MARS, the MAGIC Analysis and Reconstruction Software

With the commissioning of the second MAGIC gamma-ray Cherenkov telescope situated close to MAGIC-I, the standard analysis package of the MAGIC collaboration, MARS, has been upgraded in order to perform the stereoscopic reconstruction of the detected atmospheric showers. MARS is a ROOT-based code written in C++, which includes all the necessary algorithms to transform the raw data recorded by the telescopes into information about the physics parameters of the observed targets. An overview of the methods for extracting the basic shower parameters is presented, together with a description of the tools used in the background discrimination and in the estimation of the gamma-ray source spectra.Comment: 4 pages, 0 figures, submitted to the 31st International Cosmic Ray Conference, {\L}odz 200

Corazonin Neurons Function in Sexually Dimorphic Circuitry That Shape Behavioral Responses to Stress in Drosophila

All organisms are confronted with dynamic environmental changes that challenge homeostasis, which is the operational definition of stress. Stress produces adaptive behavioral and physiological responses, which, in the Metazoa, are mediated through the actions of various hormones. Based on its associated phenotypes and its expression profiles, a candidate stress hormone in Drosophila is the corazonin neuropeptide. We evaluated the potential roles of corazonin in mediating stress-related changes in target behaviors and physiologies through genetic alteration of corazonin neuronal excitability. Ablation of corazonin neurons confers resistance to metabolic, osmotic, and oxidative stress, as measured by survival. Silencing and activation of corazonin neurons lead to differential lifespan under stress, and these effects showed a strong dependence on sex. Additionally, altered corazonin neuron physiology leads to fundamental differences in locomotor activity, and these effects were also sex-dependent. The dynamics of altered locomotor behavior accompanying stress was likewise altered in flies with altered corazonin neuronal function. We report that corazonin transcript expression is altered under starvation and osmotic stress, and that triglyceride and dopamine levels are equally impacted in corazonin neuronal alterations and these phenotypes similarly show significant sexual dimorphisms. Notably, these sexual dimorphisms map to corazonin neurons. These results underscore the importance of central peptidergic processing within the context of stress and place corazonin signaling as a critical feature of neuroendocrine events that shape stress responses and may underlie the inherent sexual dimorphic differences in stress responses

Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization

To test the hypothesis that increased Rap1a activity specifically in retinal pigment epithelial cells resists choroidal neovascularization (CNV), self-complementary adeno-associated virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generated and introduced subretinally into Rap1b-deficient mice. Six-week-old mice that received subretinal control (scAAV2-Con) or constitutively active Rap1a (scAAV2-CARap1a) showed strong GFP at the 5 × 10(8) viral particle/µl dose 5 weeks later without altering retinal morphology or function. Compared to scAAV2-Con- or phosphate-buffered saline (PBS)-injected, eyes injected with scAAV2-CARap1a had increased Rap1 in retinal pigment epithelial (RPE)/choroidal lysates and a significant reduction in CNV volume 7 days after laser, comparable to eyes that received intravitreal anti-VEGF versus IgG control. scAAV2-CARap1a-, but not anti-VEGF-, injected eyes had increased pan-cadherin in RPE/choroids. In cultured RPE cells, increased active Rap1a inhibited TNFα-induced disassociation of junctional pan-cadherin/β-catenin complexes, increased transepithelial electrical resistance through an interaction of β-catenin with phosphorylated scaffold protein, IQGAP1, and inhibited choroidal endothelial cell (CEC) transmigration of an RPE monolayer. This evidence shows that increased Rap1a activity specifically in RPE cells is sufficient to reduce CEC transmigration and CNV and involves IQGAP1-mediated protection of RPE junctional complexes

Unprecedented study of the broadband emission of Mrk 421 during flaring activity in March 2010

