DIETARY METHODS USING LACTOBACILLUS PARACASEI SUBSP. PARACASEI F19 AS NAPE-PLD GENE CARRIER FOR PRODUCING ON DEMAND PEA OR OEA AND RELATIVE BIOLOGICAL DIETARY COMPOSITIONS THEREOF

Method enabling to modulate and customize the production of active lipids involved in exerting an antagonistic action to local inflammation and in modulating the mast cell reactivity, comprising the administering to an host the probiotic Lactobacillus paracasei subsp. Paracasei F19, genetically modified with a nucleotide vector comprising a nucleic acid encoding the human N-acyl-phosphatidylethanolamine phospholipase D (NAPE-PLD), in association with lipid substrates and precursors, to influence the enzymatic reactions of said probiotic agent in the host. The method is useful in the treatment of inflammatory bowel disorder and in the treatment of metabolic syndrome and for controlling of obesity

Wine tourism as a non-core business strategy for small wineries

In recent years, wineries have been implementing increasingly more wine tourism activities as complementary or supplementary services to enhance their wine products. This paper adopts an inductive research paradigm based on grounded investigation; more specifically, this paper begins with a case study and expands to involve further similar evidence. The findings of this study show that, for wineries, wine tourism represents a fundamental opportunity for communication (institutional and commercial), distribution (as a form of direct channel), and growth (to include tasting, catering, hospitality, and so on). Most importantly, for both scholars and managers, the results of the research highlight that wine tourism can become the main source of the business value, especially in the case of small wineries (an example of which is examined in the case study under analysis). In these situations, however, wine production still characterizes the business because, otherwise, there can be no wine tourism, but wine production is not realistically critical to the business in terms of survival, competitiveness, and development

Country-of-origin effect and millennials’ wine preferences-a comparative experiment

For wine consumers, the country-of-origin effect still exerts significant influence, even though probably differently from what it was earlier, especially for newer consumer seg-ments. Among these, millennials represent the most interesting segment of the present and future, even though studies on millennials’ behaviour are insidious and newer consumer segments are emerging (Generation Z). This study focuses on this parameter through a comparative analysis of French and Italian wines—first, on the country-of-origin effect on millennials’ wine preferences, and second, on the possibility of managing this influence by adopting a wine marketing mix based on the innovative 4Es model. The outcomes of the ex-periment on 121 millennials, despite the limitations of the study, highlight interesting changes—compared with the wine consumption behaviours of the past—regarding the coun-try-of-origin effect and the possibility of managing it. The results confirm, similar to the lit-erature on the 4Es model, the possibility of wide areas of action for wine educational mar-keting initiatives that can change or enhance the country-of-origin perception

Breaking projective chaos synchronization secure communication using filtering and generalized synchronization

This paper describes the security weaknesses of a recently proposed secure communication method based on chaotic masking using projective synchronization of two chaotic systems. We show that the system is insecure and how to break it in two different ways, by high-pass filtering and by generalized synchronization.Comment: 14 pages, 6 figures, latex forma

Practice parameters for the treatment of colonic diverticular disease: Italian Society of Colon and Rectal Surgery (SICCR) guidelines

The mission of the Italian Society of Colorectal Surgery (SICCR) is to optimize patient care. Providing evidence-based practice guidelines is therefore of key importance. About the present report it concernes the SICCR practice guidelines for the diagnosis and treatment of diverticular disease of the colon. The guidelines are not intended to define the sole standard of care but to provide evidence-based recommendations regarding the available therapeutic options

Digital transformation and tourist experience co-design: big social data for planning cultural tourism

Digital transformation has completely changed the demand/offering interaction in the travel industry, as well as largely affecting the customer journey. In this direction, “big social data” and user-generated content have become key sources of well-timed and rich knowledge supporting data driven decision approaches addressed the managing of complex relationships. Based on this theoretical framework, the paper suggests how to apply “big social data” in the tourist experience co-design, providing an increased value for the visitors and a better decision making approach for managers. In this respect, the field analysis concentrated specifically on user-generated content regarding the Pompeii Archaeological Site (P.A.S.), to trace valuable insights for the tourist experience. Based on double stage of research – netnographic analysis and a supplementary online survey – the study aimed to detect: (a) tourist perception on the P.A.S.; (b) random chat on the part of internet users (tourists and other browsers, not necessarily visitors) on the topic of the P.A.S.; (c) the main characteristics of the P.A.S. that attract internet user attention; (d) the main topics debated by influencers/opinion leaders managing online discussions on the P.A.S. managerial and theoretical implications were investigated highlighting the main limitations of the study as well

The challenge of perioperative pain management in opioid-tolerant patients

The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals. Anesthesiologists, surgeons, and nurses should be familiar with some pharmacological phenomena which are typical of opioid users and abusers, such as tolerance, physical dependence, hyperalgesia, and addiction. Inadequate pain management is very common in these patients, due to common prejudices and fears. The target of preoperative evaluation is to identify comorbidities and risk factors and recognize signs and symptoms of opioid abuse and opioid withdrawal. Clinicians are encouraged to plan perioperative pain medications and to refer these patients to psychiatrists and addiction specialists for their evaluation. The aim of this review was to give practical suggestions for perioperative management of surgical opioid-tolerant patients, together with schemes of opioid conversion for chronic pain patients assuming oral or transdermal opioids, and patients under maintenance programs with methadone, buprenorphine, or naltrexone