Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system.

BACKGROUND: Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms. METHODS: In this study, the acute effects of recovery between mild head injuries and the frequency of injuries on a headache behavior, trigeminal allodynia, was assessed using von Frey testing up to one week after injury, while histopathological changes in the trigeminal pain pathway were evaluated using western blot, ELISA and immunohistochemistry. RESULTS: A decreased recovery time combined with an increased mild closed head injury (CHI) frequency results in reduced trigeminal allodynia thresholds compared to controls. The repetitive CHI group with the highest injury frequency showed the greatest reduction in trigeminal thresholds along with greatest increased levels of calcitonin gene-related peptide (CGRP) in the trigeminal nucleus caudalis. Repetitive CHI resulted in astrogliosis in the central trigeminal system, increased GFAP protein levels in the sensory barrel cortex, and an increased number of microglia cells in the trigeminal nucleus caudalis. CONCLUSIONS: Headache behavior in rats is dependent on the injury frequency and recovery interval between mild head injuries. A worsening of headache behavior after repetitive mild head injuries was concomitant with increases in CGRP levels, the presence of astrocytosis, and microglia proliferation in the central trigeminal pathway. Signaling between neurons and proliferating microglia in the trigeminal pain system may contribute to the initiation of acute headache after concussion or other traumatic brain injuries

CANDELS Multi-wavelength Catalogs: Source Identification and Photometry in the CANDELS COSMOS Survey Field

We present a multi-wavelength photometric catalog in the COSMOS field as part of the observations by the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey. The catalog is based on Hubble Space Telescope Wide Field Camera 3 (HST/WFC3) and Advanced Camera for Surveys observations of the COSMOS field (centered at R.A.: 10^h00^m28^s, Decl.:+02^º12^'21^"). The final catalog has 38671 sources with photometric data in 42 bands from UV to the infrared (~ 0.3-8 µm). This includes broadband photometry from HST, CFHT, Subaru, the Visible and Infrared Survey Telescope for Astronomy, and Spitzer Space Telescope in the visible, near-infrared, and infrared bands along with intermediate- and narrowband photometry from Subaru and medium-band data from Mayall NEWFIRM. Source detection was conducted in the WFC3 F160W band (at 1.6 μm) and photometry is generated using the Template FITting algorithm. We further present a catalog of the physical properties of sources as identified in the HST F160W band and measured from the multi-band photometry by fitting the observed spectral energy distributions of sources against templates

The SiC/SiO Nanostructured Core-Shell as Anode Material for Lithium Ion Batteries: Synthesis and HRTEM Characterization

The SiC/SiO nanocmposite was synthesized by a sol-gel method with a following heat-treatment process. The SiC nanoparticles were coated with SiO, as a result, a core-shell nanostructured was formed. The processed material was characterized using X-ray energy dispersive spectroscopy (XEDS), high resolution transmission electron microscopy(HRTEM), fourier-transform IR spectroscopy (FTIR). Data obtained in this research showed that core-shell nanoparticles of SiC/SiO with an average range size of 20- 40 (nm) may be produced through sol-gel processing. The SiC/SiO core-shell nanocomposite can act as regarded candidate for high performance anode materials for lithium ion battery applications. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3525

The effects of prebiotic oligofructose on hematological, serum biochemical parameters and liver enzymes of juvenile beluga (Huso huso)

The aim of the present study was to investigate the effects of dietary oligofructose (1, 2 and 3%) on blood profiles of beluga Huso huso juveniles (18.77±0.76g). After 7 weeks feeding on experimental diets hematological parameters, metabolic products (cholesterol, glucose and total protein) and serum enzymes (lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase) were measured. Compared to the control group (0% oligfructose), oligofructose had no effects on red blood cell counts (RBC), mean corposcular volume (MCV), mean cellular hemoglobin concentration (MCH) or mean cell hemoglobin concentration (MCHC) (P>0.05). However, hematocrit (Hct), hemoglobin concentration (Hb) and leucocyte counts (WBC) were significantly higher in fish fed 2% oligofructose (P0.05). These results indicate an immunomodulatory effect and the potential to reduce serum cholesterol levels in beluga sturgeon

On Autonomous Robotic Cooperation Capabilities within Factory and Logistic Scenarios