Context. Because of its proximity, Mrk 421 is one of the best sources on which to study the nature of BL Lac objects. Its proximity allows us to characterize its broadband spectral energy distribution (SED). Aims. The goal is to better understand the mechanisms responsible for the broadband emission and the temporal evolution of Mrk 421. These mechanisms may also apply to more distant blazars that cannot be studied with the same level of detail. Methods. A flare occurring in March 2010 was observed for 13 consecutive days (from MJD 55 265 to MJD 55 277) with unprecedented wavelength coverage from radio to very high energy (VHE; E> 100 GeV) γ-rays with MAGIC, VERITAS, Whipple, Fermi-LAT, MAXI, RXTE, Swift, GASP-WEBT, and several optical and radio telescopes. We modeled the day-scale SEDs with one-zone and two-zone synchrotron self-Compton (SSC) models, investigated the physical parameters, and evaluated whether the observed broadband SED variability can be associated with variations in the relativistic particle population. Results. The activity of Mrk 421 initially was high and then slowly decreased during the 13-day period. The flux variability was remarkable at the X-ray and VHE bands, but it was minor or not significant at the other bands. The variability in optical polarization was also minor. These observations revealed an almost linear correlation between the X-ray flux at the 2–10 keV band and the VHE γ-ray flux above 200 GeV, consistent with the γ-rays being produced by inverse-Compton scattering in the Klein-Nishina regime in the framework of SSC models. The one-zone SSC model can describe the SED of each day for the 13 consecutive days reasonably well, which once more shows the success of this standard theoretical scenario to describe the SEDs of VHE BL Lacs such as Mrk 421. This flaring activity is also very well described by a two-zone SSC model, where one zone is responsible for the quiescent emission, while the other smaller zone, which is spatially separated from the first, contributes to the daily variable emission occurring at X-rays and VHE γ-rays. The second blob is assumed to have a smaller volume and a narrow electron energy distribution with 3 × 104<γ< 6 × 105, where γ is the Lorentz factor of the electrons. Such a two-zone scenario would naturally lead to the correlated variability at the X-ray and VHE bands without variability at the optical/UV band, as well as to shorter timescales for the variability at the X-ray and VHE bands with respect to the variability at the other bands. Conclusions. Both the one-zone and the two-zone SSC models can describe the daily SEDs via the variation of only four or five model parameters, under the hypothesis that the variability is associated mostly with the underlying particle population. This shows that the particle acceleration and cooling mechanism that produces the radiating particles might be the main mechanism responsible for the broadband SED variations during the flaring episodes in blazars. The two-zone SSC model provides a better agreement with the observed SED at the narrow peaks of the low- and high-energy bumps during the highest activity, although the reported one-zone SSC model could be further improved by varying the parameters related to the emitting region itself (δ, B and R), in addition to the parameters related to the particle population.Fil: Aleksic, J.. IFAE; EspañaFil: Ansoldi, S.. Università di Udine; ItaliaFil: Antonelli, L. A.. INAF National Institute for Astrophysics; ItaliaFil: Antoranz, P.. Università di Siena; ItaliaFil: Babic, A.. University of Rijeka; CroaciaFil: Bangale, P.. Max-Planck-Institut für Physik; AlemaniaFil: Barres de Almeida, U.. Max-Planck-Institut für Physik; AlemaniaFil: Barrio, J. A.. Universidad Complutense de Madrid; EspañaFil: Becerra Gonzalez, J.. Inst. de Astrofísica de Canarias; EspañaFil: Bednarek, W.. University of Łódź,; PoloniaFil: Bernardini, E.. Deutsches Elektronen-Synchrotron (DESY); AlemaniaFil: Biasuzzi, B.. Università di Udine; ItaliaFil: Biland, A.. ETH Zurich; SuizaFil: Blanch, O.. IFAE; EspañaFil: Boller, A.. ETH Zurich; SuizaFil: Bonnefoy, S.. Universidad Complutense de Madrid; EspañaFil: Bonnoli, G.. INAF National Institute for Astrophysics ; ItaliaFil: Borracci, F.. Max-Planck-Institut für Physik; AlemaniaFil: Bretz, T.. Universität Würzburg ; AlemaniaFil: Carmona, E.. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas ; EspañaFil: Carosi, A.. INAF National Institute for Astrophysics; ItaliaFil: Colin, P.. Max-Planck-Institut für Physik; AlemaniaFil: Colombo, E.. Inst. de Astrofísica de Canarias; EspañaFil: Contreras, J. L.. Universidad Complutense; EspañaFil: Cortina, J.. IFAE; EspañaFil: Covino, S.. INAF National Institute for Astrophysics; ItaliaFil: Da Vela, P.. Università di Siena; ItaliaFil: Dazzi, F.. Max-Planck-Institut für Physik; AlemaniaFil: Pichel, Ana Carolina. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Rovero, Adrian Carlos. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: The Veritas Collaboration.Fil: The MAGIC Collaboration

Simultaneous multi-frequency observation of the unknown redshift blazar PG 1553+113 in March-April 2008

