Computational Wind-Turbine Analysis with the ALE-VMS and ST-VMS Methods

We provide an overview of the aerodynamic and FSI analysis of wind turbines the first three authors’ teams carried out in recent years with the ALE-VMS and ST-VMS methods. The ALE-VMS method is the variational multiscale version of the Arbitrary Lagrangian–Eulerian (ALE) method. The VMS components are from the residual-based VMS (RBVMS) method. The ST-VMS method is the VMS version of the Deforming-Spatial-Domain/Stabilized Space–Time (DSD/SST) method. The techniques complementing these core methods include weak enforcement of the essential boundary conditions, NURBS-based isogeometric analysis, using NURBS basis functions in temporal representation of the rotor motion, mesh motion and also in remeshing, rotation representation with constant angular velocity, Kirchhoff–Love shell modeling of the rotor-blade structure, and full FSI coupling. The analysis cases include the aerodynamics of wind-turbine rotor and tower and the FSI that accounts for the deformation of the rotor blades. The specific wind turbines considered are NREL 5MW, NREL Phase VI and Micon 65/13M, all at full scale, and our analysis for NREL Phase VI and Micon 65/13M includes comparison with the experimental data

A systematic review of conceptualizations and operationalizations of youth polyvictimization

Violence against youth is a global issue impacting millions each year. Increasingly, research has focused on studying those impacted by multiple forms of violence, or polyvictims. Evidence strongly suggests that polyvictimized youth tend to have worse physical and mental health outcomes than those who have experienced single forms of violence. Moreover, minoritized youth (i.e., racial and/or sexual minority youth, youth with disabilities) are more likely to experience polyvictimization, making this a social justice and equity concern. To date, there is no universal consensus on what exactly constitutes polyvictimization. This systematic review aims to examine the ways in which polyvictimization is being studied to inform both research and practice. As such, relevant databases were searched to amass the extant literature related to youth polyvictimization internationally. Empirical studies published since 2006 that focused on youth (under age 18) polyvictimization were included. After the review process, 264 studies met eligibility criteria, however 55 studies employed person-centered/finite mixture analyses and were removed for a separate review, resulting in 209 featured in the current systematic review. Results demonstrate that researchers are defining and operationalizing polyvictimization in different ways: (a) using individual victimization event counts; (b) employing domain-based counts; and (c) taking a “highest-victimized” percentage of their sample. The most used measurement tool was the Juvenile Victimization Questionnaire, though other validated tools and researcher-constructed questions were frequently utilized. Research on polyvictimization is burgeoning worldwide; however, this research is being conducted in disparate ways, making it difficult to compare findings and further advance the field.</p

Relationships between internalized stigma and depression and suicide risk among queer youth in the United States: a systematic review and meta-analysis

Background Queer youth experience high rates of depression and suicidality. These disparities stem from stigma-based stressors, including internalized stigma (i.e., negative social views that minoritized individuals internalize about their own identity). Given the importance of this factor in understanding mental health disparities among queer youth, we completed a systematic review and meta-analysis examining the relationships between internalized stigma and outcomes of depression and suicide risk (i.e., suicidal ideation, non-suicidal self-injury, and suicidal behavior). Methods We followed the PRISMA standards. Six bibliographic databases were searched for studies in the United States from September 2008 to March 2022. Dual independent screening of search results was performed based on a priori inclusion criteria. Results A total of 22 studies were included for data extraction and review. Most studies examined general internalized homophobia, with few examining internalized biphobia or transphobia. Many studies examined depression as an outcome, few studies examined suicidal ideation or behavior, and no studies examined non-suicidal self-injury. Meta-analyses model results show the association between general internalized queer stigma and depressive symptoms ranged r = 0.19, 95% CI [0.14, 0.25] to r = 0.24, 95% CI [0.19, 0.29], the latter reflecting more uniform measures of depression. The association between internalized transphobia and depressive outcomes was small and positive (r = 0.21, 95% CI [−0.24, 0.67]). General internalized queer stigma and suicidal ideation had a very weak positive association (r = 0.07, 95% CI [−0.27, 0.41]) and an even smaller, weaker positive association with suicide attempt (r = 0.02, 95% CI [0.01, 0.03]). Conclusion Implications for clinical practice, policy, and future research are discussed

Relationships between internalized stigma and depression and suicide risk among queer youth in the United States: a systematic review and meta-analysis

