Латинська Америка в дослідженнях російських етнографів за останні тридцять років

Статья посвящена истории исследований в области латиноамериканистики российскими и советскими учёными на примере научной деятельности сотрудников Института этнографии им. Н. Н. Миклухо-Маклая АН СССР (московское и ленинградское отделения).The article is dedicated to the Latin American researches provided by the Russian and Soviet scientists illustrated with the scientific activities of the representatives of the Soviet Academy of Science’s Myklukho-Maklai Ethnographical Institute (Moscow and Leningrad branches)

Techno-economic packaging of palm wine preservation and bottling technology for entrepreneurs

The study was carried out to investigate the economic viability of setting up a small scale palm wine bottling factory with a view to providing investment data to guide entrepreneurs in making investment decisions. The economic evaluation was based on a factory capacity of 750,000 bottles (60cl) per annum with production commencing in year one at 75% capacity utilization. Production cost estimate varies between N37.85/bottle (60cl) in the first year and N35.37/bottle (60cl) in the fifth year. The annual netprofits are N8, 460,430.00 and N12, 025,710.00 in years one and five respectively. Projected cash flow is positive in year one i.e. N5,329,960.00 while the projected balance sheet shows that the net worth of theproject is N19,904,010.00 in year one and N41,887,370.00 in year five. Payback period, discounted payback period and profitability index are 1.4 years, 3.3 years and 1.5 respectively. The breakeven point in year one is 48.1% or a breakeven sales volume of N16, 236,312.35.00.  The Return on Investment (ROI) and Return on Equity (ROE) in year one are 57.5% and 86.1% respectively. Capital Turnover Ratio (CTR) varies between 2.3 and 2.9 within the first five years. Internal Rate of Return (IRR) is above 45%. The Net Present Value (NPV) at 25% is estimated at N3, 143,100.00. The Debt Service Coverage Ratio (DSCR) increases gradually from 1.33 to 2.75 between the first and the fifth year

Распределение металлической фазы в синтетических алмазах типа «карбонадо»

Studying of a structural structure synthetic «carbonado» is spent by a method of electronic scanning microscopy. It is established, that the surface «carbonado» is covered by the large diamond crystals reaching 200 microns, having obviously expressed structure of growth. On a surface of these crystals observed drops of metal-catalyst (nickel) of a submicronic range. It is established, that the structure synthetic «carbonado» represents interpenetrating skeletons from diamond and ceramic-metal phases

Термопружний стан шаруватих термочутливих циліндрів і куль за конвективно-променевого теплообміну

Розроблено методику розв’язування одновимірних статичних задач термопружності для шаруватих циліндрів і куль за конвективно-променевого нагрівання з урахуванням лінійної залежності коефіцієнтів теплопровідності та довільного характеру залежності інших фізико-механічних характеристик від температури. Задачі теплопровідності зведено, незалежно від кількості шарів, до розв’язування системи двох нелінійних алгебричних рівнянь. У задачах термопружності неперервні в межах кожного шару коефіцієнти рівнянь апроксимовано кусково-сталими функціями. Проведено числовий аналіз температурних полів і напружень у двошарових тілах.The method for solving one-dimensional static thermoelasticity problems is developed for layered cylinders and spheres under convective and radiation heating, taking into account linear dependence of heat conductivity coefficients and arbitrary character of dependence of other physical and mechanical characteristics on a temperature. Problems of heat conductivity have been reduced to the system of two nonlinear algebraic equations regardless of the number of layers. In the thermoelasticity problems the continuous within every layer coefficients of equations are approximated by piecewise constant functions. The numerical analysis of the temperature fields and stresses is conducted for two-layered bodies.Разработана методика решения одномерных статических задач термоупругости для слоистых цилиндров и сфер при конвективно-лучевом нагреве с учетом линейной зависимости коэффициентов теплопроводности и произвольного характера зависимости других физико-механических характеристик от температуры. Задачи теплопроводности сведены, независимо от количества слоев, к решению системы двух нелинейных алгебраических уравнений. В задачах термоупругости непрерывные в пределах каждого слоя коэффициенты уравнений аппроксимированы кусочно-постоянными функциями. Проведен численный анализ температурных полей и напряжений в двухслойных телах

Clinimetric analysis of outcome measures for airway clearance in people with cystic fibrosis: a systematic review

