The MMM Initiative

We’ve determined that information collected and distributed by and on news and social media outlets has manifested in political biases of its users. It is clear that this issue has subsequently led to political polarization and ethnic prejudice. To combat this problem, we have devised an online informational package and an interactive experience to teach people how to use it. Our website provides the resources to check personal biases and recognize ethnic prejudices. The seminar encourages people to apply and spread their newfound knowledge. We conducted interviews with experts, surveys, and an extensive literature review. Through our research and feedback from over 40 partners, we have found that access to social media literacy education is virtually non-existent — hence the need for a comprehensive, easily digestible informational package. It\u27s not enough to create a package, we also need people to see it. Our interviews with experts tell us that the best way to engage students is through interactive experiences. Therefore, we supplemented these educational tools with an experience that consists of a community group and the extensive use of partners to promote our package to their respective networks. Our resources use text, visuals, videos, conversation, and other interactive elements to educate users on how the use of media can exacerbate ethnic prejudices. To measure the attitude change of our viewers, we created a set of surveys concerning media usage and its relationship with bias. We also tracked the attendance of the seminar so that we could understand how widespread our message is. Hundreds of people have accessed our website with an accumulation of over 2,000 views. We expect this to continue growing exponentially as word of its existence continues to spread. Our project has a global reach with at least 15 countries and 25 states reached

Examining Long‐Term Effects Of An Infant Mental Health Home‐Based Early Head Start Program On Family Strengths And Resilience

