B
- Dulea I
- Dumais S
- Dungca E
- Dunne A
- Durì G
- Dy J
- Dyer H
- Dziekonski A
- Düngen Hd
- Easterling A
- Ebert J
- Edgell R
- Edvardsen L
- Edwards M
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- Egenrieder S
- Egresits J
- Egstrup K
- Eiben P
- Eichinger G
- Einhorn D
- Eisen A
- Eisenberg D
- Ek I
- Ekholm L
- Elberg B
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- Ensminger E
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- Eshaghian S
- Eskridge L
- Eubanks C
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- Evans-gay S
- Evenson C
- Fabbri Giorgio
- Fahrig A
- Fajardo-moser M
- Falco M
- Fam M
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- Fang X
- Fanola C
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- Feger J
- Fehling K
- Feldmann C
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- Felmeden L
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- Felthaus B
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- Feng J
- Feng T
- Ferguson D
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- Ferree L
- Ferreira J
- Ferruzzi P
- Festerling E
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- Field A
- Filippini E
- Filorizzo G
- Fink P
- Finnegan L
- Finney
- Fischer L
- Fish P
- Fisher E
- Fisher M
- Fisscher D
- Fitchet A
- Flagstad E
- Flanery V
- Fleming N
- Fleming S
- Fletcher L
- Fleury C
- Flores A
- Foley J
- Fontaine S
- Ford-tarlton M
- Forsberg K
- Forster S
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Measurements of photo-nuclear jet production in Pb plus Pb collisions with ATLAS
- Author
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- Yildirim E
- Yildiz HD
- Yorita K
- Yoshihara K
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- Yusuff I
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- Zalieckas J
- Zaman A
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- Zemla A
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- Zeng Q
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- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
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- Zhou N
- Zhu CG
- Zhu H
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- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- Zu Theenhausen HM
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Ultra-peripheral heavy ion collisions provide a unique opportunity to study the parton distributions in the colliding
nuclei via the measurement of photo-nuclear jet production. An analysis of jet production in ultra-peripheral Pb+Pb
collisions at √sNN = 5.02 TeV performed using data collected with the ATLAS detector in 2015 is described. The data
set corresponds to a total Pb+Pb integrated luminosity of 0.38 nb−1. The ultra-peripheral collisions are selected using a
combination of forward neutron and rapidity gap requirements. The cross-sections, not unfolded for detector response,
are compared to results from Pythia Monte Carlo simulations re-weighted to match a photon spectrum obtained from
the STARlight model. Qualitative agreement between data and these simulations is observed over a broad kinematic
range suggesting that using these collisions to measure nuclear parton distributions is experimentally realisable
Measurements of photo-nuclear jet production in Pb + Pb collisions with ATLAS
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam ER
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Alberich LC
- Albert J
- Albicocco P
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty M
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amorim A
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Angerami A
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Aranda CP
- Araque JP
- Araya ST
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
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- Ayoub MK
- Azuelos G
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- Baca MJ
- Bachacou H
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- Backhaus M
- Bagnaia P
- Bahrasemani H
- Baines JT
- Bajic M
- Baker OK
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Banas E
- Banerjee SW
- Bannoura AAE
- Barajas CAC
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barklow T
- Barlow N
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batley JR
- Battaglia M
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- Beacham JB
- Beattie MD
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- Beauchemin PH
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- Behr JK
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- Bellomo M
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- Beltramello O
- Belyaev NL
- Bemlochner FU
- Benary O
- Benchekroun D
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- Benhammou Y
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
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- Bilokon H
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- Black CW
- Black JE
- Black KM
- Blair RE
- Blazek T
- Bloch I
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- Blumenschein U
- Blunier S
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
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- Boehler M
- Boeriu OEV
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
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- Bomben M
- Bona M
- Boonekamp M
- Borisov A
