COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Multifunctionnal polyimine ligands and their complexes for (non)linear optics.

Ces dernières années, le développement de matériaux possédant des propriétés ONL a gagné en importance dans la recherche fondamentale et appliquée en raison de leurs utilisations dans de nombreuses disciplines comme la science des matériaux, la médecine, la biophysique etc… Ainsi cette thèse se consacre à la conception et l’élaboration de ligands polyimines multifonctionnels électro- et/ou photoactifs et de leurs complexes de coordination pour l’optique (non)linéaire. La première partie de la thèse est dédiée à la préparation de ligand multifonctionnels terpyridiniques à base de phénylethiophène (PT), benzothiophène (BT) ou tétrathiafulvalène (TTF). Ces composés construits sur le modèle push-pull ont permis la préparation de complexes mononucléaires hétéroleptiques ou homoleptiques de zinc(II), fer(II) et ruthénium(II). Ces composés ont fait l’objet d’études d’optique linéaire (absorption, emission) et nonlinéaire (THG, Z-scan, OKE). La seconde partie de la thèse concerne la préparation et l’élaboration de ligands et mutifonctionnels à base d’iminopyridine et iminobipyridine fonctionnalisés par le benzothiophène (BT) ou le tétrathiafulvalène (TTF). Ces ligands sont connues pour s’auto assembler grâce à des métaux tels que le fer(II) et le zinc(II) et former des structures métallo-supramoléculaires hélicoïdales. Ces composés ont fait l’objet d’études en optique linéaire et des résultats préliminaires en ONL montre que ces structures sont de bons candidats pour l’ONL.In recent years, development of materials possessing NLO properties has gained importance in fundamental and applied research due to their potential applications in various disciplines such as materials science, medicine, biophysics etc… Thus, this thesis is devoted to the design and development of electro- and / or photoactive multifunctional polyimine ligands and their coordination complexes for (non)linear optics. First part of the thesis is dedicated to the preparation of multifunctional terpyridinic ligands based on phenylthiophene (PT), benzothiophene (BT) or tetrathiafulvalene (TTF). These compounds built on the push-pull model allowed the preparation of heteroleptic or homoleptic mononuclear zinc(II), iron(II), and ruthenium(II) complexes. These compounds have been studied in linear optics (absorption-emission) and nonlinear optics (THG, Z-scan, OKE). The second part of the thesis concerns the preparation and development of multitopic and multifunctionnal ligands based on iminopyridine and iminobipyridine functionnalized by benzothiophene (BT) or tetrathialfulvalene (TTF). These ligands are known to self assemble with metals such as iron(II) or zinc(II) to form discret structures called helicates. These compound have been studied in linear optics and preliminary results in NLO demonstrate that these structures are good candidates for NLO applications

Ligands polyimines multifonctionnels et leurs complexes pour l’optique (non)linéaire

In recent years, development of materials possessing NLO properties has gained importance in fundamental and applied research due to their potential applications in various disciplines such as materials science, medicine, biophysics etc… Thus, this thesis is devoted to the design and development of electro- and / or photoactive multifunctional polyimine ligands and their coordination complexes for (non)linear optics. First part of the thesis is dedicated to the preparation of multifunctional terpyridinic ligands based on phenylthiophene (PT), benzothiophene (BT) or tetrathiafulvalene (TTF). These compounds built on the push-pull model allowed the preparation of heteroleptic or homoleptic mononuclear zinc(II), iron(II), and ruthenium(II) complexes. These compounds have been studied in linear optics (absorption-emission) and nonlinear optics (THG, Z-scan, OKE). The second part of the thesis concerns the preparation and development of multitopic and multifunctionnal ligands based on iminopyridine and iminobipyridine functionnalized by benzothiophene (BT) or tetrathialfulvalene (TTF). These ligands are known to self assemble with metals such as iron(II) or zinc(II) to form discret structures called helicates. These compound have been studied in linear optics and preliminary results in NLO demonstrate that these structures are good candidates for NLO applications.Ces dernières années, le développement de matériaux possédant des propriétés ONL a gagné en importance dans la recherche fondamentale et appliquée en raison de leurs utilisations dans de nombreuses disciplines comme la science des matériaux, la médecine, la biophysique etc… Ainsi cette thèse se consacre à la conception et l’élaboration de ligands polyimines multifonctionnels électro- et/ou photoactifs et de leurs complexes de coordination pour l’optique (non)linéaire. La première partie de la thèse est dédiée à la préparation de ligand multifonctionnels terpyridiniques à base de phénylethiophène (PT), benzothiophène (BT) ou tétrathiafulvalène (TTF). Ces composés construits sur le modèle push-pull ont permis la préparation de complexes mononucléaires hétéroleptiques ou homoleptiques de zinc(II), fer(II) et ruthénium(II). Ces composés ont fait l’objet d’études d’optique linéaire (absorption, emission) et nonlinéaire (THG, Z-scan, OKE). La seconde partie de la thèse concerne la préparation et l’élaboration de ligands et mutifonctionnels à base d’iminopyridine et iminobipyridine fonctionnalisés par le benzothiophène (BT) ou le tétrathiafulvalène (TTF). Ces ligands sont connues pour s’auto assembler grâce à des métaux tels que le fer(II) et le zinc(II) et former des structures métallo-supramoléculaires hélicoïdales. Ces composés ont fait l’objet d’études en optique linéaire et des résultats préliminaires en ONL montre que ces structures sont de bons candidats pour l’ONL

