208 research outputs found
Photometric quality of Dome C for the winter 2008 from ASTEP South
ASTEP South is an Antarctic Search for Transiting Exo- Planets in the South
pole field, from the Concordia station, Dome C, Antarctica. The instrument
consists of a thermalized 10 cm refractor observing a fixed 3.88\degree x
3.88\degree field of view to perform photometry of several thousand stars at
visible wavelengths (700-900 nm). The first winter campaign in 2008 led to the
retrieval of nearly 1600 hours of data. We derive the fraction of photometric
nights by measuring the number of detectable stars in the field. The method is
sensitive to the presence of small cirrus clouds which are invisible to the
naked eye. The fraction of night-time for which at least 50% of the stars are
detected is 74% from June to September 2008. Most of the lost time (18.5% out
of 26%) is due to periods of bad weather conditions lasting for a few days
("white outs"). Extended periods of clear weather exist. For example, between
July 10 and August 10, 2008, the total fraction of time (day+night) for which
photometric observations were possible was 60%. This confirms the very high
quality of Dome C for nearly continuous photometric observations during the
Antarctic winter
ASTEP South: An Antarctic Search for Transiting ExoPlanets around the celestial South pole
ASTEP South is the first phase of the ASTEP project (Antarctic Search for
Transiting ExoPlanets). The instrument is a fixed 10 cm refractor with a 4kx4k
CCD camera in a thermalized box, pointing continuously a 3.88 degree x 3.88
degree field of view centered on the celestial South pole. ASTEP South became
fully functional in June 2008 and obtained 1592 hours of data during the 2008
Antarctic winter. The data are of good quality but the analysis has to account
for changes in the point spread function due to rapid ground seeing variations
and instrumental effects. The pointing direction is stable within 10 arcseconds
on a daily timescale and drifts by only 34 arcseconds in 50 days. A truly
continuous photometry of bright stars is possible in June (the noon sky
background peaks at a magnitude R=15 arcsec-2 on June 22), but becomes
challenging in July (the noon sky background magnitude is R=12.5 arcsec?2 on
July 20). The weather conditions are estimated from the number of stars
detected in the field. For the 2008 winter, the statistics are between 56.3 %
and 68.4 % of excellent weather, 17.9 % to 30 % of veiled weather and 13.7 % of
bad weather. Using these results in a probabilistic analysis of transit
detection, we show that the detection efficiency of transiting exoplanets in
one given field is improved at Dome C compared to a temperate site such as La
Silla. For example we estimate that a year-long campaign of 10 cm refractor
could reach an efficiency of 69 % at Dome C versus 45 % at La Silla for
detecting 2-day period giant planets around target stars from magnitude 10 to
15. This shows the high potential of Dome C for photometry and future planet
discoveries. [Short abstract
The secondary eclipses of WASP-19b as seen by the ASTEP 400 telescope from Antarctica
The ASTEP (Antarctica Search for Transiting ExoPlanets) program was
originally aimed at probing the quality of the Dome C, Antarctica for the
discovery and characterization of exoplanets by photometry. In the first year
of operation of the 40 cm ASTEP 400 telescope (austral winter 2010), we
targeted the known transiting planet WASP-19b in order to try to detect its
secondary transits in the visible. This is made possible by the excellent
sub-millimagnitude precision of the binned data. The WASP-19 system was
observed during 24 nights in May 2010. The photometric variability level due to
starspots is about 1.8% (peak-to-peak), in line with the SuperWASP data from
2007 (1.4%) and larger than in 2008 (0.07%). We find a rotation period of
WASP-19 of 10.7 +/- 0.5 days, in agreement with the SuperWASP determination of
10.5 +/- 0.2 days. Theoretical models show that this can only be explained if
tidal dissipation in the star is weak, i.e. the tidal dissipation factor Q'star
> 3.10^7. Separately, we find evidence for a secondary eclipse of depth 390 +/-
190 ppm with a 2.0 sigma significance, a phase consistent with a circular orbit
and a 3% false positive probability. Given the wavelength range of the
