Skylab short-lived event alert program

During the three manned Skylab missions, the Center for Short-Lived Phenomena (CSLP) reported a total of 39 significant events to the Johnson Space Center (JSC) as part of the Skylab Short-Lived Event Alert Program. The telegraphed daily status reports included the names and locations of the events, the track number and revolution number during which the event could be observed, the time (GMT) to within plus or minus 2 sec when Skylab was closest to the event area, and the light condition (daylight or darkness) at that time and place. The messages sent to JSC during the Skylab 4 mission also included information pertaining to ground-truth studies and observations being conducted on the events. Photographic priorities were assigned for each event

Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype

Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses. This antigenic variability mediates viral escape from the host immune responses, necessitating annual vaccine updates. Influenza vaccines elicit a protective antibody response, primarily targeting the viral surface glycoprotein hemagglutinin (HA). However, the predominant humoral response is against the hypervariable head domain of HA, thereby restricting the breadth of protection. In contrast, the conserved, subdominant stem domain of HA is a potential ‘universal’ vaccine candidate. We designed an HA stem-fragment immunogen from the 1968 pandemic H3N2 strain (A/Hong Kong/1/68) guided by a comprehensive H3 HA sequence conservation analysis. The biophysical properties of the designed immunogen were further improved by C-terminal fusion of a trimerization motif, ‘isoleucine-zipper’ or ‘foldon’. These immunogens elicited cross-reactive, antiviral antibodies and conferred partial protection against a lethal, homologous HK68 virus challenge in vivo. Furthermore, bacterial expression of these immunogens is economical and facilitates rapid scale-up

Collider Interplay for Supersymmetry, Higgs and Dark Matter

We discuss the potential impacts on the CMSSM of future LHC runs and possible electron-positron and higher-energy proton-proton colliders, considering searches for supersymmetry via MET events, precision electroweak physics, Higgs measurements and dark matter searches. We validate and present estimates of the physics reach for exclusion or discovery of supersymmetry via MET searches at the LHC, which should cover the low-mass regions of the CMSSM parameter space favoured in a recent global analysis. As we illustrate with a low-mass benchmark point, a discovery would make possible accurate LHC measurements of sparticle masses using the MT2 variable, which could be combined with cross-section and other measurements to constrain the gluino, squark and stop masses and hence the soft supersymmetry-breaking parameters m_0, m_{1/2} and A_0 of the CMSSM. Slepton measurements at CLIC would enable m_0 and m_{1/2} to be determined with high precision. If supersymmetry is indeed discovered in the low-mass region, precision electroweak and Higgs measurements with a future circular electron-positron collider (FCC-ee, also known as TLEP) combined with LHC measurements would provide tests of the CMSSM at the loop level. If supersymmetry is not discovered at the LHC, is likely to lie somewhere along a focus-point, stop coannihilation strip or direct-channel A/H resonance funnel. We discuss the prospects for discovering supersymmetry along these strips at a future circular proton-proton collider such as FCC-hh. Illustrative benchmark points on these strips indicate that also in this case FCC-ee could provide tests of the CMSSM at the loop level.Comment: 47 pages, 26 figure

Emotional valence and arousal affect reading in an interactive way: neuroimaging evidence for an approach-withdrawal framework

A growing body of literature shows that the emotional content of verbal material affects reading, wherein emotional words are given processing priority compared to neutral words. Human emotions can be conceptualised within a two-dimensional model comprised of emotional valence and arousal (intensity). These variables are at least in part distinct, but recent studies report interactive effects during implicit emotion processing and relate these to stimulus-evoked approach-withdrawal tendencies. The aim of the present study was to explore how valence and arousal interact at the neural level, during implicit emotion word processing. The emotional attributes of written word stimuli were orthogonally manipulated based on behavioural ratings from a corpus of emotion words. Stimuli were presented during an fMRI experiment while 16 participants performed a lexical decision task, which did not require explicit evaluation of a word's emotional content. Results showed greater neural activation within right insular cortex in response to stimuli evoking conflicting approach-withdrawal tendencies (i.e., positive high-arousal and negative low-arousal words) compared to stimuli evoking congruent approach vs. withdrawal tendencies (i.e., positive low-arousal and negative high-arousal words). Further, a significant cluster of activation in the left extra-striate cortex was found in response to emotional than neutral words, suggesting enhanced perceptual processing of emotionally salient stimuli. These findings support an interactive two-dimensional approach to the study of emotion word recognition and suggest that the integration of valence and arousal dimensions recruits a brain region associated with interoception, emotional awareness and sympathetic functions

Pengembangan Perangkat Pembelajaran Menggunakan Media Animasi pada Materi Gelombang di SMP Negeri 9 Gorontalo