Infant Mental Health based interventions aim to promote the healthy development of infants and toddlers through promoting healthy family functioning to foster supportive relationships between the young child and his or her important caregivers. This study examined impacts of an Infant Mental Health home‐based Early Head Start (IMH‐HB EHS) program on family functioning. The sample includes 152 low‐income families in the Midwestern United States, expectant or parenting a child younger than 1 year of age, who were randomly assigned to receive IMH‐HB EHS services (n = 75) or to a comparison condition (n = 77). Mothers who received IMH‐HB EHS services reported healthier psychological and family functioning, outcomes that are consistent with the IMH focus, when their children were between the ages of 3 and 7 years of age. Specifically, mothers in the IMH‐HB EHS group reported healthier family functioning and relationships, better coping skills needed to advocate for their families, and less stress in the parenting role versus those in the comparison condition. The study also examined support seeking coping, some of which changed differently over time based on program group assignment. Overall, findings suggest that the gains families achieve from participating in IMH‐HB EHS services are maintained after services cease.RESUMENLa meta de las intervenciones con base en la salud mental infantil es promover el desarrollo sano de infantes y bebés por medio de promover un funcionamiento familiar sano para adoptar relaciones de apoyo entre el pequeño niño y sus importantes cuidadores. Este estudio examinó el impacto que sobre el funcionamiento familiar tiene un programa “Early Head Start” de salud mental infantil con base en casa (IMH‐HB EHS). El grupo muestra lo componen 152 familias de bajos recursos del Medio Oeste de Estados Unidos, en espera de o ya criando a un niño menor de un año de edad, que fueron asignadas al azar para recibir los servicios de IMH‐HB EHS (n=75) o a una condición comparativa (n=77). Las madres que recibieron los servicios de IMH‐HB EHS reportaron un funcionamiento sicológico y familiar más saludable, resultados que son consistentes con el enfoque de IMH, cuando sus niños tenían entre 3 y 7 años de edad. Específicamente, las madres en el grupo IMH‐HB EHS reportaron un funcionamiento y relaciones familiares más saludables, mejores habilidades para arreglárselas que eran necesarias para abogar por sus familias, así como menos estrés en el papel de crianza al ser comparadas con aquellas madres en la condición comparativa. El estudio también examinó la manera de arreglárselas buscando apoyo, algunas de las cuales cambiaron diferentemente a través del tiempo con base en las asignaciones de grupo del programa. En general, los resultados sugieren que los aspectos positivos que las familias alcanzan como resultado de participar en los servicios de IMH‐HB EHS se mantienen después que los servicios terminan.RÉSUMÉLes interventions fondées sur la santé mentale ont pour but de promouvoir le développement sain des nourrissons et des jeunes enfants en promouvant le fonctionnement saind'une famille afin de favoriser des relations de soutien entre le jeune enfant et ceux qui s'occupent d'elle ou de lui. Cette étude a examiné les impacts d'un programme américain de Early Head Start focalisé sur la santé mentale du nourrisson (abrégé IMH‐HB EHS) sur le fonctionnement de la famille. L’échantillon a compris 152 familles de milieu défavorisé de la région centre des Etats‐Unis, attendant un enfant ou s'occupant d'un enfant de moins d'un an, a qui on a assigné au hasard les services IMH‐HB EHS (n=75) ou une condition de comparaison (n=77). Les mères ayant reçu les services IMH‐HB EHS ont fait état d'un meilleur fonctionnement psychologique et familial, des résultats qui correspondent à l'objectif de santé mentale du nourrisson, lorsque leurs enfants avaient entre 3 et 7 ans. Plus spécifiquement, les mères du groupe IMH‐HB EHS ont fait état d'un meilleur fonctionnement familial et de meilleurs relations familiales, de meilleures capacités à s'adapter nécessaires afin de se porter les avocates de leurs familles, et de moins de stress de parentage comparé à celles du groupe de comparaison. L’étude a aussi examiné l'adaptation liée à la quête de soutien, qui a en partie changé différemment au fil du temps, en fonction du groupe de placement. Au bout du compte les résultats suggèrent que les gains obtenus par les familles comme résultat de la participation aux services du IMH‐HB EHS se maintiennent après que les services cessent.ZUSAMMENFASSUNGInterventionen, die auf der mentalen Gesundheit von Säuglingen basieren, zielen darauf ab, die gesunde Entwicklung von Säuglingen und Kleinkindern zu verbessern, indem ein gesundes familiäres Funktionieren gefördert wird, um unterstützende Beziehungen zwischen dem Kleinkind und ihren/seinen wichtigsten Bezugspersonen zu begünstigen. Diese Studie untersuchte die Effekte eines Early Head Start‐Hausbesuchs‐Programms (IMH‐HB EHS) auf das familiäre Funktionieren. Die Stichprobe umfasst 152 Familien mit niedrigem Einkommen aus dem Mittleren Westen der USA. Es handelt sich bei der Stichprobe um werdende Eltern oder Eltern mit einem Kind unter einem Jahr, die randomisiert einer Dienstleistung zugewiesen wurden: zum IMH‐HB EHS‐Programm (n = 75) oder zu einer Vergleichsbedingung (n = 77). Mütter, die das IMH‐HB EHS‐Programm erhielten, berichteten von gesünderem psychologischem und familiärem Funktionieren, wenn ihre Kinder im Alter zwischen 3 und 7 Jahren waren. Dies sind Ergebnisse, die mit dem IMH Fokus übereinstimmen. Im Speziellen berichteten Mütter, die in der IMH‐HB EHS‐Gruppe waren, von gesünderem familiären Funktionieren und familiären Beziehungen, besseren Bewältigungsstrategien, um für ihre Familien einzustehen und von weniger Stress in der Elternrolle verglichen mit den Müttern der Vergleichsbedingung. Die Studie untersuchte auch unterstützungssuchende Bewältigungsstrategien, von denen sich einige basierend auf der Gruppenzugehörigkeit im Laufe der Zeit in unterschiedlicher Weise veränderten. Insgesamt deuten die Ergebnisse darauf hin, dass die Gewinne, die die Familien infolge der Teilnahme am IMH‐HB EHS‐Programm erzielten, nach Ende des Programms aufrechterhalten werden.抄録乳幼児精神保健に基づく介入は、幼い子どもとその重要な養育者との間の支持的な関係性を育てるという健康な家族機能の促進を通して、乳幼児の健康な発達を促進することを目的としている。この研究は、乳幼児精神保健在宅早期ヘッドスタートInfant Mental Health home‐based Early Head Start (IMH‐HB EHS)プログラムが、家族機能に与える影響を調査した。対象はアメリカ合衆国中西部の妊娠中か1歳以下の子どもを育てている152の低所得家族で、IMH‐HB EHSサービスを受ける(n=75)か、比較の条件か(n=77)に、ランダムに割り当てられた。IMH‐HB EHSサービスを受けた母親は、子どもが3歳から7歳の間に、より健康的な心理機能および家族機能を報告した。これはIMHの焦点と一致している結果だった。特に、IMH‐HB EHS群の母親は、比較条件の母親と比べ、より健康な家族機能と関係性、家族を擁護するのに必要なよりよい対処機能、そして親役割にストレスが少ないことを報告した。研究はまた、支援を求める対処についても調査した。その一部はプログラム群への割り当てに基づいて時間経過により異なって変化していた。全体として、IMH‐HB EHSサービスに参加した結果として家族が達成し獲得したものは、サービスが終了した後も、維持されている。摘要以幼兒心理健康為基礎的介入旨在通過健康的家庭運作去培養小童與其重要看護者間的支持性關係, 以此促進幼兒和學步兒的健康發展。本文探討一個幼兒心理健康家訪早期搶步計畫 (IMH‐HB‐EHS) 對家庭運作的影響。樣本包括一百五十二個在美國中西部低入息的家庭。這些家庭正待產或在養育一個少於一歲的小孩。參與家庭被隨機分派到接受IMH‐HB‐EHS服務 (n=75) 或一個比較環境 (n=77)。有接受IMH‐HB‐EHS服務的母親報告在孩兒三至七歲間有較健康的心理和家庭運作, 這結果與IMH的焦點相附合。具體來說, 在IMH‐HB‐EHS組的母親較在比較環境組的母親報告有健康些的家庭運作和關係, 有好些的因應技巧為家庭作鼓吹, 及在親職角色中有少些壓力。本文亦探討尋求支持的因應, 發現這會根據組別分派而有不同的隨時間改變。總體而言, 探討結果顯示家庭從參與IMH‐HB‐EHS服務所得的收益在服務停止後仍會維持。Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/112230/1/imhj21518.pd

