Soil Surface Energy and Water Budgets during a Monsoon Season in Korea

Abstract In this study, attention has been focused on the climatology of some variables linked to the turbulent exchanges of heat and water vapor in the surface layer during a summer monsoon in Korea. In particular, the turbulent fluxes of sensible and latent heat, the hydrologic budget, and the soil temperatures and moistures have been analyzed. At large scale, because the measurements of those data are not only fragmentary and exiguously available but also infeasible for the execution of climatologic analyses, the outputs of a land surface scheme have been used as surrogate of observations to analyze surface layer processes [this idea is based on the methodology Climatology of Parameters at the Surface (CLIPS)] in the Korean monsoonal climate. Analyses have been made for the summer of 2005. As a land surface scheme, the land surface process model (LSPM) developed at the University of Torino, Italy, has been employed, along with the data collected from 635 Korean meteorological stations. The LSPM predictions showed good agreement with selected observations of soil temperature. Major results show that, during the rainfall season, soil moisture in the first tenths of centimeters frequently exceeds the field capacity, whereas most of the rainfall is "lost" as surface runoff. Evapotranspiration is the dominant component of the energy budget, sometimes even exceeding net radiation, especially during the short periods between the precipitation events; in these periods, daily mean soil temperatures are about 28°C or even more. The Gyeonggi-do region, the metropolitan area surrounding Seoul, shows some particularities when compared with the neighboring regions: solar radiation and precipitations are lower, causing high values of sensible heat flux and soil temperatures, and lower values of latent heat flux and soil moistures

Lutein and Zeaxanthin Supplementation in Preterm Very Low-Birth-Weight Neonates in Neonatal Intensive Care Units: A Multicenter Randomized Controlled Trial

Background: Human milk feeding protects against oxidative stress-induced damage in preterm neonates, including severe multifactorial diseases such as retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC), and bronchopulmonary dysplasia (BPD). The carotenoids, which are not found in formula milk, might play a key role in these actions. Methods: A multicenter, double-blind, randomized controlled trial was conducted in three tertiary Italian neonatal intensive care units. All preterm infants < 32(+6) weeks' gestational age were eligible and were randomized to a single, oral, daily 0.5-mL dose of carotenoid supplementation (0.14 mg lutein + 0.0006 mg zeaxanthin) or placebo (5% glucose solution) from birth till 36 weeks' corrected gestational age. Primary outcomes were threshold ROP, NEC > second stage, and BPD. Surveillance for detection of these diseases and for intolerance/adverse effects was performed. Results: No treatment-related adverse effect was documented in the 229 analyzed infants, whose clinical/demographical characteristics were similar in the two groups. Threshold ROP incidence did not significantly differ in treated (6.2%) versus not treated infants (10.3%; p = 0.18). The same occurred for NEC (1.7% versus 5.1%; p = 0.15) and BPD (4.5% versus 10.3%; p = 0.07). Noteworthy, the progression rate from early ROP stages to threshold ROP was decreased by 50% (0.30 versus 0.44; p = 0.23). Conclusion: Lutein/zeaxanthin supplementation in preterm infants is well tolerated. No significant effect was seen on threshold ROP, NEC, or BPD. The decreasing trends of these outcomes in the treatment group need to be assessed and confirmed on larger sample-sizes

Molecular Mechanisms Generating and Stabilizing Terminal 22q13 Deletions in 44 Subjects with Phelan/McDermid Syndrome

In this study, we used deletions at 22q13, which represent a substantial source of human pathology (Phelan/McDermid syndrome), as a model for investigating the molecular mechanisms of terminal deletions that are currently poorly understood. We characterized at the molecular level the genomic rearrangement in 44 unrelated patients with 22q13 monosomy resulting from simple terminal deletions (72%), ring chromosomes (14%), and unbalanced translocations (7%). We also discovered interstitial deletions between 17–74 kb in 9% of the patients. Haploinsufficiency of the SHANK3 gene, confirmed in all rearrangements, is very likely the cause of the major neurological features associated with PMS. SHANK3 mutations can also result in language and/or social interaction disabilities. We determined the breakpoint junctions in 29 cases, providing a realistic snapshot of the variety of mechanisms driving non-recurrent deletion and repair at chromosome ends. De novo telomere synthesis and telomere capture are used to repair terminal deletions; non-homologous end-joining or microhomology-mediated break-induced replication is probably involved in ring 22 formation and translocations; non-homologous end-joining and fork stalling and template switching prevail in cases with interstitial 22q13.3. For the first time, we also demonstrated that distinct stabilizing events of the same terminal deletion can occur in different early embryonic cells, proving that terminal deletions can be repaired by multistep healing events and supporting the recent hypothesis that rare pathogenic germline rearrangements may have mitotic origin. Finally, the progressive clinical deterioration observed throughout the longitudinal medical history of three subjects over forty years supports the hypothesis of a role for SHANK3 haploinsufficiency in neurological deterioration, in addition to its involvement in the neurobehavioral phenotype of PMS

Enhanced Light Emission from Silicon using Photonic Crystal Nanocavities

Using Photonic crystal nanocavities, we first dramatically enhance third harmonic generation from silicon. Then, by virtue of a strong Purcell factor, we significantly increase defect state photoluminescence and greatly suppress thermal quenching