The blazar PG 1553+113 is a well known TeV gamma-ray emitter. In this paper, we determine its spectral energy distribution using simultaneous multi-frequency data in order to study its emission processes. An extensive campaign was carried out between March and April 2008, where optical, X-ray, high-energy (HE) gamma-ray, and very-high-energy (VHE) gamma-ray data were obtained with the KVA, Abastumani, REM, RossiXTE/ASM, AGILE and MAGIC telescopes, respectively. This is the first simultaneous broad-band (i.e., HE+VHE) gamma-ray observation, though AGILE did not detect the source. We combine data to derive source's spectral energy distribution and interpret its double peaked shape within the framework of a synchrotron self compton modelComment: 5 pages, 2 figures, publishe

The 2009 multiwavelength campaign on Mrk 421: Variability and correlation studies

Aims: We perform an extensive characterization of the broadband emission of Mrk 421, as well as its temporal evolution, during the non-flaring (low) state. The high brightness and nearby location (z = 0.031) of Mrk 421 make it an excellent laboratory to study blazar emission. The goal is to learn about the physical processes responsible for the typical emission of Mrk 421, which might also be extended to other blazars that are located farther away and hence are more difficult to study. Methods: We performed a 4.5-month multi-instrument campaign on Mrk 421 between January 2009 and June 2009, which included VLBA, F-GAMMA, GASP-WEBT, Swift, RXTE, Fermi-LAT, MAGIC, and Whipple, among other instruments and collaborations. This extensive radio to very-high-energy (VHE; E> 100 GeV) γ-ray dataset provides excellent temporal and energy coverage, which allows detailed studies of the evolution of the broadband spectral energy distribution. Results: Mrk421 was found in its typical (non-flaring) activity state, with a VHE flux of about half that of the Crab Nebula, yet the light curves show significant variability at all wavelengths, the highest variability being in the X-rays. We determined the power spectral densities (PSD) at most wavelengths and found that all PSDs can be described by power-laws without a break, and with indices consistent with pink/red-noise behavior. We observed a harder-when-brighter behavior in the X-ray spectra and measured a positive correlation between VHE and X-ray fluxes with zero time lag. Such characteristics have been reported many times during flaring activity, but here they are reported for the first time in the non-flaring state. We also observed an overall anti-correlation between optical/UV and X-rays extending over the duration of the campaign. Conclusions: The harder-when-brighter behavior in the X-ray spectra and the measured positive X-ray/VHE correlation during the 2009 multi-wavelength campaign suggests that the physical processes dominating the emission during non-flaring states have similarities with those occurring during flaring activity. In particular, this observation supports leptonic scenarios as being responsible for the emission of Mrk 421 during non-flaring activity. Such a temporally extended X-ray/VHE correlation is not driven by any single flaring event, and hence is difficult to explain within the standard hadronic scenarios. The highest variability is observed in the X-ray band, which, within the one-zone synchrotron self-Compton scenario, indicates that the electron energy distribution is most variable at the highest energies.Fil: Aleksic, J.. IFAE; EspañaFil: Ansoldi, S.. Università di Udine; ItaliaFil: Antonelli, L. A.. INAF National Institute for Astrophysics; ItaliaFil: Antoranz, P.. Università di Siena; ItaliaFil: Babic, A.. University of Rijeka; CroaciaFil: Bangale, P.. Max-Planck-Institut für Physik; AlemaniaFil: Barres de Almeida, U.. Max-Planck-Institut für Physik; AlemaniaFil: Barrio, J. A.. Universidad Complutense de Madrid; EspañaFil: Becerra Gonzalez, J.. Inst. de Astrofísica de Canarias; EspañaFil: Bednarek, W.. University of Lodz; PoloniaFil: Berger, K.. Inst. de Astrofísica de Canarias; EspañaFil: Bernardini, E.. Deutsches Elektronen-Synchrotron (DESY); AlemaniaFil: Bijand, A.. ETH Zurich; SuizaFil: Blanch, O.. IFAE; EspañaFil: Bock, R. K.. Max-Planck-Institut für Physik; AlemaniaFil: Bonnefoy, S.. Universidad Complutense; EspañaFil: Bonnoli, G.. INAF National Institute for Astrophysics; ItaliaFil: Borracci, F.. Max-Planck-Institut für Physik; AlemaniaFil: Bretz, T.. Universität Würzburg,; AlemaniaFil: Carmona, E.. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas; EspañaFil: Carosi, A.. INAF National Institute for Astrophysics; EspañaFil: Carreto Fidalgo, D.. Universität Würzburg; AlemaniaFil: Colin, P.. Max-Planck-Institut für Physik; AlemaniaFil: Colombo, E.. Inst. de Astrofísica de Canarias; EspañaFil: Contreras, J. L.. Universidad Complutense; EspañaFil: Cortina, J.. IFAE; EspañaFil: Covino, S.. INAF National Institute for Astrophysics; ItaliaFil: Pichel, Ana Carolina. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Rovero, Adrian Carlos. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: The Magic Collaboration.Fil: The Veritas Collaboration

