La violencia filio-parental

Treball Final de Grau en Criminologia i Seguretat. Codi: CS1044. Curs: 2019-2020El objetivo de este trabajo es conocer las causas que dan lugar a la violencia filio-parental y de qué manera influye en los hijos. Indagar sobre los factores de riesgo sociales e individuales desencadenantes y así abordar una serie de conclusiones que nos guíen hacia la posible solución del problema. Entendemos la violencia doméstica como todo tipo de maltrato ejercido en el seno de la unidad familiar y dentro de esta, la violencia filio-parental es la llevada a cabo de hijos a padres, ahora bien, ¿qué es, en qué consiste dicha violencia y qué comportamiento adoptan los hijos frente a los padres? A lo largo del trabajo hablaremos de las diferentes formas en las que se puede manifestar dicha conducta, qué es lo que le ocurre al sujeto para llegar a cometer estos actos agresivos contra sus padres sin ningún tipo de sentimiento de culpa o arrepentimiento. Conoceremos el llamado síndrome del emperador y posteriormente abordaremos una serie de medidas para poder hacer frente a este fenómeno.The aim of this work is to know the causes that give rise to filio-parental violence and how that affects children, to investigate social and individual risk factors triggered due to this type of violence, and consequently, approach a number of conclusions that provide us the possible solution to that problem. We understand domestic violence as all types of abuse committed within the family unit and filio-parental violence, is the violence commited by children against parents. However, what does that term mean? What does it consist of? And what is the behaviour of children have towards their parents? Throughout the work, we will talk about the different ways in which such behavior can be manifested, we will analyse what happens in the individual to get to commit these aggressive acts against his parents without any feeling of guilt or repentance and we will know the so-called “emperor syndrome”. Finally, to bring the matter to a conclusion, a series of measures will be addressed to be able to confront this phenomenon

Satb2 Regulates Callosal Projection Neuron Identity in the Developing Cerebral Cortex

SummarySatb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ gene. In mutant mice, β-galactosidase-labeled axons are absent from the corpus callosum and instead descend along the corticospinal tract. Satb2 mutant neurons acquire expression of Ctip2, a transcription factor that is necessary and sufficient for the extension of subcortical projections by cortical neurons. Conversely, ectopic expression of Satb2 in neural stem cells markedly decreases Ctip2 expression. Finally, we find that Satb2 binds directly to regulatory regions of Ctip2 and induces changes in chromatin structure. These data suggest that Satb2 functions as a repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex

The essentials of marine biotechnology.

Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech – European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs

Innocampus Explora: una aproximación multidisciplinar a la problemática ambiental

[ES] Presentamos las actividades del proyecto de innovación Innocampus Explora desarrollado en el campus de Burjassot-Paterna de la Universitat de València y cuyo objetivo principal es mostrar la interrelación existente entre los diferentes grados científicos y técnicos del campus. En la presente anualidad, el equipo de trabajo integrado por estudiantes y profesores de todos las facultades y escuelas del campus de Burjassot-Paterna, ha desarrollado actividades en torno a la problemática medioambiental. Una visión transversal e interdisciplinar de los problemas de los usos del plástico y de la energía nuclear que enlaza con varios de los Objetivos de Desarrollo Sostenible (ODS) dictados por Naciones Unidas. Con el desarrollo de este proyecto contribuimos a una formación transversal de calidad para todos los estudiantes participantes.[EN] We present the activities of the Innocampus Explora innovation project developed on the Burjassot-Paterna campus of the Universitat de València and whose main objective is to show the interrelation between the different scientific and technical degrees on campus. In this year, the work team made up of students and professors from all the faculties and schools of the Burjassot-Paterna campus, have carried out activities around environmental issues. A cross-sectional and interdisciplinary vision of the problems of the uses of plastic and nuclear energy that link with several of the Sustainable Development Goals (SDGs) dictated by the United Nations. With the development of this project we contribute to quality transversal training for all participating students.Moros Gregorio, J.; Quílez Asensio, A.; Jimenez Romero, D.; Blas Medina, A.; Giménez Escamilla, I.; Amorós Hernández, L.; Giner, L.... (2021). Innocampus Explora: una aproximación multidisciplinar a la problemática ambiental. En IN-RED 2020: VI Congreso de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 1003-1014. https://doi.org/10.4995/INRED2020.2020.11996OCS1003101

