234 research outputs found
Translational neuroscience: the state of the nation (a PhD student perspective)
Many brain disorders are currently untreatable. It has been suggested that taking a âtranslationalâ approach to neuroscientific research might change this. We discuss what âtranslational neuroscienceâ is and argue for the need to expand the traditional translational model if we are to make further advances in treating brain disorders
Resonant transmission through an open quantum dot
We have measured the low-temperature transport properties of a quantum dot
formed in a one-dimensional channel. In zero magnetic field this device shows
quantized ballistic conductance plateaus with resonant tunneling peaks in each
transition region between plateaus. Studies of this structure as a function of
applied perpendicular magnetic field and source-drain bias indicate that
resonant structure deriving from tightly bound states is split by Coulomb
charging at zero magnetic field.Comment: To be published in Phys. Rev. B (1997). 8 LaTex pages with 5 figure
Dynamical modelling of the elliptical galaxy NGC 2974
In this paper we analyse the relations between a previously described oblate
Jaffe model for an ellipsoidal galaxy and the observed quantities for NGC 2974,
and obtain the length and velocity scales for a relevant elliptical galaxy
model. We then derive the finite total mass of the model from these scales, and
finally find a good fit of an isotropic oblate Jaffe model by using the
Gauss-Hermite fit parameters and the observed ellipticity of the galaxy NGC
2974. The model is also used to predict the total luminous mass of NGC 2974,
assuming that the influence of dark matter in this galaxy on the image,
ellipticity and Gauss-Hermite fit parameters of this galaxy is negligible
within the central region, of radius Comment: 7 figure
Geometric and thermodynamic properties in Gauss-Bonnet gravity
In this paper, the generalized second law (GSL) of thermodynamics and entropy
is revisited in the context of cosmological models in Gauss-Bonnet gravity with
the boundary of the universe is assumed to be enclosed by the dynamical
apparent horizon. The model is best fitted with the observational data for
distance modulus. The best fitted geometric and thermodynamic parameters such
as equation of state parameter, deceleration parameter and entropy are derived.
To link between thermodynamic and geometric parameters, the "entropy rate of
change multiplied by the temperature" as a model independent thermodynamic
state parameter is also derived. The results show that the model is in good
agreement with the observational analysis.Comment: 13 pages, 13 figures, to be published in Astrophysics and Space Sc
VERITAS: the Very Energetic Radiation Imaging Telescope Array System
The Very Energetic Radiation Imaging Telescope Array System (VERITAS)
represents an important step forward in the study of extreme astrophysical
processes in the universe. It combines the power of the atmospheric Cherenkov
imaging technique using a large optical reflector with the power of
stereoscopic observatories using arrays of separated telescopes looking at the
same shower. The seven identical telescopes in VERITAS, each of aperture 10 m,
will be deployed in a filled hexagonal pattern of side 80 m; each telescope
will have a camera consisting of 499 pixels with a field of view of 3.5 deg
VERITAS will substantially increase the catalog of very high energy (E >
100GeV) gamma-ray sources and greatly improve measurements of established
sources.Comment: 44 pages, 16 figure
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Assessing the accuracy of current near infra-red reflectance spectroscopy analysis for fresh grass-clover mixture silages and development of new equations for this purpose
The purpose of this study was to ascertain whether Near Infra-Red Reflectance Spectroscopy (NIRS) prediction equations calibrated on grass silage samples, could accurately predict the chemical composition of mixed grass-clover silage samples, and furthermore, to develop and calibrate new grass-clover equations should the grass-based equations be insufficiently accurate for these silages. A set of 94 silage samples from mixed grass-clover swards (clover concentration (CC) ranging from 4 to 1000 g/kg as fed; determined manually) were analysed for chemical composition using reference laboratory techniques, in vivo digestible organic matter in the dry matter (DOMD, in sheep), and in situ degradability of dry matter and crude protein (in cows). The same samples were scanned fresh (undried and unmilled, as is standard practice for silage analysis within UK laboratories) using NIRS (at AFBI, Northern Ireland) and grass-based prediction equations applied. Predicted and observed results were compared. Of 15 chemical components that were tested for prediction accuracy, only volatile-corrected dry matter