Cross-Over between universality classes in a magnetically disordered metallic wire

In this article we present numerical results of conduction in a disordered quasi-1D wire in the possible presence of magnetic impurities. Our analysis leads us to the study of universal properties in different conduction regimes such as the localized and metallic ones. In particular, we analyse the cross-over between universality classes occurring when the strength of magnetic disorder is increased. For this purpose, we use a numerical Landauer approach, and derive the scattering matrix of the wire from electron's Green's function.Comment: Final version, accepted for publication in New Journ. of Physics, 27 pages, 28 figures. Replaces the earlier shorter preprint arXiv:0910.427

Two dimensional anisotropic non Fermi-liquid phase of coupled Luttinger liquids

We show using bosonization techniques, that strong forward scattering interactions between one dimensional spinless Luttinger liquids (LL) can stabilize a phase where charge-density wave, superconducting and transverse single particle hopping perturbations are irrelevant. This new phase retains its LL like properties in the directions of the chains, but with relations between exponents modified by the transverse interactions, whereas, it is a perfect insulator in the transverse direction. The mechanism that stabilizes this phase are strong transverse charge density wave fluctuations at incommensurate wavevector, which frustrates crystal formation by preventing lock-in of the in-chain density waves.Comment: (4 pages, 2 figures

Melting of two dimensional solids on disordered substrate

We study 2D solids with weak substrate disorder, using Coulomb gas renormalisation. The melting transition is found to be replaced by a sharp crossover between a high $T$ liquid with thermally induced dislocations, and a low $T$ glassy regime with disorder induced dislocations at scales larger than $\xi_{d}$ which we compute ($\xi_{d}\gg R_{c}\sim R_{a}$, the Larkin and translational correlation lengths). We discuss experimental consequences, reminiscent of melting, such as size effects in vortex flow and AC response in superconducting films.Comment: 4 pages, uses RevTeX, Amssymb, multicol,eps

Dynamical response of a pinned two-dimensional Wigner crystal

We re-examine a long-standing problem of a finite-frequency conductivity of a weakly pinned two-dimensional classical Wigner crystal. In this system an inhomogeneously broadened absorption line (pinning mode) centered at disorder and magnetic field dependent frequency $\omega_p$ is known to appear. We show that the relative linewidth $\Delta \omega_p / \omega_p$ of the pinning mode is of the order of one in weak magnetic fields, exhibits a power-law decrease in intermediate fields, and eventually saturates at a small value in strong magnetic fields. The linewidth narrowing is due to a peculiar mechanism of mixing between the stiffer longitudinal and the softer transverse components of the collective excitations. The width of the high-field resonance proves to be related to the density of states in the low-frequency tail of the zero-field phonon spectrum. We find a qualitative agreement with recent experiments and point out differences from the previous theoretical work on the subject.Comment: 19 pages, 11 figures. Supersedes cond-mat/990424

Particle-hole symmetric localization in two dimensions

We revisit two-dimensional particle-hole symmetric sublattice localization problem, focusing on the origin of the observed singularities in the density of states $\rho(E)$ at the band center E=0. The most general such system [R. Gade, Nucl. Phys. B {\bf 398}, 499 (1993)] exhibits critical behavior and has $\rho(E)$ that diverges stronger than any integrable power-law, while the special {\it random vector potential model} of Ludwiget al [Phys. Rev. B {\bf 50}, 7526 (1994)] has instead a power-law density of states with a continuously varying dynamical exponent. We show that the latter model undergoes a dynamical transition with increasing disorder--this transition is a counterpart of the static transition known to occur in this system; in the strong-disorder regime, we identify the low-energy states of this model with the local extrema of the defining two-dimensional Gaussian random surface. Furthermore, combining this ``surface fluctuation'' mechanism with a renormalization group treatment of a related vortex glass problem leads us to argue that the asymptotic low $E$ behavior of the density of states in the {\it general} case is $\rho(E) \sim E^{-1} e^{-|\ln E|^{2/3}}$, different from earlier prediction of Gade. We also study the localized phases of such particle-hole symmetric systems and identify a Griffiths ``string'' mechanism that generates singular power-law contributions to the low-energy density of states in this case.Comment: 18 pages (two-column PRB format), 10 eps figures include

