INFLUENCIA DEL VOLUMEN DE ENTRENAMIENTO EN LA SINTOMATOLOGÍA DE ANSIEDAD Y DEPRESIÓN DURANTE LA ADOLESCENCIA TARDÍA

Objetivo: determinar las asociaciones transversales entre la práctica o no de deporte y según el nivel de competición con la sintomatología de ansiedad y depresión durante la adolescencia tardía.Metodología: evaluamos en 6791 adolescentes (3220 chicas), 5327 de 14-16 años y 1464 de 17-19 años la sintomatología de ansiedad (Escala de Ansiedad de Zung) y depresión (Inventario de Depresión de Beck). 918 sujetos no hacían deporte, 2521 hacían deporte no competitivo, 1914 competían a nivel local-autonómico y 1438 a nivel nacional-internacional en modalidades incluidas en el programa de los JJOO de verano.Resultados: los adolescentes que no realizaban deporte mostraron mayor sintomatología de ansiedad y depresión que los que realizaban deporte no competitivo (p = 0.000). Los adolescentes que realizaban deporte no competitivo mostraron mayor sintomatología de ansiedad y depresión que los que realizaban deporte competitivo (p = 0.000). Los adolescentes que competían a nivel nacional-internacional tuvieron menores niveles de ansiedad y depresión que los que competían a nivel local-regional, pero las diferencias fueron menores y solo significativas para la ansiedad en chicos. Las chicas, especialmente las de mayor edad, tuvieron mayor sintomatología de ansiedad y depresión que los chicos (p = 0.000), pero sin influencia en la asociación con la práctica de deporte y con el nivel de competición.Conclusiones: la práctica de deporte, especialmente de deporte competitivo está asociado con menor sintomatología de ansiedad y depresión en sujetos de ambos sexos durante la adolescencia tardía. La competición al máximo nivel durante la adolescencia tardía no se asocia con mayor sintomatología de ansiedad y depresión.Palabras clave: ansiedad, depresión, nivel de competición, sexo, adolescencia.<br /

Morphometry of Conception Bank: Evidence of geological and biological processes on a large volcanic seamount of the Canary Islands Seamount Province.

Concepcion Bank is the largest seamount in the Canary Islands Seamount Province (CISP), an oceanic area off NW Africa including 16 main seamounts, the Canaries archipelago and the Selvagens subarchipelago. The Bank is located 90 km northeast of Lanzarote Island and has been identified as a candidate Marine Protected Area (MPA) to be included in the Natura 2000 network. A compilation of complementary datasets consisting of multibeam bathymetry, TOPAS seismic reflection profiles, side scan sonar sonographs, Remotely Operated Vehicle video records and seafloor samples allowed describing in detail and ground truthing the submarine landforms and bioconstructions exhibited by the bank. The Concepcion Bank presently rises up to 2,433 m above the adjacent seafloor and exhibits two main domains: an extensive summit plateau and steep flanks. The sub-round summit plateau is 50km by 45 km and ranges from 158 to 1,485 m depth. The steep flanks that bound it descend to depths ranging between 1,700 and 2,500 m and define a seamount base that is 66km by 53 km. This morphology is the result of constructive and erosive processes involving different time scales, volumes of material and rates of change. The volcanic emplacement phase probably lasted 25-30 million years and was likely responsible for most of the 2,730 km3 of material that presently form the seamount. Subsequently, marine abrasion and, possibly, subaerial erosion modulated by global sea level oscillations, levelled the formerly emerging seamount summit plateau, in particular its shallower (<400 m), flatter (<0.5°) eastern half. Subsidence associated to the crustal cooling that followed the emplacement phase further contributed the current depth range of the seamount. The deeper and steeper (2.3°) western half of Concepcion Bank may result from tectonic tilting normal to a NNE-SSW fracture line. This fracture may still be expressed on the seafloor surface at some scarps detected on the seamount's summit. Sediment waves and cold-water coral (CWC) mounds on the bank summit plateau are the youngest features contributing to its final shaping, and may be indicative of internal wave effects. Numerous submarine canyons generally less than 10 km in length are incised on the bank's flanks. The most developed, hierarchized canyon system runs southwest of the bank, where it merges with other canyons coming from the southern bulges attached to some sections of the seamount flanks. These bulges are postulated as having an intrusive origin, as no major headwall landslide scars have been detected and their role as deposition areas for the submarine canyons seems to be minor. The results presented document how geological processes in the past and recent to subrecent oceanographic conditions and associated active processes determined the current physiography, morphology and sedimentary patterns of Concepcion Bank, including the development and decline of CWC mounds The setting of the seamount in the regional crustal structure is also discussed

Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles

Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors. Approach and Results We analyzed serum metabolome from 1154 individuals with biopsy-proven NAFLD, and from four mouse models of NAFLD with impaired VLDL-triglyceride (TG) secretion, and one with normal VLDL-TG secretion. We identified three metabolic subtypes: A (47%), B (27%), and C (26%). Subtype A phenocopied the metabolome of mice with impaired VLDL-TG secretion; subtype C phenocopied the metabolome of mice with normal VLDL-TG; and subtype B showed an intermediate signature. The percent of patients with NASH and fibrosis was comparable among subtypes, although subtypes B and C exhibited higher liver enzymes. Serum VLDL-TG levels and secretion rate were lower among subtype A compared with subtypes B and C. Subtype A VLDL-TG and VLDL-apolipoprotein B concentrations were independent of steatosis, whereas subtypes B and C showed an association with these parameters. Serum TG, cholesterol, VLDL, small dense LDL5,6, and remnant lipoprotein cholesterol were lower among subtype A compared with subtypes B and C. The 10-year high risk of CVD, measured with the Framingham risk score, and the frequency of patatin-like phospholipase domain-containing protein 3 NAFLD risk allele were lower in subtype A. Conclusions Metabolomic signatures identify three NAFLD subgroups, independent of histological disease severity. These signatures align with known CVD and genetic risk factors, with subtype A exhibiting a lower CVD risk profile. This may account for the variation in hepatic versus cardiovascular outcomes, offering clinically relevant risk stratification.National Institutes of Health (R01DK123763, R01DK119437, HL151328, P30DK52574, P30DK56341, and UL1TR002345); Ministerio de Economía y Competitividad de España (SAF2017-88041-R); Ministerio de Economía y Competitividad de España for the Severo Ochoa Excellence Accreditation (SEV-2016-0644); CIBERehd (Biomedical Research Center in Hepatic and Digestive Diseases) and Netherlands Organization for Applied Scientific Research Program (PMC13 and PMC15); Spanish Carlos III Health Institute (PI15/01132 and PI18/01075); Miguel Servet Program (CON14/00129 and CPII19/00008); Fondo Europeo de Desarrollo Regional, CIBERehd, Department of Industry of the Basque Country (Elkartek: KK-2020/00008); La Caixa Scientific Foundation (HR17-00601); Liver Investigation: Testing Marker Utility in Steatohepatitis consortium funded by the Innovative Medicines Initiative Program of the European Union (777377), which receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA; Newcastle NIHR Biomedical Research Center; Czech Ministry of Health (RVO-VFN64165/2020); Fondo Nacional De Ciencia y Tecnología de Chile (1191145); and the Comisión Nacional de Investigación, Ciencia y Tecnología (AFB170005, CARE Chile UC); Agencia Nacional de Investigación y Desarrollo (ANID ACE 210009); European Union's Horizon 2020 Research and Innovation Program (825510)

The Major Yolk Protein Vitellogenin Interferes with the Anti-Plasmodium Response in the Malaria Mosquito Anopheles gambiae

Functional gene analysis in malaria mosquitoes reveals molecules underpinning the trade-off between efficient reproduction and the antiparasitic response

An RGS-Containing Sorting Nexin Controls Drosophila Lifespan

The pursuit of eternal youth has existed for centuries and recent data indicate that fat-storing tissues control lifespan. In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we identified a regulator of G protein signaling (RGS) domain containing sorting nexin, termed snazarus (sorting nexin lazarus, snz). Flies with insertions into the 5′ UTR of snz live up to twice as long as controls. Transgenic expression of UAS-Snz from the snz Gal4 enhancer trap insertion, active in fat metabolic tissues, rescued lifespan extension. Further, the lifespan extension of snz mutants was independent of endosymbiont, e.g., Wolbachia, effects. Notably, old snz mutant flies remain active and fertile indicating that snz mutants have prolonged youthfulness, a goal of aging research. Since mammals have snz-related genes, it is possible that the functions of the snz family may be conserved to humans

Additive effects of heatwave and water stresses on soybean seed yield is caused by impaired carbon assimilation at pod formation but not at flowering

Heatwave (HW) combined with water stress (WS) are critical environmental factors negatively affecting crop development. This study aimed to quantify the individual and combined effects of HW and WS during early reproductive stages on leaf and nodule functioning and their relation with final soybean seed yield (SY). For this purpose, during flowering (R2) and pod formation (R4) soybean (Glycine max L. Merr.) plants were exposed to different temperature (ambient[25ºC] versus HW[40ºC]) and water availability (full capacity versus WS[20% field capacity]). HW, WS and their combined impact on yield depended on the phenological stage at which stress was applied being more affected at R4. For gas exchange, WS severely impaired photosynthetic machinery, especially when combined with HS. Impaired photoassimilate supply at flowering caused flower abortion and a significant reduction in final SY due to interacting stresses and WS. On the other hand, at pod formation (R4), decreased leaf performance caused additive effect on SY by decreasing pod setting and seed size with combined stresses. At the nodule level, WS (alone or in combination with HW) caused nodule impairment, which was reflected by lower leaf N. Such response was linked with a poor malate supply to bacteroids and feed-back inhibition caused by nitrogenous compounds accumulation. In summary, our study noted that soybean sensitivity to interacting heat and water stresses was highly conditioned by the phenological stage at which it occurs with, R4 stage being the critical moment. To our knowledge this is the first soybean work integrating combined stresses at early reproductive stages.D.S. was a recipient of a PhD fellowship from the Public University of Navarra