Metal-poor, Strongly Star-Forming Galaxies in the DEEP2 Survey: The Relationship between Stellar Mass, Temperature-based Metallicity, and Star Formation Rate

We report on the discovery of 28 $z\approx0.8$ metal-poor galaxies in DEEP2. These galaxies were selected for their detection of the weak [OIII]$\lambda$4363 emission line, which provides a "direct" measure of the gas-phase metallicity. A primary goal for identifying these rare galaxies is to examine whether the fundamental metallicity relation (FMR) between stellar mass, gas metallicity, and star formation rate (SFR) holds for low stellar mass and high SFR galaxies. The FMR suggests that higher SFR galaxies have lower metallicity (at fixed stellar mass). To test this trend, we combine spectroscopic measurements of metallicity and dust-corrected SFRs, with stellar mass estimates from modeling the optical photometry. We find that these galaxies are $1.05\pm0.61$ dex above the z~1 stellar mass-SFR relation, and $0.23\pm0.23$ dex below the local mass-metallicity relation. Relative to the FMR, the latter offset is reduced to 0.01 dex, but significant dispersion remains (0.29 dex with 0.16 dex due to measurement uncertainties). This dispersion suggests that gas accretion, star formation and chemical enrichment have not reached equilibrium in these galaxies. This is evident by their short stellar mass doubling timescale of $\approx100^{+310}_{-75}$ Myr that suggests stochastic star formation. Combining our sample with other z~1 metal-poor galaxies, we find a weak positive SFR-metallicity dependence (at fixed stellar mass) that is significant at 94.4% confidence. We interpret this positive correlation as recent star formation that has enriched the gas, but has not had time to drive the metal-enriched gas out with feedback mechanisms.Comment: Resubmitted to ApJ on March 6, 2015. Revised to discuss selection biases and methodologies, and address the former by including more metal-rich galaxies with robust non-detections of [OIII]4363. Primary results on FMR analyses are unchanged. Additional figures are included to illustrate selection biases; previous figures have been revised to improve presentatio

VRLE: Lifelog Interaction Prototype in Virtual Reality:Lifelog Search Challenge at ACM ICMR 2020

The Lifelog Search Challenge (LSC) invites researchers to share their prototypes for interactive lifelog retrieval and encourages competition to develop and evaluate effective methodologies to achieve this. With this paper we present a novel approach to visual lifelog exploration based on our research to date utilising virtual reality as a medium for interactive information retrieval. The VRLE prototype presented is an iteration on a previous system which won the first LSC competition at ACM ICMR 2018

High star formation activity in the central region of a distant cluster at z=1.46

We present an unbiased deep [OII] emission survey of a cluster XMMXCS J2215.9-1738 at z=1.46, the most distant cluster to date with a detection of extended X-ray emission. With wide-field optical and near-infrared cameras (Suprime-Cam and MOIRCS, respectively) on Subaru telescope, we performed deep imaging with a narrow-band filter NB912 (lambda_c=9139A, Delta_lambda=134A) as well as broad-band filters (B, z', J and Ks). From the photometric catalogues, we have identified 44 [OII] emitters in the cluster central region of 6'x6' down to a dust-free star formation rate of 2.6 Msun/yr (3 sigma). Interestingly, it is found that there are many [OII] emitters even in the central high density region. In fact, the fraction of [OII] emitters to the cluster members as well as their star formation rates and equivalent widths stay almost constant with decreasing cluster-centric distance up to the cluster core. Unlike clusters at lower redshifts (z<1) where star formation activity is mostly quenched in their central regions, this higher redshift 2215 cluster shows its high star formation activity even at its centre, suggesting that we are beginning to enter the formation epoch of some galaxies in the cluster core eventually. Moreover, we find a deficit of galaxies on the red sequence at magnitudes fainter than ~M*+0.5 on the colour-magnitude diagram. This break magnitude is brighter than that of lower redshift clusters, and it is likely that we are seeing the formation phase of more massive red galaxies in the cluster core at z~1. These results may indicate inside-out and down-sizing propagation of star formation activity in the course of cluster evolution.Comment: 12 pages, 9 figures, 1 table, accepted for publication in MNRA

Diarrhoea in critical care is rarely infective in origin, associated with increased length of stay and higher mortality