observations (420 to 950 nm), the secondary transit depth translates into a day
side brightness temperature of 2690(-220/+150) K, in line with measurements in
the z' and K bands. The day side emission observed in the visible could be due
either to thermal emission of an extremely hot day side with very little
redistribution of heat to the night side, or to direct reflection of stellar
light with a maximum geometrical albedo Ag=0.27 +/- 0.13. We also report a
low-frequency oscillation well in phase at the planet orbital period, but with
a lower-limit amplitude that could not be attributed to the planet phase alone,
and possibly contaminated with residual lightcurve trends.Comment: Accepted for publication in Astronomy and Astrophysics, 13 pages, 13
figure
MOA-2010-BLG-477Lb: constraining the mass of a microlensing planet from microlensing parallax, orbital motion and detection of blended light
Microlensing detections of cool planets are important for the construction of
an unbiased sample to estimate the frequency of planets beyond the snow line,
which is where giant planets are thought to form according to the core
accretion theory of planet formation. In this paper, we report the discovery of
a giant planet detected from the analysis of the light curve of a
high-magnification microlensing event MOA-2010-BLG-477. The measured
planet-star mass ratio is and the projected
separation is in units of the Einstein radius. The angular
Einstein radius is unusually large mas. Combining
this measurement with constraints on the "microlens parallax" and the lens
flux, we can only limit the host mass to the range . In
this particular case, the strong degeneracy between microlensing parallax and
planet orbital motion prevents us from measuring more accurate host and planet
masses. However, we find that adding Bayesian priors from two effects (Galactic
model and Keplerian orbit) each independently favors the upper end of this mass
range, yielding star and planet masses of
and at a distance of kpc,
and with a semi-major axis of AU. Finally, we show that the
lens mass can be determined from future high-resolution near-IR adaptive optics
observations independently from two effects, photometric and astrometric.Comment: 3 Tables, 12 Figures, accepted in Ap
Single-molecule experiments in biological physics: methods and applications
I review single-molecule experiments (SME) in biological physics. Recent
technological developments have provided the tools to design and build
scientific instruments of high enough sensitivity and precision to manipulate
and visualize individual molecules and measure microscopic forces. Using SME it
is possible to: manipulate molecules one at a time and measure distributions
describing molecular properties; characterize the kinetics of biomolecular
reactions and; detect molecular intermediates. SME provide the additional
information about thermodynamics and kinetics of biomolecular processes. This
complements information obtained in traditional bulk assays. In SME it is also
possible to measure small energies and detect large Brownian deviations in
biomolecular reactions, thereby offering new methods and systems to scrutinize
the basic foundations of statistical mechanics. This review is written at a
very introductory level emphasizing the importance of SME to scientists
interested in knowing the common playground of ideas and the interdisciplinary
topics accessible by these techniques. The review discusses SME from an
experimental perspective, first exposing the most common experimental
methodologies and later presenting various molecular systems where such
techniques have been applied. I briefly discuss experimental techniques such as
atomic-force microscopy (AFM), laser optical tweezers (LOT), magnetic tweezers
(MT), biomembrane force probe (BFP) and single-molecule fluorescence (SMF). I
then present several applications of SME to the study of nucleic acids (DNA,
RNA and DNA condensation), proteins (protein-protein interactions, protein
folding and molecular motors). Finally, I discuss applications of SME to the
study of the nonequilibrium thermodynamics of small systems and the
experimental verification of fluctuation theorems. I conclude with a discussion
of open questions and future perspectives.Comment: Latex, 60 pages, 12 figures, Topical Review for J. Phys. C (Cond.
