Topological representation for monadic implication algebras

In this paper, every monadic implication algebra is represented as a union of a unique family of monadic filters of a suitable monadic Boolean algebra. Inspired by this representation, we introduce the notion of a monadic implication space, we give a topological representation for monadic implication algebras and we prove a dual equivalence between the category of monadic implication algebras and the category of monadic implication spaces.Fil: Abad, Manuel. Universidad Nacional del Sur. Departamento de Matemática; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cimadamore, Cecilia Rossana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; ArgentinaFil: Díaz Varela, José Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; Argentin

Ciencia de la sustentabilidad, pobreza y desarrollo en la Argentina del siglo XX

Production of INCASI Project H2020-MSCA-RISE-2015 GA 69100

Monadic Wajsberg hoops

Wajsberg hoops are the { , →, 1}-subreducts (hoop-subreducts) of Wajsberg algebras, which are term equivalent to MV-algebras and are the algebraic models of Lukasiewicz infinite-valued logic. Monadic MV-algebras were introduced by Rutledge [Ph.D. thesis, Cornell University, 1959] as an algebraic model for the monadic predicate calculus of Lukasiewicz infinitevalued logic, in which only a single individual variable occurs. In this paper we study the class of { , →, ∀, 1}-subreducts (monadic hoop-subreducts) of monadic MV-algebras. We prove that this class, denoted by MWH, is an equational class and we give the identities that define it. An algebra in MWH is called a monadic Wajsberg hoop. We characterize the subdirectly irreducible members in MWH and the congruences by monadic filters. We prove that MWH is generated by its finite members. Then, we introduce the notion of width of a monadic Wajsberg hoop and study some of the subvarieties of monadic Wajsberg hoops of finite width k. Finally, we describe a monadic Wajsberg hoop as a monadic maximal filter within a certain monadic MValgebra such that the quotient is the two element chain.Fil: Díaz Varela, José Patricio. Universidad Nacional del Sur. Departamento de Matemática; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; ArgentinaFil: Cimadamore, Cecilia Rossana. Universidad Nacional del Sur. Departamento de Matemática; Argentin

Soporte de decisiones multicriterio para la compra de productos online : Una propuesta desde la Aumentación Web

La toma de decisión es objeto de estudio hace varias décadas. Los métodos de toma de decisión generalmente son utilizados en escenarios con un alto impacto financiero, ambiental o social. Un trabajo de investigación realizado propone Lógikos, un sistema que busca utilizar el método de toma de decisión AHP para asistir a usuarios en la compra de productos online. Este informe retoma el trabajo iniciado por Lógikos realizando un reimplementación del mismo buscando resolver diferentes problemas y, principalmente, proponiendo una serie de técnicas y herramientas para facilitar y agilizar el uso del método AHP. Se condujo un experimento con un conjunto de participantes con el fin de comparar, desde diferentes aspectos, las nuevas metodologías con las utilizadas normalmente en AHP.Facultad de Informátic

Molecular diagnostics in uro-oncology.

Research on molecular diagnostics in uro-oncology goes along with the development of complex emerging techniques, ranging from the application of next generation sequencing (NGS) platforms to archi..

Early Acquisition of Neural Crest Competence During hESCs Neuralization

Background: Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates. The neural crest (NC) gives rise to many derivatives including the neurons and glia of the sensory and autonomic ganglia of the peripheral nervous system, enteric neurons and glia, melanocytes, and the cartilaginous, bony and connective tissue of the craniofacial skeleton, cephalic neuroendocrine organs, and some heart vessels. Methodology/Principal Findings: We present evidence that neural crest (NC) competence can be acquired very early when human embryonic stem cells (hESCs) are selectively neuralized towards dorsal neuroepithelium in the absence of feeder cells in fully defined conditions. When hESC-derived neurospheres are plated on fibronectin, some cells emigrate onto the substrate. These early migratory Neural Crest Stem Cells (emNCSCs) uniformly upregulate Sox10 and vimentin, downregulate N-cadherin, and remodel F-actin, consistent with a transition from neuroepithelium to a mesenchymal NC cell. Over 13% of emNCSCs upregulate CD73, a marker of mesenchymal lineage characteristic of cephalic NC and connexin 43, found on early migratory NC cells. We demonstrated that emNCSCs give rise in vitro to all NC lineages, are multipotent on clonal level, and appropriately respond to developmental factors. We suggest that human emNCSC resemble cephalic NC described in model organisms. Ex vivo emNCSCs can differentiate into neurons in Ret.k- mouse embryonic gut tissue cultures and transplanted emNCSCs incorporate into NC-derived structures but not CNS tissues in chick embryos. Conclusions/Significance: These findings will provide a framework for further studying early human NC development including the epithelial to mesenchymal transition during NC delamination

Digital pathology and COVID-19 and future crises: pathologists can safely diagnose cases from home using a consumer monitor and a mini PC

This article is made available for unrestricted research re-use and secondary analysis in any form or be any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.COVID-19 pandemic has a profound impact on routine pathology services.1 Digital pathology can play a role ‘to safeguarding clinical services and pathology-based research in the current climate and in the future’.1 This digital-based approach to diagnosis represents a new way in the evaluation of surgical pathology slides from formalin-fixed paraffin-embedded tissue (FFPE). It makes the pathologist free from the constraints of using an optical microscope in his/her office. At the same time, it can have an effect on ‘social interaction’ among pathologists, including their interplay with clinicians and even patients. A recent contribution from our group briefly dealt with the changing aspects of such a relationship at the peak of the COVID-19 pandemic.2 The aim was to try to foresee how the kind of experience acquired during the pandemic could have influenced the approach to histopathology in the digital and postdigital eras. Our laboratories as well as many others worldwide, even though not yet ready for substituting and replacing the optical microscope with a scanner for digital pathology image creation, already have digital cameras and scanners for ‘sharing images and consulting, teaching and communicating with clinicians and patients’

Emerging prognostic biomarkers in testicular germ cell tumors: Looking beyond established practice

none6siTesticular germ cell tumors are unique among solid cancers. Historically, this disease was deadly if progressed beyond the stage I. The implementation of cisplatin-based chemotherapy regimens has drastically changed the clinical outcome of metastatic testicular cancer. Several biomarkers were established to refine the prognosis by International Germ Cell Collaborative Group in 1997. Among these, the most significant were primary tumor site; metastatic sites, such as non-pulmonary visceral metastases; and the amplitude of serum tumor markers α-fetoprotein, β-chorionic gonadotropin, and lactate dehydrogenase. Since then, oncology has experienced discoveries of various molecular biomarkers to further refine the prognosis and treatment of malignancies. However, the ability to predict the prognosis and treatment response in germ cell tumors did not improve for many years. Clinical trials with novel targeting agents that were conducted in refractory germ cell tumor patients have proven to have negative outcomes. With the recent advances and developments, novel biomarkers emerge in the field of germ cell tumor oncology. This review article aims to summarize the current knowledge in the research of novel prognostic biomarkers in testicular germ cell tumors.openChovanec M.; Albany C.; Mego M.; Montironi R.; Cimadamore A.; Cheng L.Chovanec, M.; Albany, C.; Mego, M.; Montironi, R.; Cimadamore, A.; Cheng, L