Consumption and perceived use of licit and illicit drugs among university students, Antioquia, Medellin, Colombia

O objetivo deste estudo foi avaliar a diferença entre o consumo percebido entre os pares e o consumo real das drogas que fazem os estudantes universitários do segundo e terceiro ano, entre 18 e 24 anos de idade, em uma universidade pública na cidade de Medellín, Colômbia. Este é um estudo descritivo transversal, baseado em censo. Todos os alunos do segundo e terceiro ano das faculdades de medicina, odontologia, enfermagem e saúde pública foram convidados a responder, anonimamente, um questionário. Participaram 427 estudantes. Quanto aos resultados foi observada superestimação do consumo de tabaco, maconha e cocaína nos últimos doze meses. O consumo de álcool foi percebido com precisão. Os alunos que consumiram no período mencionado, superestimam mais do que aqueles que não o fizeram, como as mulheres sobreestimam mais do que os homens o consumo de maconha.El propósito de este estudio fue estimar la diferencia entre el consumo percibido en los pares y el uso real de drogas que tienen los estudiantes universitarios de segundo y tercer año, entre 18 y 24 años de edad, de una universidad pública en la ciudad de Medellín, Colombia. Se trata de un estudio descriptivo transversal basado en una encuesta. Todos los estudiantes de segundo y tercer año de las facultades de Medicina, Odontología, Enfermería y Salud Publica fueron invitados a responder un cuestionario anónimo. Participaron 427 estudiantes. Se encontró una sobreestimacion del consumo de tabaco, marihuana y cocaina en los ultimos doce meses. El consumo de alcohol es percibido de manera exacta. Los estudiantes que consumieron drogas, en el periodo mencionado, sobreestiman más que los que no lo hicieron; también se encontró que las mujeres sobreestiman más que los hombres el consumo de marihuana.The purpose of this study was to estimate differences between perceived and reported drug use among sophomore and junior university students, aged 18 to 24 years, from a public university in Medellin, Colombia. Method: this is a descriptive and cross-sectional study. All second- and third-year students at the Schools of Medicine, Dentistry, Nursing and Public Health were invited to answer an anonymous questionnaire. In total, 427 students participated. RESULTS: data suggest that students overestimate the use of tobacco, marijuana and cocaine over the last 12 months. Alcohol use was perceived accurately. Students who reported using those substances during that period overestimated their peers' drug use more than those who did not. Furthermore, more women than men overestimated marijuana use

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.

Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleotide polymorphisms (SNPs) at the HNF1B locus to be associated with endometrial cancer, and now report extensive fine-mapping and in silico and laboratory analyses of this locus. Analysis of 1184 genotyped and imputed SNPs in 6608 Caucasian cases and 37 925 controls, and 895 Asian cases and 1968 controls, revealed the best signal of association for SNP rs11263763 (P = 8.4 × 10(-14), odds ratio = 0.86, 95% confidence interval = 0.82-0.89), located within HNF1B intron 1. Haplotype analysis and conditional analyses provide no evidence of further independent endometrial cancer risk variants at this locus. SNP rs11263763 genotype was associated with HNF1B mRNA expression but not with HNF1B methylation in endometrial tumor samples from The Cancer Genome Atlas. Genetic analyses prioritized rs11263763 and four other SNPs in high-to-moderate linkage disequilibrium as the most likely causal SNPs. Three of these SNPs map to the extended HNF1B promoter based on chromatin marks extending from the minimal promoter region. Reporter assays demonstrated that this extended region reduces activity in combination with the minimal HNF1B promoter, and that the minor alleles of rs11263763 or rs8064454 are associated with decreased HNF1B promoter activity. Our findings provide evidence for a single signal associated with endometrial cancer risk at the HNF1B locus, and that risk is likely mediated via altered HNF1B gene expression

Optimization of percutaneous biopsy for diagnosis and pretreatment risk assessment of neuroblastoma

BackgroundImage- guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study is to determine whether PCNB is adequate for modern biologic characterization of neuroblastoma.ProcedureA multi- institutional retrospective study was performed by the Pediatric Surgical Oncology Research Collaborative on children with neuroblastoma at 12 institutions over a 3- year period. Data collected included demographics, clinical details, biopsy technique, complications, and adequacy of biopsies for cytogenetic markers utilized by the Children’s Oncology Group for risk stratification.ResultsA total of 243 children were identified with a diagnosis of neuroblastoma: 79 (32.5%) tumor excision at diagnosis, 94 (38.7%) open incisional biopsy (IB), and 70 (28.8%) PCNB. Compared to IB, there was no significant difference in ability to accurately obtain a primary diagnosis by PCNB (95.7% vs 98.9%, P = .314) or determine MYCN copy number (92.4% vs 97.8%, P = .111). The yield for loss of heterozygosity and tumor ploidy was lower with PCNB versus IB (56.1% vs 90.9%, P < .05; and 58.0% vs. 88.5%, P < .05). Complications did not differ between groups (2.9 % vs 3.3%, P = 1.000), though the PCNB group had fewer blood transfusions and lower opioid usage. Efficacy of PCNB was improved for loss of heterozygosity when a pediatric pathologist evaluated the fresh specimen for adequacy.ConclusionsPCNB is a less invasive alternative to open biopsy for primary diagnosis and MYCN oncogene status in patients with neuroblastoma. Our data suggest that PCNB could be optimized for complete genetic analysis by standardized protocols and real- time pathology assessment of specimen quality.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154667/1/pbc28153_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154667/2/pbc28153.pd

Interventions to prevent youth violence in Latin America: a systematic review

Objectives: This review aims to summarise evidence on the effectiveness of interventions to prevent youth violence in Latin America. Methods: A systematic search on 13 academic databases was conducted to locate studies evaluating a primary or secondary prevention intervention in Latin America. Studies could use any type of quantitative design to assess outcomes related to youth violence. A search of websites, references and citation searching was also carried out. The quality of each study was assessed. Results: Nine studies were identified. Most documented positive effects of the interventions on the perception of youth violence present in the community/school. Evidence was found of a reduction in homicides and juvenile crimes in three studies, two of which evaluated a community-based intervention. There were mixed results for the self-report of participation on violent acts. The majority of the studies lacked of a rigorous design. Conclusions: Most of the interventions had some promising results, including the reduction of homicides within communities. Community-based programmes were the most consistent regarding an effectiveness to prevent violence. However, the evidence for Latin America is still scarce and relies on non-rigorously designed studies