The paper presents the development of a unified functional, algorithmic and Software (Sw) architecture, which can be adopted as a standard for controlling, at action level only, any robotic structure within a given wide class of them; even of reconfigurable type within the class. Such control architecture is therefore deemed very suitable for operating within factory and/or logistic, possibly reconfigurable, scenarios. Moreover, for the few cases of cooperative activities to be established between agents not allowed to be cable connected, an effective coordination policy, based on the exchange of a reduced information set, only regarding the cooperation goals, is developed; and relevant simulative and experimental trials are briefly outlined. Moreover, the advantage of having, in whatever operative condition, the possibility of commanding the involved structures only in terms of the ultimate goals of each action, also seems to be the right basis for having non-negligible improvements within their integration with automated action planning, and even learning, techniques

The probiotic effects of dietary inactive yeast Saccharomyces cerevisiae var. ellipsoideus on growth factors, survival, body composition and intestinal microbiota of Beluga juvenile (Huso huso)

The probiotic effects of inactive yeast, Saccharomyces cerevisiae var. ellipsoideus was studied on growth performance, survival and intestinal microbiota of beluga juveniles (Huso huso). The study was done in complete randomize design that included feeding of beluga juveniles with diets supplemented with 0 (control), 1, 2 and 5% yeast (4 treatments with 3 replicates). Beluga juveniles (11.40±0.56g) were randomly allocated in 12 oval tanks at a density of 35 fish per tank and triplicate group were fed with experimental diets. At the end of the trial, growth factors (final weight, weight gain, SGR, CF) as well as feed conversion ratio (FCR), body composition (protein, lipid, ash, moisture) and intestinal microbiota (total viable bacteria and Lactobacillus spp. levels) were determined. Our results confirmed that juveniles fed on diet supplemented with 5% S. cerevisiae var. ellipsoideus had significantly higher final weight, weight gain, specific growth rate (SGR) and lower food conversion ratio compared to control and 1% treatment (P0.05). The study of body composition showed no significant difference between treatments (P>0.05). Total viable bacteria and Lactobacillus spp. count were significantly higher in 5% treatment compared to control (P0.05)

The Bright and Dark Sides of High-Redshift starburst galaxies from {\it Herschel} and {\it Subaru} observations

We present rest-frame optical spectra from the FMOS-COSMOS survey of twelve $z \sim 1.6$ \textit{Herschel} starburst galaxies, with Star Formation Rate (SFR) elevated by $\times$8, on average, above the star-forming Main Sequence (MS). Comparing the H$\alpha$ to IR luminosity ratio and the Balmer Decrement we find that the optically-thin regions of the sources contain on average only $\sim 10$ percent of the total SFR whereas $\sim90$ percent comes from an extremely obscured component which is revealed only by far-IR observations and is optically-thick even in H$\alpha$. We measure the [NII]$_{6583}$/H$\alpha$ ratio, suggesting that the less obscured regions have a metal content similar to that of the MS population at the same stellar masses and redshifts. However, our objects appear to be metal-rich outliers from the metallicity-SFR anticorrelation observed at fixed stellar mass for the MS population. The [SII]$_{6732}$/[SII]$_{6717}$ ratio from the average spectrum indicates an electron density $n_{\rm e} \sim 1,100\ \mathrm{cm}^{-3}$, larger than what estimated for MS galaxies but only at the 1.5$\sigma$ level. Our results provide supporting evidence that high-$z$ MS outliers are the analogous of local ULIRGs, and are consistent with a major merger origin for the starburst event.Comment: 6 pages, 4 figures, Accepted for publication in ApJ Letter

The relation of cosmic environment and morphology with the star formation and stellar populations of AGN and non-AGN galaxies

