Validation of RUDAS: A screening tool for dementia in Primary Health Care settings

Objetivo: Validar la escala Rowland Dementia Assessment Scale (RUDAS) como instrumento de cribado de deterioro cognitivo y demencia en atención primaria (AP). Es un test breve, válido para población con bajo nivel educativo formal y fácilmente traducible en entornos multiculturales. Diseño: Se realizó un estudio epidemiológico descriptivo, de corte transversal, con seguimiento a los 5 años. Emplazamiento: Centro de salud de atención primaria de O Grove, que atiende a una población de 10.650 habitantes en Pontevedra. Participantes: Ciento cincuenta personas aleatoriamente seleccionadas, con una edad media de 76,35 ± 7,12 años, bajo nivel educativo, origen predominantemente rural y semirrural y nivel socioeconómico bajo. Intervención: Se analizó la viabilidad, la aceptabilidad, la validez y la fiabilidad de la escala. Mediciones principales: RUDAS, Mini Mental State Examination , Clinical Dementia Rating , Índice de Katz, Índice de Barthel, Índice de Lawton y Escala de Depresión Geriátrica de Yesavage. Resultados: El test fue bien acogido por los pacientes y rápido de aplicar (7,58 ± 2,10 min). El área bajo la curva COR para el diagnóstico de demencia fue 0,983 (IC 95%: 0,97-1,00). Para un punto de corte óptimo de 22,5 presentó una sensibilidad del 89,3% y una especificidad del 100%. El área bajo la curva COR para discriminar personas con DCL de personas con demencia fue 0,965 (IC 95%: 0,91-1,00). Conclusiones: El RUDAS ha demostrado ser un instrumento viable y eficiente para cribar demencias en AP, libre de influencias educativas y socioculturales. Es especialmente sensible para discriminar población con deterioro cognitivo leve de población con demenciaObjective: To validate Rowland Dementia Assessment Scale (RUDAS), as an instrument for the screening of people with dementia and cognitive impairment in Primary Health Care (PHC). RUDAS is a brief cognitive test, appropriate for people with minimum completed level of education and easily adaptable to multicultural contexts. For these reason it could be a good instrument for dementia screening in PHC. Design: Cross-sectional descriptive epidemiological study with a five-year follow up. Location: O Grove PHC centre, Galicia, Spain (covering a population of 10,650 individuals). Outcome measures: RUDAS; Mini Mental State Examination; Clinical Dementia Rating; Katz, Barthel and Lawton Indexes; MMSE and Yesavage Geriatric Depression Scale. Participants: A total of 150 older adults (mean age 76.35 ± 7.12 years) randomly selected, from a low sociocultural and economical background and mainly rural and semirural origin. Intervention: RUDAS viability in PHC was checked, and its psychometric properties assessed: reliability, sensitivity, specificity, positive and negative predictive values. Results: RUDAS application was brief (7.58 ± 2.10 min) and well accepted. RUDAS area under receiver operating characteristic (ROC) curve for the detection of dementia was 0.983 (95% confidence interval (CI): 0.97-1.00) for an optimal cut-off point of 22.5, with sensitivity of 89.3%, and a specificity of 100%. Area under ROC curve for discriminating dementia from mild cognitive impairment was 0.965 (95% CI: 0.91-1.00). Conclusions: RUDAS test is fit for dementia screening in PHC and it is especially sensitive to discriminate PWD from people with MCIS

The Acoustics of Aggregation Sites: Listening to the Rock Art Landscape of Cuevas de la Araña (Spain)

Since the 1980s, research into aggregation sites has focused on the material dimension of the archaeological record and has thus led to an incomplete view of the prehistoric reality. Early communities chose sites for many reasons. In this article, we explore the possibility that something as immaterial in nature as the acoustics of the sites may have influenced the selective choices made by the prehistoric peoples who created and used rock art in these meeting places. Employing the Impulse Response (IR) methodology, we systematically analyze the acoustic properties of Cuevas de la Araña, an aggregation site in eastern Spain with Levantine rock art, and 16 satellite sites in its surroundings. The results indicate that the acoustics of La Araña could have been important for creating affective engagement through musical performances carried out during the production and use of rock art, as well as for the choice of the site as a meeting place for Levantine populations.This study forms part of the ERC Advanced Grant Artsoundscapes project “The sound of special places: exploring rock art soundscapes and the sacred” (EC Grant Agreement 787842), whose PI is Margarita Díaz-Andreu

Preparation of activated carbon from pine (Pinus radiata) sawdust by chemical activation with zinc chloride for wood dye adsorption

Wastewater containing dyes are released into water bodies generating serious problems in human health and marine life. To contribute to the solution of this problem, a novel activated carbon was prepared from untreated pine (Pinus radiata) sawdust by dry chemical activation with ZnCl2 and was used for wood dye adsorption. The carbon was characterized by point of zero charge, N2 and CO2 adsorption isotherms, SEM-EDX, and FTIR. N2 and CO2 surface areas were 471.4 and 319.5 m2 g−1, respectively, with 91% of micropores. Wood dye adsorption was studied in function of pH (2–12), adsorbent dose (0.1–4 g L−1), time (up to 48 h for blue and red and 12 h for black), and initial concentration (5–500 mg L−1). The equilibrium data for the blue and black dyes were satisfactorily fitted to the Freundlich model while those for the red dye to the Langmuir model. Kinetic data were explained by the pseudo-second order (chemisorption process) and intraparticle diffusion models. At 5 mg L−1, a 100% removal efficiency was achieved at all pH for the blue dye, whereas for the red and black, natural pH (5.1) and pH = 2, respectively, led to the best removal efficiencies, 96 and 56%. Increasing concentration above 25 mg L−1 significantly reduced adsorption efficiency for blue and red dyes. For the black dye increasing the dose to 1 g L−1, the adsorption efficiency reached 82% at 25 mg L−1. High removal efficiencies were achieved for all dyes at 25 mg L−1 and 4 g L−1Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by Consellería de Educación, Universidade e Formación Profesional, Xunta de Galicia, grant number ED431B 2020/039S