The INSIEME seismic network: a research infrastructure for studying induced seismicity in the High Agri Valley (southern Italy)

International audienceAbstract. The High Agri Valley is a tectonically active area in southern Italy characterized by high seismic hazard related to fault systems capable of generating up to M=7 earthquakes (i.e. the 1857 Mw=7 Basilicata earthquake). In addition to the natural seismicity, two different clusters of induced microseismicity were recognized to be caused by industrial operations carried out in the area: (1) the water loading and unloading operations in the Pertusillo artificial reservoir and (2) the wastewater disposal at the Costa Molina 2 injection well. The twofold nature of the recorded seismicity in the High Agri Valley makes it an ideal study area to deepen the understanding of driving processes of both natural and anthropogenic earthquakes and to improve the current methodologies for the discrimination between natural and induced seismic events by collecting high-quality seismic data. Here we present the dataset gathered by the INSIEME seismic network that was installed in the High Agri Valley within the SIR-MIUR research project INSIEME (INduced Seismicity in Italy: Estimation, Monitoring, and sEismic risk mitigation). The seismic network was planned with the aim to study the two induced seismicity clusters and to collect a full range of open-access data to be shared with the whole scientific community. The seismic network is composed of eight stations deployed in an area of 17 km×11 km around the two clusters of induced microearthquakes, and it is equipped with triaxial weak-motion broadband sensors placed at different depths down to 50 m. It allows us to detect induced microearthquakes, local and regional earthquakes, and teleseismic events from continuous data streams transmitted in real time to the CNR-IMAA Data Centre. The network has been registered at the International Federation of Digital Seismograph Networks (FDSN) with code 3F. Data collected until the end of the INSIEME project (23 March 2019) are already released with open-access policy through the FDSN web services and are available from IRIS DMC (https://doi.org/10.7914/SN/3F_2016; Stabile and INSIEME Team, 2016). Data collected after the project will be available with the permanent network code VD (https://doi.org/10.7914/SN/VD, CNR IMAA Consiglio Nazionale delle Ricerche, 2019) as part of the High Agri Valley geophysical Observatory (HAVO), a multi-parametric network managed by the CNR-IMAA research institute

A prospective observational study of associated anomalies in Hirschsprung's disease.

none20Associated anomalies have been reported in around 20\% of Hirschsprung patients but many Authors suggested a measure of underestimation. We therefore implemented a prospective observational study on 106 consecutive HSCR patients aimed at defining the percentage of associated anomalies and implementing a personalized and up-to-date diagnostic algorithm.After Institutional Ethical Committee approval, 106 consecutive Hirschsprung patients admitted to our Institution between January 2010 and December 2012 were included. All families were asked to sign a specific Informed Consent form and in case of acceptance each patient underwent an advanced diagnostic algorithm, including renal ultrasound scan (US), cardiologic assessment with cardiac US, cerebral US, audiometry, ENT and ophthalmologic assessments plus further specialist evaluations based on specific clinical features.Male to female ratio of our series of patients was 3,4:1. Aganglionosis was confined to the rectosigmoid colon (classic forms) in 74,5\% of cases. We detected 112 associated anomalies in 61 (57,5\%) patients. The percentage did not significantly differ according to gender or length of aganglionosis. Overall, 43,4\% of patients complained ophthalmologic issues (mostly refraction anomalies), 9,4\% visual impairment, 20,7\% congenital anomalies of the kidney and urinary tract, 4,7\% congenital heart disease, 4,7\% hearing impairment or deafness, 2,3\% central nervous system anomalies, 8,5\% chromosomal abnormalities or syndromes and 12,3\% other associated anomalies.Our study confirmed the underestimation of certain associated anomalies in Hirschsprung patients, such as hearing impairment and congenital anomalies of the kidney and urinary tract. Subsequently, based on our results we strongly suggest performing renal US and audiometry in all patients. Conversely, ophthalmologic assessment and cerebral and heart US can be performed according to guidelines applied to the general population or in case of patients with suspected clinical features or chromosomal abnormalities. This updated diagnostic algorithm aims at improving overall outcome thanks to better prognostic expectations, prevention strategies and early rehabilitation modalities. The investigation of genetic background of patients with associated anomalies might be the next step to explore this intriguing multifactorial congenital disease.Pini Prato, A; Rossi, V; Mosconi, M; Holm, C; Lantieri, F; Griseri, P; Ceccherini, I; Mavilio, D; Jasonni, V; Tuo, G; Derchi, M; Marasini, M; Magnano, G; Granata, C; Ghiggeri, G; Priolo, E; Sposetti, L; Porcu, A; Buffa, P; Mattioli, GPini Prato, A; Rossi, V; Mosconi, M; Holm, C; Lantieri, Francesca; Griseri, P; Ceccherini, I; Mavilio, D; Jasonni, Vincenzo; Tuo, G; Derchi, M; Marasini, M; Magnano, G; Granata, C; Ghiggeri, G; Priolo, E; Sposetti, L; Porcu, A; Buffa, P; Mattioli, Girolam