1,159 research outputs found
GeneLab: NASA's Open Access, Collaborative Platform for Systems Biology and Space Medicine
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- Field of study
NASA is investing in GeneLab1 (http:genelab.nasa.gov), a multi-year effort to maximize utilization of the limited resources to conduct biological and medical research in space, principally aboard the International Space Station (ISS). High-throughput genomic, transcriptomic, proteomic or other omics analyses from experiments conducted on the ISS will be stored in the GeneLab Data Systems (GLDS), an open-science information system that will also include a biocomputation platform with collaborative science capabilities, to enable the discovery and validation of molecular networks
Biospheric Monitoring and Ecological Forecasting
- Author
- Publication venue
- ScholarWorks at University of Montana
- Publication date
- 01/01/2003
- Field of study
The latest generation of NASA Earth Observing System (EOS) satellites has brought a new dimension to monitoring the living part of the Earth system - the biosphere. EOS data can now measure weekly global productivity of plants and ocean chlorophyll and of related biophysical factors, such as changes to land cover and to the rate of snowmelt. However, the greatest economic impact would be realized by forecasting biosphere conditions. This predictive ability would be an advanced decision-making tool used to mitigate dangers or to exploit positive trends
Asymmetric warming over coastal California and its impact on the premium wine industry
- Author
- Publication venue
- ScholarWorks at University of Montana
- Publication date
- 01/11/2001
- Field of study
Climatic changes over coastal California from 1951 to 1997 may have benefited the premium wine industry, as seen in higher quality wines and larger grape yields. Observed temperature warming trends were asymmetric, with greatest warming at night and during spring. Warming was associated with large increases in eastern Pacific sea surface temperatures (SST) and amounts of atmospheric water vapor. Although the average annual temperature warming trend was modest (1.13°C/47 yr), there was a 20 d reduction in frost occurrence and a 65 d increase in frost-free growing season length. In the Napa and Sonoma valleys, warmer winter and spring temperatures advanced the start of the growing season by 18 to 24 d, and enhanced atmospheric water vapor resulted in a 7 % reduction in evaporative demand. Given the strong coupling between Pacific SSTs and the coastal California climate, and because regional-scale SSTs persist for 6 to 12 mo, additional research may allow the possibility of predicting vintage quantity and quality from previous winter conditions
GeneLab: "Omics" Data Systems for Translational Space Biology Research
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No abstract availabl
How to Deal with Unprofitable Customers? A Salesforce Compensation Perspective
- Author
- A A Zoltners
- A Goldfarb
- A K Basu
- A Shaked
- A T Coughlan
- Alex Thevaranjan
- B Holmstr�m
- B K Mishra
- B Mishra
- B P S Murthi
- C K Prahalad
- D K Rigby
- E Gal-Or
- F Chen
- G Iyer
- G L Urban
- G Mcwilliams
- H Gatignon
- J Shin
- J Tirole
- K Bagwell
- K Joseph
- L Y Chu
- M Ahearne
- N C Smith
- P Bhardwaj
- P Bolton
- P Kotler
- P Sinha
- R Inderst
- R Lal
- R Lal
- S Krishnamurthy
- S Srivastava
- Sumitro Banerjee
- U Subramanian
- V Mittal
- Y C Chen
- Y Cao
- Y Chen
- Y Moon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
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- Adolfsson A
- Aflori L
- Africander C
- Afshari A
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- Aguero Vera M
- Aguzzoli C
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- Aignatoaie M
- Aimoniotou-Georgiou E
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- Akinwale M
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- Al-Soudaine Y
- Aladin H
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- Allsop J
- Almeida W
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- Zoulamoglou M
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Study of Z boson production in pPb collisions at √sNN=5.02 TeV
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- Zaganidis Nikolaos
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- Zucchetta A.