Multiwavelength observations of Mrk 501 in 2008

Context. Blazars are variable sources on various timescales over a broad energy range spanning from radio to very high energy (>100 GeV, hereafter VHE). Mrk 501 is one of the brightest blazars at TeV energies and has been extensively studied since its first VHE detection in 1996. However, most of the γ-ray studies performed on Mrk 501 during the past years relate to flaring activity, when the source detection and characterization with the available γ-ray instrumentation was easier toperform. Aims: Our goal is to characterize the source γ-ray emission in detail, together with the radio-to-X-ray emission, during the non-flaring (low) activity, which is less often studied than the occasional flaring (high) activity. Methods: We organized a multiwavelength (MW) campaign on Mrk 501 between March and May 2008. This multi-instrument effort included the most sensitive VHE γ-ray instruments in the northern hemisphere, namely the imaging atmospheric Cherenkov telescopes MAGIC and VERITAS, as well as Swift, RXTE, the F-GAMMA, GASP-WEBT, and other collaborations and instruments. This provided extensive energy and temporal coverage of Mrk 501 throughout the entire campaign. Results: Mrk 501 was found to be in a low state of activity during the campaign, with a VHE flux in the range of 10%-20% of the Crab nebula flux. Nevertheless, significant flux variations were detected with various instruments, with a trend of increasing variability with energy and a tentative correlation between the X-ray and VHE fluxes. The broadband spectral energy distribution during the two different emission states of the campaign can be adequately described within the homogeneous one-zone synchrotron self-Compton model, with the (slightly) higher state described by an increase in the electron number density. Conclusions: The one-zone SSC model can adequately describe the broadband spectral energy distribution of the source during the two months covered by the MW campaign. This agrees with previous studies of the broadband emission of this source during flaring and non-flaring states. We report for the first time a tentative X-ray-to-VHE correlation during such a low VHE activity. Although marginally significant, this positive correlation between X-ray and VHE, which has been reported many times during flaring activity, suggests that the mechanisms that dominate the X-ray/VHE emission during non-flaring-activity are not substantially different from those that are responsible for the emission during flaring activity.Fil: Aleksic, J.. IFAE; EspañaFil: Ansoldi, S.. Università di Udine; ItaliaFil: Antonelli, L. A.. INAF National Institute for Astrophysics; ItaliaFil: Antoranz, P.. Università di Siena; ItaliaFil: Babic, A.. University of Rijeka ; Croacia. University of Split; CroaciaFil: Bangale, P.. Max-Planck-Institut für Physik; AlemaniaFil: Barres de Almeida, U.. Max-Planck-Institut für Physik; AlemaniaFil: Barrio, J. A.. Universidad Complutense de Madrid; EspañaFil: Becerra Gonzalez, J.. Inst. de Astrofísica de Canarias; EspañaFil: Bednarek, W.. University of Lodz; PoloniaFil: Berger, K.. Inst. de Astrofísica de Canarias; EspañaFil: Bernardini, E.. Deutsches Elektronen-Synchrotron (DESY); AlemaniaFil: Biland, A.. ETH Zurich; SuizaFil: Blanch, O.. IFAE; EspañaFil: Bock, R. K.. Max-Planck-Institut für Physik; AlemaniaFil: Bonnefoy, S.. Universidad Complutense de Madrid; EspañaFil: Bonnoli, G.. INAF National Institute for Astrophysics; ItaliaFil: Borracci, F.. Max-Planck-Institut für Physik; AlemaniaFil: Bretz, T.. Universität Würzburg; Alemania. Now at École polytechnique fédérale de Lausanne (EPFL); SuizaFil: Carmona, E.. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas; EspañaFil: Carosi, A.. INAF National Institute for Astrophysics; ItaliaFil: Carreto Fidalgo, D.. Universität Würzburg; AlemaniaFil: Colin, P.. Max-Planck-Institut für Physik; AlemaniaFil: Colombo, E.. Inst. de Astrofísica de Canarias; EspañaFil: Contreras, J. L.. Universidad Complutense de Madrid; EspañaFil: Cortina, J.. IFAE; EspañaFil: Covino, S.. INAF National Institute for Astrophysics; ItaliaFil: Da Vela, P.. Università di Siena; ItaliaFil: Dazzi, F.. Università di Udine; ItaliaFil: Pichel, Ana Carolina. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: The MAGIC collaboration.Fil: The VERITAS collaboration

