Treating Patients Following Hospitalisation for Acute Decompensated Heart Failure: An Insight into Reducing Early Rehospitalisations

Heart failure (HF) is a pandemic syndrome characterised by raised morbidity and mortality. An acute HF event requiring hospitalisation is associated with a poor prognosis, in both the short and the long term. Moreover, early rehospitalisation after discharge negatively affects HF management and survival rates. Cardiovascular and non-cardiovascular conditions combine to increase rates of HF hospital readmission at 30 days. A tailored approach for HF pharmacotherapy while the patient is in hospital and immediately after discharge could be useful in reducing early adverse events that cause rehospitalisation and, consequently, prevent worsening HF and readmission during the vulnerable phase after discharge

Are the forearm muscles excited equally in different, professional piano players?

Background and objectives Professional pianists tend to develop playing-related musculoskeletal disorders mostly in the forearm. These injuries are often due to overuse, suggesting the existence of a common forearm region where muscles are often excited during piano playing across subjects. Here we use a grid of electrodes to test this hypothesis, assessing where EMGs with greatest amplitude are more likely to be detected when expert pianists perform different excerpts. Methods Tasks were separated into two groups: classical excerpts and octaves, performed by eight, healthy, professional pianists. Monopolar electromyograms (EMGs) were sampled with a grid of 96 electrodes, covering the forearm region where hand and wrist muscles reside. Regions providing consistently high EMG amplitude across subjects were assessed with a non-parametric permutation test, designed for the statistical analysis of neuroimaging experiments. Spatial consistency across trials was assessed with the Binomial test. Results Spatial consistency of muscle excitation was found across subjects but not across tasks, confining at most 20% of the electrodes in the grid. These local groups of electrodes providing high EMG amplitude were found at the ventral forearm region during classical excerpts and at the dorsal region during octaves, when performed both at preferred and at high, playing speeds. Discussion Our results revealed that professional pianists consistently load a specific forearm region, depending on whether performing octaves or classical excerpts. This spatial consistency may help furthering our understanding on the incidence of playing-related muscular disorders and provide an anatomical reference for the study of active muscle loading in piano players using surface EMG

GRB 081029: A Gamma-Ray Burst with a Multi-Component Afterglow

We present an analysis of the unusual optical light curve of the gamma-ray burst GRB 081029, a long-soft burst with a redshift of z = 3.8479. We combine X-ray and optical observations from the Swift X-Ray Telescope and the Swift UltraViolet/Optical Telescope with ground-based optical and infrared data obtained using the REM, ROTSE, and CTIO 1.3-m telescopes to construct a detailed data set extending from 86 s to approximately 100,000 s after the BAT trigger. Our data cover a wide energy range, from 10 keV to 0.77 eV (1.24 to 16,000 Angstrom). The X-ray afterglow shows a shallow initial decay followed by a rapid decay starting at about 18,000 s. The optical and infrared afterglow, however, shows an uncharacteristic rise at about 3000 s that does not correspond to any feature in the X-ray light curve. Our data are not consistent with synchrotron radiation from a jet interacting with an external medium, a two-component jet, or continuous energy injection from the central engine. We find that the optical light curves can be broadly explained by a collision between two ejecta shells within a two-component jet. A growing number of gamma-ray burst afterglows are consistent with complex jets, which suggests that some (or all) gamma-ray burst jets are complex and will require detailed modelling to fully understand them.Comment: ApJ, in press; 29 pages, 8 figure

Different definitions of the chemical potential with identical partition function in QCD on a lattice

It is shown that starting from one and the same transfer matrix formulation of QCD on a lattice, it is possible to obtain both the action of Hasenfratz and Karsch as well as an action where the chemical potential is not coupled to the temporal links.Comment: 4 page

The XMM-Newton wide-field survey in the COSMOS field: V. Angular Clustering of the X-ray Point Sources

We present the first results of the measurements of angular auto-correlation functions (ACFs) of X-ray point sources detected in the XMM-Newton observations of the 2 deg2 COSMOS field (XMM-COSMOS). A significant positive signals have been detected in the 0.5-2 (SFT) band, in the angle range of 0.5-24 arcminutes, while the positive signals were at the 2 and 3 sigma levels in the 2-4.5 (MED) and 4.5-10 (UHD) keV bands respectively. Correctly taking integral constraints into account is a major limitation in interpreting our results. With power-law fits to the ACFs without the integral constraint term, we find correlation lengths of theta_c=1.9+-0.3, 0.8+0.5-0.4 and 6+-2 arcseconds for the SFT, MED, and UHD bands respectively for gamma=1.8. The inferred comoving correlation lengths, also taking into account the bias by the source merging due to XMM-Newton PSF, are 9.8+-0.7, 5.8+1.4-1.7 and 12+-2 h-1 Mpc at the effective redshifts of 1.1, 0.9, and 0.6 for the SFT, MED, and UHD bands respectively. If we include the integral constraint term in the fitting process,assuming that the power-law extends to the scale length of the entire XMM-COSMOSfield, the correlation lengths become larger by 20%-90%. Comparing the inferred rms fluctuations of the spatial distribution of AGNs with those of the underlying mass, the bias parameters of the X-ray source clustering at these effective redshifts are in the range b(AGN)=1.5-4. (Edited to simple ascii.)Comment: 17 pages, 3 figures Accepted for Astrophysical Journal Supplement series (COSMOS Special issue

