Knee Osteoarthritis and the Efficacy of Kinesthesia, Balance & Agility Exercise Training: A Pilot Study

Kinesthesia, balance and agility (KBA) neuromuscular exercises are commonly used for rehabilitation of lower extremity injuries. KBA combined with strength training (ST) reportedly improves function among persons with knee osteoarthritis (OA), but independent effects of KBA are unknown. The purpose of this study was to determine the efficacy of KBA exercises, independent of ST, to improve function among persons with knee OA. Twenty participants (69.3, SD 11.4 y) were randomized to 8 weeks, 3-days per week, instructor-lead KBA or ST groups. Self-reported physical function (difficulty with daily living activities such as walking, bending, stair climbing, etc.) was measured at baseline and every two weeks. Community physical activity level, negative and positive outcome expectancies for exercise, self-reported knee stability, and timed 10-stair climb, 10-stair descent, and ‘get up and go’ 15 m walk were measured at baseline and follow-up. Physical function improved 59% (p = 0.02) with KBA and 40% (p = 0.02) with ST at 8 weeks. Community physical activity level improved only in KBA (p = 0.04); knee stability improved in both KBA (p = 0.04) and ST (p = 0.01). There were no significant between-group differences (p \u3e 0.05). In conclusion, both interventions appear to improve function and knee stability among persons with symptomatic knee OA. As KBA has never been studied as an independent treatment program, our results indicate it is a promising stand-alone intervention worthy of further study

Comparison of clinic-based versus home-based balance and agility training for the symptoms of knee osteo-arthritis

Objective. To compare clinic-based (CB) and home-based (HB) deliveries of a knee osteoarthritis (OA) exercise programme. Methods. Outcomes from a CB exercise study (N=6) utilising kinesthesia, balance and agility (KBA) exercises were compared with those from a HB KBA study (N=6). Both conditions trained 30 minutes, 3 days per week for 8 weeks. CB sessions were conducted in a group led by an exercise physiologist (EP); HB participants received an initial 3 sessions of one-to-one training from an EP, written/pictorial instructions, telephone and e-mail follow-up, and in-person refresher sessions during weeks 4 and 6. The primary outcome was an OA-specific physical function survey. Community activity level, self-report knee stability, 15-m get up and go walk, and stair climb and descent were also measured. Results. Adherence was 94% in both conditions. KBA improved PF in both CB (59%; 18±12.5 pts; p=0.008) and HB (33%; 7.3±7.5 pts; p=0.03), with no difference between conditions. All outcome improvements were somewhat larger for CB, but these differences did not reach statistical significance. Conclusion. We found no difference in outcomes between CB and HB exercise in this preliminary comparison. Our results support that KBA is an effective intervention for symptomatic knee OA that may be delivered in CB or HB settings

Consistent use of paradoxes in deriving constraints on the dynamics of physical systems and of no-go-theorems

The classical methods used by recursion theory and formal logic to block paradoxes do not work in quantum information theory. Since quantum information can exist as a coherent superposition of the classical ``yes'' and ``no'' states, certain tasks which are not conceivable in the classical setting can be performed in the quantum setting. Classical logical inconsistencies do not arise, since there exist fixed point states of the diagonalization operator. In particular, closed timelike curves need not be eliminated in the quantum setting, since they would not lead to any paradoxical outcome controllability. Quantum information theory can also be subjected to the treatment of inconsistent information in databases and expert systems. It is suggested that any two pieces of contradicting information are stored and processed as coherent superposition. In order to be tractable, this strategy requires quantum computation.Comment: 10 pages, latex, no figure

A SPAK Isoform Switch Modulates Renal Salt Transport and Blood Pressure

SummaryThe renal thick ascending limb (TAL) and distal convoluted tubule (DCT) play central roles in salt homeostasis and blood pressure regulation. An emerging model suggests that bumetanide- and thiazide-sensitive NaCl transporters (NKCC2 and NCC) along these segments are phosphorylated and activated by WNK kinases, via SPAK and OSR1. Here, we show that a kidney-specific SPAK isoform, which lacks the kinase domain, inhibits phosphorylation of NCC and NKCC2 by full-length SPAK in vitro. Kidney-specific SPAK is highly expressed along the TAL, whereas full-length SPAK is more highly expressed along the DCT. As predicted from the differential expression, SPAK knockout in animals has divergent effects along TAL and DCT, with increased phosphorylated NKCC2 along TAL and decreased phosphorylated NCC along DCT. In mice, extracellular fluid volume depletion shifts SPAK isoform abundance to favor NaCl retention along both segments, indicating that a SPAK isoform switch modulates sodium avidity along the distal nephron

