Resilience of the Internet to random breakdowns

A common property of many large networks, including the Internet, is that the connectivity of the various nodes follows a scale-free power-law distribution, P(k)=ck^-a. We study the stability of such networks with respect to crashes, such as random removal of sites. Our approach, based on percolation theory, leads to a general condition for the critical fraction of nodes, p_c, that need to be removed before the network disintegrates. We show that for a<=3 the transition never takes place, unless the network is finite. In the special case of the Internet (a=2.5), we find that it is impressively robust, where p_c is approximately 0.99.Comment: latex, 3 pages, 1 figure (eps), explanations added, Phys. Rev. Lett., in pres

G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila.

We combined Gal4-UAS and the FLP recombinase-FRT and fluorescent reporters to generate cell clones that provide spatial, temporal and genetic information about the origins of individual cells in Drosophila melanogaster. We named this combination the Gal4 technique for real-time and clonal expression (G-TRACE). The approach should allow for screening and the identification of real-time and lineage-traced expression patterns on a genomic scale

Seismic stratigraphy of Lago Fagnano sediments (Tierra del Fuego, Argentina) - A potencial archive of paleoclimatic change and tectonic activity since the Late Glacial

Located at 54ºS in the heart of the Island of Tierra del Fuego, Lago Fagnano occupies the deepest of a chain of en-echelon tectonic depressions along the Magallanes-Fagnano Transform system (MFT). A recent geophysical campaign combining 3.5 kHz (pinger) single-channel with 1 in3 airgun multi-channel systems surveyed more than 100 m of glacio-lacustrine sediments filling two main sub-basins. These data provide a unique opportunity to visualize the most recent lacustrine sequence with high-resolution while simultaneously imaging the oldest infill. A preliminary seismic stratigraphic analysis of the high-resolution 3.5 kHz pinger data allowed the identification of three major seismostratigraphic units (A, the oldest and C, the youngest). While unit A is interpreted as glacially derived sediments, the overlying unit B is interpreted as fining upward sequences of proglacial turbidites reflecting sediment pulses released by the retreating Fagnano glacier during the last deglaciation. A major environmental change occurred during deposition of unit C when pelagic style of sedimentation is intercalated by sequences of downslope mass flow events probably triggered by relatively strong tectonic pulses along the MFT system. Gravity cores show a regular alternation of light and dark laminae occasionally interrupted by homogenous sedimentary units interpreted as turbidites. Ultra-high resolution X-ray fluorescence micro-profiles show fluctuations in major trace elements at mm scale that may indicate seasonal variations in the sedimentary influx. These core data provide a unique record of decadal changes in regional climate that can be compared with other marine and continental archives to improve our understanding of the forcing mechanisms behind climate change

Spatial Structure and Activity of Sedimentary Microbial Communities Underlying a Beggiatoa spp. Mat in a Gulf of Mexico Hydrocarbon Seep

Background: Subsurface fluids from deep-sea hydrocarbon seeps undergo methane- and sulfur-cycling microbial transformations near the sediment surface. Hydrocarbon seep habitats are naturally patchy, with a mosaic of active seep sediments and non-seep sediments. Microbial community shifts and changing activity patterns on small spatial scales from seep to non-seep sediment remain to be examined in a comprehensive habitat study. Methodology/Principal Findings: We conducted a transect of biogeochemical measurements and gene expression related to methane- and sulfur-cycling at different sediment depths across a broad Beggiatoa spp. mat at Mississippi Canyon 118 (MC118) in the Gulf of Mexico. High process rates within the mat (,400 cm and,10 cm from the mat’s edge) contrasted with sharply diminished activity at,50 cm outside the mat, as shown by sulfate and methane concentration profiles, radiotracer rates of sulfate reduction and methane oxidation, and stable carbon isotopes. Likewise, 16S ribosomal rRNA, dsrAB (dissimilatory sulfite reductase) and mcrA (methyl coenzyme M reductase) mRNA transcripts of sulfate-reducing bacteria (Desulfobacteraceae and Desulfobulbaceae) and methane-cycling archaea (ANME-1 and ANME-2) were prevalent at the sediment surface under the mat and at its edge. Outside the mat at the surface, 16S rRNA sequences indicated mostly aerobes commonly found in seawater. The seep-related communities persisted at 12–20 cm depth inside and outside the mat. 16S rRNA transcripts and V6-tags reveal that bacterial and archaeal diversity underneath the mat are similar to eac

Gifted Education in German-Speaking Europe

The authors first briefly describe how the concepts of talents and giftedness found in German-speaking Europe have evolved in the school system and in general over the past two centuries, and how the variety of gifted-education efforts found within and beyond schools as well as counseling efforts attest to these changes. They then discuss four hallmarks of gifted education in German-speaking Europe: (a) the ongoing development of gifted promotion methods through the integration of newer insights about learning and social aspects; (b) the development of new methods of gifted education, particularly in the areas of mentoring, self-regulated learning, and hybrid approaches; (c) a decidedly scientific approach, which is increasingly characterized by systemic perspectives; and (d) the results of research on the effectiveness of various approaches to gifted education in German-speaking Europe

Early intervention for obsessive compulsive disorder : An expert consensus statement

© 2019 Elsevier B.V.and ECNP. All rights reserved.Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD. The statement draws together evidence from epidemiological, clinical, health economic and brain imaging studies documenting the negative impact associated with treatment delay on clinical outcomes, and supporting the importance of early clinical intervention. It draws parallels between OCD and other disorders for which early intervention is recognized as beneficial, such as psychotic disorders and impulsive-compulsive disorders associated with problematic usage of the Internet, for which early intervention may prevent the development of later addictive disorders. It also generates new heuristics for exploring the brain-based mechanisms moderating the ‘toxic’ effect of an extended DUI in OCD. The statement concludes that there is a global unmet need for early intervention services for OC related disorders to reduce the unnecessary suffering and costly disability associated with under-treatment. New clinical staging models for OCD that may be used to facilitate primary, secondary and tertiary prevention within this context are proposed.Peer reviewe

Versatile transporter apparatus for experiments with optically trapped Bose-Einstein condensates

We describe a versatile and simple scheme for producing magnetically and optically-trapped Rb-87 Bose-Einstein condensates, based on a moving-coil transporter apparatus. The apparatus features a TOP trap that incorporates the movable quadrupole coils used for magneto-optical trapping and long-distance magnetic transport of atomic clouds. As a stand-alone device, this trap allows for the stable production of condensates containing up to one million atoms. In combination with an optical dipole trap, the TOP trap acts as a funnel for efficient loading, after which the quadrupole coils can be retracted, thereby maximizing optical access. The robustness of this scheme is illustrated by realizing the superfluid-to-Mott insulator transition in a three-dimensional optical lattice

RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins

The sea urchin larval skeleton offers a simple model for formation of developmental patterns. The calcium carbonate skeleton is secreted by primary mesenchyme cells (PMCs) in response to largely unknown patterning cues expressed by the ectoderm. To discover novel ectodermal cues, we performed an unbiased RNA-Seq-based screen and functionally tested candidates; we thereby identified several novel skeletal patterning cues. Among these, we show that SLC26a2/7 is a ventrally expressed sulfate transporter that promotes a ventral accumulation of sulfated proteoglycans, which is required for ventral PMC positioning and skeletal patterning. We show that the effects of SLC perturbation are mimicked by manipulation of either external sulfate levels or proteoglycan sulfation. These results identify novel skeletal patterning genes and demonstrate that ventral proteoglycan sulfation serves as a positional cue for sea urchin skeletal patterning