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- Zuranski A.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
The production of Z bosons in pPb collisions at root S-NN = 5.02 TeV is studied by the CMS experiment via the electron and muon decay channels. The inclusive cross section is compared to pp collision predictions, and found to scale with the number of elementary nucleon-nucleon collisions. The differential cross sections as a function of the Z boson rapidity and transverse momentum are measured. Though they are found to be consistent within uncertainty with theoretical predictions both with and without nuclear effects, the forward-backward asymmetry suggests the presence of nuclear effects at large rapidities. These results provide new data for constraining nuclear parton distribution functions
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
- TJ Gibson
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- Z Tong
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- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial
- Author
- Abeywickrama Movin
- Adams Kirsty
- Ahmed Nabeela Nazir
- Aley Parvinder K
- Aley Parvinder K
- Allen Lauren
- Alves Carlota Pereira Dias
- Ambihapathy Wythehi
- Andrews Antonette
- Andrews Nick
- Andrews Nick
- Appleby Kim
- Askoolam Krishna
- Aslam Suahil
- Babbage Gavin
- Babbage Gavin
- Baker Helena
- Baker Holly
- Baker Jonathan
- Baker Natalie
- Barcella Lara
- Barker Dominique
- Barry Joshua
- Baryschpolec Sonia
- Batham Sally
- Bawa Tanveer
- Bawa Tanveer
- Baxter David
- Baxter David
- Beckett Helen
- Bell Judith
- Bennett Sara
- Bentley Ian
- Berry Lisa
- Bibi Sagida
- Bisnauthsing Karen
- Bonnaud Avril
- Borca Alessandro
- Boubriak Iryna
- Bousfield Rachel
- Brandon Jacqueline
- Branney Debbie
- Broadhead Samantha
- Brown Claire
- Brown Phillip
- Brunt Emily
- Buadi Amanda
- Bula Marcin
- Bula Marcin
- Burton Holly
- Burton Katharine
- Buttigieg Karen
- Calderwood James
- Campbell Marion
- Cathie Katrina
- Cathie Katrina
- Chalwin Olivia
- Champaneri Trishna
- Charlton Sue
- Charlton Sue
- Chatterjee Krishna
- Chatterjee Krishna
- Chiplin Emily
- Choi Bea
- Clutterbuck Elizabeth A
- Cole Christine
- Colquhoun Suzie
- Cooper Alison
- Cooper Chris
- Cornelius Victoria
- Cornelius Victoria
- Corrah Tumena
- Coughlan Tricia
- Cox Stephen
- Cullinane James
- Cutts Rebecca
- Dare Tracey
- Davies Ceri
- Davies-Dear Sharon
- DeLosSantosDominguez Pamela
- Desai Amisha
- Dineen Emily
- Dodd Kate
- Dodd Kate
- Domingo Jason
- Drake-Brockman Rachael
- Driver Kimberley
- Edwards Christopher J
- Egbo Akamino
- Elliott Ryan Stephen
- Elliott Scott
- Ellis Kate
- Enever Yvanne
- Enever Yvanne
- Evans Julie
- Farooqi Sadaf
- Farrier Adam
- Faust Saul N
- Faust Saul N
- Feng Shuo
- Feng Shuo
- Fowler Simon
- Fox Lauren
- Frankham Jorden
- Fraser Sara
- Freedman Andrew
- Galvin Dominic
- Gardside Ben
- Garrahy Sarah
- Gavin John
- Gibney Jennifer
- Giddins Beth
- Godwin Kerry
- Gokani Karishma
- Goncalvescordeiro Lillian
- Goodman Anna L
- Goodman Anna L
- Gordon Elizabeth
- Gouriet Jade
- Gowland Andrew
- Graham Victoria
- Green Christopher A
- Green Christopher A
- Grierson Jacques
- Grundy Lynne
- Gutteridge Helen
- Habash-Bailey Haniah
- Hailstone Jessica
- Hale Colin
- Hall Fran
- Hall Jane
- Hallis Bassam
- Hallis Bassam
- Hamal Shama