Diarrhoea, defined as > 3 loose or liquid stools per day, affects 9.7–41% of intensive care unit patients, negatively impacting on patient dignity, intensifying nursing workload and increasing morbidity. Its pathogenesis is poorly understood, but infective agents, intensive care unit therapies (such as enteral feed) and critical illness changes in the gut microbiome are thought to play a role. We analysed a consecutive cohort of 3737 patients admitted to a mixed general intensive care unit. Diarrhoea prevalence was lower than previously reported (5.3%), rarely infective in origin (6.5%) and associated with increased length of stay (median (inter-quartile range) 2.3 (1.0–5.0) days vs. 10 days (5.0–22.0), p < 0.001, sub-distribution hazard ratio 0.55 (95% CI 0.48–0.63), p < 0.001) and mortality (9.5% vs. 18.1%, p = 0.005, sub-distribution hazard ratio 1.20 (95% CI 0.79–1.81), p = 0.40), compared to patients without diarrhoea. In addition, 17.1% of patients received laxatives <24 h prior to diarrhoea onset. Further research on diarrhoea's pathogenesis in critical care is required; robust treatment protocols, investigation rationalisation and improved laxative prescribing may reduce its incidence and improve related outcomes

Average Metallicity and Star Formation Rate of Lya Emitters Probed by a Triple Narrow-Band Survey

We present the average metallicity and star-formation rate of Lya emitters (LAEs) measured from our large-area survey with three narrow-band (NB) filters covering the Lya, [OII]3727, and Ha+[NII] lines of LAEs at z=2.2. We select 919 z=2.2 LAEs from Subaru/Suprime-Cam NB data in conjunction with Magellan/IMACS spectroscopy. Of these LAEs, 561 and 105 are observed with KPNO/NEWFIRM near-infrared NB filters whose central wavelengths are matched to redshifted [OII] and Ha nebular lines, respectively. By stacking the near-infrared images of the LAEs, we successfully obtain average nebular-line fluxes of LAEs, the majority of which are too faint to be identified individually by narrow-band imaging or deep spectroscopy. The stacked object has an Ha luminosity of 1.7x10^{42} erg s^{-1} corresponding to a star formation rate (SFR) of 14 M_{sun} yr^{-1}. We place, for the first time, a firm lower limit to the average metallicity of LAEs of Z>~0.09 Z_{sun} (2sigma) based on the [OII]/(Ha+[NII]) index together with photo-ionization models and empirical relations. This lower limit of metallicity rules out the hypothesis that LAEs, so far observed at z~2, are extremely metal poor (Z<2x10^{-2} Z_{sun}) young galaxies at the 4sigma level. This limit is higher than a simple extrapolation of the observed mass-metallicity relation of z~2 UV-selected galaxies toward lower masses (5x10^{8} M_{sun}), but roughly consistent with a recently proposed fundamental mass-metallicity relation when the LAEs' relatively low SFR is taken into account. The Ha and Lya luminosities of our NB-selected LAEs indicate that the escape fraction of Lya photons is ~12-30 %, much higher than the values derived for other galaxy populations at z~2.Comment: 21 pages, 15 figures, 8 tables. Accepted for publication in Ap

MOJAVE: Monitoring of Jets in Active Galactic Nuclei with VLBA Experiments. VI. Kinematics Analysis of a Complete Sample of Blazar Jets

We discuss the jet kinematics of a complete flux-density-limited sample of 135 radio-loud active galactic nuclei (AGN) resulting from a 13 year program to investigate the structure and evolution of parsec-scale jet phenomena. Our analysis is based on new 2 cm Very Long Baseline Array (VLBA) images obtained between 2002 and 2007, but includes our previously published observations made at the same wavelength, and is supplemented by VLBA archive data. In all, we have used 2424 images spanning the years 1994-2007 to study and determine the motions of 526 separate jet features in 127 jets. The data quality and temporal coverage (a median of 15 epochs per source) of this complete AGN jet sample represents a significant advance over previous kinematics surveys. In all but five AGNs, the jets appear one-sided, most likely the result of differential Doppler boosting. In general the observed motions are directed along the jet ridge line, outward from the optically thick core feature. We directly observe changes in speed and/or direction in one third of the well-sampled jet components in our survey. While there is some spread in the apparent speeds of separate features within an individual jet, the dispersion is about three times smaller than the overall dispersion of speeds among all jets. This supports the idea that there is a characteristic flow that describes each jet, which we have characterized by the fastest observed component speed. The observed maximum speed distribution is peaked at ~10c, with a tail that extends out to ~50c. This requires a distribution of intrinsic Lorentz factors in the parent population that range up to ~50. We also note the presence of some rare low-pattern speeds or even stationary features in otherwise rapidly flowing jets... (abridged)Comment: 19 pages, 10 figures, 2 tables, accepted by the Astronomical Journal; online only material is available from http://www.cv.nrao.edu/2cmVLBA/pub/MOJAVE_VI_suppl.zi

Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells

Previously, we analyzed protein abundance changes across a ‘minimally perturbed’ cell cycle by using centrifugal elutriation to differentially enrich distinct cell cycle phases in human NB4 cells (Ly et al., 2014). In this study, we compare data from elutriated cells with NB4 cells arrested at comparable phases using serum starvation, hydroxyurea, or RO-3306. While elutriated and arrested cells have similar patterns of DNA content and cyclin expression, a large fraction of the proteome changes detected in arrested cells are found to reflect arrest-specific responses (i.e., starvation, DNA damage, CDK1 inhibition), rather than physiological cell cycle regulation. For example, we show most cells arrested in G2 by CDK1 inhibition express abnormally high levels of replication and origin licensing factors and are likely poised for genome re-replication. The protein data are available in the Encyclopedia of Proteome Dynamics (http://www.peptracker.com/epd/), an online, searchable resource. DOI: http://dx.doi.org/10.7554/eLife.04534.00

A large scale structure traced by [OII] emitters hosting a distant cluster at z=1.62

We present a panoramic narrow-band imaging survey of [OII] emitters in and around the ClG J0218.3-0510 cluster at z=1.62 with Suprime-Cam on Subaru telescope. 352 [OII] emitters were identified on the basis of narrow-band excesses and photometric redshifts. We discovered a huge filamentary structure with some clumps traced by [OII] emitters and found that the ClG J0218.3-0510 cluster is embedded in an even larger super-structure than the one reported previously. 31 [OII] emitters were spectroscopically confirmed with the detection of H-alpha and/or [OIII] emission lines by FMOS observations. In the high density regions such as cluster core and clumps, star-forming [OII] emitters show a high overdensity by a factor of more than 10 compared to the field region. Although the star formation activity is very high even in the cluster core, some massive quiescent galaxies also exits at the same time. Furthermore, the properties of the individual [OII] emitters, such as star formation rates, stellar masses and specific star formation rates, do not show a significant dependence on the local density, either. Such lack of environmental dependence is consistent with our earlier result by Hayashi et al. (2011) on a z=1.5 cluster and its surrounding region. The fact that the star-forming activity of galaxies in the cluster core is as high as that in the field at z~1.6 may suggest that the star-forming galaxies are probably just in a transition phase from a starburst mode to a quiescent mode, and are thus showing comparable level of star formation rates to those in lower density environments. We may be witnessing the start of the reversal of the local SFR--density relation due to the "biased" galaxy formation and evolution in high density regions at high this redshift, beyond which massive galaxies would be forming vigorously in a more biased way in proto-cluster cores.Comment: 11 pages, 9 figures, 1 table, accepted for publication in MNRA

Impact of 13-Valent Pneumococcal Conjugate Vaccine on Colonization and Invasive Disease in Cambodian Children

Background Cambodia introduced the 13-valent pneumococcal conjugate vaccine (PCV13) in January 2015 using a 3 + 0 dosing schedule and no catch-up campaign. We investigated the effects of this introduction on pneumococcal colonization and invasive disease in children aged <5 years. Methods There were 6 colonization surveys done between January 2014 and January 2018 in children attending the outpatient department of a nongovernmental pediatric hospital in Siem Reap. Nasopharyngeal swabs were analyzed by phenotypic and genotypic methods to detect pneumococcal serotypes and antimicrobial resistance. Invasive pneumococcal disease (IPD) data for January 2012–December 2018 were retrieved from hospital databases. Pre-PCV IPD data and pre-/post-PCV colonization data were modelled to estimate vaccine effectiveness (VE). Results Comparing 2014 with 2016–2018, and using adjusted prevalence ratios, VE estimates for colonization were 16.6% (95% confidence interval [CI] 10.6–21.8) for all pneumococci and 39.2% (95% CI 26.7–46.1) for vaccine serotype (VT) pneumococci. There was a 26.0% (95% CI 17.7–33.0) decrease in multidrug-resistant pneumococcal colonization. The IPD incidence was estimated to have declined by 26.4% (95% CI 14.4–35.8) by 2018, with a decrease of 36.3% (95% CI 23.8–46.9) for VT IPD and an increase of 101.4% (95% CI 62.0–145.4) for non-VT IPD. Conclusions Following PCV13 introduction into the Cambodian immunization schedule, there have been declines in VT pneumococcal colonization and disease in children aged <5 years. Modelling of dominant serotype colonization data produced plausible VE estimates

Cancer cells exploit an orphan RNA to drive metastatic progression.

Here we performed a systematic search to identify breast-cancer-specific small noncoding RNAs, which we have collectively termed orphan noncoding RNAs (oncRNAs). We subsequently discovered that one of these oncRNAs, which originates from the 3' end of TERC, acts as a regulator of gene expression and is a robust promoter of breast cancer metastasis. This oncRNA, which we have named T3p, exerts its prometastatic effects by acting as an inhibitor of RISC complex activity and increasing the expression of the prometastatic genes NUPR1 and PANX2. Furthermore, we have shown that oncRNAs are present in cancer-cell-derived extracellular vesicles, raising the possibility that these circulating oncRNAs may also have a role in non-cell autonomous disease pathogenesis. Additionally, these circulating oncRNAs present a novel avenue for cancer fingerprinting using liquid biopsies