MAGIC Upper Limits for two Milagro-detected, Bright Fermi Sources in the Region of SNR G65.1+0.6

We report on the observation of the region around supernova remnant G65.1+0.6 with the stand-alone MAGIC-I telescope. This region hosts the two bright GeV gamma-ray sources 1FGL J1954.3+2836 and 1FGL J1958.6+2845. They are identified as GeV pulsars and both have a possible counterpart detected at about 35 TeV by the Milagro observatory. MAGIC collected 25.5 hours of good quality data, and found no significant emission in the range around 1 TeV. We therefore report differential flux upper limits, assuming the emission to be point-like (<0.1 deg) or within a radius of 0.3 deg. In the point-like scenario, the flux limits around 1 TeV are at the level of 3 % and 2 % of the Crab Nebula flux, for the two sources respectively. This implies that the Milagro emission is either extended over a much larger area than our point spread function, or it must be peaked at energies beyond 1 TeV, resulting in a photon index harder than 2.2 in the TeV band.Comment: 8 pages, 3 figures, 1 tabl

Detection of very high energy gamma-ray emission from the gravitationally-lensed blazar QSO B0218+357 with the MAGIC telescopes

Context. QSO B0218+357 is a gravitationally lensed blazar located at a redshift of 0.944. The gravitational lensing splits the emitted radiation into two components, spatially indistinguishable by gamma-ray instruments, but separated by a 10-12 day delay. In July 2014, QSO B0218+357 experienced a violent flare observed by the Fermi-LAT and followed by the MAGIC telescopes. Aims. The spectral energy distribution of QSO B0218+357 can give information on the energetics of z ~ 1 very high energy gamma- ray sources. Moreover the gamma-ray emission can also be used as a probe of the extragalactic background light at z ~ 1. Methods. MAGIC performed observations of QSO B0218+357 during the expected arrival time of the delayed component of the emission. The MAGIC and Fermi-LAT observations were accompanied by quasi-simultaneous optical data from the KVA telescope and X-ray observations by Swift-XRT. We construct a multiwavelength spectral energy distribution of QSO B0218+357 and use it to model the source. The GeV and sub-TeV data, obtained by Fermi-LAT and MAGIC, are used to set constraints on the extragalactic background light. Results. Very high energy gamma-ray emission was detected from the direction of QSO B0218+357 by the MAGIC telescopes during the expected time of arrival of the trailing component of the flare, making it the farthest very high energy gamma-ray sources detected to date. The observed emission spans the energy range from 65 to 175 GeV. The combined MAGIC and Fermi-LAT spectral energy distribution of QSO B0218+357 is consistent with current extragalactic background light models. The broad band emission can be modeled in the framework of a two zone external Compton scenario, where the GeV emission comes from an emission region in the jet, located outside the broad line region.Comment: 11 pages, 6 figures, accepted for publication in A&

Investigating the peculiar emission from the new VHE gamma-ray source H1722+119

The MAGIC (Major Atmospheric Gamma-ray Imaging Cherenkov) telescopes observed the BL Lac object H1722+119 (redshift unknown) for six consecutive nights between 2013 May 17 and 22, for a total of 12.5 h. The observations were triggered by high activity in the optical band measured by the KVA (Kungliga Vetenskapsakademien) telescope. The source was for the first time detected in the very high energy (VHE, $E > 100$ GeV) $\gamma$-ray band with a statistical significance of 5.9 $\sigma$. The integral flux above 150 GeV is estimated to be $(2.0\pm 0.5)$ per cent of the Crab Nebula flux. We used contemporaneous high energy (HE, 100 MeV $< E < 100$ GeV) $\gamma$-ray observations from Fermi-LAT (Large Area Telescope) to estimate the redshift of the source. Within the framework of the current extragalactic background light models, we estimate the redshift to be $z = 0.34 \pm 0.15$. Additionally, we used contemporaneous X-ray to radio data collected by the instruments on board the Swift satellite, the KVA, and the OVRO (Owens Valley Radio Observatory) telescope to study multifrequency characteristics of the source. We found no significant temporal variability of the flux in the HE and VHE bands. The flux in the optical and radio wavebands, on the other hand, did vary with different patterns. The spectral energy distribution (SED) of H1722+119 shows surprising behaviour in the $\sim 3\times10^{14} - 10^{18}$ Hz frequency range. It can be modelled using an inhomogeneous helical jet synchrotron self-Compton model.Comment: 12 pages, 5 figures, 2 table