"John Palmers ökonomisch-commerzielle Reise durch Nordamerika" im mährischen Nachdruck

Die von mir verfasste Diplomarbeit trägt den Titel „John Palmers ökonomisch-commerzielle Reise durch Nordamerika im mährischen Nachdruck. Vom Emigrations-Ratgeber zum Reisebericht.“ Sie befasst sich in erster Linie mit der Präsentation der Palmerschen Reisebeschreibung in der Ausgabe des Traßler-Verlages, die am Ende einer Entwicklung mit Verlagerung des thematischen Schwerpunktes steht. Dieser Themenschwerpunkt liegt im englischsprachigen Original auf der Informationsvermittlung für zukünftige Emigranten. In der deutschen Übersetzung und Bearbeitung, sowie der Veröffentlichung in der Zeitschrift Ethnographisches Archiv durch den Verlag der Bran´schen Buchhandlung in Jena, verschiebt sich die thematische Ausrichtung nur geringfügig. Der Brünner Traßler-Verlag benutzte diese Jenaer Publikation als Vorlage für einen Nachdruck und dessen Veröffentlichung in der verlagseigenen Zeitschrift Neueste Gallerie der auserlesensten Reisebeschreibungen. Da der Text in seiner ursprünglichen Form aber nicht der Zeitschriftenintention entsprach, wurden umfangreiche thematische Änderungen durchgeführt, die sich folgendermaßen klassifizieren lassen. Der Text wurde, um dem Bildungsanspruch der Neuesten Gallerie gerecht zu werden, um eine allgemeine Beschreibung der USA eines bekannten Geographen erweitert, die ebenfalls in Ausschnitten nachgedruckt wurde. Die Auswanderungsthematik wurde zugunsten dieser Abhandlung gestrichen. Aus dem Auswanderungsratgeber, der vom Autor als solcher konzipiert worden war, blieb allein der unterhaltsame Bericht seiner Reise übrig. Um die Aktualität des Emigrationsthemas zu verdeutlichen, und die nötigen Hintergrundinformationen zu liefern wurden dem Vergleich der Ausgaben einige Kapitel vorangestellt, die sich mit der historischen Situation der USA, der Informationslage im deutschsprachigen Raum zum Entwicklungsstand der USA, der Situation der Auswanderer, sowie der Auswanderungs-bestimmungen im deutschsprachigen Raum befassen. Im Abschnitt Textgeschichte werden die einzelnen Ausgaben dargestellt. Danach zeige ich anhand einiger ausgewählter Textstellen die Abweichungen und Veränderungen im Textvergleich. Das Ergebnis stellt die oben genannte Schwerpunktveränderung dar

A systems biology approach to the evolution of plant–virus interactions

Omic approaches to the analysis of plant-virus interactions are becoming increasingly popular. These types of data, in combination with models of interaction networks, will aid in revealing not only host components that are important for the virus life cycle, but also general patterns about the way in which different viruses manipulate host regulation of gene expression for their own benefit and possible mechanisms by which viruses evade host defenses. Here, we review studies identifying host genes regulated by viruses and discuss how these genes integrate in host regulatory and interaction networks, with a particular focus on the physical properties of these networks.This work was supported by grants from the Spanish MICINN (BFU2009-06993) and Generalitat Valenciana (PROMETEO2010/019). GR is supported by a fellowship from Generalitat Valenciana (BFPI2007-160) and JC by a contract from MICINN (Grant TIN2006-12860).Peer reviewe

The Exozodiacal Dust Problem for Direct Observations of ExoEarths

Debris dust in the habitable zones of stars - otherwise known as exozodiacal dust - comes from extrasolar asteroids and comets and is thus an expected part of a planetary system. Background flux from the Solar System's zodiacal dust and the exozodiacal dust in the target system is likely to be the largest source of astrophysical noise in direct observations of terrestrial planets in the habitable zones of nearby stars. Furthermore, dust structures like clumps, thought to be produced by dynamical interactions with exoplanets, are a possible source of confusion. In this paper, we qualitatively assess the primary impact of exozodical dust on high-contrast direct imaging at optical wavelengths, such as would be performed with a coronagraph. Then we present the sensitivity of previous, current, and near-term facilities to thermal emission from debris dust at all distances from nearby solar-type stars, as well as our current knowledge of dust levels from recent surveys. Finally, we address the other method of detecting debris dust, through high-contrast imaging in scattered light. This method is currently far less sensitive than thermal emission observations, but provides high spatial resolution for studying dust structures. This paper represents the first report of NASA's Exoplanet Exploration Program Analysis Group (ExoPAG).Comment: 21 pages, 5 figures, 2 tables. Accepted for publication in PASP 2012-06-0

HD 101088, An Accreting 14 AU Binary in Lower Centaurus Crux With Very Little Circumstellar Dust

We present high resolution (R=55,000) optical spectra obtained with MIKE on the 6.5 m Magellan Clay Telescope as well as Spitzer MIPS photometry and IRS low resolution (R~60) spectroscopy of the close (14 AU separation) binary, HD 101088, a member of the ~12 Myr old southern region of the Lower Centaurus Crux (LCC) subgroup of the Scorpius-Centaurus OB association. We find that the primary and/or secondary is accreting from a tenuous circumprimary and/or circumsecondary disk despite the apparent lack of a massive circumbinary disk. We estimate a lower limit to the accretion rate of > 1x10^-9 solar masses per year, which our multiple observation epochs show varies over a timescale of months. The upper limit on the 70 micron flux allows us to place an upper limit on the mass of dust grains smaller than several microns present in a circumbinary disk of 0.16 moon masses. We conclude that the classification of disks into either protoplanetary or debris disks based on fractional infrared luminosity alone may be misleading.Comment: 8 pages, 2 figures, ApJ accepte

