684 research outputs found
Pushing the Limits: Cognitive, Affective, and Neural Plasticity Revealed by an Intensive Multifaceted Intervention.
Scientific understanding of how much the adult brain can be shaped by experience requires examination of how multiple influences combine to elicit cognitive, affective, and neural plasticity. Using an intensive multifaceted intervention, we discovered that substantial and enduring improvements can occur in parallel across multiple cognitive and neuroimaging measures in healthy young adults. The intervention elicited substantial improvements in physical health, working memory, standardized test performance, mood, self-esteem, self-efficacy, mindfulness, and life satisfaction. Improvements in mindfulness were associated with increased degree centrality of the insula, greater functional connectivity between insula and somatosensory cortex, and reduced functional connectivity between posterior cingulate cortex (PCC) and somatosensory cortex. Improvements in working memory and reading comprehension were associated with increased degree centrality of a region within the middle temporal gyrus (MTG) that was extensively and predominately integrated with the executive control network. The scope and magnitude of the observed improvements represent the most extensive demonstration to date of the considerable human capacity for change. These findings point to higher limits for rapid and concurrent cognitive, affective, and neural plasticity than is widely assumed
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Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection.
"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood mononuclear cells (PBMC), predominately dendritic cells, monocytes/macrophages, and activated T cells. As these cell types are the primary targets for human immunodeficiency virus type 1 (HIV-1) infection, we examined the utility of recombinant human vaults for targeted delivery of antiretroviral drugs. We chemically modified three different antiretroviral drugs, zidovudine, tenofovir, and elvitegravir, for direct conjugation to vaults. Tested in infection assays, drug-conjugated vaults inhibited HIV-1 infection of PBMC with equivalent activity to free drugs, indicating vault delivery and drug release in the cytoplasm of HIV-1-susceptible cells. The ability to deliver functional drugs via vault nanoparticle conjugates suggests their potential utility for targeted drug delivery against HIV-1
Insulation for Daydreams: A Role for Tonic Norepinephrine in the Facilitation of Internally Guided Thought
Although consciousness can be brought to bear on both perceptual and internally generated information, little is known about how these different cognitive modes are coordinated. Here we show that between-participant variance in thoughts unrelated to the task being performed (known as task unrelated thought, TUT) is associated with longer response times (RT) when target presentation occurs during periods when baseline Pupil Diameter (PD) is increased. As behavioral interference due to high baseline PD can reflect increased tonic activity in the norepinephrine system (NE), these results might implicate high tonic NE activity in the facilitation of TUTs. Based on these findings, it is hypothesised that high tonic mode NE leads to a generalised de-amplification of task relevant information that prioritses internally generated thought and insulates it from the potentially disruptive events taking place in the external environment
Automated diffeomorphic registration of anatomical structures with rigid parts: application to dynamic cervical MRI.
International audienceWe propose an iterative two-step method to compute a diffeomorphic non-rigid transformation between images of anatomical structures with rigid parts, without any user intervention or prior knowledge on the image intensities. First we compute spatially sparse, locally optimal rigid transformations between the two images using a new block matching strategy and an efficient numerical optimiser (BOBYQA). Then we derive a dense, regularised velocity field based on these local transformations using matrix logarithms and M-smoothing. These two steps are iterated until convergence and the final diffeomorphic transformation is defined as the exponential of the accumulated velocity field. We show our algorithm to outperform the state-of-the-art log-domain diffeomorphic demons method on dynamic cervical MRI data
Generalized methods and solvers for noise removal from piecewise constant signals. II. New methods
Removing noise from signals which are piecewise constant (PWC) is a challenging signal processing problem that arises in many practical scientific and engineering contexts. In the first paper (part I) of this series of two, we presented background theory building on results from the image processing community to show that the majority of these algorithms, and more proposed in the wider literature, are each associated with a special case of a generalized functional, that, when minimized, solves the PWC denoising problem. It shows how the minimizer can be obtained by a range of computational solver algorithms. In this second paper (part II), using this understanding developed in part I, we introduce several novel PWC denoising methods, which, for example, combine the global behaviour of mean shift clustering with the local smoothing of total variation diffusion, and show example solver algorithms for these new methods. Comparisons between these methods are performed on synthetic and real signals, revealing that our new methods have a useful role to play. Finally, overlaps between the generalized methods of these two papers and others such as wavelet shrinkage, hidden Markov models, and piecewise smooth filtering are touched on
Measurement of the 20 and 90 keV resonances in the N reaction via THM
The reaction is of primary importance in
several astrophysical scenarios, including fluorine nucleosynthesis inside AGB
stars as well as oxygen and nitrogen isotopic ratios in meteorite grains. Thus
the indirect measurement of the low energy region of the reaction has been performed to reduce the nuclear
uncertainty on theoretical predictions. In particular the strength of the 20
and 90 keV resonances have been deduced and the change in the reaction rate
evaluated.Comment: 4 pages, 4 figures, submitted to PR
Search for new resonant states in 10C and 11C and their impact on the cosmological lithium problem
The observed primordial 7Li abundance in metal-poor halo stars is found to be
lower than its Big-Bang nucleosynthesis (BBN) calculated value by a factor of
approximately three. Some recent works suggested the possibility that this
discrepancy originates from missing resonant reactions which would destroy the
7Be, parent of 7Li. The most promising candidate resonances which were found
include a possibly missed 1- or 2- narrow state around 15 MeV in the compound
nucleus 10C formed by 7Be+3He and a state close to 7.8 MeV in the compound
nucleus 11C formed by 7Be+4He. In this work, we studied the high excitation
energy region of 10C and the low excitation energy region in 11C via the
reactions 10B(3He,t)10C and 11B(3He,t)11C, respectively, at the incident energy
of 35 MeV. Our results for 10C do not support 7Be+3He as a possible solution
for the 7Li problem. Concerning 11C results, the data show no new resonances in
the excitation energy region of interest and this excludes 7Be+4He reaction
channel as an explanation for the 7Li deficit.Comment: Accepted for publication in Phys. Rev. C (Rapid Communication
Collapse of the N=28 shell closure in Si
The energies of the excited states in very neutron-rich Si and
P have been measured using in-beam -ray spectroscopy from the
fragmentation of secondary beams of S at 39 A.MeV. The low 2
energy of Si, 770(19) keV, together with the level schemes of
P provide evidence for the disappearance of the Z=14 and N=28
spherical shell closures, which is ascribed mainly to the action of
proton-neutron tensor forces. New shell model calculations indicate that
Si is best described as a well deformed oblate rotor.Comment: 4 pages, 3 figures, accepted for publication in Phys. Rev. let
Resonance Strength Measurement at Astrophysical Energies: The 17O(p,α)14N Reaction Studied via THM
In recent years, the Trojan Horse Method (THM) has been used to investigate the low-energy cross sections of proton-induced reactions on 17 O nuclei, overcoming extrapolation procedures and enhancement effects due to electron screening. We will report on the indirect study of the 17 O(p, α ) 14 N reaction via the Trojan Horse Method by applying the approach developed for extracting the resonance strength of narrow resonance in the ultralow energy region. The mean value of the strengths obtained in the two measurements was calculated and compared with the direct data available in literature
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