Background: Airway clearance techniques (ACTs) are integral to cystic fibrosis (CF) management. However, there is no consensus as to which outcome measures (OMs) are best for assessing ACT efficacy. Objectives: To summarise OMs that have been assessed for their clinimetric properties (including validity, feasibility, reliability, and reproducibility) within the context of ACT research in CF. Design and Methods: A systematic review was conducted according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) standards. Any parallel or cross-over randomised controlled trial (RCT) investigating outcome measures for ACT in the CF population were eligible for inclusion. The search was performed in five medical databases, clinicaltrials.gov, and abstracts from international CF conferences. The authors planned to independently assess study quality and risk of bias using the COnsensus-based Standards for the selection of health status Measurement InstrumeNts (COSMIN) risk of bias checklist with external validity assessment based upon study details (participants and study intervention). Two review authors (GS and MJ) independently screened search results against inclusion criteria, and further data extraction were planned but not required. Results: No completed RCTs from the 187 studies identified met inclusion criteria for the primary or post hoc secondary objective. Two ongoing trials were identified. Discussion and conclusion: This empty systematic review highlights that high-quality RCTs are urgently needed to investigate and validate the clinimetric properties of OMs used to assess ACT efficacy. With the changing demographics of CF combined with the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies, an accurate assessment of the current benefit of ACT or the effect of ACT withdrawal is a high priority for clinical practice and future research; OMs which have been validated for this purpose are essential. Registration: This systematic review was registered on the PROSPERO database (CRD42020206033)

Clinimetric analysis of outcome measures for airway clearance in people with cystic fibrosis: a systematic review

Availability of data and materials: The data sets used and/or analysed during the current study are available from the corresponding author on reasonable request. The search strategy for OVID has been provided in the supplementary material.Copyright © The Author(s), 2022. Background: Airway clearance techniques (ACTs) are integral to cystic fibrosis (CF) management. However, there is no consensus as to which outcome measures (OMs) are best for assessing ACT efficacy. Objectives: To summarise OMs that have been assessed for their clinimetric properties (including validity, feasibility, reliability, and reproducibility) within the context of ACT research in CF. Design and Methods: A systematic review was conducted according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) standards. Any parallel or cross-over randomised controlled trial (RCT) investigating outcome measures for ACT in the CF population were eligible for inclusion. The search was performed in five medical databases, clinicaltrials.gov, and abstracts from international CF conferences. The authors planned to independently assess study quality and risk of bias using the COnsensus-based Standards for the selection of health status Measurement InstrumeNts (COSMIN) risk of bias checklist with external validity assessment based upon study details (participants and study intervention). Two review authors (GS and MJ) independently screened search results against inclusion criteria, and further data extraction were planned but not required. Results: No completed RCTs from the 187 studies identified met inclusion criteria for the primary or post hoc secondary objective. Two ongoing trials were identified. Discussion and conclusion: This empty systematic review highlights that high-quality RCTs are urgently needed to investigate and validate the clinimetric properties of OMs used to assess ACT efficacy. With the changing demographics of CF combined with the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies, an accurate assessment of the current benefit of ACT or the effect of ACT withdrawal is a high priority for clinical practice and future research; OMs which have been validated for this purpose are essential. Registration: This systematic review was registered on the PROSPERO database (CRD42020206033).NIHR Clinical Doctoral Fellowship grant for GS (reference CDRF-2014-05-055)

A Systematic Review of Music Therapy Practice and Outcomes with Acute Adult Psychiatric In-Patients

PMCID: PMC3732280This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics

Background The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits. Methods Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randox’s Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185). Results Overall, 10-year CHD risk ranged from 2–72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the CoRDia SMI plus risk group (n = 66) (p = 0.80) and a sample of UK healthy men (n = 1360). The GS was also associated with LDL-cholesterol (p = 0.05) and family history (p = 0.03) in a sample of UK healthy men (n = 1360). Conclusions CHD risk is high in this group of T2D subjects. The risk array is an accurate genotyping assay, and is suitable for estimating an individual’s genetic CHD risk. Trial registration This study has been registered at ClinicalTrials.gov; registration identifier NCT0189178

Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk

To understand the pathophysiology of neuropsychiatric disorders such as schizophrenia requires consideration of multiple genetic and non-genetic factors. However, very little is known about the consequences of combining models of synaptic dysfunction with controlled environmental manipulations. Therefore, to generate new insights into gene–environment interactions and complex behaviour, we examined the influence of variable prenatal stress (PNS) on two mouse lines with mutations in synaptosomal-associated protein of 25 kDa (Snap-25): the blind-drunk (Bdr) point mutant and heterozygous Snap-25 knockout mice. Neonatal development was analysed in addition to an assessment of adult behavioural phenotypes relevant to the psychotic, cognitive and negative aspects of schizophrenia. These data show that PNS influenced specific anxiety-related behaviour in all animals. In addition, sensorimotor gating deficits previously noted in Bdr mutants were markedly enhanced by PNS; significantly, these effects could be reversed with the application of anti-psychotic drugs. Moreover, social interaction abnormalities were observed only in Bdr animals from stressed dams but not in wild-type littermates or mutants from non-stressed mothers. These results show for the first time that combining a synaptic mouse point mutant with a controlled prenatal stressor paradigm produces both modified and previously unseen phenotypes, generating new insights into the interactions between genetics and the environment relevant to the study of psychiatric disease