- Hansen Daniel
- Hardy Anna
- Harndahl Linda
- Harndahl Linda
- Harrison Elizabeth
- Haskell Louise
- Haughney John
- Haughney John
- Haydock Helen
- Haye Anastasia de la
- Herbert Christopher
- Hicks Alexander
- Hicks Alexander
- Hladkiwskyj John
- Hogan Alison
- Holliday Kyra
- Holliday Kyra
- Honey Thomas
- Horsfall Emily
- Hughes Kerry
- Hughes Rachel
- Hurdover Steve
- Irwin Margaret
- James Rob
- Janani Leila
- Janani Leila
- John Laurence
- Jones Lona Tudor
- Justice Edwin
- Kamal Mohammed
- Kanji Nasir
- Kanji Nasir
- Kasanyinga Mwila
- Katechia Kashyap
- Keenan Samantha
- Khan Mohammed
- King Mikayala
- Klaauw Agatha A van der
- Klaauw Agatha A van der
- Knight Chanice
- Kourampa Evgenia
- Kownacka Alicia
- Kumar Dileep
- Ladikou Eleni
- Lakeman Nicki
- Lall Paminder
- Lambe Teresa
- Lambe Teresa
- Lee Kim
- Leung Stephanie
- Lewis-Taylor Jessica
- Li Grace
- Libri Vincenzo
- Libri Vincenzo
- Lingwood Aidan
- Littlewood Kelly
- Liu Xinxue
- Liu Xinxue
- Llewelyn Martin J
- Llewelyn Martin J
- Locke Emily
- Longhurst Beverley
- Lyon Rebecca
- Maallah Mina
- Maallah Mina
- Macdonald Jonathan
- Magan Javier
- Magee Alan
- Males Samantha
- Mallon Lewis
- Mansfield Becky
- Marius Phedra
- McDonnell Chloe
- McGreevy Caitlin
- McGregor Alastair C
- McGregor Alastair C
- McMillan Gillian
- Merida-Morillas Marta
- Minassian Angela M
- Minassian Angela M
- Minnis Christine
- Moon Maria
- Moorbey Chantelle
- Moore Patrick
- Moore Patrick
- Moore Sophie
- Morshead Gertraud
- Mouland Johanna
- Mpelembue Mushiya
- Mughal Mehmood
- Mughal Mehmood
- Mujadidi Yama F
- Mujadidi Yama F
- Mullan Dee
- Munro Alasdair P S
- Munro Alasdair P S
- Munusamy Malathi
- Murira Jennifer
- Nabunjo Martha
- Naker Kush
- Newman Joseph
- Nguyen-Van-Tam Jonathan S
- Nguyen-Van-Tam Jonathan S
- Nightingale Kari
- Oliver Abigail
- Osanlou Orod
- Osanlou Orod
- Osanlou Rostam
- Osanlou Rostam
- Osuji Carol
- Owens Daniel R
- Owens Daniel R
- Packham Alice
- Pacurar Mihaela
- Pacurar Mihaela
- Palfreeman Adrian
- Palfreeman Adrian
- Palmer Emily
- Pan Daniel
- Pan Daniel
- Parungao Nina
- Patel Gita
- Perkins Jonathan
- Peters Erica
- Phillips Rachael
- Pickup Lorinda
- Piper Jo
- Plested Emma
- Presland Laura
- Qureshi Ehsaan
- Qureshi Ehsaan
- Radford Helen
- Raj Sreena
- Rampling Tommy
- Rampling Tommy
- Ramsay Mary
- Ramsay Mary
- Rashid-Gardner Zalina
- Rawlins Todd
- Read Robert C
- Read Robert C
- Regan Karen
- Regan Karen
- Renals Valerie
- Ricamara Marivic
- Richmond Leah
- Riordan Andrew
- Robinson Hannah
- Roche Siobhan
- Rogers Chris
- Romani Rossana
- Ronan Nicholas
- Roy Subarna
- Russell Amy Ross
- Sabine Charlette
- Saich Stephen
- Saich Stephen
- Sakagami Yukari
- Santos Filipa Dos
- Saralaya Dinesh
- Saralaya Dinesh
- Savage Mary
- Seath Ingrid
- Seaton Andrew
- Seenan John Paul
- Serafimova Teona
- Shaik Imam
- Shamtally Djamila
- Sharma Rajni
- Sharma Sunil
- Sharma Sunil
- Shenoy Anil
- Sheridan Ray
- Sheridan Ray
- Silva Carla Ferreira Da
- Singh Michael
- Singh Stephen
- Smith Catherine
- Snape Matthew D
- Snape Matthew D
- Snashall Emma
- Soussi Najwa
- Spence Niamh
- Spencer Joanne
- Stackpoole Michael
- Starinskij Igor
- Stewart Anna
- Stokes Matthew
- Stone Megan
- Storton Kim
- Sturdy Ann
- Suggitt Debbie
- Summerton Eloise
- Tandy Bridget
- Tasker Suzanne
- Thomas Steve