Metal-organic polyhedron from flexible tetrakis(thiobenzyl-carboxylate)-Tetrathiafulvalene

The synthesis of crystalline self-assembled materials starting from building blocks with a large degree of freedom is challenging. Furthermore, incorporating redox-active moieties in self-assembled metal organic polyhedra is of the outmost interest to modulate the properties of the cavity through redox stimuli. Herein is presented the synthesis of a novel electroactive ligand bearing four coordinating moieties around an S-alkylated tetrathiafulvalene (TTF) scaffold. The redox behavior of the ligand is similar to a tetra-S-alkylated TTF. In the solid state, it presents a densely packed H-bonded 1D polymeric structure. Upon reaction with Cu(OAc)2 in the presence of dimethylformamide or dimethylacetamide, two novel M4L4-type metal-organic polyhedra (MOPs) bearing paddlewheel metal clusters as connecting nodes are obtained. The structural features and electrochemical properties of the ligand and the MOPs are devised. Both MOPs adopt the same structure characterized by a tetrahedral arrangement of the four TTF moieties

Zinc and copper complexes of stilbene iminopyridine ligands with eta 2-Olefin binding mode

International audienceTwo stilbene based iminopyridine ligands (L1-L2) synthesized by a condensation reaction between N, N-Dimethyl-4,4'-azodianiline and 2-pyridinecarboxaldehyde or 2,6-pyridinedicarboxaldehyde, with 73% and 65% yield, are described. The two ligands have been characterized by elemental analysis and spectroscopic techniques. The complexation of ligand L1 with ZnCl2 afforded neutral tetrahedral zinc(II) metal complex C1 formulated as [ZnL1Cl(2)] with a 2D supramolecular architecture reinforced by pi center dot center dot center dot pi stacking and hydrogen bonding in the solid state. Interestingly in the case of copper(I) complex C2, ligand L1 acts as a ditopic ligand since it coordinates one Cu(I) with an iminopyridyl fragment and a second metal center with an eta(2)-olefin binding mode giving rise to a 1D-polymeric structure. The coordination sphere is completed with an acetonitrile solvent molecule leading to a distorted tetrahedral geometry around copper cation and the resulting coordination polymer can be formulated as {[Cu(L1)(2)CH3CN] BF4}. In addition complexation of L2 with zinc chloride afforded complex C3 formulated as [ZnL2Cl(2)]. DFT and TDDFT computations permitted to investigate the frontier MOs of all species and to assign their UV-visible absorption bands

Strong solid-state luminescence enhancement in supramolecular assemblies of polyoxometalate and "Aggregation-Induced Emission"-active phospholium

International audienc

Is total community viral load a robust predictive marker of the efficacy of the TasP strategy?

International audienceA mild but significant association between a decrease in the total community viral load (CVL) and a decrease in the number of new HIV diagnoses was observed between 2005 and 2010 in the population of northern and eastern France. This result suggests that CVL could be used as robust marker of the efficacy of the "Treatment as Prevention" strategy, and it may even be stronger if a large number of undiagnosed patients and early HIV infection cases indicated by extend screening are included in the CVL measurement

Impact on disease mortality of clinical, biological, and virological characteristics at hospital admission and overtime in COVID‐19 patients

International audienc