Matt
Bipolar disorder and age-related functional impairment
OBJECTIVE: Although bipolar disorder is a major contributor to functional impairment worldwide, an independent impact of bipolar disorder and ageing on functioning has yet to be demonstrated. The objective of the present study was to evaluate the effect of bipolar disorder on age-related functional status using matched controls as a standard. METHOD: One-hundred patients with bipolar disorder and matched controls were evaluated for disability. Age-related effects controlled for confounders were cross-sectionally evaluated. RESULTS: Patients were significantly more impaired than controls. Regression showed effects for aging in both groups. The effect, size, however, was significantly stronger in patients. CONCLUSION: Bipolar disorder was an important effect modifier of the age impact on functioning. While a longitudinal design is needed to effectively demonstrate this different impact, this study further depicts bipolar disorder as a chronic and progressively impairing illness
Beyond Repair Foci: DNA Double-Strand Break Repair in Euchromatic and Heterochromatic Compartments Analyzed by Transmission Electron Microscopy
DNA double-strand breaks (DSBs) generated by ionizing radiation pose a serious threat to the preservation of genetic and epigenetic information. The known importance of local chromatin configuration in DSB repair raises the question of whether breaks in different chromatin environments are recognized and repaired by the same repair machinery and with similar efficiency. An essential step in DSB processing by non-homologous end joining is the high-affinity binding of Ku70-Ku80 and DNA-PKcs to double-stranded DNA ends that holds the ends in physical proximity for subsequent repair.Using transmission electron microscopy to localize gold-labeled pKu70 and pDNA-PKcs within nuclear ultrastructure, we monitored the formation and repair of actual DSBs within euchromatin (electron-lucent) and heterochromatin (electron-dense) in cortical neurons of irradiated mouse brain.While DNA lesions in euchromatin (characterized by two pKu70-gold beads, reflecting the Ku70-Ku80 heterodimer) are promptly sensed and rejoined, DNA packaging in heterochromatin appears to retard DSB processing, due to the time needed to unravel higher-order chromatin structures. Complex pKu70-clusters formed in heterochromatin (consisting of 4 or â„ 6 gold beads) may represent multiple breaks in close proximity caused by ionizing radiation of highly-compacted DNA. All pKu70-clusters disappeared within 72 hours post-irradiation, indicating efficient DSB rejoining. However, persistent 53BP1 clusters in heterochromatin (comprising â„ 10 gold beads), occasionally co-localizing with ÎłH2AX, but not pKu70 or pDNA-PKcs, may reflect incomplete or incorrect restoration of chromatin structure rather than persistently unrepaired DNA damage.Higher-order organization of chromatin determines the accessibility of DNA lesions to repair complexes, defining how readily DSBs are detected and processed. DNA lesions in heterochromatin appear to be more complex, with multiple breaks in spatial vicinity inducing severe chromatin disruptions. Imperfect restoration of chromatin configurations may leave DSB-induced epigenetic memory of damage with potentially pathological repercussions
Cognitive impairment in patients with a schizoaffective disorder: a comparison with bipolar patients in euthymia
OBJECTIVES: Several studies have shown persistent neurocognitive impairment in patients with a bipolar affective disorder (BD) even in euthymia as well as in patients with a schizoaffective disorder (SAD). The aim of our study was to compare the neuropsychological performance between these two groups. Confounding variables were controlled to enhance our understanding of cognitive dysfunction in both BD and SAD. METHODS: Several domains of neurocognitive function, executive function, memory, attention, concentration and perceptuomotor function were examined in 28 euthymic SAD patients and 32 BD patients by using a neuropsychological test battery. The Hamilton Depression Rating Scale (HAMD), Montgomery-Asberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) were used to evaluate the patients' clinical status. Data analysis was performed by using a multivariate analysis of covariance (ANCOVA/MANCOVA). RESULTS: Euthymic SAD patients showed greater cognitive impairment than euthymic BD patients in the tested domains including declarative memory and attention. Putative significant group differences concerning cognitive flexibility vanished when controlled for demographic and clinical variables. Age and medication were robust predictors to cognitive performance of both SAD and BD patients. CONCLUSIONS: Our results point out the worse cognitive outcome of SAD compared to BD patients in remission. Remarkably, the variance is higher for some of the test results between the groups than within each group, this being discussed in light of the contradictive concept of SAD
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