Seeking information superiority: Strategies for business in the commercial application of information operations

Information superiority is a condition that many businesses attempt to attain without truly understanding what it is, or how to get there. This paper presents an overview to help businesspeople recognize the road to information superiority, and some of the essential strategies to implement along the way. Information operations is a concept described to enable information superiority, when used with a network form of organization (as opposed to simply being networked). This paper describes information operations across their fundamental structure of intelligence, surveillance, and reconnaissance (ISR); and suggests a separation between industrial espionage and legitimate business information gathering. A model for establishing information superiority is presented, outlining the importance of \u27cradle-to-grave\u27 implementation throughout the business lifecycle. This brings together key doctrinal points from the information security, information operations and information warfare fields. Supplementary material is drawn from sociology, risk analysis, and business management theory to complete the applicability of the text to business readers

Evaluating staff attitudes, intentions, and behaviors related to cyber security in large Australian health care environments: Mixed methods study

Background: Previous studies have identified that the effective management of cyber security in large health care environments is likely to be significantly impacted by human and social factors, as well as by technical controls. However, there have been limited attempts to confirm this by using measured and integrated studies to identify specific user motivations and behaviors that can be managed to achieve improved outcomes. Objective: This study aims to document and analyze survey and interview data from a diverse range of health care staff members, to determine the primary motivations and behaviors that influence their acceptance and application of cyber security messaging and controls. By identifying these issues, recommendations can be made to positively influence future cyber security governance in health care. Methods: An explanatory sequential mixed methods approach was undertaken to analyze quantitative data from a web-based staff survey (N=103), with a concurrent qualitative investigation applied to data gathered via in-depth staff interviews (N=9). Data from both stages of this methodology were mapped to descriptive variables based on a modified version of the Technology Acceptance Model (TAM; TAM2). After normalization, the quantitative data were verified and analyzed using descriptive statistics, distribution and linearity measures, and a bivariate correlation of the TAM variables to identify the Pearson coefficient (r) and significance (P) values. Finally, after confirming Cronbach , the determinant score for multicollinearity, and the Kaiser-Meyer-Olkin measure, and applying the Bartlett test of sphericity (X2), an exploratory factor analysis (EFA) was conducted to identify the primary factors with an eigenvalue ( ) \u3e 1.0. Comments captured during the qualitative interviews were coded using NVivo software (QSR International) to create an emic-to-etic understanding, which was subsequently integrated with the quantitative results to produce verified conclusions. Results: Using the explanatory sequential methodology, this study showed that the perceived usefulness of security controls emerged as the most significant factor influencing staff beliefs and behaviors. This variable represented 24% of all the variances measured in the EFA and was also the most common category identified across all coded interviews (281/692, 40.6%). The word frequency analysis showed that systems, patients, and people represented the top 3 recurring themes reported by the interviewees. Conclusions: To improve cyber security governance in large health care environments, efforts should be focused on demonstrating how confidentiality, integrity, availability, policies, and cloud or vendor-based controls (the main contributors of usefulness measured by the EFA) can directly improve outcomes for systems, staff, and patients. Further consideration also needs to be given to how clinicians should share data and collaborate on patient care, with tools and processes provided to support and manage data sharing securely and to achieve a consistent baseline of secure and normalized behaviors

Trust and Credibility in Web-Based Health Information: A Review and Agenda for Future Research

Background: Online sources are becoming increasingly important in health information seeking, such that they may have a significant effect on health care decisions and outcomes. Hence, given the wide range of different sources of online health information from different organisations and individuals, it is important to understand how information seekers evaluate and select the sources that they use, and, more specifically how they assess their credibility and trustworthiness. Objectives: This article reviews empirical studies on trust and credibility in the use of online health information. The article seeks to present a profile of the research conducted on trust and credibility in online health information seeking, to identify the factors that impact judgements of trustworthiness and credibility, and to explore the role of demographic factors affecting trust formation. On this basis, it aims to identify the gaps in current knowledge and to propose an agenda for future research. Methods: A systematic literature review was conducted. Searches were conducted using a variety of combinations of the terms: online health information, trust, credibility, and their variants, in four multi-disciplinary and four health-oriented databases. Articles selected were published in English from 2000 onwards; this process generated 3827 unique records. After the application of exclusion criteria, this was reduced to a final dataset of 73 articles, which was analysed in full. Results: Interest in this topic has persisted over the last 15 years, with articles being published in medicine, social science and computer science, and focussing mostly on the USA and the UK. Documents in the dataset fell into three categories: those using trust or credibility as a dependent variable, those using trust or credibility as an independent variable, and studies of the demographic factors that influence the role of trust or credibility in online health information seeking. There is a consensus that in terms of website design, clear layout and design, interactive features and the authority of the owner have a positive effect on trust or credibility, whilst advertising has a negative effect. With regard to content features, authority of the author, ease of use and content have a positive effect on trust or credibility formation. Demographic factors influencing trust formation are age, gender and perceived health status. Conclusions: There is considerable scope for further research. This includes: increased clarity of the interaction between the variables associated with health information seeking; increased consistency on the measurement of trust and credibility; a greater focus on specific online health information sources; and, enhanced understanding of the impact of demographic variables on trust and credibility judgement