A Nomenclature for Vertebral Fossae in Sauropods and Other Saurischian Dinosaurs

The axial skeleton of extinct saurischian dinosaurs (i.e., theropods, sauropodomorphs), like living birds, was pneumatized by epithelial outpocketings of the respiratory system. Pneumatic signatures in the vertebral column of fossil saurischians include complex branching chambers within the bone (internal pneumaticity) and large chambers visible externally that are bounded by neural arch laminae (external pneumaticity). Although general aspects of internal pneumaticity are synapomorphic for saurischian subgroups, the individual internal pneumatic spaces cannot be homologized across species or even along the vertebral column, due to their variability and absence of topographical landmarks. External pneumatic structures, in contrast, are defined by ready topological landmarks (vertebral laminae), but no consistent nomenclatural system exists. This deficiency has fostered confusion and limited their use as character data in phylogenetic analysis.We present a simple system for naming external neural arch fossae that parallels the one developed for the vertebral laminae that bound them. The nomenclatural system identifies fossae by pointing to reference landmarks (e.g., neural spine, centrum, costal articulations, zygapophyses). We standardize the naming process by creating tripartite names from “primary landmarks,” which form the zygodiapophyseal table, “secondary landmarks,” which orient with respect to that table, and “tertiary landmarks,” which further delineate a given fossa.The proposed nomenclatural system for lamina-bounded fossae adds clarity to descriptions of complex vertebrae and allows these structures to be sourced as character data for phylogenetic analyses. These anatomical terms denote potentially homologous pneumatic structures within Saurischia, but they could be applied to any vertebrate with vertebral laminae that enclose spaces, regardless of their developmental origin or phylogenetic distribution

Pre-registration of CT pulmonary volumetric image data

Bakalárska práca sa zaoberá predregistráciou pľúcnych objemových CT obrazových dát. Predregistrácia je riešená metódou fázovej korelácie pri rozklade 3D obrazu na 2D rezy usporiadané za sebou. Práca ďalej popisuje geometrické transformácie, interpolácie, výpočet podobnostných kritérií, optimalizáciu registrácie obrazu a proces samotnej registrácie obrazu. Predregistračný softvér je navrhnutý v programovom prostredí MATLAB^®, kde prebieha predregistrácia 3D reálnych CT obrazových dát s dôrazom na rýchlosť procesu.This bachelor thesis is dealing with pre-registration of CT pulmonary volumetric image data. Pre-registration is solved by phase correlation method, which decomposes 3D images into 2D slices arranged in a row. It further describes the geometric transformations, interpolation, calculations of similarity criteria, optimization of registration of images and the image registration process itself. The pre-registration software runs in MATLAB^®, which works with 3D images of real CT image data with an emphasis on process speed.

Implementing complex innovations in fluid multi-stakeholder environments: Experiences of 'telecare'

Accepted versio

The transition to adulthood from care as a struggle for recognition

Introduction In this article we focus on young people transitioning to adulthood from child welfare services, and how the concept of recognition can be useful for understanding the complexity of young people’s needs in this transition. We draw upon Honneth’s (1996) theory of intersubjective recognition as a way of understanding young people’s experiences of their contact with child welfare services. We ask how recognition theory can help us to understand young people’s experiences and needs in their transition to adulthood from child welfare services, and what are the practical implications. We focus on relationships, participation and social support as the three components highlighted by the young people who participated in interviews. Previous research also indicates that young people leaving care often face challenges related to creating and maintaining good relationships (Marion et al., 2017; Rutman & Hubberstey, 2016), participating effectively in decisions (Authors reference 1) and receiving good quality social support (Barry, 2010; Höjer & Sjöblom, 2010; Authors reference 2; Authors reference 3; Thomas, 2005). We argue that Honneth’s theory is potentially useful, in that these three elements appear to depend on, and imply, the kinds of recognition that he identifies. This theoretical framework provides us with an analytical tool that enables us to understand the young people’s negative stories as experiences of misrecognition, and to show the complexity of the dynamics that shape recognition and misrecognition for this group (Warming, 2015)