BackgroundQueer youth experience high rates of depression and suicidality. These disparities stem from stigma-based stressors, including internalized stigma (i.e., negative social views that minoritized individuals internalize about their own identity). Given the importance of this factor in understanding mental health disparities among queer youth, we completed a systematic review and meta-analysis examining the relationships between internalized stigma and outcomes of depression and suicide risk (i.e., suicidal ideation, non-suicidal self-injury, and suicidal behavior).MethodsWe followed the PRISMA standards. Six bibliographic databases were searched for studies in the United States from September 2008 to March 2022. Dual independent screening of search results was performed based on a priori inclusion criteria.ResultsA total of 22 studies were included for data extraction and review. Most studies examined general internalized homophobia, with few examining internalized biphobia or transphobia. Many studies examined depression as an outcome, few studies examined suicidal ideation or behavior, and no studies examined non-suicidal self-injury. Meta-analyses model results show the association between general internalized queer stigma and depressive symptoms ranged r = 0.19, 95% CI [0.14, 0.25] to r = 0.24, 95% CI [0.19, 0.29], the latter reflecting more uniform measures of depression. The association between internalized transphobia and depressive outcomes was small and positive (r = 0.21, 95% CI [−0.24, 0.67]). General internalized queer stigma and suicidal ideation had a very weak positive association (r = 0.07, 95% CI [−0.27, 0.41]) and an even smaller, weaker positive association with suicide attempt (r = 0.02, 95% CI [0.01, 0.03]).ConclusionImplications for clinical practice, policy, and future research are discussed

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

Hedgehog signaling drives oncogenesis in several cancers and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened. However, resistance to Smoothened inhibitors occurs via genetic changes of Smoothened or other downstream Hedgehog components. Here, we overcome these resistance mechanisms by modulating GLI transcription via inhibition of BET bromodomain proteins. We show the BET bromodomain protein, BRD4, regulates GLI transcription downstream of SMO and SUFU and chromatin immunoprecipitation studies reveal BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites upon treatment with JQ1, a small molecule inhibitor targeting BRD4. Globally, genes associated with medulloblastoma-specific GLI1 binding sites are downregulated in response to JQ1 treatment, supporting direct regulation of GLI activity by BRD4. Notably, patient- and GEMM-derived Hedgehog-driven tumors (basal cell carcinoma, medulloblastoma and atypical teratoid/rhabdoid tumor) respond to JQ1 even when harboring genetic lesions rendering them resistant to Smoothened antagonists

Perspectives on Immunoglobulins in Colostrum and Milk

Immunoglobulins form an important component of the immunological activity found in milk and colostrum. They are central to the immunological link that occurs when the mother transfers passive immunity to the offspring. The mechanism of transfer varies among mammalian species. Cattle provide a readily available immune rich colostrum and milk in large quantities, making those secretions important potential sources of immune products that may benefit humans. Immune milk is a term used to describe a range of products of the bovine mammary gland that have been tested against several human diseases. The use of colostrum or milk as a source of immunoglobulins, whether intended for the neonate of the species producing the secretion or for a different species, can be viewed in the context of the types of immunoglobulins in the secretion, the mechanisms by which the immunoglobulins are secreted, and the mechanisms by which the neonate or adult consuming the milk then gains immunological benefit. The stability of immunoglobulins as they undergo processing in the milk, or undergo digestion in the intestine, is an additional consideration for evaluating the value of milk immunoglobulins. This review summarizes the fundamental knowledge of immunoglobulins found in colostrum, milk, and immune milk

Analytical solution to a simplified circulatory model using piecewise linear elastance function

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.Includes bibliographical references (p. 105-106).by Jinn Jiau Spenser Chen.S.M

Computational Wind-Turbine Analysis with the ALE-VMS and ST-VMS Methods

We provide an overview of the aerodynamic and FSI analysis of wind turbines the first three authors’ teams carried out in recent years with the ALE-VMS and ST-VMS methods. The ALE-VMS method is the variational multiscale version of the Arbitrary Lagrangian–Eulerian (ALE) method. The VMS components are from the residual-based VMS (RBVMS) method. The ST-VMS method is the VMS version of the Deforming-Spatial-Domain/Stabilized Space–Time (DSD/SST) method. The techniques complementing these core methods include weak enforcement of the essential boundary conditions, NURBS-based isogeometric analysis, using NURBS basis functions in temporal representation of the rotor motion, mesh motion and also in remeshing, rotation representation with constant angular velocity, Kirchhoff–Love shell modeling of the rotor-blade structure, and full FSI coupling. The analysis cases include the aerodynamics of wind-turbine rotor and tower and the FSI that accounts for the deformation of the rotor blades. The specific wind turbines considered are NREL 5MW, NREL Phase VI and Micon 65/13M, all at full scale, and our analysis for NREL Phase VI and Micon 65/13M includes comparison with the experimental data.This is a chapter from Bazilevs Y., Takizawa K., Tezduyar T.E., Hsu MC., Kostov N., McIntyre S. "Computational Wind-Turbine Analysis with the ALE-VMS and ST-VMS Methods." In: Idelsohn S. (ed.) Numerical Simulations of Coupled Problems in Engineering. Computational Methods in Applied Sciences 33 (2014): 355-386. DOI: 10.1007/978-3-319-06136-8_14. Posted with permission.</p