3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing

This work aims to use carboxymethyl cellulose (CMC) as main structural and functional component of 3D printed scaffolds for healing of diabetic wounds. Differently from previous inks involving small contents in CMC, herein sterile (steam-heated) concentrated CMC solely dispersions (10–20%w/v) were screened regarding printability and fidelity properties. CMC (15%w/v)-citric acid inks showed excellent self-healing rheological properties and stability during storage. CMC scaffolds loaded with platelet rich plasma (PRP) sustained the release of relevant growth factors. CMC scaffolds both with and without PRP promoted angiogenesis in ovo, stem cell migration in vitro, and wound healing in a diabetic model in vivo. Transparent CMC scaffolds allowed direct monitoring of bilateral full-thickness wounds created in rat dorsum. CMC scaffolds facilitated re-epithelialization, granulation, and angiogenesis in full-thickness skin defects, and the performance was improved when combined with PRP. Overall, CMC is pointed out as outstanding component of active dressings for diabetic woundsS

Living landscapes and sound ontologies in Altai (Siberia, Russia): the European Artsoundscapes project (ERC ref. 787842) and the challenge of the intangible context of rock art

En este artículo explicamos varios de los avances obtenidos en el proyecto del ERC Artsoundscapes. Comenzamos encuadrando la arqueoacústica en la evolución del pensamiento arqueológico de estas últimas décadas y en concreto en la importancia del estudio de los sentidos en arqueología. Como explicamos en el trabajo, para el desarrollo de esta subdisciplina el diseño de una metodología rigurosa e interdisciplinar ha constituido una de las principales preocupaciones. Nuestro trabajo de campo en Altai sirve para ejemplificar cómo hemos llevado a cabo nuestro cometido en la práctica. En esta área el arte rupestre, con una cronología de principios del III milenio aproximadamente a mitad del I milenio de nuestra era, con añadidos esporádicos posteriores, se concentra en algunos lugares hoy denominados santuarios. Los destacables datos obtenidos para claridad del habla y musical se consideran dentro del marco ontológico de las poblaciones indígenas de Altai, quienes mantienen que la dimensión acústica es un factor importante en la relación entre los seres humanos y los paisajes que habitan

Putative Role of MCT1 rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus.

Monocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La-) producer and La- recipient (consumer) cells. Previous studies have suggested that the MCT1 A1470T genotype could be related to different physical performance phenotypes. This study followed the guidelines for Strengthening the Reporting of Genetic Association Studies (STREGA) and aimed to evaluate the distribution of the MCT1 polymorphism rs1049434 in endurance-trained athletes compared to the untrained population. Moreover, this study explored the potential influence of the polymorphism alleles phenotypes on high-intensity exercise performance. In a cross-sectional study fashion, a total of 85 triathletes from northern Spain were genotyped for MCT1 rs1049434 and compared to a control group of 107 healthy male participants (1000 Genomes Research Study for Iberian Populations in Spain). All athletes performed a 30 s Wingate all-out test (WAnT) on a cycle ergometer. Peak and mean power (absolute and relative) were measured. After verification of the Hardy-Weinberg equilibrium, the findings indicated that the MCT1 TT genotype was overrepresented in triathletes in comparison to the genotypic frequency of the general Spanish population. No significant associations were found between any MCT1 genotype and peak or mean power performance in the WAnT. Further studies are required to understand the relationship among MCT1 A1470T polymorphism, endurance-trained athletes, and high-intensity performance

NEXT-100 Technical Design Report (TDR). Executive Summary

In this Technical Design Report (TDR) we describe the NEXT-100 detector that will search for neutrinoless double beta decay (bbonu) in Xe-136 at the Laboratorio Subterraneo de Canfranc (LSC), in Spain. The document formalizes the design presented in our Conceptual Design Report (CDR): an electroluminescence time projection chamber, with separate readout planes for calorimetry and tracking, located, respectively, behind cathode and anode. The detector is designed to hold a maximum of about 150 kg of xenon at 15 bar, or 100 kg at 10 bar. This option builds in the capability to increase the total isotope mass by 50% while keeping the operating pressure at a manageable level. The readout plane performing the energy measurement is composed of Hamamatsu R11410-10 photomultipliers, specially designed for operation in low-background, xenon-based detectors. Each individual PMT will be isolated from the gas by an individual, pressure resistant enclosure and will be coupled to the sensitive volume through a sapphire window. The tracking plane consists in an array of Hamamatsu S10362-11-050P MPPCs used as tracking pixels. They will be arranged in square boards holding 64 sensors (8 times8) with a 1-cm pitch. The inner walls of the TPC, the sapphire windows and the boards holding the MPPCs will be coated with tetraphenyl butadiene (TPB), a wavelength shifter, to improve the light collection.Comment: 32 pages, 22 figures, 5 table

encontros, trocas e desvios na diferença. Livro de resumos

UIDB/04666/2020 UIDP/04666/2020publishersversionpublishe