and nitrogen were well predicted (RPD values of 4.9 and 2.4 respectively, with low root mean square errors of prediction (RMSEP)). Neutral detergent fibre and DOMD showed low RPD values, however the predicted and observed datasets had no significant bias between them and were therefore also considered as fit for purpose. Variables with significant bias between predicted and observed datasets that were not considered suitably accurate included crude protein, acid detergent fibre, microbial dry matter yield and the effective degradability of protein. For many components, bias could be attributed at least in part to CC and changes in the fractionation of nutrients present. For some variables such as crude protein, grass-based equations were sufficiently accurate at low CCs but became inaccurate as CC increased, as expected. In response to inadequate prediction accuracy of certain nutrients, new grass-clover equations were calibrated using the obtained spectra. These were validated and results indicated that the grass-clover-based equations outperformed their grass-based counterparts. The adoption of new grass-clover equations, or alternatively, with further development, the use of a CC correction factor to the existing grass-based equations, is recommended for commercial laboratories offering undried and unmilled silage analysis on samples containing clover
Entropy and statefinder diagnosis in chameleon cosmology
In this paper, the generalized second law (GSL) of thermodynamics and entropy
is revisited in the context of cosmological models with bouncing behavior such
as chameleon cosmology where the boundary of the universe is assumed to be
enclosed by the dynamical apparent horizon. From a thermodynamic point of view,
to link between thermodynamic and geometric parameters in cosmological models,
we introduce "entropy rate of change multiplied by the temperature" as a model
independent thermodynamic state parameter together with the well known statefinder to differentiate the dark energy models.Comment: 11 pages, 5 figures. will be published in Astrophys. Space Sc
Dialysis initiation, modality choice, access, and prescription: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Globally, the number of patients undergoing maintenance dialysis is increasing, yet throughout the world there is significant variability in the practice of initiating dialysis. Factors such as availability of resources, reasons for starting dialysis, timing of dialysis initiation, patient education and preparedness, dialysis modality and access, as well as varied \u201ccountry-specific\u201d factors significantly affect patient experiences and outcomes. As the burden of end-stage kidney disease (ESKD) has increased globally, there has also been a growing recognition of the importance of patient involvement in determining the goals of care and decisions regarding treatment. In January 2018, KDIGO (Kidney Disease: Improving Global Outcomes) convened a Controversies Conference focused on dialysis initiation, including modality choice, access, and prescription. Here we present a summary of the conference discussions, including identified knowledge gaps, areas of controversy, and priorities for research. A major novel theme represented during the conference was the need to move away from a \u201cone-size-fits-all\u201d approach to dialysis and provide more individualized care that incorporates patient goals and preferences while still maintaining best practices for quality and safety. Identifying and including patient-centered goals that can be validated as quality indicators in the context of diverse health care systems to achieve equity of outcomes will require alignment of goals and incentives between patients, providers, regulators, and payers that will vary across health care jurisdictions
Measurement of the Lambda^0_b lifetime in the decay Lambda^0_b -> J/psi Lambda^0 with the D0 Detector
We present measurements of the Lambda^0_b lifetime in the exclusive decay
channel Lambda^0_{b}->J/psi Lambda^0, with J/psi to mu+ mu- and Lambda^0 to p
pi-, the B^0 lifetime in the decay B^0 -> J/psi K^0_S with J/psi to mu+ mu- and
K^0_S to pi+ pi-, and the ratio of these lifetimes. The analysis is based on
approximately 250 pb^{-1} of data recorded with the D0 detector in pp(bar)
collisions at sqrt{s}=1.96 TeV. The Lambda^0_b lifetime is determined to be
tau(Lambda^0_b) = 1.22 +0.22/-0.18 (stat) +/- 0.04 (syst) ps, the B^0 lifetime
tau(B^0) = 1.40 +0.11/-0.10 (stat) +/- 0.03 (syst) ps, and the ratio
tau(Lambda^0_b)/tau(B^0) = 0.87 +0.17/-0.14 (stat) +/- 0.03 (syst). In contrast
with previous measurements using semileptonic decays, this is the first
determination of the Lambda^0_b lifetime based on a fully reconstructed decay
channel.Comment: 7 pages, 4 figures, Submitted to Physical Review Letters, v2: Added
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