Functional Renormalization Group and the Field Theory of Disordered Elastic Systems

We study elastic systems such as interfaces or lattices, pinned by quenched disorder. To escape triviality as a result of ``dimensional reduction'', we use the functional renormalization group. Difficulties arise in the calculation of the renormalization group functions beyond 1-loop order. Even worse, observables such as the 2-point correlation function exhibit the same problem already at 1-loop order. These difficulties are due to the non-analyticity of the renormalized disorder correlator at zero temperature, which is inherent to the physics beyond the Larkin length, characterized by many metastable states. As a result, 2-loop diagrams, which involve derivatives of the disorder correlator at the non-analytic point, are naively "ambiguous''. We examine several routes out of this dilemma, which lead to a unique renormalizable field-theory at 2-loop order. It is also the only theory consistent with the potentiality of the problem. The beta-function differs from previous work and the one at depinning by novel "anomalous terms''. For interfaces and random bond disorder we find a roughness exponent zeta = 0.20829804 epsilon + 0.006858 epsilon^2, epsilon = 4-d. For random field disorder we find zeta = epsilon/3 and compute universal amplitudes to order epsilon^2. For periodic systems we evaluate the universal amplitude of the 2-point function. We also clarify the dependence of universal amplitudes on the boundary conditions at large scale. All predictions are in good agreement with numerical and exact results, and an improvement over one loop. Finally we calculate higher correlation functions, which turn out to be equivalent to those at depinning to leading order in epsilon.Comment: 42 pages, 41 figure

Rest and Dobutamine stress echocardiography in the evaluation of mid-term results of mitral valve repair in Barlow's disease

BACKGROUND: Surgical "anatomical" repair is the most frequent technique used to correct mitral regurgitation due to severe myxomatous valve disease. Debate, however, persists on the efficacy of this technique, as well as on the durability of the repaired valve, and on its functioning and hemodynamics under stress conditions. Thus, a basal and Dobutamine echocardiographic (DSE) study was carried out to evaluate these parameters at mid-term follow-up. METHODS AND RESULTS: Twenty patients selected for the study (12 men and 8 women, mean age 60 ± 9 years) underwent pre- and post-operative transthoracic echocardiography (TTE) and intra-operative transesophageal echocardiography (TEE). At mid-term follow-up (20 ± 5 months) all patients underwent rest TTE and DSE (3 min. dose increments up to 40 microg/Kg/min protocol). Pre-discharge and one-month TTE showed absence of MR in 11 pts., trivial or mild MR in 9 pts. and normal mitral valve area and gradients. Mid-term TTE showed decrease in left atrial and ventricular dimension, in pulmonary artery pressure (sPAP) and grade of MR. During DSE a significant increase in mitral valve area, maximum and mean gradients, sPAP, heart rate and cardiac output and a decrease in systolic annular diameter and left ventricular volume were found; in 6 pts. a transient left ventricular outflow tract obstruction was observed. CONCLUSION: Basal and Dobutamine stress echocardiography proved to be valuable tools for evaluation of mid-term results of mitral valve repair. In our study population, the surgical technique employed had a favourable impact on several cardiac parameters, evaluated by these methods

Respective Prognostic Value of Genomic Grade and Histological Proliferation Markers in Early Stage (pN0) Breast Carcinoma

Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the prognostic value of GG, Mitotic Index and Ki67 score.A series of 163 consecutive breast cancers was retained (pT1-2, pN0, pM0, 10-yr follow-up). GG was computed using MapQuant Dx(R).GG was low (GG-1) in 48%, high (GG-3) in 31% and equivocal in 21% of cases. For HG-2 tumors, 50% were classified as GG-1, 18% as GG-3 whereas 31% remained equivocal. In a subgroup of 132 ER+/HER2- tumors GG was the most significant prognostic factor in multivariate Cox regression analysis adjusted for age and tumor size (HR = 5.23, p = 0.02).In a reference comprehensive cancer center setting, compared to histological grade, GG added significant information on cell proliferation in breast cancers. In patients with HG-2 carcinoma, applying the GG to guide the treatment scheme could lead to a reduction in adjuvant therapy prescription. However, based on the results observed and considering (i) the relatively close prognostic values of GG and Ki67, (ii) the reclassification of about 30% of HG-2 tumors as Equivocal GG and (iii) the economical and technical requirements of the MapQuant micro-array GG test, the availability in the near future of a PCR-based Genomic Grade test with improved performances may lead to an introduction in clinical routine of this test for histological grade 2, ER positive, HER2 negative breast carcinoma

c-Type Cytochrome-Dependent Formation of U(IV) Nanoparticles by Shewanella oneidensis

Modern approaches for bioremediation of radionuclide contaminated environments are based on the ability of microorganisms to effectively catalyze changes in the oxidation states of metals that in turn influence their solubility. Although microbial metal reduction has been identified as an effective means for immobilizing highly-soluble uranium(VI) complexes in situ, the biomolecular mechanisms of U(VI) reduction are not well understood. Here, we show that c-type cytochromes of a dissimilatory metal-reducing bacterium, Shewanella oneidensis MR-1, are essential for the reduction of U(VI) and formation of extracelluar UO (2) nanoparticles. In particular, the outer membrane (OM) decaheme cytochrome MtrC (metal reduction), previously implicated in Mn(IV) and Fe(III) reduction, directly transferred electrons to U(VI). Additionally, deletions of mtrC and/or omcA significantly affected the in vivo U(VI) reduction rate relative to wild-type MR-1. Similar to the wild-type, the mutants accumulated UO (2) nanoparticles extracellularly to high densities in association with an extracellular polymeric substance (EPS). In wild-type cells, this UO (2)-EPS matrix exhibited glycocalyx-like properties and contained multiple elements of the OM, polysaccharide, and heme-containing proteins. Using a novel combination of methods including synchrotron-based X-ray fluorescence microscopy and high-resolution immune-electron microscopy, we demonstrate a close association of the extracellular UO (2) nanoparticles with MtrC and OmcA (outer membrane cytochrome). This is the first study to our knowledge to directly localize the OM-associated cytochromes with EPS, which contains biogenic UO (2) nanoparticles. In the environment, such association of UO (2) nanoparticles with biopolymers may exert a strong influence on subsequent behavior including susceptibility to oxidation by O (2) or transport in soils and sediments

Updated European Consensus Statement on diagnosis and treatment of adult ADHD

Background Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that often persists into adulthood and old age. Yet ADHD is currently underdiagnosed and undertreated in many European countries, leading to chronicity of symptoms and impairment, due to lack of, or ineffective treatment, and higher costs of illness. Methods The European Network Adult ADHD and the Section for Neurodevelopmental Disorders Across the Lifespan (NDAL) of the European Psychiatric Association (EPA), aim to increase awareness and knowledge of adult ADHD in and outside Europe. This Updated European Consensus Statement aims to support clinicians with research evidence and clinical experience from 63 experts of European and other countries in which ADHD in adults is recognized and treated. Results Besides reviewing the latest research on prevalence, persistence, genetics and neurobiology of ADHD, three major questions are addressed: (1) What is the clinical picture of ADHD in adults? (2) How should ADHD be properly diagnosed in adults? (3) How should adult ADHDbe effectively treated? Conclusions ADHD often presents as a lifelong impairing condition. The stigma surrounding ADHD, mainly due to lack of knowledge, increases the suffering of patients. Education on the lifespan perspective, diagnostic assessment, and treatment of ADHD must increase for students of general and mental health, and for psychiatry professionals. Instruments for screening and diagnosis of ADHD in adults are available, as are effective evidence-based treatments for ADHD and its negative outcomes. More research is needed on gender differences, and in older adults with ADHD. (c) 2018 The Author(s). Published by Elsevier Masson SAS.Peer reviewe