Expert Consensus Guidelines for Stocking of Antidotes in Hospitals That Provide Emergency Care

We provide recommendations for stocking of antidotes used in emergency departments (EDs). An expert panel representing diverse perspectives (clinical pharmacology, medical toxicology, critical care medicine, hematology/oncology, hospital pharmacy, emergency medicine, emergency medical services, pediatric emergency medicine, pediatric critical care medicine, poison centers, hospital administration, and public health) was formed to create recommendations for antidote stocking. Using a standardized summary of the medical literature, the primary reviewer for each antidote proposed guidelines for antidote stocking to the full panel. The panel used a formal iterative process to reach their recommendation for both the quantity of antidote that should be stocked and the acceptable timeframe for its delivery. The panel recommended consideration of 45 antidotes; 44 were recommended for stocking, of which 23 should be immediately available. In most hospitals, this timeframe requires that the antidote be stocked in a location that allows immediate availability. Another 14 antidotes were recommended for availability within 1 hour of the decision to administer, allowing the antidote to be stocked in the hospital pharmacy if the hospital has a mechanism for prompt delivery of antidotes. The panel recommended that each hospital perform a formal antidote hazard vulnerability assessment to determine its specific need for antidote stocking. Antidote administration is an important part of emergency care. These expert recommendations provide a tool for hospitals that offer emergency care to provide appropriate care of poisoned patients

The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) project: Overview of design and methods

Background: Nephrotic syndrome is a commonly acquired kidney disease in children that causes significant morbidity due to recurrent episodes of heavy proteinuria. The management of childhood nephrotic syndrome is known to be highly variable among physicians and care centres. Objectives: The primary objective of the study is to determine centre-, physician-, and patient-level characteristics associated with steroid exposure and length of steroid treatment. We will also determine the association of dose and duration of steroid treatment and time to first relapse as a secondary aim. An embedded qualitative study utilizing focus groups with health care providers will enrich the quantitative results by providing an understanding of the attitudes, beliefs and local contextual factors driving variation in care. Design: Mixed-methods study; prospective observational cohort (quantitative component), with additional semi-structured focus groups of healthcare professionals (qualitative component). Setting: National study, comprised of all 13 Canadian pediatric nephrology clinics. Patients: 400 patients under 18 years of age to be recruited over 2.5 years. Measurements: Steroid doses for all episodes (first presentation, first and subsequent relapses) tracked over course of the study. Physician and centre-level characteristics catalogued, with reasons for treatment preferences documented during focus groups. Methods: All patients tracked prospectively over the course of the study, with data comprising a prospective registry. One focus group at each site to enrich understanding of variation in care. Limitations: Contamination of treatment protocols between physicians may occur as a result of concurrent focus groups. Conclusions: Quantitative and qualitative results will be integrated at end of study and will collectively inform strategies for the development and implementation of standardized evidence-based protocols across centres

Patient and caregiver perspectives on blood pressure in children with chronic kidney disease

