Bidirectional Psychoneuroimmune Interactions in the Early Postpartum Period Influence Risk of Postpartum Depression

More than 500,000 U.S. women develop postpartum depression (PPD) annually. Although psychosocial risks are known, the underlying biology remains unclear. Dysregulation of the immune inflammatory response and the hypothalamic–pituitary–adrenal (HPA) axis are associated with depression in other populations. While significant research on the contribution of these systems to the development of PPD has been conducted, results have been inconclusive. This is partly because few studies have focused on whether disruption in the bidirectional and dynamic interaction between the inflammatory response and the HPA axis together influence PPD. In this study, we tested the hypothesis that disruption in the inflammatory-HPA axis bidirectional relationship would increase the risk of PPD. Plasma pro- and anti-inflammatory cytokines were measured in women during the 3rd trimester of pregnancy and on Days 7 and 14, and Months 1, 2, 3, and 6 after childbirth. Saliva was collected 5 times the day preceding blood draws for determination of cortisol area under the curve (AUC) and depressive symptoms were measured using the Edinburgh Postpartum Depression Survey (EPDS). Of the 152 women who completed the EPDS, 18% were depressed according to EDPS criteria within the 6 months postpartum. Cortisol AUC was higher in symptomatic women on Day 14 (p = .017). To consider the combined effects of cytokines and cortisol on predicting symptoms of PPD, a multiple logistic regression model was developed that included predictors identified in bivariate analyses to have an effect on depressive symptoms. Results indicated that family history of depression, day 14 cortisol AUC, and the day 14 IL8/IL10 ratio were significant predictors of PPD symptoms. One unit increase each in the IL8/IL10 ratio and cortisol AUC resulted in 1.50 (p = 0.06) and 2.16 (p = 0.02) fold increases respectively in the development of PPD. Overall, this model correctly classified 84.2% of individuals in their respective groups. Findings suggest that variability in the complex interaction between the inflammatory response and the HPA axis influence the risk of PPD

Suppressed radio emission in supercluster galaxies: enhanced ram pressure in merging clusters?

The environmental influence on the 1.4 GHz continuum radio emission of galaxies is analyzed in a 600 deg2 region of the local Universe containing the Shapley Supercluster (SSC). Galaxies in the FLASH and 6dFGS redshift surveys are cross-identified with NVSS radio sources, selected in a subsample doubly complete in volume and luminosity. Environmental effects are studied through a smoothed density field (normalized with random catalogs with the same survey edges and redshift selection function) and the distance to the nearest cluster (R/r200, where r200 is the virial radius, whose relation to the aperture velocity dispersion is quantified). The fraction of high radio loudness (R_K=L_radio/L_K) galaxies in the 10 Mpc Abell 3558 cluster complex at the core of the SSC (SSC-CR) is half as large than elsewhere. In the SSC-CR, R_K is anti-correlated with the density of the large-scale environment and correlated with R/r200: central brightest cluster galaxies (BCGs) in the SSC-CR are 10x less radio-loud than BCGs elsewhere, with signs of suppressed radio loudness in the SSC-CR also present beyond the BCGs, out to at least 0.3 r200. This correlation is nearly as strong as the tight correlation of L_K with R/r200 (K-luminosity segregation), inside the SSC-CR. The suppression of radio loudness in SSC-CR BCGs can be attributed to cluster-cluster mergers that destroy the cool core and thus the supply of gas to the central AGN. We analytically demonstrate that the low radio loudness of non-BCG galaxies within SSC-CR clusters cannot be explained by direct major galaxy mergers or rapid galaxy flyby collisions, but by the loss of gas supply through the enhanced ram pressure felt when these galaxies cross the shock front between the 2 merging clusters and are later subjected to the stronger wind from the 2nd cluster.Comment: Version consolidated with Erratum A&A 499, 4

Insuring Against Losses from Transgenic Contamination: The Case of Pharmaceutical Maize

Concerns about the risk of food supply contamination and the resulting financial losses have limited the development and commercialization of certain pharmaceutical plants. This article develops an insurance pricing model that helps translate these concerns into a cost-benefit analysis. The model first estimates the physical dispersal of maize pollen subject to a number of weather parameters. This distribution is then validated with the limited amount of currently available field trial data. The physical distribution is then used to calculate the premium for a fair-valued insurance policy that would fund the destruction of possibly contaminated fields. The flexible framework can be readily adapted to other crops, management practices, and regions

Antidepressant-Like Actions of Inhibitors of Poly(ADP-Ribose) Polymerase in Rodent Models

Many patients suffering from depressive disorders are refractory to treatment with currently available antidepressant medications, while many more exhibit only a partial response. These factors drive research to discover new pharmacological approaches to treat depression. Numerous studies demonstrate evidence of inflammation and elevated oxidative stress in major depression. Recently, major depression has been shown to be associated with elevated levels of DNA oxidation in brain cells, accompanied by increased gene expression of the nuclear base excision repair enzyme, poly(ADP-ribose) polymerase-1. Given these findings and evidence that drugs that inhibit poly(ADP-ribose) polymerase-1 activity have antiinflammatory and neuroprotective properties, the present study was undertaken to examine the potential antidepressant properties of poly(ADP-ribose) polymerase inhibitors

“Pay for Success” Financing and Home‐Based Multicomponent Childhood Asthma Interventions: Modeling Results From the Detroit Medicaid Population

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144303/1/milq12325_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144303/2/milq12325.pd

Theory of an optical dipole trap for cold atoms

The theory of an atom dipole trap composed of a focused, far red-detuned, trapping laser beam, and a pair of red-detuned, counterpropagating, cooling beams is developed for the simplest realistic multilevel dipole interaction scheme based on a model of a (3+5)-level atom. The description of atomic motion in the trap is based on the quantum kinetic equations for the atomic density matrix and the reduced quasiclassical kinetic equation for atomic distribution function. It is shown that when the detuning of the trapping field is much larger than the detuning of the cooling field, and with low saturation, the one-photon absorption (emission) processes responsible for the trapping potential can be well separated from the two-photon processes responsible for sub-Doppler cooling atoms in the trap. Two conditions are derived that are necessary and sufficient for stable atomic trapping. The conditions show that stable atomic trapping in the optical dipole trap can be achieved when the trapping field has no effect on the two-photon cooling process and when the cooling field does not change the structure of the trapping potential but changes only the numerical value of the trapping potential well. It is concluded that the separation of the trapping and cooling processes in a pure optical dipole trap allows one to cool trapped atoms down to a minimum temperature close to the recoil temperature, keeping simultaneously a deep potential well

Manipulation of Cold Atomic Collisions by Cavity QED Effects

We show how the dynamics of collisions between cold atoms can be manipulated by a modification of spontaneous emission times. This is achieved by placing the atomic sample in a resonant optical cavity. Spontaneous emission is enhanced by a combination of multiparticle entanglement together with a higher density of modes of the modified vacuum field, in a situation akin to superradiance. A specific situation is considered and we show that this effect can be experimentally observed as a large suppression in trap-loss rates.Comment: RevTex, 2 EPS figures; scheduled for Phys. Rev. Lett. 19 Feb 01, with minor change

The Law Presidential Studies, Behavioralism, and Public Law

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109319/1/psq12159.pd