In this work, we study the relation of cosmic environment and morphology with the star-formation (SF) and the stellar population of galaxies. Most importantly, we examine if this relation differs for systems with active and non-active supermassive black holes. For that purpose, we use 551 X-ray detected active galactic nuclei (AGN) and 16,917 non-AGN galaxies in the COSMOS-Legacy survey, for which the surface-density field measurements are available. The sources lie at redshift of $\rm 0.3<z<1.2$, probe X-ray luminosities of $\rm 42<log\,[L_{X,2-10keV}(erg\,s^{-1})]<44$ and have stellar masses, $\rm 10.5<log\,[M_*(M_\odot)]<11.5$. Our results show that isolated AGN (field) have lower SFR compared to non AGN, at all L$_X$ spanned by our sample. However, in denser environments (filaments, clusters), moderate L$_X$ AGN ($\rm log\,[L_{X,2-10keV}(erg\,s^{-1})]>43$) and non-AGN galaxies have similar SFR. We, also, examine the stellar populations and the morphology of the sources in different cosmic fields. For the same morphological type, non-AGN galaxies tend to have older stellar populations and are less likely to have undergone a recent burst in denser environments compared to their field counterparts. The differences in the stellar populations with the density field are, mainly, driven by quiescent systems. Moreover, low L$_X$ AGN present negligible variations of their stellar populations, in all cosmic environments, whereas moderate L$_X$ AGN have, on average, younger stellar populations and are more likely to have undergone a recent burst, in high density fields. Finally, in the case of non-AGN galaxies, the fraction of bulge-dominated (BD) systems increases with the density field, while BD AGN are scarce in denser environments. Our results are consistent with a scenario in which a common mechanism, such as mergers, triggers both the SF and the AGN activity.Comment: Accepted for publication in A&A. 10 pages, 5 figures, 3 table

The clustering of H β\beta + [O III] and [O II] emitters since z \tilde 5: dependencies with line luminosity and stellar mass

We investigate the clustering properties of ∼7000 H β + [O III] and [O II] narrowband-selected emitters at z ∼ 0.8–4.7 from the High-z Emission Line Survey. We find clustering lengths, r0, of 1.5–4.0 h−1 Mpc and minimum dark matter halo masses of 1010.7–12.1 M⊙ for our z = 0.8–3.2 H β + [O III] emitters and r0 ∼ 2.0–8.3 h−1 Mpc and halo masses of 1011.5–12.6 M⊙ for our z = 1.5–4.7 [O II] emitters. We find r0 to strongly increase both with increasing line luminosity and redshift. By taking into account the evolution of the characteristic line luminosity, L⋆(z), and using our model predictions of halo mass given r0, we find a strong, redshift-independent increasing trend between L/L⋆(z) and minimum halo mass. The faintest H β + [O III] emitters are found to reside in 109.5 M⊙ haloes and the brightest emitters in 1013.0 M⊙ haloes. For [O II] emitters, the faintest emitters are found in 1010.5 M⊙ haloes and the brightest emitters in 1012.6 M⊙ haloes. A redshift-independent stellar mass dependency is also observed where the halo mass increases from 1011 to 1012.5 M⊙ for stellar masses of 108.5 to 1011.5 M⊙, respectively. We investigate the interdependencies of these trends by repeating our analysis in a Lline−Mstar grid space for our most populated samples (H β + [O III] z = 0.84 and [O II] z = 1.47) and find that the line luminosity dependency is stronger than the stellar mass dependency on halo mass. For L > L⋆ emitters at all epochs, we find a relatively flat trend with halo masses of 1012.5–13 M⊙, which may be due to quenching mechanisms in massive haloes that is consistent with a transitional halo mass predicted by models

Effects of Stellar Feedback on Stellar and Gas Kinematics of Star-forming Galaxies at 0.6 &lt; z &lt; 1.0

Recent zoom-in cosmological simulations have shown that stellar feedback can flatten the inner density profile of the dark matter halo in low-mass galaxies. A correlation between the stellar/gas velocity dispersion (σ star, σ gas) and the specific star formation rate (sSFR) is predicted as an observational test of the role of stellar feedback in re-shaping the dark matter density profile. In this work we test the validity of this prediction by studying a sample of star-forming galaxies at 0.6 &lt; z &lt; 1.0 from the LEGA-C survey, which provides high signal-to-noise measurements of stellar and gas kinematics. We find that a weak but significant correlation between σ star (and σ gas) and sSFR indeed exists for galaxies in the lowest mass bin (M ∗ ∼ 1010 M o˙). This correlation, albeit with a ∼35% scatter, holds for different tracers of star formation, and becomes stronger with redshift. This result generally agrees with the picture that at higher redshifts star formation rate was generally higher, and galaxies at M ∗ ≲ 1010 M o˙ have not yet settled into a disk. As a consequence, they have shallower gravitational potentials more easily perturbed by stellar feedback. The observed correlation between σ star (and σ gas) and sSFR supports the scenario predicted by cosmological simulations, in which feedback-driven outflows cause fluctuations in the gravitation potential that flatten the density profiles of low-mass galaxies