Penelitian ini bertujuan untuk menghasilkan produk yang efektif, praktis, dan layak berupa perangkat pembelajaran Fisika yang menggunakan media animasi pada materi Gelombang. Model yang digunakan yaitu model 4-D (four-D model) yang terdiri atas empat tahap pengembangan yaitu, Define (pendefinisian), Desaign (perancangan), Develop (pengembangan), dan Disseminate (penyebaran). Perangkat pembelajaran yang dikembangkan meliputi: Silabus, Rencana Pelaksanaan Pembelajaran (RPP), Media Pembelajaran, Lembar Kerja Peserta Didik (LKPD), dan Tes Hasil Belajar (THB) pada pokok bahasan Gelombang. Perangkat pembelajaran ini telah memenuhi kriteria layak dengan hasil yang diperoleh dari 3 validator ahli yaitu perangkat pembelajaran yang dikembangkan memiliki kualitas baik. Untuk keterlaksanaan pembelajaran yang dilihat dari aktivitas guru dan aktivitas peserta didik memiliki kualitas baik dan memenuhi kriteria kepraktisan, hal ini dapat dilihat dari uji coba terbatas yaitu rata-ratanya sebesar 93 dan 92 % sedangkan untuk uji coba terluas yaitu rata-ratanya sebesar 93 dan 99 %. Dan untuk penilaian tes hasil belajar, penilaian sikap, dan penilaian keterampilan memiliki kualitas baik dan memenuhi kriteria keefektifan

Linux kernel compaction through cold code swapping

There is a growing trend to use general-purpose operating systems like Linux in embedded systems. Previous research focused on using compaction and specialization techniques to adapt a general-purpose OS to the memory-constrained environment, presented by most, embedded systems. However, there is still room for improvement: it has been shown that even after application of the aforementioned techniques more than 50% of the kernel code remains unexecuted under normal system operation. We introduce a new technique that reduces the Linux kernel code memory footprint, through on-demand code loading of infrequently executed code, for systems that support virtual memory. In this paper, we describe our general approach, and we study code placement algorithms to minimize the performance impact of the code loading. A code, size reduction of 68% is achieved, with a 2.2% execution speedup of the system-mode execution time, for a case study based on the MediaBench II benchmark suite

Supersymmetric Dark Matter after LHC Run 1

Different mechanisms operate in various regions of the MSSM parameter space to bring the relic density of the lightest neutralino, neutralino_1, assumed here to be the LSP and thus the Dark Matter (DM) particle, into the range allowed by astrophysics and cosmology. These mechanisms include coannihilation with some nearly-degenerate next-to-lightest supersymmetric particle (NLSP) such as the lighter stau (stau_1), stop (stop_1) or chargino (chargino_1), resonant annihilation via direct-channel heavy Higgs bosons H/A, the light Higgs boson h or the Z boson, and enhanced annihilation via a larger Higgsino component of the LSP in the focus-point region. These mechanisms typically select lower-dimensional subspaces in MSSM scenarios such as the CMSSM, NUHM1, NUHM2 and pMSSM10. We analyze how future LHC and direct DM searches can complement each other in the exploration of the different DM mechanisms within these scenarios. We find that the stau_1 coannihilation regions of the CMSSM, NUHM1, NUHM2 can largely be explored at the LHC via searches for missing E_T events and long-lived charged particles, whereas their H/A funnel, focus-point and chargino_1 coannihilation regions can largely be explored by the LZ and Darwin DM direct detection experiments. We find that the dominant DM mechanism in our pMSSM10 analysis is chargino_1 coannihilation: {parts of its parameter space can be explored by the LHC, and a larger portion by future direct DM searches.Comment: 21 pages, 8 figure

The NUHM2 after LHC Run 1

We make a frequentist analysis of the parameter space of the NUHM2, in which the soft supersymmetry (SUSY)-breaking contributions to the masses of the two Higgs multiplets, $m^2_{H_{u,d}}$, vary independently from the universal soft SUSY-breaking contributions $m^2_0$ to the masses of squarks and sleptons. Our analysis uses the MultiNest sampling algorithm with over $4 \times 10^8$ points to sample the NUHM2 parameter space. It includes the ATLAS and CMS Higgs mass measurements as well as their searches for supersymmetric jets + MET signals using the full LHC Run~1 data, the measurements of $B_s \to \mu^+ \mu^-$ by LHCb and CMS together with other B-physics observables, electroweak precision observables and the XENON100 and LUX searches for spin-independent dark matter scattering. We find that the preferred regions of the NUHM2 parameter space have negative SUSY-breaking scalar masses squared for squarks and sleptons, $m_0^2 < 0$, as well as $m^2_{H_u} < m^2_{H_d} < 0$. The tension present in the CMSSM and NUHM1 between the supersymmetric interpretation of $g_\mu - 2$ and the absence to date of SUSY at the LHC is not significantly alleviated in the NUHM2. We find that the minimum $\chi^2 = 32.5$ with 21 degrees of freedom (dof) in the NUHM2, to be compared with $\chi^2/{\rm dof} = 35.0/23$ in the CMSSM, and $\chi^2/{\rm dof} = 32.7/22$ in the NUHM1. We find that the one-dimensional likelihood functions for sparticle masses and other observables are similar to those found previously in the CMSSM and NUHM1.Comment: 20 pages latex, 13 figure