- Thomson Emma C
- Thomson Emma C
- Thorp Helen
- Thorpe Jeanette
- Todd Shirley
- Todd Shirley
- Trinham Charlotte
- Tulloch Hayley
- Tunstall Simon
- Turnbull Iain
- Turner Nicola
- Twelves Chris
- Twelves Chris
- Underwood Karen
- Ustianowski Andrew
- Vail Denny
- Vamplew Luke
- Wagstaff Lynda
- Warren Sarah
- Watson Tara
- Weighell Rowena
- Welham Benjamin
- Welsenes Donald van
- Wenn Victoria
- Westwell Fran
- Whitbred Tim
- White Rachel
- Whittington Ashley
- Whittley Sarah
- Wilkins Suzanne
- Wiselka Martin
- Wixted Donna
- Woodyatt Wiesia
- Yim Yee Ting Nicole
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2022
- Field of study
Mitochondrial physiology
- Author
- >Gonzalez-Francesqua A
- Aasander Frostner Eleonor
- Abdel-Rahman Engy Ali
- Abdul Karim Norwahidah
- Abumrad Nada A
- Acuna-Castroviejo Dario
- Adiele Reginald C
- Ahn Bumsoo
- Alencar MB
- Ali Sameh S
- Almeida Angeles
- Alton Lesley
- Alves Marco G
- Amati Francesca
- Amoedo Nivea Dias
- Amorim Ricardo
- Anderson Ethan J
- Andreadou Ioanna
- Antunes Diana
- Arago Marc
- Aral Cenk
- Arandarcikaite Odeta
- Arias-Reyes Christian
- Armand Anne-Sophie
- Arnould Thierry
- Avram Vlad Florian
- Axelrod Christopher L
- Bailey Damian M
- Bairam Aida
- Bajpeyi Sudip
- Bajzikova Martina
- Bakker Barbara M
- Banni A
- Bardal Tora
- Barlow Jonathan
- Bastos Sant'Anna Silva Ana Carolina
- Batterson Philip
- Battino Maurizio
- Bazil Jason
- Beard Daniel A
- Bednarczyk Piotr
- Beleza Jorge
- Bello Fiona
- Ben-Shachar Dorit
- Bergdahl Andreas
- Berge Rolf K
- Bergmeister Lisa
- Bernardi Paolo
- Berridge Michael V
- Bettinazzi Stefano
- Bishop David
- Blier Pierre U
- Blindheim Dan Filip
- Boardman Neoma T
- Boetker Hans Erik
- Borchard Sabine
- Boros Mihaly
- Borras Consuelo
- Borsheim Elisabet
- Borutaite Vilma
- Botella Javier
- Bouillaud Frederic
- Bouitbir Jamal
- Boushel Robert C
- Bovard Josh
- Bravo-Sagua Roberto
- Breton Sophie
- Brown David A
- Brown Guy C
- Brown Robert A
- Brozinick Joseph T
- Buettner Garry R
- Burtscher Johannes
- Bustos Matilde
- Calabria Elisa
- Calbet Jose A
- Calzia Enrico
- Cannon Daniel T
- Cano Sanchez Maria
- Canto Alvarez Carlos
- Cardinale D
- Cardoso Luiza Helena Daltro
- Carvalho Eugenia
- Casado Pinna Marta
- Cassar Samantha
- Castelo Maria P
- Castilho Roger F
- Cavalcanti-de-Albuquerque Joao Paulo
- Cecatto Cristiane
- Celen Murat C
- Cervinkova Zuzana
- Chabi Beatrice
- Chakrabarti Lisa
- Chakrabarti Sasanka
- Chaurasia Bhagirath
- Chen Qi
- Chicco Adam J
- Chinopoulos Christos
- Chowdhury Subir K
- Cizmarova Beata
- Clementi Emilio
- Coen Paul M
- Cohen Bruce H
- Coker Robert H
- Collin-Chenot Anne
- Coughlan MT
- Coxito Pedro
- Crisostomo Luis
- Crispim Marcell
- Crossland Hannah
- Dahdah Norma
- Dalgaard Louise T
- Dambrova Maija
- Danhelovska Tereza
- Darveau Charles A
- Darwin Paula M
- Das Anibh M
- Dash Ranjan K
- Davidova Eliska
- Davis Michael S
- Dayanidhi Sudarshan
- De Bem Andreza Fabro
- De Goede Paul
- De Palma Clara
- De Pinto Vito
- Dela Flemming
- Dembinska-Kiec Aldona
- Detraux Damien
- Devaux Yvan
- Di Marcello Marco
- Di Paola Floriana Jessica
- Dias Candida
- Dias Tania R
- Diederich Marc
- Distefano Giovanna
- Djafarzadeh Siamak
- Doermann Niklas
- Doerrier Carolina
- Dong Lan-Feng
- Donnelly Chris
- Drahota Zdenek
- Duarte Filipe Valente
- Dubouchaud Herve