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- Wildauer A
- Wilk F
- Wilkens HG
- Williams HH
- Williams S
- Willis C
- Willocq S
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf TMH
- Wolff R
- Wolter MW
- Wolters H
- Wong KHY
- Wong VWS
- Worm SD
- Wosiek BK
- Wotschack J
- Wozniak KW
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
- Xia L
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yamaguchi D
- Yamaguchi Y
- Yamamoto A
- Yamamoto S
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang Y
- Yang Z
- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu DR
- Yu J
- Yu J
- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
- Zeque SO
- Zerwas D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- Zu Theenhausen HM
- zur Nedden M
- Zwalinski L
- Publication venue
- 26th International Conference on Ultrarelativistic Nucleus-Nucleus Collissions (Quark Matter)
- Publication date
- 01/11/2017
- Field of study
Ultra-peripheral heavy ion collisions provide a unique opportunity to study the parton distributions in the colliding nuclei via the measurement of photo-nuclear jet production. An analysis of jet production in ultra-peripheral Pb+Pb collisions at √sNN = 5.02 TeV performed using data collected with the ATLAS detector in 2015 is described. The data set corresponds to a total Pb+Pb integrated luminosity of 0.38 nb⁻¹. The ultra-peripheral collisions are selected using a combination of forward neutron and rapidity gap requirements. The cross-sections, not unfolded for detector response, are compared to results from Pythia Monte Carlo simulations re-weighted to match a photon spectrum obtained from the STARlight model. Qualitative agreement between data and these simulations is observed over a broad kinematic range suggesting that using these collisions to measure nuclear parton distributions is experimentally realisable
Determination of apoptosis in actinic prurigo by TUNEL technique
- Publication venue
- 'Wiley'
- Publication date
- Field of study
New Poems
- Author
- Publication venue
- The Johns Hopkins University Press
- Publication date
- 01/07/1974
- Field of study
Directions for advancing the study of work transitions in the 21st century
- Author
- Akande Victor
- Backman Catherine
- Bossers Ann
- Bragg Mandy
- Bryson Mikelle
- Cowls Jocelyn
- Dawe Evan
- Dennhardt Silke
- Dennis Donna
- Foster Julia
- Friesen Margaret
- Galheigo Sandra
- Gichuri Jane
- Gruhl Karen Rebeiro
- Hocking Clare
- Hughes Ian
- Huot Suzanne
- Isaac Anthony
- Jacobs Karen
- Jarus Tal
- Kinsella Anne
- Klinger Lisa
- Leyshon Rhysa
- Lysaght Rosemary
- Magalhaes Lilian
- Mandich Angie
- McKay Elizabeth
- Orchard Treena
- Phelan Shanon
- Prodinger Birgit
- Ravenek Mike
- Robb Liz
- Rudman Debbie
- Shaw Lynn
- Stadnyk Robin
- Stone Sharon Dale
- Sumsion Thelma
- Suto Melinda
- Publication venue
- AMSTERDAM
- Publication date
- 01/01/2012
- Field of study
Objectives: The purpose of this article is to share the details, outcomes and deliverables from an international workshop on work transitions in London, Ontario, Canada. Participants: Researchers, graduate students, and community group members met to identity ways to advance the knowledge base of strategies to enhance work participation for those in the most disadvantaged groups within society. Methods: A participatory approach was used in this workshop with presentations by researchers and graduate students. This approach included dialogue and discussion with community members. In addition, small group dialogue and debate, world cafe discussions, written summaries of group discussion and reflection boards were used to bring new ideas to the discussion and to build upon what we know. Findings: Two research imperatives and six research recommendations were identified to advance global dialogue on work transitions and to advance the knowledge base. Occupational justice can be used to support future research directions in the study of work transitions. Conclusions: Moving forward requires a commitment of community of researchers, clinicians and stakeholders to address work disparities and implement solutions to promote participation in work
The Role of Stromal-Epithelial Interactions in the Regulation of Growth and Differentiation in Adult Epithelial Cells
- Author
- A Botero
- A Jost
- BH Donn
- BL Neubauer
- BL Neubauer
- CAB Jahoda
- CJ Dawe
- CP Leblond
- CS Potten
- CS Potten
- CW Daniel
- CW Daniel
- CW Daniel
- D Price
- DB Lubahn
- DP DeKlerk
- DS Coffey
- EA Bauer
- EJ Kollar
- EJ Kollar
- EYH Lee
- FR Lillie
- G Michalopoulos
- G Wasner
- GM Hodges
- GR Cimba
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- GR Cunha
- H Fujii
- H Takeda
- H Wang
- HM Evan
- I Lasnitzki
- J Cohen
- J Smolev
- JC Mackenzie
- JE McNeal
- JH Lillie
- JJ Cosse De
- JJ DeCosse
- JK Smolev
- JL Blum
- JM Shannon
- JM Shannon
- JM Shannon
- JP Bernimoulin
- JT Isaacs
- JT Norman
- JW Saunders
- K Haffen
- K Kratochwil
- K Kratochwil
- K Oishi
- L Ibrahim
- L Saxen
- LM Reid
- LWK Chung
- LWK Chung
- M Cooper
- M Kedinger
- MJ Bissell
- NE Fusenig
- NE Fusenig
- P Ekblom
- P Saiag
- PD Nieuwkoop
- PS Cooke
- RA Briggaman
- RE Billingham
- RF Oliver
- RH Sawyer
- RIC Spearman
- RM Hicks
- RM Weisman
- S Chaudhuri
- S Cohen
- S Ohno
- T Karring
- T Sakakura
- T Sakakura
- T Sakakura
- T Sakakura
- TC Thompson
- U Drews
- WF Dunning
- Y Sugimura
- Y Sugimura
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study