Introduction: Analytic, Continental and the question of a bridge

This is the peer reviewed version of the following article: Introduction: Analytic, Continental and the question of a bridge, which has been published in final form at 10.1177/1474885115582078. This article may be used for non-commercial purposes in accordance with SAGE’s Terms and Conditions for Self-Archiving.In philosophy and political theory, divisions come and go, but some persist despite beingobviously problematic. The analytic and Continental divide is one such division. Inpolitical philosophy and political theory, the division has been particularly pronounced.Analytic and Continental thinkers are divided not only over substantial issues but also over the very nature of political theorising. In spite of this fundamental nature, theorists often seem to assume that, as a division, the analytic/Continental divide requires no explanation. We suggest that, as a central division within political theory, and despite being acknowledged as problematic for quite some time, it has persisted because it has not been adequately examined. Once examined, the division turns out to be operationally weaker than it once was. In recent years, there has been a growing interest in engaging thinkers from the other side. This has been accompanied by a corresponding tendency, among both analytic and Continental philosophers and political thinkers, to reflect on the nature of their own tradition and ‘philosophy’. Both traditions have entered a self-conscious period of meta-reflection. Such questioning indicates the possibility of transformation within both groups, in the absence of settled frameworks and divisions. However, it is also clear that such signs are the beginning of the possibility of a new relation rather than a sign of the eclipse of the division. The continued institutional separation and the space between their respective philosophical vocabularies suggest that, while the time is ripe for work here, there is still much to be done

Donald Trump’s use of post-truth double-think politics is a threat to liberal democratic norms.

The election of Donald Trump to the presidency has sparked new debates over the nature of “truth” as the new administration uses “alternative facts” to support its own narratives. Simon Kaye and Clayton Chin write that the wider implications of this new discourse about truth have been largely missed. They argue that Trump and his followers’ use of “alternative facts” is an anti-democratic refusal to engage in liberal democracy under its established norms

Pragmatism, liberalism and the conditions of critique: the connection between philosophy and politics in the work of Richard Rorty

PhDIn the context of a global crisis, it is necessary to ask what are the philosophical limitations of political critique? This thesis addresses this broad question through a critical reading of the work of Richard Rorty and his theorization of the connection between philosophy and politics. Rorty’s philosophy dissociates philosophical questioning and political thinking. Through a critique of foundationalism, Rorty establishes new limits to philosophy which prescribe its involvement in politics. However, the critical literature fails to connect these two aspects. They accept Rorty’s position that his philosophical pragmatism is unconnected to his political liberalism. In contrast, this thesis is a critical account of Rorty’s theorization of the connection between philosophy and politics that explicitly links his pragmatism to his liberalism. It refutes Rorty’s wider philosophical claim from within a reading of his own work. By situating Rorty within his critique of epistemology and his relation to the philosophy of John Dewey, and confronting him with an alternative, ontological line of thinking that runs from the work of Martin Heidegger to that of Herbert Marcuse, this thesis exposes the mechanisms by which Rorty reduces philosophical and political thinking. It reveals that rather than opening thinking and providing a basis for political criticism, Rorty’s political pragmatism restricts thought to the present range of options. What Rorty offers is not a method for cultural change, as he claims, but a self-reinforcing mode of thought for contemporary liberalism. The implications of this analysis exceed Rorty scholarship. Rorty attempts to theorize the implicit assumptions of the liberal West. While he could never exhaust that culture, he does reveal a real set of pragmatic assumptions and justifications for liberal democracy. As such, he offers a opportunity to critically engage a particular form of liberalism that informs much of the dominant discourse about democracy toda

ASSET: Auto-Segmentation of the Seventeen SEgments for ventricular Tachycardia ablation in radiation therapy

There has been a recent effort to treat high-risk ventricular tachycardia (VT) patients through radio-ablation. However, manual segmentation of the VT target is complex and time-consuming. This work introduces ASSET, or Auto-segmentation of the Seventeen SEgments for Tachycardia ablation, to aid in radiation therapy (RT) planning. ASSET was retrospectively applied to CTs for 26 thoracic RT patients (13 undergoing VT ablation). The physician-defined parasternal long-axis of the left ventricle (LV) and the axes generated from principal component analysis (PCA) were compared using mean distance to agreement (MDA) and angle of separation. The manually selected right ventricle insertion point and LVs were used to apply the ASSET model to automatically generate the 17 segments of the LV myocardium (LVM). Physician-defined parasternal long-axis differed from PCA by 1.2 ± 0.3 mm MDA and 6.9 ± 0.7 degrees. Segments differed by 0.69 ± 0.29 mm MDA and 0.89 ± 0.03 Dice similarity coefficient. Running ASSET takes \u3c5 min where manual segmentation took \u3e2 h/patient. Agreement between ASSET and expert contours was comparable to inter-observer variability. Qualitative scoring conducted by three experts revealed automatically generated segmentations were clinically useable as-is. ASSET offers efficient and reliable automatic segmentations for the 17 segments of the LVM for target generation in RT planning

