The death road and the soul calling in Zilu-jing, or Sutra of indicating route, of the Yi in China : A study on the discourse of ancestral migration route with special reference to its relations with ethnic identity making

The Yi people in China conduct a magnificent funeral for the dead in which the Bi-mo, or the priest, recites Zilu-jing. Throughthis supra they see off the soul back along the believed ancestral migration route to Zizipow, their place of origin. The teaching ofZilu-jing is essentially to guide the souls of the dead, but at the same time it induces the spirits of the living people attending thefuneral too to escort the souls of the dead to their place of origin, where the spirits of the living people part from the souls of thedead and then are brought back to their place of living Through this experience the people of the Yi vividly learn their ethnicmigration history by retrieving their ancestors migration route recalled in Zilu-jin.All the versions of Zilu-jing handed down invarious places refer to Zizipow, Apudumu the Founder, and the ethnic migration route of the six ancestors.It means that the con-tents of Zilu-jing constitute a very significant part in making the ethnic identity of the Yi, though they have been dispersed to dateand thus formed no durable unified government

Projected WIMP sensitivity of the LUX-ZEPLIN dark matter experiment

LUX-ZEPLIN (LZ) is a next-generation dark matter direct detection experiment that will operate 4850 feet underground at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. Using a two-phase xenon detector with an active mass of 7 tonnes, LZ will search primarily for low-energy interactions with weakly interacting massive particles (WIMPs), which are hypothesized to make up the dark matter in our galactic halo. In this paper, the projected WIMP sensitivity of LZ is presented based on the latest background estimates and simulations of the detector. For a 1000 live day run using a 5.6-tonne fiducial mass, LZ is projected to exclude at 90% confidence level spin-independent WIMP-nucleon cross sections above 1.4 × 10-48cm2 for a 40 GeV/c2 mass WIMP. Additionally, a 5σ discovery potential is projected, reaching cross sections below the exclusion limits of recent experiments. For spin-dependent WIMP-neutron(-proton) scattering, a sensitivity of 2.3 × 10−43 cm2 (7.1 × 10−42 cm2) for a 40 GeV/c2 mass WIMP is expected. With underground installation well underway, LZ is on track for commissioning at SURF in 2020

Genome-wide association study identifies 30 loci associated with bipolar disorder

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10−4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10−8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder