253 research outputs found
Fallback Supernovae: A Possible Origin of Peculiar Supernovae with Extremely Low Explosion Energies
We perform hydrodynamical calculations of core-collapse supernovae (SNe) with
low explosion energies. These SNe do not have enough energy to eject the whole
progenitor and most of the progenitor falls back to the central remnant. We
show that such fallback SNe can have a variety of light curves (LCs) but their
photospheric velocities can only have some limited values with lower limits. We
also perform calculations of nucleosynthesis and LCs of several fallback SN
model, and find that a fallback SN from the progenitor with a main-sequence
mass of 13 Msun can account for the properties of the peculiar Type Ia
supernova SN 2008ha. The kinetic energy and ejecta mass of the model are
1.2*10^{48} erg and 0.074 Msun, respectively, and the ejected 56Ni mass is
0.003 Msun. Thus, SN 2008ha can be a core-collapse SN with a large amount of
fallback. We also suggest that SN 2008ha could have been accompanied with long
gamma-ray bursts and long gamma-ray bursts without associated SNe may be
accompanied with very faint SNe with significant amount of fallback which are
similar to SN 2008ha.Comment: 9 pages, 11 figures, 2 tables, accepted by The Astrophysical Journal,
proofed and some references added in v
A Nanofiber-Based Optical Conveyor Belt for Cold Atoms
We demonstrate optical transport of cold cesium atoms over millimeter-scale
distances along an optical nanofiber. The atoms are trapped in a
one-dimensional optical lattice formed by a two-color evanescent field
surrounding the nanofiber, far red- and blue-detuned with respect to the atomic
transition. The blue-detuned field is a propagating nanofiber-guided mode while
the red-detuned field is a standing-wave mode which leads to the periodic axial
confinement of the atoms. Here, this standing wave is used for transporting the
atoms along the nanofiber by mutually detuning the two counter-propagating
fields which form the standing wave. The performance and limitations of the
nanofiber-based transport are evaluated and possible applications are
discussed
Risk factors and outcome in patients with primary sclerosing cholangitis with persistent biliary candidiasis
Background: Candidiasis is commonly observed in patients with primary sclerosing cholangitis (PSC), but the clinical risk factors associated with its presence have not been fully investigated. In this study, we aimed to analyse the incidence, risk factors, and transplantation-free survival in primary sclerosing cholangitis (PSC) patients with persistent biliary candidiasis. Methods: We retrospectively analysed patients diagnosed with PSC who were admitted to our department during 2002 to 2012. One-hundred fifty patients whose bile cultures were tested for fungal species were selected, and their clinical and laboratory parameters were investigated. The results of endoscopic retrograde cholangiography (ERC) and bile cultures were analysed using chart reviews. The cases of biliary candidiasis were sub-classified as transient or persistent. Results: Thirty out of 150 (20.0%) patients had biliary candidiasis. Although all patients demonstrated comparable baseline characteristics, those with biliary candidiasis showed significantly reduced transplantation-free survival (p < 0.0001) along with a markedly elevated frequency of cholangiocarcinoma (CCA) (p = 0.04). The patients were further sub-classified according to the transient (15/30) or persistent (15/30) nature of their biliary candidiasis. A subgroup analysis showed reduced survival with a greater necessity for orthotopic liver transplantation (OLT) only in patients with persistence of Candida (p = 0.007). The survival in the patients with transient biliary candidiasis was comparable to that in candidiasis-free patients. In a multivariate regression analysis that included Mayo risk score (MRS), sex, age, dominant stenosis, inflammatory bowel disease, autoimmune hepatitis overlap syndrome, and number of times ERC was performed, biliary candidiasis was an independent risk factor for reduced survival (p = 0.008). Risk factors associated with acquisition of biliary candidiasis were age at PSC diagnosis and number of ERCs. Conclusions: The persistence of biliary candidiasis is associated with markedly reduced transplantation-free survival in PSC patients. By contrast, actuarial survival in patients with transient biliary candidiasis approaches that for patients without any evidence of biliary candidiasis. Further studies on the treatment of persistent biliary candidiasis in patients with PSC are warranted
Variable Sodium Absorption in a Low-Extinction Type Ia Supernova
Recent observations have revealed that some Type Ia supernovae exhibit
narrow, time-variable Na I D absorption features. The origin of the absorbing
material is controversial, but it may suggest the presence of circumstellar gas
in the progenitor system prior to the explosion, with significant implications
for the nature of the supernova progenitors. We present the third detection of
such variable absorption, based on six epochs of high-resolution spectroscopy
of the Type Ia supernova SN 2007le from Keck and the HET. The data span ~3
months, from 5 days before maximum light to 90 days after maximum. We find that
one component of the Na D absorption lines strengthened significantly with
time, indicating a total column density increase of ~2.5 x 10^12 cm^-2. The
changes are most prominent after maximum light rather than at earlier times
when the UV flux from the SN peaks. As with SN 2006X, we detect no change in
the Ca II H&K lines over the same time period, rendering line-of-sight effects
improbable and suggesting a circumstellar origin for the absorbing material.
Unlike the previous two SNe exhibiting variable absorption, SN 2007le is not
highly reddened (E_B-V = 0.27 mag), also pointing toward circumstellar rather
than interstellar absorption. Photoionization models show that the data are
consistent with a dense (10^7 cm^-3) cloud or clouds of gas located ~0.1 pc
from the explosion. These results broadly support the single-degenerate
scenario previously proposed to explain the variable absorption, with mass loss
from a nondegenerate companion star responsible for providing the circumstellar
gas. We also present tentative evidence for narrow Halpha emission associated
with the SN, which will require followup observations at late times to confirm.
[abridged]Comment: 16 pages, 10 figures (8 in color), 5 tables. Accepted for publication
in Ap
c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress.
Published versio
Inhibition of the inositol kinase Itpkb augments calcium signaling in lymphocytes and reveals a novel strategy to treat autoimmune disease
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inositol kinase Itpkb in mature T lymphocytes results in enhanced intracellular calcium levels following antigen receptor activation leading to T cell death. Using Itpkb conditional knockout mice and LMW Itpkb inhibitors these studies reveal that Itpkb through its product IP4 inhibits the Orai1/Stim1 calcium channel on lymphocytes. Pharmacological inhibition or genetic deletion of Itpkb results in elevated intracellular Ca2+ and induction of FasL and Bim resulting in T cell apoptosis. Deletion of Itpkb or treatment with Itpkb inhibitors blocks T-cell dependent antibody responses in vivo and prevents T cell driven arthritis in rats. These data identify Itpkb as an essential mediator of T cell activation and suggest Itpkb inhibition as a novel approach to treat autoimmune disease
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis in 456,693 volunteers found associations of haplotypes of SMPD3 coding for NSM-2 (NSM) with alcohol consumption, but also with affective state, and bone mineralisation. Functional analysis in mice showed that NSM controls alcohol consumption, affective behaviour, and their interaction by regulating hippocampal volume, cortical connectivity, and monoaminergic responses. Furthermore, NSM controlled bone–brain communication by enhancing osteocalcin signalling, which can independently supress alcohol consumption and reduce depressive behaviour. Altogether, we identified a single gene source for multiple pathways originating in the brain and bone, which interlink disorders of a mental–physical co-morbidity trias of alcohol abuse—depression/anxiety—bone disorder. Targeting NSM and osteocalcin signalling may, thus, provide a new systems approach in the treatment of a mental–physical co-morbidity trias
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