Designing citizen science tools for learning: lessons learnt from the iterative development of nQuire

This paper reports on a 4-year research and development case study about the design of citizen science tools for inquiry learning. It details the process of iterative pedagogy-led design and evaluation of the nQuire toolkit, a set of web-based and mobile tools scaffolding the creation of online citizen science investigations. The design involved an expert review of inquiry learning and citizen science, combined with user experience studies involving more than 200 users. These have informed a concept that we have termed ‘citizen inquiry’, which engages members of the public alongside scientists in setting up, running, managing or contributing to citizen science projects with a main aim of learning about the scientific method through doing science by interaction with others. A design-based research (DBR) methodology was adopted for the iterative design and evaluation of citizen science tools. DBR was focused on the refinement of a central concept, ‘citizen inquiry’, by exploring how it can be instantiated in educational technologies and interventions. The empirical evaluation and iteration of technologies involved three design experiments with end users, user interviews, and insights from pedagogy and user experience experts. Evidence from the iterative development of nQuire led to the production of a set of interaction design principles that aim to guide the development of online, learning-centred, citizen science projects. Eight design guidelines are proposed: users as producers of knowledge, topics before tools, mobile affordances, scaffolds to the process of scientific inquiry, learning by doing as key message, being part of a community as key message, every visit brings a reward, and value users and their time

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography

The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments. The 18F-radiolabeled polyamides were prepared by oxime ligation between 4-[18F]-fluorobenzaldehyde and a hydroxylamine moiety at the polyamide C terminus. Small animal PET imaging of radiolabeled polyamides administered to mice revealed distinct differences in the biodistribution of a 5-ring β-linked polyamide versus an 8-ring hairpin, which exhibited better overall bioavailability. In vivo imaging of pyrrole-imidazole polyamides by PET is a minimum first step toward the translation of polyamide-based gene regulation from cell culture to small animal studies

X-ray variability of AGNs in the soft and the hard X-ray bands

We investigate the X-ray variability characteristics of hard X-ray selected AGNs (based on Swift/BAT data) in the soft X-ray band using the RXTE/ASM data. The uncertainties involved in the individual dwell measurements of ASM are critically examined and a method is developed to combine a large number of dwells with appropriate error propagation to derive long duration flux measurements (greater than 10 days). We also provide a general prescription to estimate the errors in variability derived from rms values from unequally spaced data. Though the derived variability for individual sources are not of very high significance, we find that, in general, the soft X-ray variability is higher than those in hard X-rays and the variability strengths decrease with energy for the diverse classes of AGN. We also examine the strength of variability as a function of the break time scale in the power density spectrum (derived from the estimated mass and bolometric luminosity of the sources) and find that the data are consistent with the idea of higher variability at time scales longer than the break time scale.Comment: 17 pages, 15 Postscript figures, 3 tables, accepted for publication in Ap

Telecommunications systems design techniques handbook

Handbook presents design and analysis of tracking, telemetry, and command functions utilized in these systems with particular emphasis on deep-space telecommunications. Antenna requirements are also discussed. Handbook provides number of tables outlining various performance criteria. Block diagrams and performance charts are also presented

Optical Microvariability in Quasars: Spectral Variability

We present a method that we developed to discern where the optical microvariability (OM) in quasars originates: in the accretion disk (related to thermal processes) or in the jet (related to non-thermal processes). Analyzing nearly simultaneous observations in three different optical bands of continuum emission, we are able to determine the origin of several isolated OM events. In particular, our method indicates that from nine events reported by Ramirez et al. (2009), three of them are consistent with a thermal origin, three to non-thermal, and three cannot be discerned. The implications for the emission models of OM are briefly discussed.Comment: Accepted for publication in the Astrophysical Journa