- Duchen Michael R
- Dumas Jean-Francois
- Durham William J
- Dymkowska Dorota
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- Isola Raffaella
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- Jadiya Pooja
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- Jang Young C
- Janowska Joanna
- Jansen Kirsten
- Jansen-Duerr Pidder
- Jansone Baiba
- Jarmuszkiewicz Wieslawa
- Jaskiewicz Anna
- Jaspers Richard T
- Jedlicka Jan
- Jerome Estaquier
- Jespersen Nichlas R
- Jha Rajan K
- John G JG
- Joseph Vincent
- Juhasz Laszlo
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- Jurk Diana
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- Kaambre Tuuli
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- Kainulainen Heikki
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- Kapferer Werner
- Kapnick Senta
- Kappler Lisa
- Karabatsiakis Alexander
- Karavaeva Iuliia
- Karkucinska-Wieckowska Agnieszka
- Kaur Sarbjot
- Keijer Jaap
- Keller Markus A
- Keppner Gloria
- Khamoui Andy V
- Kidere Dita
- Kilbaugh Todd
- Kim Hyoung Kyu
- Kim Julian KS
- Kimoloi Sammy
- Klepinin Aleksandr
- Klepinina Lyudmila
- Klingenspor Martin
- Klocker Helmut
- Kolasa Iris
- Komlódi Timea
- Koopman Werner JH
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- Krajcova Adela
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- Kristal Bruce S
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- Kuang Jujiao
- Kucera Otto
- Kuka Janis
- Kwak Hyo Bum
- Kwast Kurt
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- Labieniec-Watala Magdalena
- Lagarrigue Sylviane
- Lai Nicola
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- Laner Verena
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- Szabo Ildiko
- Szewczyk Adam
- Szibor Marten
- Tanaka Masashi
- Tandler Bernard
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- Teodoro J
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- Truu Laura
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- Turan Belma
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- Urban Tomas
- Urner Sofia
- Valentine Joseph Marco
- Van Bergen Nicole J
- Varricchio Frederick
- Vella Joanna
- Vendelin Marko
- Vercesi Anibal E
- Verdaguer Ignasi Bofill
- Vernerova Andrea
- Victor Victor Manuel
- Vidimce Josif
- Vieira Ligo Teixeira Camila
- Viel Christian
- Vieyra Adalberto
- Vilks Karlis
- Villena Joseph A
- Vincent Vinnyfred
- Vinogradov Andrey D
- Viscomi Carlo
- Vitorino Rui Miguel Pinheiro
- Vogt Sebastian
- Volani Chiara
- Volska Kristine
- Votion Dominique-Marie
- Vujacic-Mirski Ksenija
- Wagner Brett A
- Ward Marie Louise
- Warnsmann Verena
- Wasserman David H
- Watala Cezary
- Wei Yau-Huei
- Weissig Volkmar
- Whitfield Jamie
- Wickert Anika
- Wieckowski Mariusz R
- Wiesner Rudolf J
- Williams Caroline M
- Winwood-Smith Hugh
- Wohlgemuth Stephanie E
- Wohlwend Martin
- Wolff Jonci Nikolai
- Wrutniak-Cabello Chantal
- Wuest Rob C I
- Yokota Takashi
- Zablocki Krzysztof
- Zanon Alessandra
- Zanou Nadege
- Zaugg Kathrin
- Zaugg Michael
- Zdrazilova Lucie
- Zhang Yi Zhu
- Zhang Yong
- Zikova Alena
- Zischka Hans
- Zorzano Antonio
- Zvejniece Liga
- Publication venue
- Oroboros Ecosystem
- Publication date
- 20/05/2020
- Field of study
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
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