Background: More than 50% of children with chronic kidney disease (CKD) have uncontrolled hypertension, increasing their long-term risk of cardiovascular disease and progression to kidney failure. Children receiving medications or dialysis may also experience acute blood pressure fluctuations accompanied by debilitating symptoms. We aimed to describe the perspectives of children with CKD and their parental caregivers on blood pressure to inform patient-centered care. / Methods: Secondary thematic analysis was conducted on qualitative data from the Standardized Outcomes in Nephrology—Children and Adolescents initiative, encompassing 16 focus groups, an international Delphi survey and two consensus workshops. We analyzed responses from children with CKD (ages 8–21 years) and caregivers (of children ages 0–21 years) pertaining to blood pressure. / Results: Overall, 120 patients and 250 caregivers from 22 countries participated. We identified five themes: invisibility and normalization (reassured by apparent normotension, absence of symptoms and expected links with CKD), confused by ambiguity (hypertension indistinguishable from cardiovascular disease, questioning the need for prophylactic intervention, frustrated by inconsistent messages and struggling with technical skills in measurement), enabling monitoring and maintaining health (gaging well-being and preventing vascular complications), debilitating and constraining daily living (provoking anxiety and agitation, helpless and powerless and limiting life activities) and burden of medications (overwhelmed by the quantity of tablets and distress from unexpected side effects). / Conclusions: For children with CKD and their caregivers, blood pressure was an important heath indicator, but uncertainty around its implications and treatment hampered management. Providing educational resources to track blood pressure and minimizing symptoms and treatment burden may improve outcomes in children with CKD

Improving Latin American soil information database for digital soil mapping enhances its usability and scalability

Spatial soil databases can help model complex phenomena in which soils are decisive, for example, evaluating agricultural potential or estimating carbon storage capacity. The Soil Information System for Latin America and the Caribbean, SISLAC, is a regional initiative promoted by the FAO's South American Soil Partnership to contribute to the sustainable management of soil. SISLAC includes data coming from 49,084 soil profiles distributed unevenly across the continent, making it the region's largest soil database. However, some problems hinder its usages, such as the quality of the data and its high dimensionality. The objective of this research is twofold. First, to evaluate the quality of SISLAC and its data values and generate a new, improved version that meets the minimum quality requirements to be used by different interests or practical applications. Second, to demonstrate the potential of improved soil profile databases to generate more accurate information on soil properties, by conducting a case study to estimate the spatial variability of the percentage of soil organic carbon using 192 profiles in a 1473 km2 region located in the department of Valle del Cauca, Colombia. The findings show that 15 percent of the existing soil profiles had an inaccurate description of the diagnostic horizons. Further correction of an 4.5 additional percent of existing inconsistencies improved overall data quality. The improved database consists of 41,691 profiles and is available for public use at ttps://doi.org/10.5281/zenodo.6540710 (Díaz-Guadarrama, S. & Guevara, M., 2022). The updated profiles were segmented using algorithms for quantitative pedology to estimate the spatial variability. We generated segments one centimeter thick along with each soil profile data, then the values of these segments were adjusted using a spline-type function to enhance vertical continuity and reliability. Vertical variability was estimated up to 150 cm in-depth, while ordinary kriging predicts horizontal variability at three depth intervals, 0 to 5, 5 to 15, and 15 to 30 cm, at 250 m-spatial resolution, following the standards of the GlobalSoilMap project. Finally, the leave-one-out cross validation provides information for evaluating the kriging model performance, obtaining values for the RMSE index between 1.77% and 1.79% and the R2 index greater than 0.5. The results show the usability of SISLAC database to generate spatial information on soil properties and suggest further efforts to collect a more significant amount of data to guide sustainable soil management.Fil: Diaz Guadamarra, Sergio. Universidad Nacional de Colombia. Facultad de Ciencias Agrarias. Departamento de Agronomía; ColombiaFil: Lizarazo, Iván. Universidad Nacional de Colombia. Facultad de Ciencias Agrarias. Departamento de Agronomía; ColombiaFil: Guevara, Mario. Universidad Nacional Autónoma de México. Campus Juriquilla. Centro de Geociencias; MéxicoFil: Guevara, Mario. Universidad Nacional Autónoma de México.Campus Juriquilla. Centro de Geociencias; México. United States Department of Agriculture. Soil Salinity National Laboratory, Estados UnidosFil: Angelini, Marcos Esteban. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; Argentina. Wageningen University. Soil Geography and Landscape Group; Países Bajos. International Soil Reference and Information Centre. World Soil Information; Países BajosFil: Araujo Carrillo, Gustavo A. Corporación Colombiana de Investigación Agropecuaria AGROSAVIA; ColombiaFil: Argeñal, Jainer. Universidad Nacional Autónoma de Honduras. Facultad de Ciencias; Honduras.Fil: Armas, Daphne. Universidad de Almería. Departamento de Agronomía, Edif. CITEIIB, España.Fil: Balsa, Rafael A. Ministerio de Desarrollo Agrario y Riego. Dirección General de Asuntos Ambientales Agrarios, Perú.Fil: Bolivar, Adriana. Instituto Geográfico Agustín Codazzi. Subdirección Agrología; ColombiaFil: Bustamante, Nelson. Servicio Agrícola y Ganadero; Chile.Fil: Dart, Ricardo O. Embrapa Solos; BrasilFil: Dell Acqua, Martín. Ministerio de Ganadería, Agricultura y Pesca. Dirección General de Recursos Naturales; UruguayFil: Lencina, Arnulfo. Universidad Nacional de Asunción. Facultad de Ciencias Agrarias; ParaguayFil: Figueredo, Hernán. Sociedad Boliviana de la Ciencia del Suelo; Bolivia.Fil: Fontes, Fernando. Ministerio de Ganadería, Agricultura y Pesca. Dirección General de Recursos Naturales; UruguayFil: Gutierrez Diaz, Joan S. Aarhus University. Faculty of Science and Technology,.Department of Agroecology; DinamarcaFil: Jiménez, Wilmer. Ministerio de Agricultura y Ganadería; Ecuador.Fil: Rodriguez, Dario Martin. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; ArgentinaFil: Schulz, Guillermo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; ArgentinaFil: Tenti Vuegen, Leonardo Mauricio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; Argentin

Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes

Nicotinic acetylcholine receptors (nAChRs) are pentameric, neurotransmitter-gated ion channels responsible for rapid excitatory neurotransmission in the central and peripheral nervous systems, resulting in skeletal muscle tone and various cognitive effects in the brain. These complex proteins are activated by the endogenous neurotransmitter ACh as well as by nicotine and structurally related agonists. Activation and modulation of nAChRs has been implicated in the pathology of multiple neurological disorders, and as such, these proteins are established therapeutic targets. Here we use unnatural amino acid mutagenesis to examine the ligand binding mechanisms of two homologous neuronal nAChRs: the α4β4 and α7 receptors. Despite sequence identity among the residues that form the core of the agonist-binding site, we find that the α4β4 and α7 nAChRs employ different agonist-receptor binding interactions in this region. The α4β4 receptor utilizes a strong cation-π interaction to a conserved tryptophan (TrpB) of the receptor for both ACh and nicotine, and nicotine participates in a strong hydrogen bond with a backbone carbonyl contributed by TrpB. Interestingly, we find that the α7 receptor also employs a cation-π interaction for ligand recognition, but the site has moved to a different aromatic amino acid of the agonist-binding site depending on the agonist. ACh participates in a cation-π interaction with TyrA, whereas epibatidine participates in a cation-π interaction with TyrC2

LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery

Neurotransmitter receptor trafficking during synaptic plasticity requires the concerted action of multiple signaling pathways and the protein transport machinery. However, little is known about the contribution of lipid metabolism during these processes. In this paper, we addressed the question of the role of cholesterol in synaptic changes during long-term potentiation (LTP). We found that N-methyl-d-aspartate-type glutamate receptor (NMDAR) activation during LTP induction leads to a rapid and sustained loss or redistribution of intracellular cholesterol in the neuron. A reduction in cholesterol, in turn, leads to the activation of Cdc42 and the mobilization of GluA1-containing α-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) from Rab11-recycling endosomes into the synaptic membrane, leading to synaptic potentiation. This process is accompanied by an increase of NMDAR function and an enhancement of LTP. These results imply that cholesterol acts as a sensor of NMDAR activation and as a trigger of downstream signaling to engage small GTPase (guanosine triphosphatase) activation and AMPAR synaptic delivery during LTP.Peer Reviewe

Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency associated with low AAT blood concentrations is an established genetic COPD risk factor. Less is known about the respiratory health impact of variation in AAT serum concentrations in the general population. We cross-sectionally investigated correlates of circulating AAT concentrations and its association with FEV1. METHODS: In 5187 adults (2669 females) with high-sensitive c-reactive protein (CRP) levels < or = 10 mg/l from the population-based Swiss SAPALDIA cohort, blood was collected at the time of follow-up examination for measuring serum AAT and CRP. RESULTS: Female gender, hormone intake, systolic blood pressure, age in men and in postmenopausal women, as well as active and passive smoking were positively, whereas alcohol intake and BMI inversely correlated with serum AAT levels, independent of CRP adjustment. We observed an inverse association of AAT with FEV1 in the total study population (p < 0.001), that disappeared after adjustment for CRP (p = 0.28). In addition, the AAT and FEV1 association was modified by gender, menopausal status in women, and smoking. CONCLUSION: The results of this population-based study reflect a complex interrelationship between tobacco exposure, gender related factors, circulating AAT, systemic inflammatory status and lung function