On the Morphology and Chemical Composition of the HR 4796A Debris Disk

[abridged] We present resolved images of the HR 4796A debris disk using the Magellan adaptive optics system paired with Clio-2 and VisAO. We detect the disk at 0.77 \microns, 0.91 \microns, 0.99 \microns, 2.15 \microns, 3.1 \microns, 3.3 \microns, and 3.8 \microns. We find that the deprojected center of the ring is offset from the star by 4.76$\pm$1.6 AU and that the deprojected eccentricity is 0.06$\pm$0.02, in general agreement with previous studies. We find that the average width of the ring is 14$^{+3}_{-2}$, also comparable to previous measurements. Such a narrow ring precludes the existence of shepherding planets more massive than \about 4 \mj, comparable to hot-start planets we could have detected beyond \about 60 AU in projected separation. Combining our new scattered light data with archival HST/STIS and HST/NICMOS data at \about 0.5-2 \microns, along with previously unpublished Spitzer/MIPS thermal emission data and all other literature thermal data, we set out to constrain the chemical composition of the dust grains. After testing 19 individual root compositions and more than 8,400 unique mixtures of these compositions, we find that good fits to the scattered light alone and thermal emission alone are discrepant, suggesting that caution should be exercised if fitting to only one or the other. When we fit to both the scattered light and thermal emission simultaneously, we find mediocre fits (reduced chi-square \about 2). In general, however, we find that silicates and organics are the most favored, and that water ice is usually not favored. These results suggest that the common constituents of both interstellar dust and solar system comets also may reside around HR 4796A, though improved modeling is necessary to place better constraints on the exact chemical composition of the dust.Comment: Accepted to ApJ on October 27, 2014. 21 pages, 12 figures, 4 table

Persisting Viral Sequences Shape Microbial CRISPR-based Immunity

Well-studied innate immune systems exist throughout bacteria and archaea, but a more recently discovered genomic locus may offer prokaryotes surprising immunological adaptability. Mediated by a cassette-like genomic locus termed Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), the microbial adaptive immune system differs from its eukaryotic immune analogues by incorporating new immunities unidirectionally. CRISPR thus stores genomically recoverable timelines of virus-host coevolution in natural organisms refractory to laboratory cultivation. Here we combined a population genetic mathematical model of CRISPR-virus coevolution with six years of metagenomic sequencing to link the recoverable genomic dynamics of CRISPR loci to the unknown population dynamics of virus and host in natural communities. Metagenomic reconstructions in an acid-mine drainage system document CRISPR loci conserving ancestral immune elements to the base-pair across thousands of microbial generations. This ‘trailer-end conservation’ occurs despite rapid viral mutation and despite rapid prokaryotic genomic deletion. The trailer-ends of many reconstructed CRISPR loci are also largely identical across a population. ‘Trailer-end clonality’ occurs despite predictions of host immunological diversity due to negative frequency dependent selection (kill the winner dynamics). Statistical clustering and model simulations explain this lack of diversity by capturing rapid selective sweeps by highly immune CRISPR lineages. Potentially explaining ‘trailer-end conservation,’ we record the first example of a viral bloom overwhelming a CRISPR system. The polyclonal viruses bloom even though they share sequences previously targeted by host CRISPR loci. Simulations show how increasing random genomic deletions in CRISPR loci purges immunological controls on long-lived viral sequences, allowing polyclonal viruses to bloom and depressing host fitness. Our results thus link documented patterns of genomic conservation in CRISPR loci to an evolutionary advantage against persistent viruses. By maintaining old immunities, selection may be tuning CRISPR-mediated immunity against viruses reemerging from lysogeny or migration

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.

We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received functional excitatory inputs from host neurons, and induced GABA-mediated inhibition in host neurons in vivo. However, schizophrenia cINs had dysregulated expression of protocadherin genes, which lie within documented schizophrenia loci. Mice lacking protocadherin-α showed defective arborization and synaptic density of prefrontal cortex cINs and behavioral abnormalities. Schizophrenia cINs similarly showed defects in synaptic density and arborization that were reversed by inhibitors of protein kinase C, a downstream kinase in the protocadherin pathway. These findings reveal an intrinsic abnormality in schizophrenia cINs in the absence of any circuit-driven pathology. They also demonstrate the utility of homogenous and functional populations of a relevant neuronal subtype for probing pathogenesis mechanisms during development

Совершенствование системы делопроизводства угольной компании

В процессе исследования проводилось изучение содержания понятий "делопроизводство" и "документационное обеспечение управления"; исследование нормативно – правовой базы современного делопроизводства, принципов его организации; изучение цели, задач, функций и назначения службы делопроизводства; анализировалась система делопроизводства ООО "Угольная компания "Заречная"; были выработаны рекомендации по совершенствованию системы документационного обеспечения управления. Результаты исследования и выработанные рекомендации были внедрены в практику работы ООО "Угольная компания "Заречная".In the course of the research, the content of the notions of "office work" and "document management provision" was studied; research of the legal base of modern office work, principles of its organization; the study of the purpose, tasks, functions and appointment of the office work; the system of record keeping of LLC "Coal Company "Zarechnaya" was analyzed; Recommendations were developed to improve the system of document management support. The results of the study and the recommendations developed were introduced into the practice of the LLC "Coal Company "Zarechnaya "

Combined analysis of HPV DNA, p16, p21 and p53 to predict prognosis in patients with stage IV hypopharyngeal carcinoma

We examined p16, p21 and p53 expression in combination with the presence of human papillomavirus (HPV) DNA as molecular markers to predict survival in patients with stage IV hypopharyngeal squamous cell carcinoma (HSCC).Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe