Burrowing through the heterogeneity: Review of mouse models of PTCL-NOS

Currently, there are 19 different peripheral T-cell lymphoma (PTCL) entities recognized by the World Health Organization; however, ~70% of PTCL diagnoses fall within one of three subtypes [i.e., peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), anaplastic large-cell lymphoma, and angioimmunoblastic T-cell lymphoma]. PTCL-NOS is a grouping of extra-thymic neoplasms that represent a challenging and heterogeneous subset of non-Hodgkin’s lymphomas. Research into peripheral T-cell lymphomas has been cumbersome as the lack of defining cytogenetic, histological, and molecular features has stymied diagnosis and treatment of these diseases. Similarly, the lacks of genetically manipulated murine models that faithfully recapitulate disease characteristics were absent prior to the turn of the century. Herein, we review the literature concerning existing mouse models for PTLC-NOS, while paying particular attention to the etiology of this heterogeneous disease

Different Levels of Oregano (Origanum vulgari) Leaf Extract on the Growth Performance of Broilers (Gallus gallus domesticus)

This research was conducted at Animal Science experimental area, DEBESMSCAT, Mandaon, Masbate. Ninety-six (96) head of Cobb day-old chicks were raised in twelve (12) broiler cages with eight (8) chicks in each cage. Four (4) treatments replicated three (3) times were randomly assigned to the cage birds using a completely randomized design (CRD) of experiment. The experimental treatments were as follows: Treatment A, 20 ml of Oregano leaf extract per liter of drinking water; Treatment B, 40 ml of Oregano leaf extract per liter of drinking water; Treatment C, 60 ml of Oregano leaf extract per liter of drinking water; and Treatment D, control (no addition of leaf extract in the drinking water). Broilers treated with 20 ml Oregano leaf extract per liter of drinking water had the highest body weights, body weight gains and improved feed conversion efficiency at 45 days of age. Although not significantly different, broilers treated with 60 ml Oregano leaf extract per liter of drinking water had slightly higher body weight, body weight gains but with significant feed consumption against the control. Broilers treated with 20 ml and 60 ml Oregano leaf extract per liter of drinking water had slightly higher net income as compared to the birds in the control treatment. Based on the results of this study, it is therefore recommended that broilers can be treated with 60 ml Oregano leaf extract per liter of drinking water to attain maximum overall performance. Further study may be conducted to obtain more conclusive results