Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Antología Plataformas de Aprendizaje Virtual LIAD9 2023-B

En la presente antología se desarrollan los temas de las unidades de aprendizaje de plataformas de aprendizaje virtual de la licenciatura en Informática Administrativa. Las plataformas de aprendizaje virtual han adquirido una gran relevancia en las organizaciones ya que son una opción para la gestión del conocimiento y la generación del capital intelectual. No son solo las instituciones educativas hacen uso de ellas, las instituciones publicas de gobierno, empresas privadas y organizaciones sin fines de lucro

HEM as an Environmental Friendly Alternative to Produce UFC

High fineness is one of the most important characteristics of the Ultrafine Cements (UFC) with maximum particle size below 20 μm. Usually, UFC is obtained once the Ordinary Portland Cement (OPC) is grinded in common grinding devices e.g. drum mills; however this is a time consuming process, as it becomes complicated to reduce such a size once the particles have reached ultrafine powder dimensions. Some modern grinding devices as High Energy-Ball Mills (HEM) and shaker mills, have been used for ultrafine grinding-processes, especially at the advanced materials processing research field, but not in the cement industry. The most suitable combination of parameters (time, ball/powder (B/P) ratio and milling speed) was determined after the characterization of processed cement powder, in order to obtain UFC at laboratory level. The optimal combination of parameters produced an UFC having a maximum particle size below 15 μm. The HEM horizontal-rotary-ball-mill device used herein is not only intended for laboratory purposes, but also has one of the advantages of a direct-scaling-up, as it could be used for industrial purposes by means of more capacity mills. Furthermore, it is more efficient than both a shaker mill and a traditional ball milling device. As a result, if this kind of device is used instead of the traditional ball mill, the environmental impact due to the UFC production process could be minimized. This represents an environmental friendly alternative process for obtaining UFC from OPC.</jats:p

Acaulospora alpina y Ambispora fennica , dos registros nuevos de hongos micorrizógenos arbusculares para México

Acaulospora alpina y Ambispora fennica se reportan por primera vez para México. Estos taxones se aislaron de la rizósfera de Adiantum capillus-veneris, Baccharis conferta, Quercus candicans, Q. crassifolia, Salvia lavanduloides y Selaginella lepidophylla que crecen en los bosques templados de México. Los especímenes revisados se describen en extenso y se comparan con las especies de hongos micorrizógenos arbusculares más parecidas