PBX1 acts as terminal selector for olfactory bulb dopaminergic neurons

15 páginas, 8 figuras. Supplementary information available online at http://dev.biologists.org/lookup/doi/10.1242/dev.186841.supplementalNeuronal specification is a protracted process that begins with the commitment of progenitor cells and culminates with the generation of mature neurons. Many transcription factors are continuously expressed during this process but it is presently unclear how these factors modify their targets as cells transition through different stages of specification. In olfactory bulb adult neurogenesis, the transcription factor PBX1 controls neurogenesis in progenitor cells and the survival of migrating neuroblasts. Here, we show that, at later differentiation stages, PBX1 also acts as a terminal selector for the dopaminergic neuron fate. PBX1 is also required for the morphological maturation of dopaminergic neurons and to repress alternative interneuron fates, findings that expand the known repertoire of terminal-selector actions. Finally, we reveal that the temporal diversification of PBX1 functions in neuronal specification is achieved, at least in part, through the dynamic regulation of alternative splicing. In Caenorhabditis elegans, PBX/CEH-20 also acts as a dopaminergic neuron terminal selector, which suggests an ancient role for PBX factors in the regulation of terminal differentiation of dopaminergic neurons.This work was supported by PhD fellowships from the Ministerio de Educación, Cultura y Deporte (FPU16/02008 to I.R.-B.) and the Ministerio de Economıa y ́Competitividad (BES-2012-053847 to L.R.. and BES-2015-072799 to R.B.-R.); by European Research Council grant (ERC-StG-2011-281920); by Ministerio de Economıa y Competitividad grants (SAF2017-84790-R and SAF2016-75004R) and ́ by the Generalitat Valenciana (PROMETEO/2018/055).Peer reviewe

Goals in artificial turf: more sustainable and lasting

[EN] Currently there are installed approximately 25 millions of square meters of artificial turf for contact sports use in Europe (football, rugby, etc.). It means that at the end of their cycle of life 400.000 tones of non-dangerous materials will be placed in controlled landfills. The first aim of this project is to increase the useful life of artificial turf pitches in good conditions of use; and the second objective is to reuse and/or recycle the materials of artificial turf surfaces at the end of their cycle of life with the aim of reducing at maximum the quantity of materials placed on landfills.[ES] Se estima que en Europa hay instalados en la actualidad aproximadamente 25 millones de metros cuadrados de césped artificial destinados a deportes de contacto (fútbol, rugby, etc.), lo que generará al final de su ciclo de vida útil alrededor de 400.000 toneladas de material considerado no peligroso que deberá ser trasladado a vertederos controlados. El objetivo de este proyecto es, en primer lugar, velar por un incremento de la vida útil de los campos de césped artificial en condiciones óptimas de uso para, una vez alcanzado el final de su ciclo de vida, reutilizar y/o revalorizar los materiales que componen este tipo de superficies deportivas, reduciendo al máximo la cantidad de material depositado en vertederos.Este trabajo ha sido posible gracias a la financiación del programa CIP ECO-INNOVATION Pilot and market replication projects (ECO/08/239059/SI2.53788)Sanchís Almenara, M.; Rosa Mañez, D.; Magraner Llavador, L.; Pellicer Chenoll, MT.; Garcia Belenguer, AC.; Ballester Fernandez, A.; Chirivella Moreno, C.... (2012). Goles en césped artificial: más duradero y sostenible. Revista de biomecánica. (58):15-17. http://hdl.handle.net/10251/38493S15175

Goles en césped artificial: más duradero y sostenible

Currently there are installed approximately 25 millions of square meters of artificial turf for contact sports use in Europe (football, rugby, etc.). It means that at the end of their cycle of life 400.000 tones of non-dangerous materials will be placed in controlled landfills. The first aim of this project is to increase the useful life of artificial turf pitches in good conditions of use; and the second objective is to reuse and/or recycle the materials of artificial turf surfaces at the end of their cycle of life with the aim of reducing at maximum the quantity of materials placed on landfills.Se estima que en Europa hay instalados en la actualidad aproximadamente 25 millones de metros cuadrados de césped artificial destinados a deportes de contacto (fútbol, rugby, etc.), lo que generará al final de su ciclo de vida útil alrededor de 400.000 toneladas de material considerado no peligroso que deberá ser trasladado a vertederos controlados. El objetivo de este proyecto es, en primer lugar, velar por un incremento de la vida útil de los campos de césped artificial en condiciones óptimas de uso para, una vez alcanzado el final de su ciclo de vida, reutilizar y/o revalorizar los materiales que componen este tipo de superficies deportivas, reduciendo al máximo la cantidad de material depositado en vertederos

