Improving Eulerian two-phase flow finite element approximation with discontinuous gradient pressure shape functions

In this paper we present a problem we have encountered using a stabilized finite element method on fixed grids for flows with interfaces modelled with the level set approach. We propose a solution based on enriching the pressure shape functions on the elements cut by the interface. The enrichment is used to enable the pressure gradient to be discontinuous at the interface, thus improving the ability to simulate the behaviour of fluids with different density under a gravitational force. The additional shape function used is local to each element and the corresponding degree of freedom can therefore be condensed prior to assembly, making the implementation quite simple on any existing finite element code

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

On the modelling of liquid steel processes

An iterative (k-L)-predictor / (epsilon)- corrector algorithm that models turbulent flow was developed in previous publications. In this paper, the 3D finite element turbulent model was used to analyze the liquid steel movement produced by gravity force, inert gas stirring or electromagnetic force stirring

On the application of two-fluid flows solver to the casting problem

This book presents and discusses mathematical models, numerical methods and computational techniques used for solving coupled problems in science and engineering. It takes a step forward in the formulation and solution of real-life problems with a multidisciplinary vision, accounting for all of the complex couplings involved in the physical description. Simulation of multifaceted physics problems is a common task in applied research and industry. Often a suitable solver is built by connecting together several single-aspect solvers into a network. In this book, research in various fields was selected for consideration: adaptive methodology for multi-physics solvers, multi-physics phenomena and coupled-field solutions, leading to computationally intensive structural analysis. The strategies which are used to keep these problems computationally affordable are of special interest, and make this an essential book.Peer ReviewedPostprint (published version