CMS physics technical design report : Addendum on high density QCD with heavy ions

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Valutazione dell’esposizione ambientale ad IPA e benzene in popolazioni residenti in prossimità di un impianto siderurgico ed in un’area rurale

General population is exposed to benzene and polycyclic aromatic hydrocarbons (PAH). The aim of the study was to evaluate the relationships between personal environmental exposures to the above chemicals and several biomarkers. The paper reports the environmental and biological monitoring data collected from 15 people living in the rural area of Alberobello (Bari, Italy) and 18 people living in Taranto (Italy), near an important steel plant. Airborne PAH and benzene personal exposure levels were determined as well as urinary concentrations of benzene, trans,trans-muconic acid and 1- hydroxypyrene. PAH-DNA adducts levels in peripheral blood lymphocytes were also determined. The influence of genetic polymorphism of cytochrome P450 1A1 (CYP1A1), glutathione transferases μ, θ (GSTM1, GSTT1) and DNA repair gene (XPD) on biomarkers levels was investigated

Environmental exposure assessment to PAH and benzene in population groups living near a steel plant and in a rural area

aromatic hydrocarbons (PAH). The aim of the study was to evaluate the relationships between personal environmental exposures to the above chemicals and several biomarkers. The paper reports the environmental and biological monitoring data collected from 15 people living in the rural area of Alberobello (Bari, Italy) and 18 people living in Taranto (Italy), near an important steel plant. Airborne PAH and benzene personal exposure levels were determined as well as urinary concentrations of benzene, trans,trans-muconic acid and 1-hydroxypyrene. PAH-DNA adducts levels in peripheral blood lymphocytes were also determined. The influence of genetic polymorphism of cytochrome P450 1A1 (CYP1A1), glutathione transferases μ, θ (GSTM1, GSTT1) and DNA repair gene (XPD) on biomarkers levels was investigate

Environmental exposure assessment to PAH and Benzene in population groups living near a steel plant and in arural area

aromatic hydrocarbons (PAH). The aim of the study was to evaluate the relationships between personal environmental exposures to the above chemicals and several biomarkers. The paper reports the environmental and biological monitoring data collected from 15 people living in the rural area of Alberobello (Bari, Italy) and 18 people living in Taranto (Italy), near an important steel plant. Airborne PAH and benzene personal exposure levels were determined as well as urinary concentrations of benzene, trans,trans-muconic acid and 1-hydroxypyrene. PAH-DNA adducts levels in peripheral blood lymphocytes were also determined. The influence of genetic polymorphism of cytochrome P450 1A1 (CYP1A1), glutathione transferases μ, θ (GSTM1, GSTT1) and DNA repair gene (XPD) on biomarkers levels was investigate

Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke

Purpose The management of tandem extracranial internal carotid artery and intracranial large vessel occlusion during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) has been under-investigated. We sought to investigate outcomes of AIS patients with tandem occlusion (TO) treated with carotid artery stenting (CAS) compared to those not treated with CAS (no-CAS) during EVT. Methods We performed a cohort study using data from AIS patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke. Outcomes were 3 months' mortality, functional outcome, complete and successful recanalization, any intracranial hemorrhage, parenchymal hematoma and symptomatic intracerebral hemorrhage. Results Among 466 AIS patients with TO, CAS patients were 122 and no-CAS patients were 226 (118 excluded). After adjustment for unbalanced variables, CAS was associated with a lower rate of 3 months' mortality (OR 0.407, 95% CI 0.171-0.969, p = 0.042). After adjustment for pre-defined variables, CAS was associated with a lower rate of 3 months' mortality (aOR 0.430, 95% CI 0.187-0.989, p = 0.047) and a higher rate of complete recanalization (aOR 1.986, 95% CI 1.121-3.518, p = 0.019), successful recanalization (aOR 2.433, 95% CI 1.263-4.686, p = 0.008) and parenchymal hematoma (aOR 2.876, 95% CI 1.173-7.050, p = 0.021). CAS was associated with lower 3 months mortality (OR 0.373, 95% CI 0.141-0.982, p = 0.046) and higher rates of successful recanalization (OR 2.082, 95% CI 1.099-3.942, p = 0.024) after adjustment for variables associated with 3 months' mortality and successful recanalization, respectively. Conclusions Among AIS patients with TO, CAS during EVT was associated with a higher rate of successful reperfusion and a lower rate of 3 months' mortality

