A forward speed effects study on jet noise from several suppressor nozzles in the NASA/Ames 40- by 80-foot wind tunnel

A test program was conducted in a 40 by 80 foot wind tunnel to evaluate the effect of relative velocity on the jet noise signature of a conical ejector, auxiliary inlet ejector, 32 spokes and 104 tube nozzle with and without an acoustically treated shroud. The freestream velocities in the wind tunnel were varied from 0 to 103.6 m/sec (300 ft/sec) for exhaust jet velocities of 259.1 m/sec (850 ft/sec) to 609.6 m/sec (2000 ft/sec). Reverberation corrections for the wind tunnel were developed and the procedure is explained. In conjunction with wind tunnel testing the nozzles were also evaluated on an outdoor test stand. The wind tunnel microphone arrays were duplicated during the outdoor testing. The data were then extrapolated for comparisons with data measured using a microphone array placed on a 30.5 meter (100 ft) arc. Using these data as a basis, farfield to nearfield arguments are presented with regards to the data measured in the wind tunnel. Finally, comparisons are presented between predictions made using existing methods and the measured data

December 1965

Massachusetts Turf and Lawn Grass Council Better Turf Through Research and Educatio

Spring 1958

Dedication of Turf Clippings to Robert Williams (1) Picture - Stockbridge Turf majors (2) Title page and contents (3) Greetings from Dean Sieling - College of Agriculture (4) Outstanding Men in Turfgrass Honored (4) Word From the Editor of Turf Clippings (5) Message From the 1958 Winter School President (6) Summary of 1958 University of Massachusetts Turfgrass Conference - Al Radko (6-9) Importance of Superintendences Associations - Anthony B. Caranci (10) Picture - Turf Grass Interest Stretch from Coast to Coast (11) Picture - 1958 Winter School for Turf Managers (12) Golf Courses in California - James C. Scott (13) The Constant Battle - Joseph Troll (13) Recognition of the Golf Course Superintendent - Frederick Bove (14-15) 1958 Winter School Comments (16) Maintenance of Insurance Grounds - George J. Moore Jr. (17-18) Don\u27t Get Caught Short - Bruce Silven (19-20) We Have had It - They Now Have it - These Two Shall Have it - Orville O. Clapper (21) The Golf Course Superintendent - Prof. L. S. Dickinson (22-23) Picture - Winter School Alumni Meet at Conference (24) Cartoons (25) Cost of Lawn and Golf Course Construction - Geoffrey Cornish (26-27) Turf Club News (28-29) 1957 Horticulture Show Winner (30) Frosting on the Cake (30) Number One Graduate (31) 1957 Stockbridge Turf majors - Work (32) Turf management Club Associate Memberships (32

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors

Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence. Conversely, THC also has potentially therapeutic effects, including analgesia, muscle relaxation, and neuroprotection. However, the mechanisms that dissociate these responses are still not known. Using mice lacking the serotonin receptor 5-HT2A, we revealed that the analgesic and amnesic effects of THC are independent of each other: while amnesia induced by THC disappears in the mutant mice, THC can still promote analgesia in these animals. In subsequent molecular studies, we showed that in specific brain regions involved in memory formation, the receptors for THC and the 5-HT2A receptors work together by physically interacting with each other. Experimentally interfering with this interaction prevented the memory deficits induced by THC, but not its analgesic properties. Our results highlight a novel mechanism by which the beneficial analgesic properties of THC can be dissociated from its cognitive side effects

The Lysosome and Intracellular Signalling.

In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The cytosolic surface of the limiting membrane of the lysosome is the site of activation of the multiprotein complex mammalian target of rapamycin complex 1 (mTORC1), which phosphorylates numerous cell growth-related substrates, including transcription factor EB (TFEB). Under conditions in which mTORC1 is inhibited including starvation, TFEB becomes dephosphorylated and translocates to the nucleus where it functions as a master regulator of lysosome biogenesis. The signalling role of lysosomes is not limited to this pathway. They act as an intracellular Ca2+ store, which can release Ca2+ into the cytosol for both local effects on membrane fusion and pleiotropic effects within the cell. The relationship and crosstalk between the lysosomal and endoplasmic reticulum (ER) Ca2+ stores play a role in shaping intracellular Ca2+ signalling. Lysosomes also perform other signalling functions, which are discussed. Current views of the lysosomal compartment recognize its dynamic nature. It includes endolysosomes, autolysosome and storage lysosomes that are constantly engaged in fusion/fission events and lysosome regeneration. How signalling is affected by individual lysosomal organelles being at different stages of these processes and/or at different sites within the cell is poorly understood, but is discussed

Development of a Multigram Synthesis of URB937, a Peripherally Restricted FAAH Inhibitor

A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield. © 2013 American Chemical Society

Keep off the grass?:Cannabis, cognition and addiction

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.In an increasing number of states and countries, cannabis now stands poised to join alcohol and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of cannabis and its constituent cannabinoids should therefore be prioritized. Whereas newspaper headlines have focused on links between cannabis and psychosis, less attention has been paid to the much more common problem of cannabis addiction. Certain cognitive changes have also been attributed to cannabis use, although their causality and longevity are fiercely debated. Identifying why some individuals are more vulnerable than others to the adverse effects of cannabis is now of paramount importance to public health. Here, we review the current state of knowledge about such vulnerability factors, the variations in types of cannabis, and the relationship between these and cognition and addiction.This work was supported by grants from the US National Institutes of Health to L.H.P. (AA020404, AA006420, AA022249 and AA017447) and by grants from the UK Medical Research Council to H.V.C. and C.J.A.M. (G0800268; MR/K015524/1)