Connection between the Accretion Disk and Jet in the Radio Galaxy 3C 111

We present the results of extensive multi-frequency monitoring of the radio galaxy 3C 111 between 2004 and 2010 at X-ray (2.4--10 keV), optical (R band), and radio (14.5, 37, and 230 GHz) wave bands, as well as multi-epoch imaging with the Very Long Baseline Array (VLBA) at 43 GHz. Over the six years of observation, significant dips in the X-ray light curve are followed by ejections of bright superluminal knots in the VLBA images. This shows a clear connection between the radiative state near the black hole, where the X-rays are produced, and events in the jet. The X-ray continuum flux and Fe line intensity are strongly correlated, with a time lag shorter than 90 days and consistent with zero. This implies that the Fe line is generated within 90 light-days of the source of the X-ray continuum. The power spectral density function of X-ray variations contains a break, with steeper slope at shorter timescales. The break timescale of 13 (+12,-6) days is commensurate with scaling according to the mass of the central black hole based on observations of Seyfert galaxies and black hole X-ray binaries (BHXRBs). The data are consistent with the standard paradigm, in which the X-rays are predominantly produced by inverse Compton scattering of thermal optical/UV seed photons from the accretion disk by a distribution of hot electrons --- the corona --- situated near the disk. Most of the optical emission is generated in the accretion disk due to reprocessing of the X-ray emission. The relationships that we have uncovered between the accretion disk and the jet in 3C 111, as well as in the FR I radio galaxy 3C 120 in a previous paper, support the paradigm that active galactic nuclei and Galactic BHXRBs are fundamentally similar, with characteristic time and size scales proportional to the mass of the central black holeComment: Accepted for publication in ApJ. 18 pages, 17 figures, 11 tables (full machine readable data-tables online in ApJ website

Soft X-ray spectral variations of the narrow line Seyfert l galaxy Markarian 766

The X-ray variability of the narrow-line Seyfert 1 galaxy Markarian 766 is studied using nine ROSAT PSPC data sets. The spectrum is well described by a power law combined with a blackbody (kT ∼ 70 eV) soft excess. Examination of flux ratio changes and variability amplitude in three X-ray bands shows that the power-law component varies continuously on time-scales of ∼ 5000 s and is steeper when it is brighter. In contrast, variability of the soft excess is not detected. Spectral modelling of 31 spectra from different observations and at a range of count rates is also consistent with a picture in which the power law is steeper when it is brighter, and in which the soft-excess component does not vary. The power-law variability can be explained if the power law is produced by variable thermal or non-thermal Comptonization of soft photons. This behaviour is similar to that of Galactic black hole candidates in the low state. The X-ray and multiwavelength properties of Markarian 766 are shown to be very similar to those of other narrow-line Seyfert 1s. This may mean that the rapid X-ray variability seen in other narrow-line Seyfert 1s may also not originate in their strong soft-excess components

Analysing the Suzaku Spectra of the Broad-Line Seyfert 1 Galaxy CBS 126

We analysed new simultaneous \emph{Suzaku} and \emph{Swift} data of the Broad Line Seyfert 1 (BLS1) galaxy CBS 126. A clear Fe emission line and a strong soft excess are present in the source spectra. We fit the spectra with a relativistic reflection model and find the model tends to fit the data with a high iron abundance possibly due to the large soft excess present. By checking the difference and the RMS spectra, we find there is likely an absorption edge at $\sim$ 0.89 keV, which might be caused by oxygen or neon. We also produced an analysis of the time-resolved spectra in order to examine the existence of the edge. Although high iron abundance is required more in the time-resolved spectra, a model of solar iron abundance together with an absorption edge gives a more physical explanation. Variation of the ionisation parameter is an alternative, plausible explanation for the excess seen in the difference spectra. It is difficult to know if there are warm absorbers in this source from the current data. To further investigate the presence of possible warm absorbers, higher signal-to-noise low-energy data are needed. The work presented here tentatively suggests that the spectra of a BLS1 can be explained by a relativistic reflection model similar to that often seen in their narrow-line cousins.Comment: 10 pages, 12 figures, accepted for publication in MNRA