Mechanical Thrombectomy for Acute Intracranial Carotid Occlusion with Patent Intracranial Arteries : The Italian Registry of Endovascular Treatment in Acute Stroke

I Purpose: Intracranial carotid artery occlusion represents an underinvestigated cause of acute ischemic stroke as well as an indication for mechanical thrombectomy. We investigated baseline and procedural characteristics, outcomes and predictors of outcome in patients with acute ischemic stroke secondary to intracranial carotid artery occlusion. Methods: A retrospective analysis of the Italian Registry of Endovascular Treatment in Acute Stroke was performed. Patients with intracranial carotid artery occlusion (infraclinoid and supraclinoid) with or without cervical artery occlusion but with patent intracranial arteries were included. The 3‑month functional independence, mortality, successful reperfusion and symptomatic intracranial hemorrhage were evaluated. Results: Intracranial carotid artery occlusion with patent intracranial arteries was diagnosed in 387 out of 4940 (7.8%) patients. The median age was 74 years and median baseline National Institute of Health Stroke Scale (NIHSS) was 18. Functional independence was achieved in 130 (34%) patients, successful reperfusion in 289 (75%) and symptomatic intracranial hemorrhage in 33 (9%), whereas mortality occurred in 111 (29%) patients. In univariate analysis functional independence was associated with lower age, lower NIHSS at presentation, higher rate of successful reperfusion and lower rate of symptomatic intracranial hemorrhage. Multivariable regression analysis found age (odds ratio, OR:1.03; P = 0.006), NIHSS at presentation (OR: 1.07; P < 0.001), diabetes (OR: 2.60; P = 0.002), successful reperfusion (OR:0.20; P < 0.001) and symptomatic intracranial hemorrhage (OR: 4.17; P < 0.001) as the best independent predictors of outcome. Conclusion: Our study showed a not negligible rate of intracranial carotid artery occlusion with patent intracranial arteries, presenting mostly as severe stroke, with an acceptable rate of 3‑month functional independence. Age, NIHSS at presentation and successful reperfusion were the best independent predictors of outcom

General Anesthesia Versus Conscious Sedation and Local Anesthesia During Thrombectomy for Acute Ischemic Stroke

As numerous questions remain about the best anesthetic strategy during thrombectomy, we assessed functional and radiological outcomes in stroke patients treated with thrombectomy in presence of general anesthesia (GA) versus conscious sedation (CS) and local anesthesia (LA)

Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study

Background and purpose We sought to investigate whether there are gender differences in clinical outcome after stroke due to large vessel occlusion (LVO) after mechanical thrombectomy (EVT) in a large population of real-world patients.Methods From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke due to large vessel occlusion. We compared clinical and safety outcomes in men and women who underwent EVT alone or in combination with intravenous thrombolysis (IVT) in the total population and in a Propensity Score matched set.Results Among 3422 patients included in the study, 1801 (52.6%) were women. Despite older age at onset (mean 72.4 vs 68.7; p < 0.001), and higher rate of atrial fibrillation (41.7% vs 28.6%; p < 0.001), women had higher probability of 3-month functional independence (adjusted odds ratio-adjOR 1.19; 95% CI 1.02-1.38), of complete recanalization (adjOR 1.25; 95% CI 1.09-1.44) and lower probability of death (adjOR 0.75; 95% CI 0.62-0.90). After propensity-score matching, a well-balanced cohort comprising 1150 men and 1150women was analyzed, confirming the same results regarding functional outcome (3-month functional independence: OR 1.25; 95% CI 1.04-1.51), and complete recanalization (OR 1.29; 95% CI 1.09-1.53).Conclusions Subject to the limitations of a non-randomized comparison, women with stroke due to LVO treated with mechanical thrombectomy had a better chance to achieve complete recanalization, and 3-month functional independence than men. The results could be driven by women who underwent combined treatment