Theta-dependence and center symmetry in Yang-Mills theories

We investigate the relation between the realization of center symmetry and the dependence on the topological parameter theta in SU(N) Yang-Mills theories, exploiting trace deformations as a tool to regulate center symmetry breaking in a theory with a small compactified direction. We consider, in particular, SU(4) gauge theory, which admits two possible independent deformations, and study, as a first step, its phase diagram in the deformation plane for two values of the inverse compactified radius going up to L-1 similar to 500 MeV, comparing the predictions of the effective one-loop potential of the Polyakov loop with lattice results. The theta-dependence of the various phases is then addressed, up to the fourth order in theta, by numerical simulations; results are found to coincide, within statistical errors, with those of the standard confined phase iff center symmetry is completely restored and independently of the particular way this happens, i.e., either by local suppression of the Polyakov loop traces or by long range disorder

Biologically inspired 4D printing of high performance composite materials with temperature triggered shape-change for space applications

International audienc

FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability

Abstract Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder emerging in early life characterized by impairments in social interaction, poor verbal and non-verbal communication, and repetitive patterns of behaviors. Among the best-known genetic risk factors for ASD, there are mutations causing the loss of the Fragile X Messenger Ribonucleoprotein 1 (FMRP) leading to Fragile X syndrome (FXS), a common form of inherited intellectual disability and the leading monogenic cause of ASD. Being a pivotal regulator of motor activity, motivation, attention, and reward processing, dopaminergic neurotransmission has a key role in several neuropsychiatric disorders, including ASD. Fmr1 Δ exon 8 rats have been validated as a genetic model of ASD based on FMR1 deletion, and they are also a rat model of FXS. Here, we performed behavioral, biochemical and in vivo SPECT neuroimaging experiments to investigate whether Fmr1 Δ exon 8 rats display ASD-like repetitive behaviors associated with changes in striatal dopamine transporter (DAT) availability assessed through in vivo SPECT neuroimaging. At the behavioral level, Fmr1 Δ exon 8 rats displayed hyperactivity in the open field test in the absence of repetitive behaviors in the hole board test. However, these behavioral alterations were not associated with changes in striatal DAT availability as assessed by non-invasive in vivo SPECT and Western blot analyses

Crowdsensing IoT Architecture for Pervasive Air Quality and Exposome Monitoring: Design, Development, Calibration, and Long-Term Validation

A pervasive assessment of air quality in an urban or mobile scenario is paramount for personal or city-wide exposure reduction action design and implementation. The capability to deploy a high-resolution hybrid network of regulatory grade and low-cost fixed and mobile devices is a primary enabler for the development of such knowledge, both as a primary source of information and for validating high-resolution air quality predictive models. The capability of real-time and cumulative personal exposure monitoring is also considered a primary driver for exposome monitoring and future predictive medicine approaches. Leveraging on chemical sensing, machine learning, and Internet of Things (IoT) expertise, we developed an integrated architecture capable of meeting the demanding requirements of this challenging problem. A detailed account of the design, development, and validation procedures is reported here, along with the results of a two-year field validation effort

Inflammation and pericarditis: Are neutrophils actors behind the scenes?

reserved2noThe morbidity of acute pericarditis is increasing over time impacting on patient quality of life. Recent clinical trials focused especially on clinical aspects, with a modest interest in pathophysiological mechanisms. This narrative review, based on papers in English language obtained via PubMed up to April 2018, aims at focusing on the role of the innate immunity in pericarditis and discussing future potential therapeutic strategies impacting on disease pathophysiology. In developed countries, most cases of pericarditis are referred to as idiopathic, although etiological causes have been described, with autoreactive/lymphocytic, malignant, and infectious ones as the most frequent causes. Apart the known impairment of the adaptive immunity, recently a large body evidence indicated the central role of the innate immune system in the pathogenesis of recurrent pericarditis, starting from similarities with autoinflammatory diseases. Accordingly, the "inflammasome" has been shown to behave as an important player in pericarditis development. Similarly, the beneficial effect of colchicine in recurrent pericarditis confirms that neutrophils are important effectors as colchicine, which can block neutrophil chemotaxis, interferes with neutrophil adhesion and recruitment to injured tissues and abrogate superoxide production. Anyway, the role of the adaptive immune system in pericarditis cannot be reduced to a black or white issue as mechanisms often overlap. Therefore, we believe that more efficient therapeutic strategies have to be investigated by targeting neutrophil-derived mediators (such as metalloproteinases) and disentangling the strict interplay between neutrophils and platelets. In this view, some progress has been done by using the recombinant human interleukin-1 receptor antagonist anakinra.mixedBonaventura, Aldo; Montecucco, FabrizioBonaventura, Aldo; Montecucco, Fabrizi