Exaggerated elastin turnover in young individuals with Marfan Syndrome – new insights from the AIMS trial

Background and aims: The fragmentation and loss of elastic fibre in the tunica media of the aorta is a pathological hallmark of Marfan syndrome (MFS) but the dynamics of elastin degradation and its relationship to aortic size and physiological growth remain poorly understood.Methods: In this post-hoc analysis of the AIMS randomised-controlled trial, the association of plasma desmosine (pDES) - a specific biomarker of mature elastin degradation - with age and aortic size was analysed in 113 patients with MFS and compared to 109 healthy controls.Results: There was a strong association between age and pDES in both groups, with higher pDES levels in the lower age groups compared to adults. During childhood, pDES increased and peaked during early adolescence, and thereafter decreased to lower adult levels. This trend was exaggerated in young individuals with MFS but in those above 25 years of age, pDES levels were comparable to controls despite the presence of aortic root dilation. In MFS children, increased aortic diameter relative to controls was seen at an early age and although the increase in diameter was less after adolescence, aortic root size continued to increase steadily with age. In MFS participants there was an indication of a positive association between baseline pDES levels and aortic root dilatation during up to 5 years of follow up.Conclusion: This study has shown that developmental age has a significant effect on levels of elastin turnover as measured by pDES in MFS individuals as well as healthy controls. This effect is exaggerated in those with MFS with increased levels seen during the period of physiologic development which plateaus towards adulthood. This suggests an early onset of pathophysiology that may present an important opportunity for disease modifying intervention

Effects of Women’s Weight Changes on Adverse Outcomes in a Second Pregnancy

Objective To estimate the effects of women’s weight changes in four sequential perinatal periods across first and second pregnancies (pregravid, first gestation, interpregnancy, second gestation) on adverse maternal and neonatal outcomes in the second pregnancy while accounting for interdependencies in weight across the four periods (Aim 1) and to test the influence of the sequential path of weight changes through the four perinatal periods of risk on maternal and neonatal outcomes in the second pregnancy (Aim 2). Design Secondary data analysis. Setting Thirty-one Wisconsin hospitals. Sample Women with 24,795 linked records from first and second births from 2006 through 2013. Methods We used a fully recursive system of linear and logistic regression equations to examine the relationships among weight changes in the four perinatal periods with maternal (gestational diabetes mellitus, gestational hypertension, cesarean birth) and neonatal (macrosomia, small for gestational age, large for gestational age, low birth weight, congenital anomalies, and perinatal death) adverse outcomes in the second pregnancy. Results Pregravid weight was weakly and inconsistently associated with weight changes in subsequent periods. Each 5-kg incremental weight change in the first pregnancy, interpregnancy, and second pregnancy contributed to a 0.75- to 5-kg weight change in subsequent periods, 9% to 25% change in risk for adverse maternal outcomes, and 8% to 47% change in risk for adverse neonatal outcomes in the second pregnancy. Fluctuations in weight across pregnancies and associations with outcomes were strongest among normal-weight and overweight women. Conclusion Weight changes across two pregnancies affected maternal and neonatal outcomes in the second pregnancy in all body mass index categories; the larger weight fluctuations observed in normal and overweight women were associated with greater risk of adverse outcomes. Attention to pregnancy weight during and between pregnancies is important for targeted weight counseling to reduce risks in subsequent pregnancies

Short-lived Nuclei in the Early Solar System: Possible AGB Sources

(Abridged) We review abundances of short-lived nuclides in the early solar system (ESS) and the methods used to determine them. We compare them to the inventory for a uniform galactic production model. Within a factor of two, observed abundances of several isotopes are compatible with this model. I-129 is an exception, with an ESS inventory much lower than expected. The isotopes Pd-107, Fe-60, Ca-41, Cl-36, Al-26, and Be-10 require late addition to the solar nebula. Be-10 is the product of particle irradiation of the solar system as probably is Cl-36. Late injection by a supernova (SN) cannot be responsible for most short-lived nuclei without excessively producing Mn-53; it can be the source of Mn-53 and maybe Fe-60. If a late SN is responsible for these two nuclei, it still cannot make Pd-107 and other isotopes. We emphasize an AGB star as a source of nuclei, including Fe-60 and explore this possibility with new stellar models. A dilution factor of about 4e-3 gives reasonable amounts of many nuclei. We discuss the role of irradiation for Al-26, Cl-36 and Ca-41. Conflict between scenarios is emphasized as well as the absence of a global interpretation for the existing data. Abundances of actinides indicate a quiescent interval of about 1e8 years for actinide group production in order to explain the data on Pu-244 and new bounds on Cm-247. This interval is not compatible with Hf-182 data, so a separate type of r-process is needed for at least the actinides, distinct from the two types previously identified. The apparent coincidence of the I-129 and trans-actinide time scales suggests that the last actinide contribution was from an r-process that produced actinides without fission recycling so that the yields at Ba and below were governed by fission.Comment: 92 pages, 14 figure files, in press at Nuclear Physics