Coches más accesibles. Una silla de ruedas como asiento de automóvil

El proyecto CARGO (FP7- SME -2010-1-261894) tenía como objetivo generar una solución que permitiese acceder a los vehículos utilitarios pequeños a personas con movilidad reducida de forma cómoda y autónoma. Para ello, se desarrolló una silla de ruedas, que se plegaba hasta poder encajarse en el espacio de un asiento de automóvil, y un mecanismo que recogía la silla con el usuario sentado y desplazaba el conjunto hasta el interior del mismo. Una de las partes más críticas fue el estudio y análisis de la trayectoria del movimiento de la silla de ruedas con el usuario desde el exterior del vehículo al interior y viceversa. La trayectoria debía asegurar que no se produjeran colisiones, un desplazamiento óptimo, y la posibilidad de adaptarse a diferentes plataformas y usuarios. Este artículo presenta los aspectos más destacados del estudio de trayectorias y colisiones

Transcriptional profile associated with clinical outcomes in metastatic hormone-sensitive prostate cancer treated with androgen deprivation and docetaxel

Background: androgen deprivation therapy (ADT) and docetaxel (DX) combination is a standard therapy for metastatic hormone-sensitive prostate cancer (mHSPC) patients. (2) Methods: We investigate if tumor transcriptomic analysis predicts mHSPC evolution in a multicenter retrospective biomarker study. A customized panel of 184 genes was tested in mRNA from tumor samples by the nCounter platform in 125 mHSPC patients treated with ADT+DX. Gene expression was correlated with castration-resistant prostate cancer-free survival (CRPC-FS) and overall survival (OS). (3) Results: High expression of androgen receptor (AR) signature was independently associated with longer CRPC-FS (hazard ratio (HR) 0.6, 95% confidence interval (CI) 0.3-0.9; p = 0.015), high expression of estrogen receptor (ESR) signature with longer CRPC-FS (HR 0.6, 95% CI 0.4-0.9; p = 0.019) and OS (HR 0.5, 95% CI 0.2-0.9, p = 0.024), and lower expression of tumor suppressor genes (TSG) (RB1, PTEN and TP53) with shorter OS (HR 2, 95% CI 1-3.8; p = 0.044). ARV7 expression was independently associated with shorter CRPC-FS (HR 1.5, 95% CI 1.1-2.1, p = 0.008) and OS (HR 1.8, 95% CI 1.2-2.6, p = 0.004), high ESR2 was associated with longer OS (HR 0.5, 95% CI 0.2-1, p = 0.048) and low expression of RB1 was independently associated with shorter OS (HR 1.9, 95% CI 1.1-3.2, p = 0.014). (4) Conclusions: AR, ESR, and TSG expression signatures, as well as ARV7, RB1, and ESR2 expression, have a prognostic value in mHSPC patients treated with ADT+DX

Sunitinib rechallenge in advanced renal cell carcinoma: outcomes of a multicenter retrospective study

Purpose: The aim of this multicenter study was to evaluate the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) who received sunitinib retreatment. Methods: Clinical data from patients treated with sunitinib rechallenge in nine Spanish centers were retrospectively analyzed. All patients received first-line sunitinib until progression or intolerance, followed by one or more successive drugs and rechallenge with sunitinib thereafter. Results: Thirty-seven patients were included. At first-line treatment, objective response rate (ORR) was 69.4% and median progression-free survival (PFS) was 19.4 months. At rechallenge, ORR was 27.2% and 39.4% of patients obtained stabilization of disease. Median PFS was 6.2 months. Clinical benefit was obtained by 21 patients (75%) with > 6-month interval between sunitinib treatments and by 1 patient (20%) among those with ≤ 6-month interval (P = 0.016). Hemoglobin levels ≥ lower level of normal were associated with clinical benefit (P = 0.019) and with PFS (P = 0.004). Median overall survival from start of first-line sunitinib was 52.7 months. No new adverse events were observed at rechallenge. Conclusions: Sunitinib rechallenge is a feasible treatment option for selected patients with mRCC